--- Log opened Thu Aug 28 00:00:23 2025
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04:02 < hprmbridge> kanzure> "Microscopic geared metamachines" https://www.nature.com/articles/s41467-025-62869-6 (2025)
04:03 < hprmbridge> kanzure> scale bar 10 microns https://cdn.discordapp.com/attachments/1064664282450628710/1410580502385004624/image0.jpg?ex=68b188f7&is=68b03777&hm=d6833c5ef9695a4d9496f9e2862dda3b0f0ad7f8f8689e7522529fc8dbaa6036&
04:05 < alethkit> kanzure: do you know what is going on with hgp-write, and whole genome synthesis? surprised I have not heard more about it.
04:05 < alethkit> Did Church fully pivot to the woolly mammoth revival project?
04:06 < hprmbridge> kanzure> AFAIK nothing going on for hgp-write; tom ellis et al just launched a UK academic initiative for synthesis of a human genome, now that they are done(?) with the synthetic yeast project.
04:07 < hprmbridge> kanzure> church has 100 or 200 lab members, he does not pivot he just does whatever
05:36 < hprmbridge> kanzure> https://www.gov.cn/zhengce/zhengceku/202508/content_7035603.htm
05:37 < hprmbridge> kanzure> https://cset.georgetown.edu/wp-content/uploads/CSET-Bibliometric-Analysis-of-Chinas-Non-Therapeutic-Brain-Computer-Interface-Research.pdf
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07:34 < kanzure> "Mounting evidence suggests human adult neurogenesis is unlikely" https://www.cell.com/neuron/fulltext/S0896-6273(22)00004-6 (2022)
07:51 < kanzure> https://support.mozilla.org/en-US/kb/bookmarks-firefox#w_how-to-use-keywords-with-bookmarks
07:55 < RangerMauve> I'm guessing adding in a brain organoid with whatever digital BCI would be useful for adults to assimilate it.
07:56 < RangerMauve> e.g., culture the hosts own cells into the organoid and do some initial training with the interface
08:00 < kanzure> someone named ethan emailed me an idea about that, something about organoid integration through a forearm nerve? trying to recall the exact idea.
08:01 < kanzure> was it an eye? that wouldn't make sense because an eye has a lot of extra structural biology besides the optic nerve and you can't just transplant the whole eye assembly to another location.
08:02 < kanzure> there was also a separate idea posted in here about using alginate gel to grow cortical neurons, and then later slot in the gel into a mammalian brain (after cutting out an equivalent volume)
08:03 < kanzure> well not just equivalent volume, equivalent geometry
08:05 < RangerMauve> IIRC the main issue in organoids right now is they don't have vascular systems figured out yet so they die after a while. Not sure if making them small enough would sidestep that
08:06 < RangerMauve> I also wonder what brain region would be the most "intuitive" for the host to train on. Visualization seems like a trainable region to affect intentionally
08:07 < RangerMauve> I'd bet it'd be psychologically horrific to have a foreign brain connected to a computer implanted into your skull
08:08 < RangerMauve> Oh! Implanting in the less dominant hemisphere could be cool. MAybe in the language center. Do an artificial "bicameral mind" sort of setup :P
08:10 < kanzure> there have been several organoid vascularization innovations mentioned in the deep backlog in here; it's not entirely unsolved.
08:11 < kanzure> and, if we for a moment imagine that vascularization for some reason was *not* yet entirely solved, then i think at this point- given how much time it has taken them to solve it-- i would simply recommend harvesting capillaries and blood vessels from donor tissues.... but yeah it's not that bleak.
08:13 < RangerMauve> Oh good! I'm not up to date on it yet. Gotta find time to dig more
08:14 < RangerMauve> Implanting outside of the head is a neat concept though. Like turning mammals into cephalopods
08:24 < hprmbridge> kanzure> my estimation is that the ventral roots control at most a few million arteriole voxels, and probably not simultaneously
08:33 < kanzure> which is to say, i would not expect to be able to get high throughput or high bandwidth neural information through the peripheral nervous system. that's just my expectation tho. if it's a real problem then use a very long nerve fiber graft and plug it into a cortex.
08:40 < RangerMauve> I was thinking they'd be mostly autonamous with maybe high level inputs sent down. Or maybe use it to remote control the boday with BCIs :P
08:42 < RangerMauve> Strap some of these and have them take over muscles and coordinate with each other for movement: https://www.youtube.com/watch?v=fpTaFBbadyE&t=189s
08:42 < RangerMauve> Yeah IDK probably pointless
08:45 < RangerMauve> I'm excited for these to replace machines: https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202501452
08:45 < kanzure> .title
08:45 < saxo> Just a moment...
08:46 < RangerMauve> Glad to be alive during the "homunculus real" era of humanity
08:47 < kanzure> i don't understand the article. two things: 1) optogenetic responsiveness to optical stimulation was already previously possible. maybe they are doing some sort of more-eye-like biology here. 2) why would the muscle contract in response to the stimulation? did they train that response?
08:49 < kanzure> 'retinal organoid' ok
08:59 < kanzure> "signals, which are then recognized by cerebral organoids and transmitted to muscle cells via the motor neuron spheroid" okay fine maybe the lack of inhibitory neurons should have caused me to be less confused.