--- Log opened Sun Aug 03 00:00:59 2025
02:29 < hprmbridge> .monokhrome> phase 1 trials for a drug that will remove 7-keto cholesterol, supposedly regressing atherosclerotic plaques: https://www.lifespan.io/news/cyclarity-launches-human-trial-for-atherosclerosis/
03:24 < jrayhawk> paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC10634755/
03:34 < jrayhawk> Oxidatively stabilizing a chemical fraction of the plaque so it doesn't overwhelm the macrophages trying to clean it up is the sort of SENS-style "put the horses back in the barn, do nothing about the door, and also the barn is on fire" thinking I've come to expect from the longevity community, but it does, at least, look workable for its very narrow purpose.
03:35 < jrayhawk> Assuming they can achieve the concentrations they need at the target site without side effects.
03:45 < jrayhawk> More fundamental questions of "why are the macrophages so fragile and sparse and what do you do about it the 600 other contexts it matters in" "why is the lipid plaque so radical and what do you do about it for the 600 other contexts it matters in" "why is ApoB100 oxidizing so much" and "why is so much endothelial transmigration occurring and what do you do about it in the 600 other contexts it 
03:45 < jrayhawk> matters in?" are presumably answered by symptom-chasing with 600 more patentable substances
03:49 < jrayhawk> maybe someday they will discover a treatment for whatever brain damage it is that makes the longevity community think like this
04:13 < jrayhawk> is it a stubborn pursuit of an old timey futurist scientism aesthetic of men with beakers and lab coats saving the world? Is it autistics getting obsessed the most peripheral details? Is it a cynical exploitation of the failures of medical institutional design?
04:41 < jrayhawk> https://www.youtube.com/watch?v=-4EDhdAHrOg
06:23 < hprmbridge> kanzure> https://cline.bot/blog/instant-code-generation-is-here-cline-x-cerebras
06:27 < hprmbridge> kanzure> https://mcpui.dev/
07:05 < hprmbridge> Eli> Probably soham parekh
08:34 < hprmbridge> kanzure> "monozygotic twins differ on average by 5.2 early developmental mutations" https://www.nature.com/articles/s41588-020-00755-1
08:42 < superkuh> And plenty more non-germline well-post-twinning somatic mutations scattered among the cells that everyone gets along the way.
08:43 < hprmbridge> kanzure> yes it's not clear to me, are they sequencing all the tissues? how are they calculating this
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10:40 < hprmbridge> nmz787> Jrayhawk $300k of medical debt seems like it would be cleared up in 2 years of working as a doctor.
11:04 < jrayhawk> with a mere 3-7 years of residency inbetween
11:05 < hprmbridge> nmz787> All i know is, 4 years after starting work in ER, my friend has 2mil in his retirement accounts and no debt
11:05 < hprmbridge> nmz787> He is particularly frugal tho, has been living in $700/mo apt for all professional life so far
11:06 < hprmbridge> nmz787> I think his residency was also just 2 years, but my timeline is blurred
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18:52 < hprmbridge> jsingh.1> https://www.youtube.com/watch?v=xTiBF2Hq40I
18:52 < hprmbridge> jsingh.1> are there any good science blogs that you guys frequent?
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20:13 < superkuh> http://superkuh.com/feeds13.html many of these science blogs are dead but many are not. no specific outstanding recommendations. 
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--- Log closed Mon Aug 04 00:00:00 2025