--- Log opened Mon Dec 22 00:00:13 2025
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04:18 < hprmbridge> kanzure> why is karpathy talking about ghosts https://karpathy.bearblog.dev/year-in-review-2025/
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06:01 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=191b79eb Bryan Bishop: various crazy longevity ideas: >> http://diyhpl.us/diyhpluswiki/longevity/
06:01 < kanzure> "Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells" https://www.pnas.org/doi/10.1073/pnas.091601198
07:16 < kanzure> "Altering DNA repair to improve radiation therapy in cancer" https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.01009/full
07:16 < kanzure> "A totally different strategy consists of mimicking DNA double-strand breaks via small interfering DNA (siDNA) to bait the whole DNA repair machinery, leading to its global inhibition." that's a cool idea.
07:19 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=581be52d Bryan Bishop: cancer has good radiation resistance to crib from >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
07:50 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cdd54b96 Bryan Bishop: move a todo >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
07:50 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=fe9a7df3 Bryan Bishop: more mutation damage ideas >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
07:50 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6a810782 Bryan Bishop: what the heck is 'alternative end joining'? >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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08:44 < hprmbridge> kanzure> "PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins" https://www.biorxiv.org/content/10.64898/2025.12.17.694911v1
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09:28 < L29Ah> no ribosome = no fun
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13:38 < L29Ah> .t https://www.lifespan.io/news/producing-thymic-factors-in-the-liver-rejuvenates-immunity/
13:38 < saxo> Producing Thymic Factors in the Liver Rejuvenates Immunity
13:46 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0e65cb75 Bryan Bishop: transcript: DARPA 'generative optogenetics' DNA synthesis program >> http://diyhpl.us/diyhpluswiki/transcripts/darpa-generative-optogenetics-dna-synthesis/
13:48 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f963ccbd Bryan Bishop: add backref >> http://diyhpl.us/diyhpluswiki/transcripts/darpa-generative-optogenetics-dna-synthesis/
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17:58 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1c427c58 bryan: fix link >> http://diyhpl.us/diyhpluswiki/gene-therapy/
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18:22 < hprmbridge> Eli> Running BPC-157/TB4 now. Trying to see how fast I can recover. https://cdn.discordapp.com/attachments/1064664282450628710/1452848804159295509/IMG_2396.mov?ex=694b4e63&is=6949fce3&hm=0dfcdf26ef7dd732fc6999c970e4849a0dcaf8f65b03d68a6e9baa525a2f957e&
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22:46 < fenn> looks actually useful https://qwen.ai/blog?id=qwen-image-layered
22:46 < fenn> the cocktail party problem for images
22:48 -!- Hooloovoo is now known as Yuleoovoo
23:14 < fenn> "Qwen-Image-Layered, a model capable of decomposing an image into multiple RGBA layers. This layered representation unlocks inherent editability: each layer can be independently manipulated without affecting other content."
23:52 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ad37ad91 Joe Rayhawk: nutrition: framing: outline false-negative aversion >> http://diyhpl.us/diyhpluswiki/nutrition/framing/
23:52 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5663d8f4 Joe Rayhawk: nutrition: add aversion false-ngative graphviz files >> http://diyhpl.us/diyhpluswiki/nutrition/gv/receptor-opioid-training.gv
23:54 < jrayhawk> [[!graph Error: Wide character in subroutine entry at /usr/share/perl5/IkiWiki/Plugin/graphviz.pm line 57.]]
23:54 < jrayhawk> perl in the year of our lord 2025
--- Log closed Tue Dec 23 00:00:14 2025