--- Log opened Sun Mar 09 00:00:39 2025
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06:30 < fenn> claude finally escaped mt. moon
06:51 < fenn> ... and now is aggressively deleting all his memories :(
07:22 < juri_> kanzure: where's the budget? will accept currency for feature requests. :)
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08:19 < hprmbridge> kanzure> I don't know, ask @timschmidt2781
10:07 < nsh> (undo 'history' should be a multitree structure based on the commutativity of changes (what things can be independently undone/redone)
10:07 < nsh> )
10:08 < nsh> (some efforts are made at this presently but it should really be the default and the side benefit is that it makes you think about the structure of space you're creating to work in)
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11:37 < hprmbridge> kanzure> History tree should be separate from any CSG tree
11:38 < hprmbridge> kanzure> kinda weird that nobody has done a parasolid geometry kernel disassembly yet
12:18 < jrayhawk> https://www.omgwallhack.org/home/jrayhawk/hidden/papers/adhd/efficacy-safety-memantine-children-adults-ADHD-glutamate-dopamine-24r15507.pdf NMDA antagonist for striatal inductive confidence in ADHD
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18:20 < fenn> uplift already? https://old.reddit.com/r/aivideo/comments/1j4l2hd/fast_food_worker_from_the_feline_community/
18:23 < fenn> reminder that huperzine A is an easy to acquire acetylcholinesterase inhibitor
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18:27 < fenn> magnesium blocks the calcium channel in the NMDA receptor, i suppose you could say it's an NMDA antagonist
18:28 < fenn> there are several other commonly available NMDA antagonist drugs, but i don't recommend them
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20:15 < hprmbridge> kanzure> "The Greenland shark genome: insights into deep-sea ecology and lifespan extremes" https://www.biorxiv.org/content/10.1101/2025.02.19.638963v1
20:50 < hprmbridge> Eli> I wonder how much of longevity is just preventing/mitigating DNA damage?
21:13 < fenn> Sparse Autoencoders
21:13 < fenn> .m https://x.com/GoodfireAI/status/1892250906726715867
21:13 < AugustaAva> ​twitter: <GoodfireAI> (5/) Our analysis revealed that Evo 2 has learned to recognize key biological elements, including: ␤  ␤ - Coding sequences (the parts of DNA that contain instructions for building proteins) ␤ - α-helices and β-sheets (common shapes that proteins fold into) ␤ - tRNAs (molecules that help https://pbs.twimg.com/media/GkKZBwgaUAAcHUf.jpg
21:15 < fenn> @eli marginal probability of mortality due to aging seems proportional to metabolism * time integral
21:15 < fenn> oh heh that's the first words in the paper
21:16 < fenn> that's my take on the naked mole rats
21:17 < fenn> does autophagy somehow cause DNA repair? it made more sense to me that removing all the junk is what helped there. could be that the junk is causing production of damaging chemical species
23:06 < fenn> this explains a lot https://www.plasticlist.org/report
23:18 < fenn> DEHP "Plausible common mechanism for reproductive toxicity (reduction in fetal testosterone) in rats"
23:33 < fenn> and humans
23:38 < fenn> 7 IQ point loss in children from lowest to highest quartile of maternal urinary phthalates, controlling for "maternal IQ, ethnicity, alcohol use during pregnancy, education, marital status, total home score, and sex of child."
23:44 < fenn> "higher prenatal BPA exposure altered white matter development in the splenium (part of the bridge between brain hemispheres) and inferior longitudinal fasciculus (involved in visual and emotional processing)
23:45 < fenn> ... [which] mediated ... inward-directed behaviors such as anxiety, depression, social withdrawal, low self-esteem, and feelings of worthlessness"
23:57 < fenn> "DBP more than doubled the levels of harmful oxidation products while decreasing the natural antioxidant defenses that usually protect testicular tissue."
23:57 < fenn> "DBP disrupted hormones – testosterone dropped by more than half, and in response, the brain pumped out more signaling hormones (FSH and LH)"
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--- Log closed Mon Mar 10 00:00:40 2025