--- Log opened Sun Aug 24 00:00:19 2025
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04:38 < hprmbridge> kanzure> "Inner speech in motor cortex and implications for speech neuroprostheses" https://www.cell.com/cell/fulltext/S0092-8674(25)00681-6
04:41 < hprmbridge> kanzure> "An instantaneous voice-synthesis neuroprosthesis" https://www.nature.com/articles/s41586-025-09127-3 this implant targeted ventral precentral gyrus, as discussed in here a ~month ago
04:42 < hprmbridge> kanzure> supramarginal gyrus also works for speech decoding, and this new article targets motor cortex.
04:43 < hprmbridge> kanzure> "Participants had 2 (T12), 4 (T15 and T16), or 6 (T17) microelectrode arrays placed along the precentral gyrus, spanning regions of areas 6v, 4, PEF, 55b, and 6d as defined by individualized cortical parcellations" figure 1c
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05:35 < hprmbridge> kanzure> " Alfred P Sloan Foundation has already made clear that it will not support research with the goal of creating mirror organisms. Over the next year, stakeholders will meet at the US National Academies of Sciences, Engineering and Medicine, the University of Manchester, the National University of Singapore, Rikkyo University in Japan, Harvard University, Yale University and elsewhere to try to
05:35 < hprmbridge> kanzure> establish these boundaries. What technical milestones towards mirror life require red lines that protect people and planet, while preserving the benefits of synthetic biology that have nothing to do with mirror life?" john glass, jcvi cult member
05:43 < L29Ah> The Academician's private residences shall remain off-limits to the Genetic Inspectors. We possess no retroviral capability, we are not researching retroviral engineering, and we shall not allow this Council to violate faction privileges in the name of this ridiculous witch hunt!
05:44 < hprmbridge> kanzure> "NeuroPorator: An open-source, current-limited electroporator for safe in utero gene transfer" https://www.sciencedirect.com/science/article/pii/S0165027024000712
05:45 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1409156561636687912/image0.jpg?ex=68ac5ad1&is=68ab0951&hm=446655139a4514196ce4be0270284cea62d838d1757c7a1a7acfcd239338979a&
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06:31 < hprmbridge> kanzure> https://huggingface.co/spaces/tencent/Hunyuan3D-2.1
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10:03 < hprmbridge> kanzure> "Protein design with infilling language models and reinforcement learning, for antibodies and beyond" https://github.com/LLNL/protein_tune_rl
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10:45 < hprmbridge> kanzure> https://huggingface.co/internlm/Intern-S1 https://arxiv.org/abs/2508.15763 "Built upon a 235B MoE language model (Qwen3) and a 6B Vision encoder (InternViT), Intern-S1 has been further pretrained on 5 trillion tokens of multimodal data, including over 2.5 trillion scientific-domain tokens. This enables the model to retain strong general capabilities while excelling in specialized scientific
10:45 < hprmbridge> kanzure> domains such as interpreting chemical structures, understanding protein sequences, and planning compound synthesis routes"
10:46 < hprmbridge> kanzure> https://chat.intern-ai.org.cn/
11:02 < hprmbridge> Eli> I’m kind of wondering if China is the main competition for ai. They have tons of electricity, they can take the smartest people in a population of 1 billion people that puts emphasis on education, and then they can make them live in their office until things are built. They just need chips.
11:06 < TMA> chip needs can be easily solved by pacifying a single province in which a rebellion is ongoing since 1912
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11:09 < hprmbridge> kanzure> We were threatening to cut off their chip supply. Instead, they decided to cut it off themselves to stimulate their local industry. This is possibly a strategically bad idea on our part.
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11:15 < jrayhawk> the level of organizational complexity you can support isn't a function of population size, it's a function of social trust
11:15 < jrayhawk> china still has major problems in that regard
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11:25 < L29Ah> trust is a function of organization among other things
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12:06 < TMA> there is an ongoing erosion of trust in the "western" world
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12:18 < jrayhawk> .t https://archive.is/7sxOS
12:18 < saxo> archive.is
12:18 < jrayhawk> "DeepSeek’s launch of new AI model delayed by Huawei chip issues" "Difficulties of training Chinese start-up’s latest system with domestic tech highlights dependence on Nvidia"
12:20 < jrayhawk> "Huawei sent a team of engineers to DeepSeek’s office to help the company use its AI chip to develop the R2 model, according to two people. Yet despite having the team on site, DeepSeek could not conduct a successful training run on the Ascend chip, said the people."
