--- Log opened Thu Jun 26 00:00:23 2025
01:19 < hprmbridge> kanzure> this is the internet that I remember https://www.sanjayjohn.com/2023/11/genetics-uber-junk-science.html?m=1
03:56 < fenn> "an invasion from the future by an artificial intelligent space that must assemble itself entirely from its enemy's resources." https://youtu.be/5_ujeWyfLeA
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05:29 < hprmbridge> kanzure> my tweet thread with all of sanjay's truths  https://x.com/kanzure/status/1938209881162416298
05:37 < hprmbridge> kanzure> https://www3.mrc-lmb.cam.ac.uk/sites/synhg/
07:42  * L29Ah yawns
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08:14 < superkuh> Bioarxiv just put itself behind a cloudflare wall and now is inaccessible. :(
08:21 < hprmbridge> Eli> tbf, he did do an unnecessary and possibly ineffective and possibly dangerous gene mod to babies with some of the consent forms being questioned. I like him as a person but whyyyy start with a ccr5 mod? It’s like shooting yourself in the foot if you want to be getting recognized for doing something novel. All these other scientists publicly rebuked him and now he happens to be taking shots at all
08:21 < hprmbridge> Eli> of them.
08:28 < kanzure> https://x.com/ProfTomEllis/status/1938256566789996902 "no - we won't do boot-up like JCVI do for the small bacteria genomes. It'll be more like the Sc2.0 project and the Syn61 and Syn57 E.coli from Chin's lab. Hierarchical assembly of synthetic genome regions in parallel, and swapping these with native regions in the chosen cell line"
09:06 < hprmbridge> nmz787> @Eli if he did some edit that wasn't controversial, then likely there'd be way less press and way less public engagement
09:16 < kanzure> call for grant applications for formal verification proposals pertaining to bitcoin's reference implementation https://x.com/kanzure/status/1938269702825881645
10:17 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=4f463e4d Jose.Junior.de.Oliveira:  >> http://diyhpl.us/diyhpluswiki/index/
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10:24 < hprmbridge> kanzure> ruh roh
10:25 < hprmbridge> kanzure> can someone revert that
10:26 < L29Ah> pwned
10:28 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=42ce3d03 Sergey Alirzaev: Revert "" >> 
10:29 < jrayhawk> Thanks.
10:29 < L29Ah> remote: hooks/post-receive: line 14: sed: command not found
10:29 < L29Ah> remote: hooks/post-receive: line 14: tail: command not found
10:29 < L29Ah> remote: hooks/post-receive: line 15: sed: command not found
10:29 < L29Ah> remote: hooks/post-receive: line 15: sed: command not found
10:29 < L29Ah> cool
10:29 < jrayhawk> oh, i should fix that
10:35 < jrayhawk> okay, that will hopefully be less broken in the future
11:07 < kanzure> thank you
11:33 < hprmbridge> Eli> Idk, any type of embryo gene editing would get press. If he chose a gene that had a 100% chance of death then maybe he wouldn’t go to jail. Babies are generally not at risk of hiv
11:34 < hprmbridge> nmz787> Most genetic mods are beneficial for the adult
11:34 < hprmbridge> nmz787> I had the unfortunate experience yesterday of seeing broadcast TV, at least twice I saw anti HIV drug commercials
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11:39 < hprmbridge> Eli> Ok, but you would start with something that would 100% kill a baby. If you accidentally kill someone while trying to save them from 100% chance of death, it's not considered super immoral. Especially if you have proper consent forms.
11:40 < hprmbridge> Eli>  https://cdn.discordapp.com/attachments/1064664282450628710/1387865082226278490/CAB9C753-67AB-481B-81DE-22284997C8D3.jpeg?ex=685ee594&is=685d9414&hm=0a285aac3bbcdd610cd88445152f29af9aa8de27a8a59b985efe2e2c5edcb14f&
11:40 < hprmbridge> nmz787> How is the ccr5 killing anyone immediately?
