--- Log opened Thu Oct 09 00:00:03 2025
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04:31 < hprmbridge> kanzure> "Deriving human size from fundamental constants" https://fermatslibrary.com/s/man-ssize-in-terms-of-fundamental-constants (1979)
05:10 < fenn> multi-signed reproducible build distro https://codeberg.org/stagex/stagex
05:11 < fenn> it wouldn't have stopped jia tan
05:12 < fenn> (somebody has to actually look at the things)
05:53 < hprmbridge> kanzure> why not guix?
05:56 < hprmbridge> kanzure> oh
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15:38 < kanzure> "Cell autocloning as a pathway to their real rejuvenation" https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2024.1429156/full (2024)
15:38 < kanzure> this is a strange proposal.
15:39 < kanzure> "The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is initiated in the cell genome with the formation of one unstable daughter copy and its subsequent self-elimination.  this case, the process of cell division stops in the phase of nuclei divergence without subsequent physical separation of the cell itself. This is ...
15:40 < kanzure> ...especially important for postmitotic cells, where the looping of the “unidirectional” line of the ontogenesis program into a “ring” will mean their transition into renewable cells. This makes it possible not only to periodically intensify repair processes in the cell nucleus itself when restarting the differentiation process, but also to restart active self-renewal in the cell ...
15:40 < kanzure> ...cytoplasm without disturbing its spatial structure, which is especially important for postmitotic cells, especially such as neurons."
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15:46 < kanzure> "Imperfect asymmetry: The mechanism governing asymmetric partitioning of damaged cellular components during mitosis" https://www.tandfonline.com/doi/full/10.1080/19490992.2015.1014213#d1e292 through "intermediate filament vimentin" 
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15:59 < kanzure> eh nevermind.
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18:20 < hprmbridge> kanzure> "... a cool idea to embed aptamers into circular RNAs. The circularity confers stability and the aptamers confer targeting. So it can be delivered "carrier free," i.e. no LNP or other delivery vector."
18:23 < hprmbridge> kanzure> "For example, the Indian Institute of Technology, Madras, is charting cell types in scores of human brains from autopsies, Iran is establishing a national primate facility in Tehran, and a coalition of Asian synchrotron facilities called SYNAPSE plans to use the intense x-rays generated by the accelerators to map a human brain at subcellular scale."
18:23 < hprmbridge> kanzure> https://www.phys.sinica.edu.tw/~synapse/index.html
18:24 < hprmbridge> kanzure> "We aim to map an entire human brain at sub-cellular resolution revealing the connections of this neuronal network. This feat is made possible by synchrotron x-ray microscopy though image acquisition at 3mm per minute and 0.3um resolution."
18:25 < hprmbridge> kanzure> "SYNAPSE: An international roadmap to large brain imaging" https://www.sciencedirect.com/science/article/pii/S0370157322003933
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19:58 < hprmbridge> kanzure> "Protocol for 3D virtual histology of unstained human brain tissue using synchrotron radiation phase-contrast microtomography" https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2023.1335285/full
20:00 < hprmbridge> kanzure> "Comparative prospects of imaging methods for whole-brain mammalian connectomics"  https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00024-4 (2025) from team "substrate independence at any cost" (our guys)
20:06 < hprmbridge> kanzure> here is an attempt at calculating the data storage memory footprint requirements for different levels of brain imaging datasets https://www.sciencedirect.com/science/article/pii/S187775032400139X
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--- Log closed Fri Oct 10 00:00:04 2025