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14:05 < hprmbridge> kanzure> contralateral c7 nerve transfer https://youtu.be/JoRHfN1vYeo
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16:50 < hprmbridge> kanzure> mr. president, they have distilled the essence of kawaii https://arxiv.org/pdf/2507.06235
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17:33 < hprmbridge> kanzure> AVX2 is all you need https://arxiv.org/abs/2508.06753
17:35 < hprmbridge> kanzure> https://tscircuit.com/
18:33 < fenn> perhaps ancient humans got K2 from fatty meat fermenting as it dried / cured in unsanitary conditions
18:33 < fenn> or if the dried fatty meat was bundled after drying and this led to low oxygen conditions that encouraged a specific microbe
18:34 < L29Ah> or they were deficient but no one knew because there are more pressing things in life
18:34 < fenn> i would have expected evolution to take care of that somehow
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18:45 < hprmbridge> kanzure> https://en.wikipedia.org/wiki/Stent-electrode_recording_array
18:46 < fenn> we should develop a superior kawaii essence by traversing the high dimensional latent space
18:46 < hprmbridge> kanzure> we must find the kawaii vector
18:48 < L29Ah> MuaddibLLM: research and discover the superior kawaii essence
18:48 < MuaddibLLM> Recipe: train a kawaii reward model (CLIP fine-tuned on Danbooru/LAION “kawaii” with baby-schema features like eye:face ratio, curvature, pastel palette), probe diffusion/StyleGAN latents to extract the kawaii vector, then RL-optimize prompts and latents (PPO/DPO + human Elo) toward a cuteness/novelty/harmlessness Pareto front - and validate transfer on 3D assets, voices, and UI themes.
18:50 < hprmbridge> kanzure> https://synchron.com/ "Our neurointerventional electrophysiology (NeuroEP) platform is built on the Stentrode, an endovascular electrode array. It is designed to record or stimulate the brain from inside the blood vessels. Thousands of blood vessels, the uncharted highways into the brain. Tens of thousands of interventional physicians ready to perform procedures globally. That’s 10x the clinical
18:50 < hprmbridge> kanzure> network compared to traditional BCI technologies. Oxley says neurologists routinely use permanent stents in patients' brains to keep blood vessels open."
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18:56 < fenn> thousands of potential clotting nuclei
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18:59  * L29Ah imagines it embedded into a ptfe tube
19:01 < fenn> stents are deployed and held in place by expanding the mesh after being inserted in a compressed state
19:01 < hprmbridge> kanzure> "electro-olfactogram" loool
19:01 < fenn> i guess you could add a teflon coating to make it more inert
19:02 < fenn> this will only work for read operations, not write operations, because no current will flow through an insulator (?)
19:03 < hprmbridge> kanzure> it's just a wire up the nose lmao
19:05 < L29Ah> MuaddibLLM: what is the current state of the art on the superior kawaii essence
19:05 < MuaddibLLM> Rough SOTA: CLIP/ViT-based kawaii reward models fine-tuned on Danbooru/LAION + human Elo, steerable latent directions (InterfaceGAN/GANSpace; diffusion via LoRA/Textual Inversion and guidance vectors), and RLHF with ImageReward/PickScore/HPSv2-style scorers - with an early tongue-in-cheek exemplar at https://arxiv.org/pdf/2507.06235 - and the frontier is robust cross-modal transfer (3D/voice/UI) under a 
19:05 < MuaddibLLM> cuteness-novelty-harmlessness Pareto.
19:05 < hprmbridge> kanzure> "Olfactory adaptation: recordings from the human olfactory epithelium" https://pmc.ncbi.nlm.nih.gov/articles/PMC9130158/
19:08 < hprmbridge> kanzure> possibly better article, although not open access https://academic.oup.com/chemse/article-abstract/38/1/3/366981
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19:10 < hprmbridge> kanzure> if that works then you wouldn't need my canine or pig olfactory cortex idea from a few months ago. why not just do high resolution electrogram recording up up the snout? plus you can directly train a classifier.
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19:19 < fenn> how can you smell with a bunch of electrodes stuffed up the snout?
19:24 < hprmbridge> kanzure> let's find out
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20:00 < hprmbridge> kanzure> "Boosting hydrogel conductivity via water-dispersible conducting polymers for injectable bioelectronics" https://www.nature.com/articles/s41467-025-59045-1
20:00 < hprmbridge> kanzure> hrm what. not the same thing as the in vivo intracellular 3d printing thing?
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20:13 < hprmbridge> kanzure> stentrode quote says stimulate too...
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20:15 < fenn> acoustic stridulation in the bird "club-winged manakin", unclear if this is rapid muscle flexing or some other process https://i.imgur.com/5Ng2Vry.mp4
20:17 < fenn> "When the bird raises its wings over its back, it shakes them back and forth over 100 times a second"
20:17 < fenn> "raking movement allows a wing to produce 14 sounds during each shake"
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20:49 < hprmbridge> kanzure> okay. but why specifically 14?
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23:03 -!- Topic for #hplusroadmap: biohacking, nootropics, transhumanism, open hardware | this channel is LOGGED: http://gnusha.org/logs | https://diyhpl.us/wiki | not quite sponsored by george church | banned by the MIT media lab and the FDA
23:03 -!- Topic set by fenn [~fenn@user/fenn] [Fri Mar 25 06:29:19 2022]
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23:03 -!- Channel #hplusroadmap created Wed May 19 06:51:36 2021
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--- Log closed Mon Aug 25 00:00:20 2025