--- Log opened Sat Oct 11 00:00:05 2025
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08:42 < hprmbridge> kanzure> distributed acoustic sensing for submarine vessels using submarine fiber optic cables https://www.sciencedirect.com/science/article/pii/S0141118725000100
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09:31 < superkuh>  https://www.biorxiv.org/content/10.1101/2025.10.03.680235v1?rss=1
09:31 < superkuh> "Highly Correlated Activity across Higher-Order Thalamic Nuclei in Awake and Anesthetized States"
09:47 < hprmbridge> kanzure> what does it mean that multiple nuclei areas are involved? what does that change?
09:50 < superkuh> The lack of local connectivity further reinforced the idea that the higher order thalmic relays are involved in consciousness itself and bind together multiple separate cortical populations.
09:50 < superkuh> If they're coherently firing without local connections.
09:51 < superkuh> Which is my personal favorite theory of consciousness I took from Rodolfo R Llinas.
10:12 < hprmbridge> kanzure> can we destroy it and make p-zombies?
10:16 < superkuh> I am not sure of the cortical populations would remain functional in terms of controlling the body without the interconnectivity... But might be worth a try in animal models.
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10:30 < hprmbridge> nmz787> kanzure FIB doesn't have enough ballistic energy I think, at least not at normal kV accel voltages
10:32 < hprmbridge> nmz787> I have etched uncoated mushroom spores before.... they definitely delayered rather than gone through the whole cell
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12:05 < kanzure> i wonder if there's enough postmortem viral propagation to do neuronal or synaptic barcoding postmortem
12:06 < kanzure> also, postmortem gene expression profiling is kind of interesting because the cells don't actually know they are in a terminal death scenario
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15:10 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=fa7d133b Bryan Bishop: genetic approaches for bilateral anterior capsulotomy for IQ enhancement >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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15:45 < kanzure> let the robots walk among us https://youtu.be/Eu5mYMavctM
15:58 < kanzure> you pass butter https://www.youtube.com/watch?v=X7HmltUWXgs
16:14 < kanzure> or we can teach them martial arts https://x.com/UnitreeRobotics/status/1970039940022239491 https://x.com/elonmusk/status/1974338806305411516
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16:50 < kanzure> if i wanted to try to make a sociopath or psychopath i think i would lesion the uncinate fasciculus
16:50 < kanzure> or ventral amygdalofugal pathway?
16:52 < kanzure> also the medial prefrontal–hypothalamic pathway to remove autonomic affect from mental distress.
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17:57 < hprmbridge> kanzure> oh, mcintyre is involved in human brain uploading startup eon systems, somehow i forgot about this.
17:58 < hprmbridge> kanzure> and at least one half of the andregg brothers
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18:24 < hprmbridge> kanzure> "TRIBE: TRImodal Brain Encoder for whole-brain fMRI response prediction" https://arxiv.org/abs/2507.22229
18:26 < hprmbridge> kanzure> "High-speed mapping of whole-mouse peripheral nerves at subcellular resolution" https://www.cell.com/cell/fulltext/S0092-8674(25)00673-7
18:27 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1426742975806836746/image0.jpg?ex=68ec5571&is=68eb03f1&hm=6193c2799667e3a18cb7092560869ded405bb523667b99c1eafca1c6801de1bd&
18:27 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1426743070761685083/image0.jpg?ex=68ec5587&is=68eb0407&hm=327483c623cfb2b0a15b161c69fd165aa13922262704fad30647c6fb74bbcede&
18:41 < hprmbridge> kanzure> https://preservinghope.substack.com/p/setting-standards-for-brain-preservation
18:45 < hprmbridge> kanzure> "Restoration of brain circulation and cellular functions hours post-mortem" https://www.nature.com/articles/s41586-019-1099-1
18:47 < hprmbridge> kanzure> https://bexorg.com/technology "Rebooting dead human brains, a biotech startup seeks to reinvent early drug testing. Bexorg has scaled Yale’s BrainEx system from pig studies to donated human brains, keeping post-mortem tissue metabolically active with an artificial blood perfusate. Four BrainEx rigs in New Haven have already run n≈100 human brains; the team targets 500 this year and 1,000 in 2026.
18:47 < hprmbridge> kanzure> Readouts include drug penetration, dose response, toxicity markers and biomarker release, giving pharma partners such as Biohaven a high-fidelity alternative to animal models and a rich physiological dataset for whole-brain simulations."
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--- Log closed Sun Oct 12 00:00:06 2025