--- Log opened Mon Jul 21 00:00:47 2025
02:35 < justanot1> I wonder why github did that
02:58 < TMA> why not
02:58 < TMA> that's the usual response for psychopats and corporations
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03:02 < fenn> automated spam prevention being stupid is my guess
03:19 < hprmbridge> Katylase> what do you mean?
03:37 < fenn> i think some botnet decided to start starring the repo (for unknown reasons) and then github saw that as someone being too clever and banned the owner of the repository
03:38 < fenn> i think github was acting on the assumption that the only reason that someone would counterfeit stars on a repo is if it's to their own benefit, i.e. the owner of the repo is to blame
03:38 < fenn> nobody considered that this automated behavior could be weaponized
03:40 < fenn> anyway it's really bad that so much development "stuff" is in issues and discussions and PRs and all that which is not actually in version control or portable across git hosting web servers
03:42 < fenn> it should be possible to export most of this "stuff" with API calls but then you still have broken links, so we also need to be crawling the webpages for all the things so that at least archive.org has a copy
03:42 < fenn> from my brief survey there doesn't seem to be a complete working solution to export all the stuff from github
03:51 < jrayhawk> ikiwiki got this right 16 years ago: all that stuff should be in git
03:55 < fenn> bugs everywhere never caught on...
03:59 < hprmbridge> kanzure> radicle.xyz might have a total github importer
03:59 < jrayhawk> unfortunately everyone involved in the git ecosystem is obnoxiously obstructionist about usability
04:01 < jrayhawk> want to do a two-byte fix a typo on a single file? too bad, the toolchain won't let you unless you first download an entire checkout's worth of objects for no reason
04:04 < hprmbridge> kanzure> https://github.com/bitcoin/bitcoin/issues/33024
04:05 < hprmbridge> Katylase> i remembered I forgot to show you the thing I did...
04:05 < hprmbridge> kanzure> oh wait, this one is more entertaining https://github.com/bitcoin/bitcoin/issues/33022
04:05 < hprmbridge> Katylase> so here it is^^ https://cdn.discordapp.com/attachments/1064664282450628710/1396810421985480797/IMG_3312.jpg?ex=687f7094&is=687e1f14&hm=b9890848a27fec5ee0375b3779cdee8638938d66d48b9d4e069391059aa8b089&
04:09 < fenn> kanzure: definitely an LLM
04:18 < fenn> Katylase: do the joysticks rotate the protein 3d view?
04:18 < fenn> looks like waterfox
04:19 < fenn> and xfce
04:22 < hprmbridge> Katylase> yea!
04:22 < hprmbridge> Katylase> it is Xfce..
04:23 < hprmbridge> Katylase> and Mozilla nightly
04:31 < hprmbridge> kanzure> here is what ChatGPT o3 says about sleep pressure invulnerability: "Candidate mechanisms, supported by transgenic or knockout studies, include: (1) overexpression of adenosine kinase (ADK), which accelerates adenosine clearance and blunts its accumulation; (2) loss-of-function or dominant-negative mutations in adenosine A₁ or A₂A receptors, rendering sleep-promoting regions insensitive to
04:31 < hprmbridge> kanzure> adenosine's somnogenic signal; (3) hyperactive ENT1 transporters, which remove adenosine too efficiently from synapses; (4) mutations in mitochondrial respiratory proteins that reduce electron leak, thereby weakening the redox trigger for pressure buildup; and (5) loss of prostaglandin D₂ synthesis (e.g., in PTGDS), blocking the immune-to-sleep cascade that normally amplifies pressure. Each of
04:31 < hprmbridge> kanzure> these could be tested via CRISPR in mice by introducing: a promoter duplication for Adk (↑ expression); a single-point mutation in Adora2a or Adora1 disrupting G-protein coupling; a gain-of-function allele in Slc29a1 (ENT1); a stabilized complex I subunit (e.g., Ndufs4) mimicking tighter coupling; or a nonsense mutation in Ptgds."
04:34 < hprmbridge> kanzure> it also claims "A microdeletion affecting the 5' regulatory region or a non-critical exon of ADK is the best candidate for a benign, inherited suppression of sleep pressure, causing minimal systemic disruption while significantly reducing brain adenosine accumulation." but I thought adenosine kinase was used everywhere?
04:57 < faceface> Eli, thanks. Yeah, I have a background in bioinf
05:47 < hprmbridge> kanzure> optochemical sleep induction https://www.nature.com/articles/s41467-024-47964-4
05:56 < hprmbridge> kanzure> adenosine A2A receptor (A2AR) antagonism promotes wakefulness https://www.nature.com/articles/s41401-024-01443-0
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07:37 < L29Ah> for your propaganda campaigns https://primal.net/e/nevent1qqsrjg2apwyrj5s498r57eac2eh5my5ajjs2494e8tgvdzzu3netdaguquscd
07:57 < kanzure> a lot of my computing experience is waiting for things to load, dealing with cache issues, RAM contention, swapping, etc. and it doesn't seem to be directly solved by "more RAM". seems like a software problem too?
07:57 < kanzure> why does it take me more than three seconds to view a stock portfolio?
07:58 < L29Ah> what is stock portfolio?