11:40 < hprmbridge> Eli> Meme: natural selection vs risking someones life for no reason
11:44 < hprmbridge> Eli> traditional CRISPR has off-target mutations. I would start with a base editor or something. IDK, someone who is smarter than me could tell me whatever is most selective. And I would do tests in a mouse model to measure off-target/bystander edits. Then you have the issue that CCR5 isn't just for HIV, it potentially affects other things. Potentially makes you more at risk for other infections. Has
11:44 < hprmbridge> Eli> other unkown effects on the brain. And the treatment itself was potentially not complete. The baby could be a mosaic. So, not entirely sure if it accomplished what they intended.
11:48 < hprmbridge> Eli> It's not necessarily even the CCR5 that is the issue. You just don't really know what's going to happen when you start modifying the DNA. There was an individual name Jesse Gelsinger who had a virus to deliver genes to correct a metabolic disorder. He dies from hyperimmune reaction. It froze research funding for many year. There's just unknown unknowns.
11:54 < hprmbridge> nmz787> Sure, but being alcoholic and pregnant isn't illegal or even disallowed
11:55 < hprmbridge> nmz787> So plenty of terrible acts happening that are way worse than He did
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14:16 < hprmbridge> kanzure> The core market inefficiency in U.S. healthcare is that providers deliver care without agreeing to prices upfront, then bill insurers and patients after the fact through opaque, variable, and often exploitative claims processes (especially in out-of-network scenarios) creating unpredictable costs, surprise billing, and corrupt prices. Insurers and self-funded employers in the US bear the brunt of
14:16 < hprmbridge> kanzure> this dysfunction, facing over $1.5 trillion annually in claims, with at least 10% driven by preventable overpricing, while patients suffer from surprise bills and lack of control. Meanwhile, a subset of providers benefit from this chaos, maximizing revenue through post-hoc billing tactics and exploiting system loopholes. My proposed solution is 'simple': pay providers 20% more than they currently
14:16 < hprmbridge> kanzure> earn--upfront (before service rendered or same day) and without denial risk--in exchange for them locking in or providing transparent, pre-service pricing (on a case by case basis that they can bid on) and waiving traditional claims-based billing. This model gives providers better cash flow and higher income (a critical variable that presently compels them to fight for today's inefficient status
14:16 < hprmbridge> kanzure> quo), while enabling insurers to regain control over long-term cost growth through mkt transparency and market forces. The insurer will finance this through global capital markets to smooth out the pain: higher upfront costs now, but significant pain amelioration over 5-10 years time (competitive pricing between service providers, inflation eats away at the early provider pay boosts which do not
14:16 < hprmbridge> kanzure> get re-negotiated).  To implement this, create a private equity-backed search fund to acquire a regional insurer or TPA, pilot the model in a select metro market, and gradually reshape healthcare pricing dynamics from the inside out. THANK YOU
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15:08 < hprmbridge> kanzure> "Instead of leveling organic and mental inequalities, we should amplify them and construct even greater men."
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17:57 < fenn> telegram founder pavel durov is providing free IVF if you use his sperm, and the kids will inherit his fortune in ~30 years
17:57 < fenn> over 100 kids so far
18:04 < fenn> apparently he didn't even know until recently: https://t.me/durov/339 and since telegram sucks and won't show the post to me without hijinks i have copied the text here for your convenience https://pastebin.com/raw/qBDHx5pz
18:07 < L29Ah> is having your dna sequence public a good argument against criminal incrimination through dna evidence in court?
18:11 < fenn> because someone could synthesize it to frame you?
18:16 < L29Ah> yes
18:53 < hprmbridge> norkatron> https://arxiv.org/abs/2505.17500
19:22 < hprmbridge> Eli> Pavel durov net worth low estimate  $13.9 billion
19:23 < hprmbridge> Eli> So, whatever the future value of $139 million for each kid is?
19:31 < L29Ah> https://www.youtube.com/watch?v=SJsbkDntrI4 premature Enhanced Games propaganda (russian rap music video)
19:33 < L29Ah> automatic youtube translation isn't great :/
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23:33 < fenn> "error rates low enough for real-world applications" but the rest is above my paygrade, is this a big deal? https://www.quantinuum.com/blog/quantinuum-overcomes-last-major-hurdle-to-deliver-scalable-universal-fault-tolerant-quantum-computers-by-2029
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--- Log closed Fri Jun 27 00:00:24 2025