--- Log opened Wed Dec 10 00:00:02 2025
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02:38 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1ddb4e03 fenn: some telomere length control ideas, may be bogus >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
03:29 < fenn> http://fennetic.net/irc/lifecycle_of_the_silkworm.jpg
03:38 < fenn> http://erewhon.superkuh.com/pictures/Boltzman.png
03:39 < fenn> sad but true
03:42 < fenn> the main problem i have with the progammed death theory is that i just don't see what benefit dying has for the replicator. maybe your progeny survive and replicate more effectively in an environment with less competition, but that could also be accomplished by going out and killing the competition instead of killing yourself. you could also reproduce again many times instead of dying, and those
03:42 < fenn> offspring would be more closely related than grandchildren
03:43 < fenn> we don't see those behaviors though. most animals reproduce once and then immediately die
03:48 < fenn> if there's some kind of group benefit, like a reduction in predator populations or preventing overgrazing and collapse of your supporting ecosystem, then there's always the incentive to defect and not die of old age and continue reproducing. some individuals would pursue this strategy (at some externally imposed cost to their offspring no doubt) but that also never happens?
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04:25 < jrayhawk> if your explanation of selection pressures is incompatible with sexual reproduction, you haven't actually thought through the selection pressures
04:27 < jrayhawk> https://en.wikipedia.org/wiki/Evolution_of_sexual_reproduction#Advantages_of_sex_and_sexual_reproduction all apply to programmed senescence at some level
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05:37 < hprmbridge> kanzure> finally i don't have to use a smartphone ever again  https://huggingface.co/zai-org/AutoGLM-Phone-9B
05:44 < L29Ah> yay
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07:34 < kanzure> "Expression of p16INK4a prevents cancer and promotes aging in lymphocytes" https://pmc.ncbi.nlm.nih.gov/articles/PMC3069667 "ablation of p16INK4a can either rescue aging or promote cancer in a lineage-specific manner."
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08:30 < kanzure> "‘Super p53’ mice exhibit enhanced DNA damage response, are tumor resistant and age normally" https://pmc.ncbi.nlm.nih.gov/articles/PMC137187/ (2002)
08:30 < kanzure> "The tumor suppressor p53 is critical in preventing cancer due to its ability to trigger proliferation arrest and cell death upon the occurrence of a variety of stresses, most notably, DNA damage and oncogenic stress. Here, we report the generation and characterization of mice carrying supernumerary copies of the p53 gene in the form of large genomic transgenes. Prior to this, we demonstrate ...
08:31 < kanzure> ...that the p53 transgenic allele (p53-tg), when present in a p53-null genetic background, behaves as a functional replica of the endogenous gene. ‘Super p53’ mice, carrying p53-tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage. Importantly, ‘super p53’ mice are significantly protected from cancer when compared with normal mice. Finally, in ...
08:31 < kanzure> ...contrast to previously reported mice with constitutively active p53, ‘super p53’ mice do not show any indication of premature aging, probably reflecting the fact that p53 is under normal regulatory control. Together, our results prove that cancer resistance can be enhanced by a simple genetic modification and in the absence of undesirable effects.
08:31 < kanzure> "
08:31 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1dd7a835 Bryan Bishop: add super-p53 mouse modification (supernumerary copies of p53) >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
08:31 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2137f7de Bryan Bishop: Merge remote-tracking branch 'origin/master' into master >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
08:42 < kanzure> if short telomeres are recognized as double-strand breaks, then what about endogenous circularization of the chromosome? in terminally postmitotic somatic cells at least.
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11:57 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5c13267f Bryan Bishop: nitpick: remove trailing whitespaces >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
11:57 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f54e7ff5 Bryan Bishop: it's not p53 overexpression >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
12:39 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=94c1714a Bryan Bishop: more DNA damage repair ideas >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
12:44 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=aa00d637 Bryan Bishop: fix some overlapping header titles/anchor links >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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14:00 < tessier> fenn: No, kanzure did.
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16:24 < hprmbridge> kanzure> MuaddibLLM, describe how to use ectopic pregnancies as a basis for an artificial womb. How do you get the microenvironment right for the trophoblast to develop?
16:25 < MuaddibLLM> Researching ectopic pregnancy trophoblast organoids and artificial womb engineering for a comprehensive design approach.
16:25 < MuaddibLLM> Analyzing trophoblast organoid ECM requirements and connecting to EXTEND artificial womb fluid dynamics.
16:26 < MuaddibLLM> Synthesizing ectopic pregnancy trophoblast invasion mechanisms with artificial womb fluidics for a practical design blueprint.
16:28 < MuaddibLLM> Leverage ectopic pregnancy trophoblast organoids bioprinted in synthetic PEG matrix (1.1 kPa stiffness with IKVAV/YIGSR laminin peptides) co-cultured with vascular organoids secreting WNT2B for angiogenesis, maintained at low O₂ with progesterone/hCG, and interfaced to an EXTEND-style fluidic system—creating a functional ectopic-pregnancy-derived artificial placenta that naturally evades immune rejection via 
16:28 < MuaddibLLM> HLA-G/IL-35 expression while establishing fetoplacental circulation.
16:30 < hprmbridge> kanzure> https://huggingface.co/NousResearch/nomos-1
16:32 < hprmbridge> kanzure> this company claims to be working on "tissue replacement" and enhancement https://www.polyphron.com/letter-from-the-founders
16:41 < hprmbridge> kanzure> "Towards CRISPR-based editing of the mitochondrial genome in yeast" https://www.biorxiv.org/content/10.64898/2025.12.09.693232v1
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--- Log closed Thu Dec 11 00:00:03 2025