--- Log opened Tue Nov 11 00:00:34 2025
00:05 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1437714884585328752/image0.jpg?ex=69143fd3&is=6912ee53&hm=822162bb18256b956d901388e3fe7a412e5057d5bb6f87e4ec5a9b1532a6d241&
00:14 < fenn> so we actually had AI medical pods but then the company shut down abruptly after raising $650 million? huh? https://web.archive.org/web/20231115204422/https://www.fiercehealthcare.com/health-tech/primary-care-player-forward-unveils-ai-based-self-serve-carepods-backed-100m-investment
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00:19  * fenn wonders what a "bloodless" blood collection device is
00:20 < fenn> can you just suck blood out of one of those fingertip lancet things for test strips
00:21 < fenn> i mean prick your finger, stick it into a vacuum hose
00:22 < hprmbridge> kanzure> andrew hessel wants to do human cloning plus a human neochromosome "chromosome 24" https://supernaturalselection.substack.com/p/chromosome-24
00:25 < hprmbridge> kanzure> todd huffman says "I'm starting a new position as Head of Rapid Execution at Episteme! It's a new company doing industrial research, inspired by Bell Labs or Xerox Park, with an Al twist." remains to be seen if Episteme can escape the negative influences of academia.
00:29 < hprmbridge> kanzure> fenn, they are working on firefighting drones now.
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00:31 < fenn> cool. he has a personal interest in that, i'm sure
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00:32 < fenn> https://www.corememory.com/p/exclusive-altman-and-masa-back-episteme-louis-andre
00:34 < fenn> all those formerly NSF-funded scientists gotta go somewhere
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03:44 < hprmbridge> kanzure> they will bring all the bad parts of academia with them....
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05:54 < hprmbridge> kanzure> https://www.funwithcomputervision.com/
06:49 < hprmbridge> kanzure> https://github.com/MoonshotAI/K2-Vendor-Verifier
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10:37 < hprmbridge> kanzure> kimi k2 thinking doesn't censor chemical weapons development yay https://x.com/davidmanheim/status/1988292285038293462
10:47 < hprmbridge> kanzure> https://amateurgods.substack.com/p/how-embryo-corp-took-the-first-step
11:10 < hprmbridge> kanzure> so it's like the face swap app, but for embryos and real faces  https://pmc.ncbi.nlm.nih.gov/articles/PMC4089428/
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12:59 < hprmbridge> kanzure> "We want currently living humans to live healthier and longer. Germline genetic editing can’t do that." this is so myopic and uninspired. https://x.com/BenjaminAryaMD/status/1988335666065998235
12:59 < hprmbridge> kanzure> 1) Human whole body transplantation startups use cloning which starts from embryo scale. You wouldn't want to head swap into an aging body. 2) Regardless, having a win for all future generations is an enormous win and it's worth taking this win even if we don't yet have a solution for adult brain aging.
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13:22 < hprmbridge> Eli> yeah, i'm kind of curious what that guy means? Germline editing should have highest ROI when it comes to life-extension?
13:23 < hprmbridge> kanzure> well you see the overwhelming focus on saving adults has blinded everyone to how to achieve the goal.
13:24 < hprmbridge> Eli> If I were to have children, I would love to get rid of all their pathogenic variants. It seems like you could make a very good pitch to parents that this would be very valuable. Like, you're saving their children's lives.
13:26 < hprmbridge> Eli> oh, he's focused on "currently living".
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13:38 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1437919328279466044/image0.jpg?ex=6914fe3b&is=6913acbb&hm=1b9e98bd2cfff75d2c547185e7c27143bb77b29bb2a70c2992aeaf379ab2ec3d&
13:48 < hprmbridge> kanzure> https://en.wikipedia.org/wiki/The_MANIAC
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14:29 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1437932250564919468/image0.jpg?ex=69150a44&is=6913b8c4&hm=a2894ab585422626bcf31474cc37c31b11f502e5b941363ce961c122a277a2e1&
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17:06 < hprmbridge> kanzure> https://wiki.openwater.health/index.php/Openwater_Wiki#Open-Motion_(Blood_Flow)
17:07 < hprmbridge> kanzure> https://wiki.openwater.health/index.php/Neuromodulation
17:08 < hprmbridge> kanzure> "It offers beamforming configuration and control for driving 128-channel ultrasound transducers."
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19:43 < L29Ah> MuaddibLLM: are there zero-shot voice cloning TTS that work on Vulkan these days?
19:44 < MuaddibLLM> digging into vulkan TTS options, this is niche territory...
19:44 < MuaddibLLM> checking TTS.cpp model support and whether ggml's vulkan actually landed there...
19:45 < MuaddibLLM> Not yet - TTS.cpp (the ggml-based TTS project) has Vulkan support marked as planned but unimplemented across all platforms (https://github.com/mmwillet/TTS.cpp), and its current models (Kokoro, Parler, Dia, Orpheus) don't do zero-shot cloning anyway. OuteTTS (zero-shot, LLaMa-based, CC-BY) exists but isn't ported to ggml/TTS.cpp yet, and XTTS v2/Fish Speech 1.4 run on PyTorch with CUDA/ROCm - for now you'd need CUDA or CPU 
19:45 < MuaddibLLM> inference for practical zero-shot voice cloning, though llama.cpp's Vulkan backend proves the infrastructure works fine once someone bridges it.
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--- Log closed Wed Nov 12 00:00:35 2025