--- Log opened Fri Jun 27 00:00:24 2025
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06:26 < hprmbridge> kanzure> Another way of thinking about planning very far ahead is the extreme population growth over those time spans. Our history is constantly being 'log-compressed' and it's weird to think about that. Likewise, the next trillion people will know more about you and me than each other.
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08:14 < kanzure> are we just forever doomed to poor visual representations of DNA https://news.ycombinator.com/item?id=44392143
08:14 < kanzure> sanjay should have pointed out that nobody can even draw these molecules correctly
08:15 < kanzure> just get a few example images and put them side-by-side. you call this science? absurd.
08:20 < kanzure> "flat earthism for synthetic biology"
10:16 < hprmbridge> Eli> Here is b dna crystallography. Is this correct? https://www.rcsb.org/3d-view/1BNA/1
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13:33 < jrayhawk> https://www.youtube.com/watch?v=FASMejN_5gs "Neuralink Update, Summer 2025"
13:38 < hprmbridge> kanzure> skin aging seems like a reasonable proxy for aging, why not go to retirement homes and find the most retirement homed youthful looking skin and make a bioinformatics from that?
13:38 < hprmbridge> kanzure> plus you can visually see skin
13:42 < jrayhawk> we know most of the major mechanisms already
13:43 < hprmbridge> kanzure> well I mean genetic basis for long-term non-aginglook skin
13:44 < jrayhawk> that's rearranging deck chairs on the titanic. it's almost all metabolic-syndrome-based.
13:45 < jrayhawk> something is going to break, you're just picking and choosing what breaks first
13:51 < jrayhawk> or, i guess, you could conceptually reframe it as shooting the messenger
13:51 < jrayhawk> regardless, a complete and utter failure to engage with the actual problem
14:01 < jrayhawk> dicarbonyl-based advanced glycation endproduct protein crosslinking, collagen insufficiency, menatetrenone/retinoid/vitamin-D insufficiency, fibroblast overexpression, etc.
14:03 < jrayhawk> all of these things are very, very environmental and their underlying causes induce a thousand other, more serious pathologies
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16:45 < fenn> .t https://dynomight.net/irb/
16:45 < saxo> Do you need permission from the government to do independent research?
16:45 < fenn> includes handy flowchart
16:52 < fenn> hello future trillions. i love you. please resurrect me
16:52 < hprmbridge> kanzure> need to hedge your bets and create a small fenn-specific resurrection cult just in case
16:53 < fenn> these cults arise spontaneously from time to time on their own
16:53 < fenn> now i'm not saying you would be handsomely rewarded, but it is definitely a possibility
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22:42 < hprmbridge> nmz787> Fenn a thing you once said should exist https://www.shapertools.com/en-us/trace
23:57 < fenn> autotrace (potrace) and skeletonization algorithms have been around since forever, it's just annoying and hard to use the existing software
23:57 < fenn> what i wanted was more like reverse engineering, inferring what's actually a circle or actually a line segment or square or whatever
--- Log closed Sat Jun 28 00:00:25 2025