--- Log opened Mon Mar 24 00:00:55 2025
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05:55 < geneh2> extropic has a little ARG on their twitter feed https://x.com/Extropic_AI
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07:02 < fenn> "You're saying I can decrypt blurred text with my eyeballs?" "When you're ready, you won't have to."
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09:19 < juri_> can confirm?
09:22 < juri_> I used to have a much larger facility full of computer equipment. I was also made intimately familiar with gabor filters as a part of a stamp recognition project, for a banking company. When I had truely internalized how gabor filters worked, I looked through my memory and found three things I had lost, by recognizing the "blurry" version of it in my own recollection.
09:22 < juri_> went right to them.
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12:18 < nsh> GABORGABORGABOR
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21:08 < fenn> https://apnews.com/article/23andme-chapter-11-bankruptcy-wojcicki-resigns-9827549d9171a537e76f60cb950d1823
23:28 < jrayhawk> 23andme always seemed like a stupid product cynically marketed to stupid people. why didn't they use their piles of investment money to transition from genotyping to whole-genome sequencing?
23:30 < nsh> science is hard and medicine is justifiable well-regulated
23:30 < nsh> +bly
23:31 < nsh> they latched onto about the laziest thing you could do with the affordability of better-than-nothing genetic typing and did a venture of capitalism, which ran its course inevitably due to lack of further imagination and initiative. 
23:32 < nsh> they could have built strong partnerships with people who have the industry savvy and domain knowledge and just acted as a customer relations and economy of scale for large-scale slurping of the genetic data but i think it was probably premature wrt to the applications
23:33 < nsh> i have a vested interest in staying healthily alive for some time yet but i am not convinced giving a swab to some cowboys is going to achieve much return toward that end 
23:34 < nsh> if you actually condensed all the things you can practically at this present moment in time do wrt to prognosis genetically into a scalable package it would be great offering (also, but sadly this is not a deal-breaker for people yet, if the customer regained agency over onwards usage of the data)
23:35 < nsh> but it's all dispersed at various cutting edges of medicine presumably
23:35 < nsh> and peripheral thereto (where it's even harder to productise)
23:36 < jrayhawk> even the simplest severity-indexed cross-reference to SNPedia is plenty actionable for most people; that's not a limiting factor
23:38 < jrayhawk> marketing that actionability without the FDA crushing you is another story
23:40  * nsh nods
23:41 < nsh> most people aren't gonna action it themselves though, you need to integrate that indicative information into some person with a white coat who tells you what to do or through whom you can pursue further diagnostics
23:41 < nsh> maybe you'll see more kinds of health tourism
23:42 < nsh> (analogous to e.g. in dental, where there's economic, availability and regulatory arbitrage)
23:51 < fenn> so is this just measuring the covariates of health-conscious behavior or what? https://www.nature.com/articles/s41591-025-03570-5
23:52 < fenn> lots of things don't make sense to me about fig 3 and fig 4
23:52 < fenn> and both figures together don't make sense
23:53 < fenn> apparently i should be chugging canola oil
23:54 < jrayhawk> also food frequency questionnaires are garbage with people filling in the gaps of memory with self-serving narratives of virtuous behavior, which turns this into a closed-loop epistemology
23:55 < fenn> yes my first instinct was to ask "is this completely made up" but i didn't want to accuse anyone of fraud without evidence
23:56 < fenn> it's "fine" if the study subjects do the fraud for you :\
--- Log closed Tue Mar 25 00:00:55 2025