--- Log opened Mon Aug 04 00:00:00 2025
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05:41 < hprmbridge> kanzure> https://willalaynick.substack.com/p/venture-capital-for-life-scientists
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07:03 < hprmbridge> kanzure> "The first adult fly connectome that unites the brain and ventral nerve cord" https://www.biorxiv.org/content/10.1101/2025.07.31.667571v2
07:05 < hprmbridge> kanzure> "Fabrication and validation of an affordable DIY coaxial 3D extrusion bioprinter" https://www.nature.com/articles/s41598-025-06478-9
07:05 < hprmbridge> kanzure> strange that 3d printer articles can still get into nature. still, useful to have a modification of a commercially available non-bioprinter.
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17:08 < L29Ah> https://pmc.ncbi.nlm.nih.gov/articles/PMC12194581/ damn, my allergic cancer-beating superhuman status is damaged :<
17:23 < jrayhawk> damn, this paper was doing so good before it got to the potential therapies
17:24 < jrayhawk> it nailed all the pathways needed to do root cause analysis, and then... didn't root cause analyze them.
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17:26 < jrayhawk> still, quite good for identifying recursive interrelation between oxidative stress and inflammation, at least.
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18:25 < hprmbridge> kanzure> "Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals" https://www.nature.com/articles/s41467-025-62534-y
18:26 < hprmbridge> kanzure> "Here we describe the UCLA 2P Miniscope, an open-source miniature 2-photon microscope capable of recording calcium dynamics from neurons in deep structures and from dendrites over a 445 µm × 380 µm field of view. The system utilizes two on-board silicon-based photon detectors for approximately 4-fold greater light collection compared to an optical fiber bundle-based approach. The microscope can
18:26 < hprmbridge> kanzure> electronically focus within a 150 µm range at a native working distance of 720 µm. To test the 2P Miniscope, we recorded calcium dynamics from place cells in hippocampus, resolved calcium transients from dendrites in retrosplenial cortex and we recorded dentate granule cell activity at a depth of over 620 µm, through an intact hippocampus during open field behavior. The miniature microscope itself
18:26 < hprmbridge> kanzure> and all supporting equipment are open-source and all files needed for building the scope can be accessed through the Golshani Lab GitHub repository"
18:36 < L29Ah> .t https://pmc.ncbi.nlm.nih.gov/articles/PMC4441436/ yeah right
18:36 < saxo> Sorry, links cannot contain spaces
18:36 < L29Ah> .t https://pmc.ncbi.nlm.nih.gov/articles/PMC4441436/
18:36 < saxo> If It’s Not One Thing, It’s Another: An Inverse Relationship of Malignancy and Atherosclerotic Disease - PMC
19:42 < hprmbridge> Eli> I like this one to stay up to date: https://www.quantamagazine.org
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--- Log closed Tue Aug 05 00:00:01 2025