--- Log opened Sun Sep 14 00:00:39 2025
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08:21 < hprmbridge> kanzure> more tab models please https://cursor.com/en/blog/tab-rl
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10:59 < fenn> https://zed.dev/blog/edit-prediction (tab model)
13:07 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=48367a7b Bryan Bishop: destroy the height polygeneity-maximalists >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
14:02 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c4a31820 Bryan Bishop: TODO: embryological platform for control over progenitor cell proliferation across any tissue or organ >> 
14:07 < kanzure> "glowing eyes of doom: activate luciferase in the eye when cortisol spikes"
14:46 < fenn> aka suddenly go blind in critical situations
14:46 < hprmbridge> kanzure> why is it on the wiki
14:50 < fenn> how about the super saiyan mouse https://cdn.abcotvs.com/dip/images/15980328_030525-wpvi-ap-woolly-mouse-img.jpg
14:50 < fenn> bonus points if you grow a tail
14:54 < fenn> oh it's patented, wow
14:54 < fenn> patent pending anyway
14:56 < fenn> "multiplex-edited mouse models with loss of function (LOF) mutations in Tgm3, Fzd6, Astn2, Fam83g, Fgf5, Tgfa and Mc1r (Fig. 1A). While the majority of these genes were selected based on previous observations of coat phenotypes in mice, comparative analyses of mammoth and elephant genomes revealed a similar loss of function variant in Tgfa that occurred in mammoth lineage after divergence from
14:56 < fenn> Asian elephants. We also introduced precision missense mutations in Krt25 and Krt27, the latter for which we inserted a residue that was also genetically fixed in mammoths"
14:57 < hprmbridge> kanzure> huh. weird. sure why not.
15:02 < fenn> "disruption of Mc1r should only alter black or agouti coats to gold coats"
15:03 < fenn> "We successfully knocked out Mc1r, resulting in gold mice with black eyes." important for visual acuity
15:06 < hprmbridge> kanzure> add em
15:07 < fenn> cute website https://www.geneticlifehacks.com/the-redhead-gene/
15:08 < hprmbridge> kanzure> a lot of this stuff just needs to be targeted to specific cell types.
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15:28 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6f895579 fenn: colossal wooly mouse and wild type closeup 40% quality >> http://diyhpl.us/diyhpluswiki/users/fenn/wooly_mouse.jpg
15:37 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=
15:41 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=965f87b6 fennwiki: add wooly mouse genes and caution on MC1R >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
15:47 < hprmbridge> kanzure> there is other MC1R content further down the page, pls
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15:53 < fenn> i just like the mouse ok
15:54 < fenn> "uncombable hair syndrome"
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--- Log closed Mon Sep 15 00:00:40 2025