--- Log opened Mon Feb 17 00:00:20 2025
02:04 -!- justanotheruser [~justanoth@gateway/tor-sasl/justanotheruser] has quit [Quit: justanotheruser]
02:31 -!- darsie [~darsie@84-113-82-174.cable.dynamic.surfer.at] has joined #hplusroadmap
03:37 < L29Ah> what's up with libgen?
03:43 < L29Ah> fenn: the off switch is located in the bone marrow
03:51 < fenn> i mean the off switch for just the part that's misbehaving
03:53 < fenn> https://open-slum.org/
03:54 < fenn> .t
03:54 < saxo> SLUM: The Shadow Library Uptime Monitor
03:59 -!- yorick [~yorick@user/yorick] has quit [Ping timeout: 265 seconds]
03:59 < fenn> there actually *are* de-sensitizing protocols for allergies, but i don't know how that works at a low level
04:14 < L29Ah> and they often don't work
04:20 < fenn> but if they do work sometimes it means there is a way to desensitize, short of dying or radiation / chemo + marrow transplant
04:23 < fenn> .t https://www.shroomery.org/forums/showflat.php/Number/19247881
04:23 < saxo> Cat allergies diminished by use of LSD - The Pub - Shroomery Message Board
04:23 < fenn> (lots of annoying animated gifs)
04:27 < L29Ah> fenn: what i mean, is that if you can push your new antigen-presenting cells into the bone marrow, you will eliminate undesired antibody production, afaik
04:29 < L29Ah> meanwhile i wonder how does fetomaternal microchimerism work
04:34 -!- yorick [~yorick@user/yorick] has joined #hplusroadmap
04:36 < fenn> https://en.wikipedia.org/wiki/Tolerogenic_dendritic_cell
04:37 < fenn> "Mouse models have suggested that modulation of Treg cells can treat autoimmune disease and cancer and can facilitate organ transplantation and wound healing"
04:38 < fenn> why only mouse
04:39 -!- andytoshi [~apoelstra@user/andytoshi] has quit [Ping timeout: 252 seconds]
04:42 < fenn> .t https://pmc.ncbi.nlm.nih.gov/articles/PMC3714563/
04:42 < saxo> Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se - PMC
04:45 < fenn> what a rabbit hole. one could spend years reading about this stuff and never get anywhere
04:45 -!- andytoshi [~apoelstra@user/andytoshi] has joined #hplusroadmap
04:47 < fenn> "how does fetomaternal microchimerism work" <- you mean why doesn't the mother's immune system instantly kill the invading fetal cells?
04:53 < fenn> llama tells me: PD-L1 on the surface of placental cells, increased anti-inflammatory cytokines such as IL-10 and TGF-β, hCG and progesterone, Fetal cells may undergo epigenetic modifications that reduce their immunogenicity, are often immature and lack the expression of co-stimulatory molecules, making them less immunogenic.
05:08 < L29Ah> yeah
05:11 < L29Ah> medllama3-v20.i1-Q5_K_M 🤖💬: The mother’s immune system does not kill the fetal cells involved with fetomaternal microchimerism because the cells that cross the placenta and remain in the mother’s body after pregnancy are mostly cells that are derived from the yolk sac, rather than the three primary germ cell layers. These cells are immunologically compatible with the mother and will not elici
05:11 < L29Ah> t an immune response.
06:19 -!- darsie [~darsie@84-113-82-174.cable.dynamic.surfer.at] has quit [Remote host closed the connection]
06:20 -!- darsie [~darsie@84-113-82-174.cable.dynamic.surfer.at] has joined #hplusroadmap
06:52 -!- streety [~streety@176-58-127-93.ip.linodeusercontent.com] has quit [Quit: ZNC 1.8.2 - https://znc.in]
06:53 -!- streety [~streety@176-58-127-93.ip.linodeusercontent.com] has joined #hplusroadmap
07:03 -!- justanotheruser [~justanoth@gateway/tor-sasl/justanotheruser] has joined #hplusroadmap
13:15 -!- TMM [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.]
13:15 -!- TMM [hp@amanda.tmm.cx] has joined #hplusroadmap
16:08 < L29Ah> https://zrthstr.github.io/libgen_torrent_cardiography/index.html libgen torrent index, can sort by seeders
16:44 -!- andytoshi [~apoelstra@user/andytoshi] has quit [Ping timeout: 244 seconds]
16:51 -!- andytoshi [~apoelstra@user/andytoshi] has joined #hplusroadmap
17:05 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has quit [Ping timeout: 260 seconds]
17:10 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has joined #hplusroadmap
19:45 -!- darsie [~darsie@84-113-82-174.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds]
20:24 -!- andytoshi [~apoelstra@user/andytoshi] has quit [Ping timeout: 244 seconds]
20:30 -!- andytoshi [~apoelstra@user/andytoshi] has joined #hplusroadmap
20:47 -!- justanotheruser [~justanoth@gateway/tor-sasl/justanotheruser] has quit [Ping timeout: 264 seconds]
21:19 -!- justanotheruser [~justanoth@gateway/tor-sasl/justanotheruser] has joined #hplusroadmap
21:57 -!- superz [~superegg@user/superegg] has quit [Ping timeout: 260 seconds]
21:57 -!- superz [~superegg@user/superegg] has joined #hplusroadmap
21:59 -!- NewtonTrendy [Newton@user/bopqod] has joined #hplusroadmap
23:39 -!- gl00ten [~gl00ten@2001:8a0:7ee5:7800:46d9:f5c:17a2:432] has joined #hplusroadmap
--- Log closed Tue Feb 18 00:00:21 2025