--- Log opened Sat Sep 20 00:00:45 2025
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05:36 < hprmbridge> kanzure> peer review but it's still unpaid? https://prereview.org/
05:36 < hprmbridge> kanzure> https://elifesciences.org/labs/57d6b284/prereview-a-new-resource-for-the-collaborative-review-of-preprints
05:38 < hprmbridge> kanzure> https://elifesciences.org/articles/83889
05:44 < hprmbridge> kanzure> their published peer review is not itself peer reviewed
06:39 < hprmbridge> kanzure> scion instead of adamw or muon https://arxiv.org/abs/2502.07529
06:51 < hprmbridge> kanzure> https://en.wikipedia.org/wiki/Dyson_Sphere_Program
06:52 < L29Ah> DSP has a great soundtrack
06:54 < L29Ah> factorio is much nicer gameplay-wise and better optimized
07:29 < jrayhawk> Factorio is very SL2-encoded, Dyson is very SL3
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11:59 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b5c145f3 Bryan Bishop: add ADAM12 mutants associated with high IQ (2018) >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
11:59 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7a0731e3 Bryan Bishop: muscle hyperplasia, more intelligence alleles, various minor changes >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
12:07 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=94f41eda Bryan Bishop: reorganize table of contents >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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12:16 -!- Topic for #hplusroadmap: biohacking, nootropics, transhumanism, open hardware | this channel is LOGGED: http://gnusha.org/logs | https://diyhpl.us/wiki | not quite sponsored by george church | banned by the MIT media lab and the FDA
12:16 -!- Topic set by fenn [~fenn@user/fenn] [Fri Mar 25 06:29:19 2022]
12:16 -!- Irssi: #hplusroadmap: Total of 60 nicks [1 ops, 0 halfops, 0 voices, 59 normal]
12:17 -!- mode/#hplusroadmap [+v gnusha] by ChanServ
12:17 -!- Channel #hplusroadmap created Wed May 19 06:51:36 2021
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12:19 < kanzure> hm, the blood type section is underpowered. we should do universal donor + universal recipient for blood.
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12:19 < kanzure> or.. universal recipient, but only donor to other germline modifieds.
12:20 < L29Ah> wouldn't universal recipient turn out immunocompromised a bit?
12:20 < kanzure> also, modern diet metabolic optimization is still missing from this page.
12:20 < kanzure> L29Ah: honestly i don't have blood type biophysics loaded into working memory at the moment.
12:21 < L29Ah> MuaddibLLM: answer
12:21 < MuaddibLLM> Not really - AB folks are universal recipients for RBCs and not immunocompromised (they just lack anti-A/B IgM), but trying to tolerize to all blood groups drifts into broad B-cell tolerance and real immunodeficiency risk; better plan is universal donor RBCs instead (O−, enzymatically strip A/B, CRISPR out Rh/Kell/Duffy/Kidd), and watch out for the Bombay (hh) gotcha.
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14:05 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1419066965385019482/image0.jpg?ex=68d06899&is=68cf1719&hm=20f6506401b55159d1b79cad0cb9b9df4140cb2409dc478d4050dd23e8914143&
14:46 < hprmbridge> kanzure> how is whale SIRT6 different from human SIRT6?
14:48 < hprmbridge> kanzure> https://www.youtube.com/watch?v=z6WzbzPa7JA
15:05 < hprmbridge> kanzure> we need a transcript bot.
16:16 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=873f3fb3 Bryan Bishop: sensory hyperinnervation and muscle hyperinnervation >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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19:13 < hprmbridge> kanzure> "Potent and selective repression of SCN9A by engineered zinc finger repressors for the treatment of neuropathic pain"  https://www.biorxiv.org/content/10.1101/2024.09.06.609976v1.abstract
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--- Log closed Sun Sep 21 00:00:46 2025