07:58 < L29Ah> `ledger bal` takes <1s
08:05 < L29Ah> perhaps you wanted it in USD
08:05 < L29Ah> ledger b -X $  0.06s user 0.02s system 98% cpu 0.078 total
08:08 < L29Ah> i believe it interprets all the transactions i ever had logged since 2013, that is 6780 transactions, and then all the individual sums of specific assets are converted to $ at the last known price and then summed together, during those 0.078s on my cheap laptop
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09:26 < kanzure> more people should start venture capital funds or micro-funds, instead of startups. for example, someone should run a human cloning venture capital fund, or a nanotech fund.
09:26 < kanzure> large scale capital formation has not happened for cloning or nanotech which means it requires coordinating smaller LPs or investors together into smaller funds, and then growing from there
09:30 < kanzure> "sputnikularity"
09:54 < L29Ah> so when are you starting one?
09:56 < kanzure> you can start one by clicking the syndicate create button on angellist
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10:34 < RangerMauve> @Katylase I love your setup! Which device is that?
10:36 < RangerMauve> fenn Regarding git I was recently talking to the lead dev of radicle.xyz trying to convince them to treat issues/etc as a regular instead of their funky "DAG that gets indexed into a materialized view" approach. It feels like there's an easy way to collect this stuff that just hasn't been taken due it not being complex enough
10:41 < hprmbridge> rangermauve> Is the source code for whatever that is published somewhere?
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10:47 < kanzure> what is radicle.xyz doing wrong about issue storage right now? i don't understand.
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10:52 < RangerMauve> It's not wrong per se, just harder to reuse outside of their context. They treat comments/prs/etc as separate branches which fork from their parent / add a single commit with whatever message. Then this needs to be traversed to build up the final view
10:53 < RangerMauve> This is analogous to using oplogs and leads to inevitable perf issues as your history gets longer
10:54 < RangerMauve> My proposal was to store things in the git tree / use sparse replication on the trees. Then the virtual FS represented in the tree could be used like a database index so you could easily say "get me the PRs for the past week" without needing to index all the data
10:54 < RangerMauve> https://blog.mauve.moe/posts/peer-to-peer-databases
10:55 < RangerMauve> I wrote about the sort of index using a non-fs database a while ago but it's isomorphic to git fs trees in its tradeoffs https://blog.mauve.moe/posts/hypertrie-timestamp-index
10:56 < RangerMauve> Skipping oplogs and using sparsely replicated indexes is the P2P hill I'll die on :P
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11:55 < kanzure> https://fiatjaf.com/3cb7c325.html https://github.com/fiatjaf/trustlines https://github.com/freedomlayer/offset/issues/196#issuecomment-490911189
11:55 < kanzure> with regards to mutual credit systems^ and ripplepay or rumplepay etc
12:46 < hprmbridge> nmz787> http://bit.ly/Tournament25
12:46 < hprmbridge> nmz787>
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13:13 < hprmbridge> Katylase> it's just the regular mol* viewer😅  the one from PDB... but I managed to run it on a gamepad...
13:19 < hprmbridge> Katylase> it works for these
13:19 < hprmbridge> Katylase>
13:19 < hprmbridge> Katylase> https://anbernic.com/products/rg35xxsp
13:19 < hprmbridge> Katylase> https://anbernic.com/products/rg40xx-h
13:19 < hprmbridge> Katylase>
13:19 < hprmbridge> Katylase> and the mod for turning it into a mini computer is this
13:19 < hprmbridge> Katylase> https://github.com/MrJackSpade/RG35XXP-XFCE
13:23 < hprmbridge> rangermauve> Nice. I do all my dev on a GPD WIN 4 so the form factor is close to my heart https://www.gpd.hk/gpdwin42025
13:25 < hprmbridge> rangermauve> I wonder if one could run wayland + electron on those things. It'd be neat to get my offgrid devkit stuff on one to see if it'd be viable
14:20 < L29Ah> oh no not my PET
14:23 < L29Ah> we'll have to use some sandwich stuff if they make PET-eating bacteria and those survive in the environment, and then PET gets a protective layer and them eco-minded people will hate us like they do with tetra-pak today because it is no longer neither biodegradable nor nicely remeltable
14:23  * L29Ah switches off doomer mode
14:33 < hprmbridge> nmz787> I burn tetrapaks in my woodstove... The ashes go into the ground.
14:33 < hprmbridge> nmz787> It was chilly last night, I burned a bunch of recent waste including plastic
14:38 < L29Ah> i hope you don't mind aluminum hydroxide in your ground
14:38 < ike8> i dont mind
14:39 < hprmbridge> nmz787> Seems like it'll quickly react with fit needle acid drainage
14:39 < hprmbridge> nmz787> Fir needle
15:22 < hprmbridge> kanzure> https://asteriskmag.com/issues/09/we-can-must-and-will-simulate-nematode-brains
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17:33 < fenn> "Can AI-guided protein design help solve the climate crisis?" is a non-sequitur
18:22 < flyback> rediculous
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22:07 < hprmbridge> kanzure> NYPD has apparently coerced thingiverse into blocking or scanning for ghost gun related 3d models :/
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--- Log closed Tue Jul 22 00:00:48 2025