--- Log opened Sun Jun 01 00:00:59 2025
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08:49 < hprmbridge> Eli> I don’t want to be too harsh, because this is just the beginning of AI in science. But I feel like hypothesis generation is not the blocker in science. It seems to me that not having enough money is the blocker. I have hypotheses rn that I would like grant money for to do trials for that I think could work. It seems like a lot of science is just researchers being salesmen and telling the
08:49 < hprmbridge> Eli> government they can cure everything. And then the government rejecting your proposals. But I’m not very smart, so i don’t really know. 🤷
08:52 < hprmbridge> Eli> Maybe robots can start doing all the in vitro stuff and that can bring down costs. And I’m guessing AI speeds up all the bioinformatics stuff. Alphafold probably speeds up the medicinal chemistry stuff, but afaik we were already pretty fast at that. Maybe it’s just better at finding possible drugs with less sides.
08:55 < jrayhawk> "Phase 3 trials, particularly those required for FDA approval, may cost a median of $41,117 per patient."
09:15 < kanzure> science has even deeper structural problems than that, even the grant-based infrastructure is sort of bizarre
09:23 < hprmbridge> Eli> Yeah I haven’t personally met any scientists who don’t have criticisms of the system. I can think of a few things off the top of my head that would improve things. And I sure others have ideas as well
09:28 < hprmbridge> kanzure> the other issue is that a lot of the biosciences are focused on disease, which certainly deserves some amount of investigation, but there's a whole aspect of 'positive' science that barely exists
09:31 < jrayhawk> the 'negative' science is also a huge waste for having normed on multifactorial unhealth as a starting place for investigating the causes of unhealth
09:35 < hprmbridge> kanzure> also science would have more money if we admit it's okay to do science in the name of money or profit
09:35 < L29Ah> who doesn't?
09:35 < hprmbridge> kanzure> and allowed research that is likely to make lots of money, but currently against 'ethics'
09:36 < L29Ah> ah
09:36 < hprmbridge> kanzure> all of academia tries to act like it's for charity
09:36 < hprmbridge> kanzure> it's a deeply confused mindset
09:36 < hprmbridge> kanzure> science is for the service to human markets and human goods, services, not our bioethicists feelings
10:26 < hprmbridge> norkatron> fund it with crypto pump and dump?
10:27 < hprmbridge> norkatron> use gambling addiction for the betterment of society
10:33 < L29Ah> yes don't forget to buy Montelibero tokens guys
12:42 < hprmbridge> kanzure> "TMEM63B functions as a mammalian hyperosmolar sensor for thirst" https://www.cell.com/neuron/abstract/S0896-6273(25)00130-8
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17:12 < fenn> typical weirdness on the sun by goode solar observatory https://nso1.b-cdn.net/wp-content/uploads/2025/05/Prominence-2-Video.mp4
17:13 < hprmbridge> kanzure> why is this not stereoscopic
17:13 < fenn> because we only have one planet with telescopes on it
17:14 < hprmbridge> kanzure> oh shit
17:14 < fenn> there is a stereo solar spacecraft but its optics aren't as good
17:14 < fenn> pair of spacecraft i mean
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--- Log closed Mon Jun 02 00:00:00 2025