--- Log opened Tue Nov 25 00:00:48 2025
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02:10 < nsh> nice (microfluidics): https://x.com/haildhruv/status/1993183746980483427
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05:47 < hprmbridge> kanzure> "IF1 protein controls aging rate" https://www.biorxiv.org/content/10.1101/2021.10.28.466310v4.full
05:48 < hprmbridge> kanzure> https://medium.com/@Michael_Forrest/attacking-cancers-achilles-heel-immortality-and-possibly-gifting-us-all-a-longer-life-1e030ec1735c
05:48 < hprmbridge> kanzure> why is he talking about himself in the third person
06:48  * TMA understands it is a habit easily acquired by IRC users
06:57 < kanzure> hmph
07:03 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a86343dc Bryan Bishop: add backref, fix typo >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
07:11 < TMA> back when IRC was my most common mode of interaction with other humans, I have acquired that habit as well and I have ocassionally used it in a face-to-face setting as well. But then I have mostly unlearned it, because I strive to mimic the mores of common freerange humans in order to reduce the chance of me being bullied.
07:16 < jrayhawk> it's true, bullies don't dare mess with anyone who talks about themselves in the manner of a WWE wrestler
07:21 < TMA> the local freerange humans do not know what WWE wrestling is and don't know how the wrestlers talk. the strategy needs to be adjusted for each pack of humans encountered
07:32 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b591ea75 Bryan Bishop: longevity: add IF1 overexpression and gain of function mutant ideas >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
07:33 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=349d420f Bryan Bishop: add ref >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
08:02 < kanzure> previously-malignant-but-irradiated cancerous cell lines are sometimes used as a cell therapy. weird!
08:02 < kanzure> the immunological version is not weird (irradiate cancerous cells and then inject them and use them as antigen source for the immune system to learn about the cancer that it will be soon fighting)
08:02 < kanzure> but this is weird:
08:02 < kanzure> "Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke" https://www.sciencedirect.com/science/article/abs/pii/S0301008208000427
08:04 < kanzure> "Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison" https://www.sciencedirect.com/science/article/pii/S2452199X2200439X (2023) this is more immunology focused and less weird.
08:04 < kanzure> "NK-92: an ‘off-the-shelf therapeutic’ for adoptive natural killer cell-based cancer immunotherapy" https://pmc.ncbi.nlm.nih.gov/articles/PMC11029582/ (2015)
08:06 < kanzure> i dunno when you would prefer a cancer-derived neuronal cell therapy versus a fetal stem cell(-derived) neuronal cell therapy.
08:07 < kanzure> "steering tumor evolution to keep treatment-resistant cells in check" hrm.
08:08 < kanzure> maybe you would use the cancer-derived cells if you did not previously have induced pluripotent stem cells, which we did not.
08:08 < kanzure> oh it was published 2008... so there you go.
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08:40 < hprmbridge> kanzure> a review on garbled circuits and bitcoin https://eprint.iacr.org/2025/1253.pdf
09:21 < kanzure> overleaf.com latex editor free tool does not support git integration? wow. that's a strange choice.
09:21 < kanzure> there's this thing but it may not be working anymore? https://github.com/moritzgloeckl/overleaf-sync 
09:28 < kanzure> wouldn't you prefer your users to intentionally share your product with others, rather than.. not use your product at all?
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09:34 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=81d28fcc Bryan Bishop: protein engineering: dimerization, trimerization, multimerization >> http://diyhpl.us/diyhpluswiki/protein_engineering/
09:34 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5d6c1665 Bryan Bishop: fix typo >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
09:34 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=aa61fb99 Bryan Bishop: add typing transcript, add physical learning systems project >> http://diyhpl.us/diyhpluswiki/transcripts/sean-wrona-typing-and-keyboard-geometry/
09:49 < superkuh> Oh no. Google scholar as "try new "scholar labs"" bits all over it. I wonder if they will finally get rid of the last good google search tool.
09:51 < kanzure> i've been looking around for an alternative just in case. semanticscholar is okay-ish. chatgpt is surprisingly good at literature search, but it's not the same as manually walking the citation graph through google scholar.
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12:34 < kanzure> max hodak invested in synchron? https://maxhodak.com/nonfiction/2022/02/04/synchron
13:03 < kanzure> https://x.com/maxhodak_/status/1993413079863115970
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15:56 < hprmbridge> jerlendds> https://www.nature.com/articles/s41467-025-65974-8
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17:27 < hprmbridge> kanzure> https://www.crowdstrike.com/en-us/blog/crowdstrike-researchers-identify-hidden-vulnerabilities-ai-coded-software/
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19:05 < hprmbridge> kanzure> ledgerx has been acquired by robinhood https://x.com/kanzure/status/1993492744460022245
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20:35 < hprmbridge> kanzure> https://www.fuisz.xyz/blog/chimerism
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21:22 < hprmbridge> kanzure> modern drug design market structure issues from AI https://x.com/richardfuisz/status/1991328765373452361 https://x.com/richardfuisz/status/1991203308179181907
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--- Log closed Wed Nov 26 00:00:48 2025