| --- Log opened Fri Jun 24 00:00:07 2011 | ||
| -!- Drakkar [~PixelScum@ip98-177-175-88.ph.ph.cox.net] has joined ##hplusroadmap | 00:19 | |
| QuantumG | heh.. if I could pick one sentence to describe you forever, it would be that one. | 00:44 |
|---|---|---|
| -!- jenzebubble [~jen@173-27-44-143.client.mchsi.com] has joined ##hplusroadmap | 01:31 | |
| -!- jennicide [jen@173-27-44-143.client.mchsi.com] has quit [Ping timeout: 252 seconds] | 01:34 | |
| -!- alystair [alystair@24-246-14-18.cable.teksavvy.com] has quit [Ping timeout: 276 seconds] | 02:28 | |
| -!- JaredW [~JaredW@118.142.17.238] has quit [Remote host closed the connection] | 02:48 | |
| -!- JaredW [~JaredW@118.142.17.238] has joined ##hplusroadmap | 02:49 | |
| -!- Helleshin [~talinck@cpe-71-67-103-109.cinci.res.rr.com] has quit [Read error: Connection reset by peer] | 02:58 | |
| -!- Helleshin [~talinck@cpe-71-67-103-109.cinci.res.rr.com] has joined ##hplusroadmap | 02:58 | |
| fenn | my CIRCLES are beautiful and unique snowflakes | 03:40 |
| -!- Jaakko [~Jaakko@host86-131-177-233.range86-131.btcentralplus.com] has joined ##hplusroadmap | 05:10 | |
| -!- Jaakko is now known as Guest89588 | 05:11 | |
| -!- jenniside [~jen@173-27-44-143.client.mchsi.com] has joined ##hplusroadmap | 05:30 | |
| -!- jenzebubble [~jen@173-27-44-143.client.mchsi.com] has quit [Ping timeout: 240 seconds] | 05:33 | |
| -!- jrayhawk [~jrayhawk@nursie.omgwallhack.org] has quit [Remote host closed the connection] | 05:36 | |
| -!- klafka [~textual@cpe-69-205-70-55.rochester.res.rr.com] has joined ##hplusroadmap | 06:06 | |
| -!- augur [~augur@208.58.6.161] has quit [Remote host closed the connection] | 07:20 | |
| -!- panax [panax@131.247.13.196] has joined ##hplusroadmap | 07:38 | |
| -!- mayko [~mayko@71-22-217-151.gar.clearwire-wmx.net] has joined ##hplusroadmap | 07:41 | |
| -!- jrayhawk [~jrayhawk@216.151.3.174] has joined ##hplusroadmap | 07:42 | |
| -!- augur [~augur@129.2.129.34] has joined ##hplusroadmap | 07:56 | |
| -!- archels [~neuralnet@541ED8B0.cm-5-7d.dynamic.ziggo.nl] has quit [Quit: Reconnecting] | 08:23 | |
| -!- archels [~neuralnet@541ED8B0.cm-5-7d.dynamic.ziggo.nl] has joined ##hplusroadmap | 08:24 | |
| kanzure | synthetic biology conference abstracts: http://sb5.biobricks.org/files/sb5-program-book-v3.pdf | 09:02 |
| -!- mayko [~mayko@71-22-217-151.gar.clearwire-wmx.net] has quit [Ping timeout: 255 seconds] | 09:12 | |
| kanzure | http://ellingtonlab.org/blog/2011/05/22/on-ribozymes | 09:14 |
| kanzure | http://ellingtonlab.org/blog/2011/04/14/on-designer-chemical-weapons | 09:14 |
| -!- panax [panax@131.247.13.196] has quit [Ping timeout: 250 seconds] | 09:36 | |
| kanzure | "Translational synthetic biology in insects" | 09:58 |
| -!- jebba [~jebba@174-29-84-140.hlrn.qwest.net] has joined ##hplusroadmap | 10:32 | |
| kanzure | and less comprehensively: http://sb5.biobricks.org/files/sb5-poster-index.pdf | 10:48 |
| kanzure | hm i didn't realize libsbol and libsbml were different things | 10:52 |
| kanzure | http://www.sbolstandard.org/ | 10:52 |
| augur | kanzure: how did you spend turing day | 10:54 |
| augur | http://blog.regehr.org/archives/546 | 10:57 |
| augur | all of this speculative execution stuff seems obvious to me but i suspect thats because im used to thinking about minds in that setting | 10:58 |
| augur | hm | 10:58 |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has joined ##hplusroadmap | 11:02 | |
| kanzure | i like ellefson's poster "Directed evolution of supercharged polymerases" | 11:11 |
| kanzure | oh.. wait that's andy ellington here in austin | 11:11 |
| kanzure | keepin' it real in austin, texas i guess | 11:11 |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has quit [Quit: Leaving] | 11:12 | |
| kanzure | "Increasing the surface charge of a protein can alter its properties allowing it to internalize into mammalian cells and be thermal/aggregation resistant." | 11:14 |
| kanzure | i'm not sure what you would do with cell-delivery of polymerases | 11:14 |
| kanzure | worst case scenario you physically inject polymerase into a cell with a puncturing device | 11:14 |
| kanzure | is phage-assisted continuous evolution the same as that recent paper about protein-based directed evolution? | 11:16 |
