--- Log opened Fri Jun 20 00:00:17 2025
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05:09 < hprmbridge> kanzure> has there been published a good description of the chemist's approach to atomic precision manufacturing? where a molecular structure is built up by iterative chemical reaction possibly in bulk, or possibly in single molecule chemistry?
05:27 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1385597024409223168/Screenshot_20250620-072725.png?ex=6856a549&is=685553c9&hm=4152790c025f162fc585a1b6366243a3b3d9f91796dd532b4755b6ee0dcf9fd2&
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06:56 < kanzure> we should just do that, but with small molecule payloads, or single atom payloads, then covalent bond on the left side and the right side, and then acid remove or otherwise cleave the linkres and oligonucleotides or nucleic acid polymers.
06:57 < fenn> nanowires and semiconductors to make self assembling circuits
06:58 < kanzure> from that you can get linear sequence-programmable molecular chains, possibly atom chains. besides david liu's 2013 publication on DNA templated non-nucleic-acid polymer synthesis, there was also the stratos genomics roche xpandomer chemistry where nucleic acids were used to deliver a molecule, then cleave everything off. (granted, their molecular payload is intentionally enormous!)
06:59 < kanzure> yeah there's probably other ways to get single-atom-wide or single-molecule-wide nanowires, although those are likely mono-monomerics? i haven't checked if anyone has made sequence-controlled nanowires with different molecules or atoms mixed into the chain-- maybe stochiometrically....
07:52 < hprmbridge> nmz787> There was some src research, I think UCSB was the group working on it, that was making combinations of dna sequences and testing their resistance
07:55 < hprmbridge> nmz787> Electronic Properties of DNA Origami Nanostructures Revealed by In Silico Calculations - PMC https://share.google/Kah8EOFVTQeoJLyIq
07:59 < hprmbridge> nmz787> Mapping DNA Conformations Using Single-Molecule Conductance Measurements - PMC https://share.google/qHPXQhgfvezdKKmgy
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09:18 < kanzure> pretty sure the logarthmic graph sampling protocol that i posted is very wrong, although i don't know enough graph theory to say why
09:19 < kanzure> using humans for inference-making is nice, although maybe overkill (meetings are extremely expensive). no social networking platform has tried basic self-tagged interest clustering, which would be cheaper than meetings.
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09:22 < kanzure> sports brackets or the political organization thing where you use hierarchical political representatives may be able to get more meaningful graph coverage and mixed matchmaking, although only if the participants can be correctly low-dimensionally classified i think?
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12:17 < juri_> kanzure: i remember you having similar discussions to this, a decade ago. you haven't just started building your own mutant lab gear in the meanwhile?
12:29 < kanzure> I apologize that things are not moving fast enough for you. But fear not, many people are telling me we're in the middle of a singularity so exponential time compression should be happening annnny moment now.
12:29 < juri_> sweeet. carry on then. ;)
12:29 < kanzure> ---
12:29 < kanzure> Bitcoin is fundamentally coming from a trustless verification-driven ideal, but in practice very few people can operate completely independently of trust. Even the most technically literate developers are still relying on layers of abstraction that may hide sources of trust: compilers, hardware, libraries, ambiguous programming languages with undefined behaviors, etc. So in that sense, some ...
12:29 < kanzure> ...trust might be presently unavoidable. And then the game changes to be more about identifying trust, minimizing trust, opt-in or out of certain trusted assumptions, and being able to reason about trust and who and why you are trusting, rather than eliminating trust from the system. Making trust optional, opt-in, and examinable is a large improvement from opaque trust-based institutions, even if ...
12:29 < kanzure> ...it doesn't get you all the way to the bitcoin verification standard. Formal verification all the way up and down the stack would be a wonderful outcome, but in our civilization we're just not there yet. I worry though that for trustcels we may not even be to the point of being able to accurately map out all the trust they are employing, either. There's so much trust stuffed into everyday life ...
12:30 < kanzure> ...that it may not be possible to catalog and identify all of it, much less all that goes on behind closed doors in our trusted institutions throughout society....
12:30 < kanzure> it would be interesting to have a "trust linter" for cognitive security (cogsec), as an alternative tool or adjacent tool to "formal verification"
12:30 < juri_> (minor update: my personal lab has grown an in-process-of-repair varian 3400 gas chromatograph)
12:34 < hprmbridge> nmz787> I was thinking about fractals recently, and how all the quantum reality stuff tells us things are all just statistical likelihoods of truth... and now with AI "fake" news/image/video... it sort of made the quantum statistical stuff more macro-apparent
12:35 < hprmbridge> nmz787> it felt sort of like a fractal appeared at the macro level as a result.... macro reflecting the micro/nano quantum-physics that we've been told for decades
14:00 < kanzure> https://diyhpl.us/~bryan/irc/chatgpt/trustlint.txt
14:02 < kanzure> the telemetry tie-in is a bit weird, not sure how to reconcile that with the OWL ontology stuff, but otherwise an interesting idea.
14:03 < kanzure> for shipments and logistics, you just get the certificate from the logistics company and make sure they sign off on the shipment or something, or you might require them to use trustlint too, and provide you a trustlint file that you incorporate into your trustlint supply chain
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18:16 < hprmbridge> kanzure> old https://www.cato-unbound.org/2009/04/13/peter-thiel/education-libertarian/
21:22 < hprmbridge> kanzure> OpenAI entering into synthetic nucleic acid screening https://openai.com/index/preparing-for-future-ai-capabilities-in-biology/
22:32 < fenn> "end Federal funding of dangerous gain-of-function research conducted by foreign entities in countries of concern (e.g., China)" is very narrowly scoped. i'm unimpressed
22:32 < fenn> business as usual, secret bioweapons programs continue unimpeded
22:33 < fenn> here's some ridiculous news https://thegrayzone.com/2025/06/18/palantir-execs-appointed-colonels/
22:34 < fenn> also OpenAI, Meta
--- Log closed Sat Jun 21 00:00:18 2025