--- Log opened Wed Jun 11 00:00:09 2025
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07:13 < hprmbridge> nmz787> Air bearings?
07:14 < hprmbridge> kanzure> you really believe in an invisible gas all around you at all times?
07:59 < hprmbridge> lordkek__> Stupid question but I want to ask:
07:59 < hprmbridge> lordkek__> Activation of Cellular Repair Mechanisms by one-electron exchange/donation
07:59 < hprmbridge> lordkek__>
07:59 < hprmbridge> lordkek__> cooperation between cells through gap junctions and the use of one-electron donors and acceptors allow for coordinated response to stress. Through these processes, cells repair damage, restore function, and protect themselves against future insults.
07:59 < hprmbridge> lordkek__>
07:59 < hprmbridge> lordkek__> the one-electron donation mechanism extends across gap junctions, where neighboring cells donate or receive electrons. (intracellular signaling, influence neighboring cells)
07:59 < hprmbridge> lordkek__>
07:59 < hprmbridge> lordkek__> Oxidative damage disrupts membrane potential and energy production, creating a cellular energy crisis and oxidative stress. (The cell detects these disruptions through changes in membrane potential…)
07:59 < hprmbridge> lordkek__>
07:59 < hprmbridge> lordkek__> exchange of electrons between cells might be seen as?
07:59 < hprmbridge> lordkek__>
07:59 < hprmbridge> lordkek__> The periodic electron exchange could lead to?
07:59 < hprmbridge> lordkek__>
07:59 < hprmbridge> lordkek__> Periodic electron exchange between cells, even when cell functions are normal, would likely be perceived by the body as?
10:08 < jrayhawk> you'll have to be more specific. "electron donation" can mean just about anything.
10:10 < hprmbridge> nmz787> Electrons move around all the time
10:11 < hprmbridge> nmz787> My body sometimes sees it as a car heading towards me
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11:01 < hprmbridge> nmz787> Giving a beggar electrons isn't alms, it's ohms
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17:54 < hprmbridge> kanzure> This study proposes a directed evolution framework to induce and identify anatomically localized memory storage within the mammalian brain, enabling the surgical extraction and functional transplantation of engram-containing neural tissue across conspecific individuals. The primary objective is to generate a lineage in which discrete brain regions harbor stable, modular memory engrams, such that
17:54 < hprmbridge> kanzure> lesioning those regions leads to selective amnesia and their transplantation into naïve hosts results in phenotypic expression of donor-acquired knowledge. Using murine models subjected to classical and operant conditioning paradigms, we will implement iterative selection across generations, based on post-lesion behavioral retention assays and histological validation of engram localization via
17:54 < hprmbridge> kanzure> activity-dependent markers (e.g., c-Fos, Arc) and optogenetic tagging. Targeted microlesion surgeries, coupled with high-resolution in vivo calcium imaging and transcriptomic profiling, will be employed to identify regions demonstrating robust, heritable memory-specific functional localization. Once such neural substrates are established, stereotaxic transplantation will be performed, followed by
17:54 < hprmbridge> kanzure> post-operative integration monitoring and cognitive testing in recipient animals to evaluate inter-animal mnemonic transfer.
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17:58 < L29Ah> bullshit bingo
18:01 < hprmbridge> kanzure> should use neurotrophic bacteria instead, and subject those to selection pressures. much faster iteration than mouse pups.
18:07 < L29Ah> https://www.lifespan.io/news/new-study-could-pave-the-way-for-better-cancer-vaccines/ now that's good news
19:38 < hprmbridge> kanzure> "Ultra-wide-field, deep, adaptive two-photon microscopy" https://www.biorxiv.org/content/10.1101/2025.06.07.658419v2
19:49 < hprmbridge> kanzure> "Megabase-scale human genome rearrangement with programmable bridge recombinases" https://www.biorxiv.org/content/10.1101/2025.05.14.653916v2
19:49 < hprmbridge> kanzure> "Reprogramming site-specific retrotransposon activity to new DNA sites" https://www.nature.com/articles/s41586-025-08877-4#Sec10
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--- Log closed Thu Jun 12 00:00:10 2025