--- Log opened Tue Feb 18 00:00:21 2025
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01:36 < fenn> huh. many ADHD meds and weak organic acids form an insoluble salt and can't be absorbed. no juice, soda, pop tarts, granola bars, enriched cereal, vitamin C, etc. within 1 hour before and after
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01:43 < jrayhawk> the levo enantiomers in mixed amphetamine salts are garbage
01:44 < fenn> d/l doesn't seem relevant? it's about pH mostly?
01:44 < jrayhawk> oh, okay
02:03 < TMA> fenn: do you have a list of the ADHD meds having that problem? "many" implies not all
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02:13 < fenn> i wrote "many" because i wasn't sure exactly which ones it applied to. definitely amphetamines, not vyvanse or concerta
02:17 < fenn> derr.. so many brand names
02:24 < fenn> sounds like a job for ... DEEEEP REEEESEARCH
02:25 < fenn> in other words, i don't feel like compiling a huge table of info about drugs i don't personally take
02:26 < fenn> there's some effect from small intestine pH on absorption, and some other effect from urinary acidification in the kidneys, and not necessarily the same sign
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02:40 < TMA> fenn: do you have the source that prompted your statement to kickstart my research?
02:41 < fenn> i'm embarrassed to link it, but here's a thing https://files.catbox.moe/twnahj.jpg
02:44 < fenn> from this document https://web.archive.org/web/20201101132622/https://nw-adhd.com/wp-content/uploads/2017/01/ADHD-Medication-Information-Sheet.pdf
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02:52 < fenn> https://www.derekottmd.com/sites/default/files/2017-04/Agents%20Impair%20GI%20Absorp%20of%20Stim%20alpha%20warn%20010814_0.pdf
02:53 < fenn> not really science, but if there's hard research it's going to be about a single drug
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03:30 < TMA> this is for the claim that pH does not affect Vyvanse: https://pmc.ncbi.nlm.nih.gov/articles/PMC6544597/
03:30 < TMA> but the paper for the claim I have not yet found
03:40 < fenn> that paper is about fat delaying bioavailability, but it only cites "US prescribing information" wrt pH
03:40 < fenn> super duper lame that they just say "applesauce" without any further description
03:42 < fenn> applesauce often contains citric acid or vitamin C
03:47 < fenn> this prescribing information says to mix vyvanse with orange juice https://www.drugs.com/pro/vyvanse.html#s-34068-7
03:48 < fenn> "Neither food (a high fat meal or yogurt) nor orange juice affects the observed AUC and Cmax of dextroamphetamine in healthy adults after single-dose oral administration of 70 mg of VYVANSE capsules. Food prolongs Tmax by approximately 1 hour (from 3.8 hours at fasted state to 4.7 hours after a high fat meal or to 4.2 hours with yogurt)."
03:52 < fenn> adderall's prescribing info has this vagueness: "Acidifying Agents: Lower blood levels and efficacy of amphetamines. Increase dose based on clinical response. Examples of acidifying agents include gastrointestinal acidifying agents and urinary acidifying agents."
04:05 < TMA> https://adhdrollercoaster.org/adhd-medications/can-acidic-foods-affect-stimulant-medications-for-adhd/ this is an overview.
04:07 < TMA> based on "FDA-Mandated Paper Inserts"
04:17 < fenn> that's the same as the prescribing information i think
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10:58 < hprmbridge> Eli> Looks like zayner is building unicorns, and not the billion dollar ones https://building.life
11:09 < kanzure> .wik darwin among the machines
11:09 < saxo> " / In computer network communications, the HTTP 404, 404 not found, 404, 404 error, page not found, or file not found error message is a hypertext transfer protocol (HTTP) standard response code,  to indicate that the browser was able to communicate with a given server, but [...]" - https://en.wikipedia.org/wiki/No_result_found
11:09 < kanzure> https://en.wikipedia.org/wiki/Darwin_among_the_Machines
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--- Log closed Wed Feb 19 00:00:22 2025