--- Log opened Mon May 19 00:00:47 2025
00:45 < fenn> just getting the LLM to translate greek letters to english words was 90% of the way there
00:52 < fenn> omniSVG model weights to be released "in june" supposedly :\
00:52 < fenn> in the meanwhile there's starvector
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06:29 < hprmbridge> kanzure> "deep tissue in vivo sono-printing" https://www.science.org/doi/10.1126/science.adt0293
06:30 < hprmbridge> kanzure> maybe you can do selective blood vessel blockage to tumors?
06:36 < hprmbridge> kanzure> targeted tumor encapsulation, possibly create or reinforce or enhance blood vessels for delivering blood to ischemic tissue, print slow release drug bladders (then do needle injection to fill it), uhh possibly multi round polymerization techniques
06:38 < hprmbridge> kanzure> maybe useless; you might be able to get polymeric structure that can collapse and be needle injectable and then re-expand to their original shape. then you don't need acoustic polymerization techniques.
06:39 < hprmbridge> kanzure> if you could deliver the material with embedded stem cells then you might have something
07:43 < RangerMauve> Anyone try glycene supplements for sleep?
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09:48 < hprmbridge> alonzoc> No but i've had some good experiences with creatine and L-theanine. I've noticed when I do take creatine I wake up much faster and don't oversleep as much and that L-theanine helps me get to sleep
10:12 < RangerMauve> Interesting. I've tried L-theanine for about a week but I didn't notice any visible differences.
10:14 < L29Ah> RangerMauve: i'm not convinced supplementing a specific common amino acid makes sense in otherwise complete-protein-rich diet 
10:17 < RangerMauve> L29Ah Yeah, that's kinda why I ask. I'm also not sure I understand whether oral intake of supplemental glycine is viable. This paper seems to indicate it makes a difference: https://pmc.ncbi.nlm.nih.gov/articles/PMC3328957/ Sadly I don't have enough context to determine if it's full of shit or legit.
10:23 < L29Ah> i sledgehammer my DSPS with routine morning caffeine
10:28 < jrayhawk> glycine is a competitive inhibitor of GABA uptake and additionally buffers methyl groups (as trimethylglycine) in the methylation cycle, making them unavailable for use in tetrahydrobiopterin or COMT for use in producing or breaking down monoamines
10:29 < hprmbridge> alonzoc> Ahh the correct way to manage a messed up sleep cycle. Copius caffine intake
10:29 < jrayhawk> l-theanine being a GABA receptor target
10:30 < RangerMauve> So more glycine would make l-theanine less effective?
10:30 < RangerMauve> Is ther a mapping of these pathways to higher level language like "This will make you tired"? 😅
10:31 < jrayhawk> yes, but it also undermines melatonin and norepinephrine production/management, so the effects are partially dependent upon genetics
10:32 < jrayhawk> the opposite process takes place in turkey dinners, where supraphysiologic ratios of methionine-to-glycine converts available glycine into TMG, leaving GABA competitively unhinhibited
10:34 < L29Ah> RangerMauve: you can be "tired" in several different ways
10:35 < hprmbridge> alonzoc> The impact of turkey dinners on biochemical pathways related to sleep... If I didn't have some minor existing knowledge I'd be convinced that's a joke
10:36 < hprmbridge> alonzoc> L29Ah: Is there a "best" way to be tired for health purposes then?
10:36 < jrayhawk> depends on your genetics
10:38 < jrayhawk> the methylation cycle and GABA are certainly reasonable places to start the process of research, observation, hypothesis, and experimentation
10:40 < hprmbridge> alonzoc> Ahh the solution to all personal health, informed trial and error
10:40 < RangerMauve> What I'm hearing too is I'd need to collect some data on what my baseline "tired" is before the adjustment along different types of tired to know for sure if it does anything?
10:41 < RangerMauve> I guess I could steal the tests from the study to see if I can recreate it :P https://pmc.ncbi.nlm.nih.gov/articles/PMC3328957/
10:42 < jrayhawk> you can also self-blind pill-taking using marked containers, gwern-style, for later analysis.
10:43 < RangerMauve> ooo, that's a good idea
10:43 < RangerMauve> Have you done experiments on yourself that way before?
10:43 < jrayhawk> No, I lack that sort of discipline.
10:43 < RangerMauve> Mood
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11:06 < RangerMauve> I think I'm gonna start by making a lil app for collecting data
11:06 < L29Ah> vim?
11:07 < RangerMauve> Lol no. Probs a p2p webapp.
11:08  * L29Ah feels maslow's hammer
11:13 < RangerMauve> It just happens to be the easiest way for me to do offline syncable stuff between my devices. 😅
11:27 < L29Ah> install syncthing?
11:43 < RangerMauve> It's funny because that's actually more of a PITA for me to set up / maintain. 🤪
11:51 < L29Ah> sounds crazy to me, syncthing is present in all them repos and is quite quick to set up
11:51 < L29Ah> and solves lots of other problems like getting photos from your smartphone to your laptop
11:52 < RangerMauve> Yup! I an intimately familiar with the different options for synchronizing files / data.
11:52 < RangerMauve> I am a "domain expert" for such things, actually
11:56 < RangerMauve> To clarify: I want to have cross platform authoring without needing servers or dealing with merge conflicts. Syncthing sucks for that use case. 🤷
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12:51 < hprmbridge> Eli> I take magnesium glycinate. First time I took it it was like being knocked out with a baseball bat. So I was probably magnesium or glycine depleted. Dunno. 🤷 the effect attenuated and now I don’t immediately crash. I do take mg and k when my muscles are tight. But a big component is probably genetic. My nervous system is already pretty jacked up and I take lamictal. For some people who take mg
12:51 < hprmbridge> Eli> they have negative side effects (sounds weird I know). Until we can make accurate predictions with biology, a lot of it is going to be trial and error.
12:53  * L29Ah takes magnesium chloride as a laxative with magnesium top-up bonus feature
12:55 < hprmbridge> Eli> Supposedly most Americans are mg depleted. Most common deficiency. Considering the price and safety profile, it’s not a terrible idea to take it. I notice performance benefits in the gym. Pretty helpful to calm tense muscles too.
12:58 < hprmbridge> Eli> Actually vit d might be the biggest deficiency. But thats probably somewhat dependent on location/lifestyle.
13:17 < kanzure> "Avoid letting it search - even halt it. Find / rg can have a thousands of tokens of output depending on the search." oh yeah
13:17 < kanzure> "The cache also goes away after 5-15 minutes or so (not sure) - so avoid leaving sessions open and coming back later."
13:17 < kanzure> "Never edit files manually during a session (that'll bust cache). THIS INCLUDES LINT."
13:30 < L29Ah> not sure if llm coding advices or irony
14:18 < hprmbridge> nmz787> fleeky: biotech + semiconductor.
14:59 < hprmbridge> nmz787> https://zdnet.co.kr/view/?no=20250311174600
14:59 < hprmbridge> nmz787> """US AI semiconductor startup Grok signed a contract with Samsung Electronics for mass production of the SF4X process in the second half of 2023. """
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15:12 < hprmbridge> kanzure> if it was 2023 then it might refer to groq not grok
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18:00 < hprmbridge> nmz787> I think it's just Korean typo
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--- Log closed Tue May 20 00:00:48 2025