--- Log opened Sat Jul 19 00:00:45 2025
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09:06 < hprmbridge> kanzure> https://boards.4chan.org/pol/thread/510733506
09:23 < hprmbridge> kanzure> choose-your-own-adventure LLM wiki https://x.com/dev_valladares/status/1946331205437423887
09:42 < hprmbridge> kanzure> "On demand synthesis of probabilistic models" https://arxiv.org/abs/2507.12547
10:15 < hprmbridge> Eli> The guy who runs fourthieves is pretty friendly and approachable. I’m surprised he’s not at h+
10:15 < hprmbridge> Eli> He seems like he would enjoy it
10:15 < L29Ah> invite him
10:17 < hprmbridge> Eli> Maybe for next year.
10:18 < hprmbridge> Eli>  https://cdn.discordapp.com/attachments/1064664282450628710/1396179408087421142/IMG_1988.png?ex=687d24e6&is=687bd366&hm=2672d82b9c52eef9609a189366fd8a1f050a93e93d98c3e6e66f454d533ca17c&
10:18 < hprmbridge> Eli> Found a possible h+ location #hotgirlsummer
10:19 < L29Ah> maybe after the Bitcoin City in El Salvador
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13:14 < hprmbridge> kanzure> mistral voxtral speech recognition https://x.com/MistralAI/status/1945130173751288311
13:17 < L29Ah> no russian
13:17 < L29Ah> but there's dutch
13:18 < L29Ah> > world’s most widely used languages
14:08 < juri_> If you want to see what an attention mechanism looks like in haskell: https://github.com/CopyLeft-AI/HaskeLLM/blob/main/programs/trainLLM.hs#L1564
14:08 < juri_> speaking of one of the world's best languages.
14:08 < juri_> ;)
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17:48 < hprmbridge> kanzure> "Kim et al. report a method (exTEM) which combines expansion microscopy, transmission electron microscopy, and immunogold labeling to precisely determine the relative spatial locations of proteins in synapses. " https://pubs.acs.org/doi/10.1021/acsnano.2c10664
17:48 < hprmbridge> kanzure> "Molecular Decrowding by Tissue Expansion Allows Precise Determination of the Spatial Distribution of Synaptic Proteins at a Nanometer Scale by exTEM"
17:49 < hprmbridge> kanzure> "To understand how the molecular machinery of synapses works, it is essential to determine an inventory of synaptic proteins at a subsynaptic resolution. Nevertheless, synaptic proteins are difficult to localize because of the low expression levels and limited access to immunostaining epitopes. Here, we report on the exTEM (epitope-exposed by expansion-transmission electron microscopy) method that
17:49 < hprmbridge> kanzure> enables the imaging of synaptic proteins in situ. This method combines TEM with nanoscale resolution and expandable tissue-hydrogel hybrids for enhanced immunolabeling with better epitope accessibility via molecular decrowding, allowing successful probing of the distribution of various synapse-organizing proteins. We propose that exTEM can be employed for studying the mechanisms underlying the
17:49 < hprmbridge> kanzure> regulation of synaptic architecture and function by providing nanoscale molecular distribution of synaptic proteins in situ. We also envision that exTEM is widely applicable for investigating protein nanostructures located in densely packed environments by immunostaining of commercially available antibodies at nanometer resolution."
17:52 < hprmbridge> kanzure> "Lipid nanoparticle screening in nonhuman primates with minimal loss of life" https://www.nature.com/articles/s41587-025-02711-y
18:02 < hprmbridge> kanzure> "Mitochondrial origins of the pressure to sleep" https://www.nature.com/articles/s41586-025-09261-y
18:03 < hprmbridge> kanzure> huh. I wonder if that holds for human sleep pressure.
18:25 < L29Ah> i'm now wondering whether he should put to use his ~10W cuts of red and orange 12V LED strips as evening room light source
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--- Log closed Sun Jul 20 00:00:46 2025