--- Log opened Wed Jan 07 00:00:29 2026
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03:02 < hprmbridge> yeep.eep> https://tenor.com/view/deus-ex-jc-denton-spin-looped-gif-9986546248234123343
03:27 < TMA> fenn: I remember a short story about such economy. Even food was licensed for a short period of time. It became inedible/poisonous after a while.
03:34 < hprmbridge> jrayhawk> Braky Girdy the First says that kind of activity embarrasses the agency more than it does you.
04:14 < hprmbridge> kanzure> I do not like the power point slop slide. It doesn't really say anything about what the problem is. Where are the force arrows?
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13:00 < hprmbridge> kanzure> "Membrane editing with proximity labeling reveals regulators of lipid homeostasis" https://www.nature.com/articles/s41589-025-02104-x (2026)
13:03 < fenn> the elastin thing is not a complete plan, just a hint of the lurking complexity
13:04 < fenn> there was also some stuff about mechanical forces that didn't make it into the diagram, i was thinking about "g-force therapy" for restoration of elasticity to aging brittle organs but i don't really understand the issues
13:04 < hprmbridge> kanzure> just add DMSO
13:05 < fenn> why?
13:05 < fenn> to better deliver the chinese watersnake oil?
13:08 < hprmbridge> kanzure> ok the slop machine tells me DMSO is not acidic enough
13:09 < fenn> to drive protein hydrolysis reactions?
13:10 < fenn> if it's a joke i'm not getting it, sorry
13:14 < hprmbridge> kanzure> no joke, just bad chemistry on my part, sorry
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18:05 < hprmbridge> kanzure> https://www.tomshardware.com/tech-industry/semiconductors/elon-musk-wants-to-build-a-dirty-fab-that-you-can-smoke-and-eat-cheeseburgers-in-bets-that-tesla-will-turn-the-concept-of-cleanrooms-upside-down
18:05 < hprmbridge> kanzure> maybe you can put wafers inside enclosures?
18:12 < hprmbridge> kanzure> "Insights into DNA repeat expansions among 900,000 biobank participants" https://www.nature.com/articles/s41586-025-09886-z
18:15 < jrayhawk> they already keep wafers inside of enclosures at all times; wtf is he on about?
18:16 < jrayhawk> this man has clearly never seen the inside of an EUV facility
18:17 < hprmbridge> kanzure> maybe he's willing to have low yield?
18:18 < jrayhawk> ketamine-induced rambling
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18:45 < pasky> psa: people like me who have terrible memory and would like to return to twitter posts they have seen scroll by a week ago (but have a habit of liking interesting posts liberally) might appreciate https://github.com/pasky/feedmem
18:46 < hprmbridge> kanzure> pasky, does the x bookmarks feature work? or not work for this?
18:47 < hprmbridge> kanzure> @biluhuang_09127 to your knowledge has anyone collected data as to the physical copy number of rDNA for different species?
18:53 < pasky> i would have tens of thousands of bookmarks, making them useless, and the search is very shitty on multiple levels
18:53 < pasky> some of it might be just habit of liking rather than bookmarking, perhaps, but the search really is terrible anyway
18:58 < kanzure> pasky: do you get your bookmarks out when you download the x archive thingy? or no?
19:17 < L29Ah> pasky: sounds like a good use case for a caching proxy server
19:22 < pasky> i asked for the x archive a week ago, nothing happened so far
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19:42 < kanzure> hello Zsuzsi
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20:39 < hprmbridge> kanzure> "Within species like Homo sapiens, typical diploid rDNA copy number is often reported around ~250–600 copies (with individual variation)"
20:57 < L29Ah> MuaddibLLM: how often should i eat collagen to optimize tissue uptake and utilization of the peptide chunks?
20:57 < MuaddibLLM> snacking on some science to see if that collagen actually does anything useful...
20:57 < MuaddibLLM> L29Ah: Since collagen-derived di/tripeptides (like Gly-Pro-Hyp) peak in plasma about 1-2 hours after ingestion and return to baseline within 6, you should dose 10-15g daily about an hour before mechanical loading (exercise) to maximize blood flow and transport to target tissues, as those "peptide chunks" act more as signaling molecules for your fibroblasts than as direct structural building blocks 
20:57 < MuaddibLLM> (https://pmc.ncbi.nlm.nih.gov/articles/PMC11325589/).
--- Log closed Thu Jan 08 00:00:30 2026