| kanzure | "It was recently discovered that some bacteria produce organelle-like compartments, contrary to the long-held belief that bacteria lack any such organization. These protein-based bacterial microcompartments (MCPs) encapsulate related enzymes involved in a metabolic process. One such MCP system, found in Salmonella enterica, allows the utilization of 1,2-propanediol as a carbon source." | 11:19 |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has joined ##hplusroadmap | 11:19 | |
| kanzure | "Engineering the next generation of genetically encoded tools using PhytochromeB" is neat.. some sort of two-color system for controlling the conformation of a protein (PhyB) which controls whether it binds/unbinds to a peptide | 11:25 |
| kanzure | hehe "Reconstructing the RNA world: evolution and engineering of improved RNA polymerase ribozymes" describes work done to make R18 RNA polymerase ribozyme capable of template-directed RNA synthesis (up to 105 nt "corresponding to half the length of the ribozyme itself" so not quite done yet) | 11:31 |
| kanzure | i should read 'Replication of Genetic Information with Self-Encoded Replicase in Liposomes' | 11:39 |
| uniqanomaly_ | "Supreme Court rules Big Pharma's right to purchase your medical records outweighs doctor-patient privilege. " lmao | 11:40 |
| -!- eudoxia [~eudoxia@r190-135-22-51.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 11:41 | |
| -!- eudoxia [~eudoxia@r190-135-22-51.dialup.adsl.anteldata.net.uy] has quit [Client Quit] | 11:41 | |
| -!- eudoxia [~eudoxia@r190-135-22-51.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 11:42 | |
| kanzure | "Error correction of synthetic genes" hrm these guys are claiming an error rate of only 1:4000 in oligonucleotide synthesis | 11:43 |
| kanzure | "Using retrosynthetic biology to design metabolic pathways for therapeutics production" | 11:46 |
| kanzure | "Retrosynthesis, a concept originally proposed for synthetic chemistr,y iteratively applies reversed biotransformations (i.e., reversed enzymes-catalyzed reactions) starting from a target product in order to reach precursors that are endogenous to the chassis." | 11:46 |
| kanzure | "In our method, substrates, products and reactions are coded into molecular signatures and metabolic maps are represented as hypergraphs. The complexity of the retrosynthetic enumeration of all feasible biosynthetic hyperpaths for a given compound [..] can be addressed in our approach by varying the specificity of the molecular signature." | 11:47 |
| kanzure | so.. yeah, retrosynthetic biology. neat. | 11:48 |
| kanzure | an ok but not great overview of dna synthesis in 2009 http://www.duke.edu/~ies2/Publications/Gene%20Synthesis%20Review-Web%20Final.pdf | 11:54 |
| -!- augur [~augur@129.2.129.34] has quit [Remote host closed the connection] | 12:16 | |
| -!- uniqanomaly_ [~ua@dynamic-78-8-216-64.ssp.dialog.net.pl] has quit [Ping timeout: 255 seconds] | 12:22 | |
| kanzure | RNA replicase story :) http://en.wikipedia.org/wiki/Spiegelman_Monster | 12:27 |
| -!- uniqanomaly_ [~ua@dynamic-78-8-218-201.ssp.dialog.net.pl] has joined ##hplusroadmap | 12:35 | |
| -!- eudoxia [~eudoxia@r190-135-22-51.dialup.adsl.anteldata.net.uy] has quit [Read error: Connection reset by peer] | 13:01 | |
| -!- augur [~augur@208.58.6.161] has joined ##hplusroadmap | 13:17 | |
| -!- eudoxia [~eudoxia@r190-135-109-227.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 13:31 | |
| -!- jebba [~jebba@174-29-84-140.hlrn.qwest.net] has quit [Ping timeout: 252 seconds] | 13:38 | |
| -!- eudoxia [~eudoxia@r190-135-109-227.dialup.adsl.anteldata.net.uy] has quit [Quit: quit] | 14:20 | |
| -!- eridu [~eridu@gateway/tor-sasl/eridu] has quit [Ping timeout: 250 seconds] | 14:38 | |
| ybit | supposedly google has these tech talks where they invite a Heath | 15:01 |
| ybit | http://www.youtube.com/watch?v=MVOm9TwM19A :: Heath@Google Series: ... | 15:02 |
| ybit | here's hoping they accept my talk :) | 15:02 |
| * ybit was expecting a rimshot | 15:20 | |
| -!- eudoxia [~eudoxia@r190-135-109-227.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 15:20 | |
| -!- Drakkar [~PixelScum@ip98-177-175-88.ph.ph.cox.net] has quit [Quit: The beer is meal.] | 15:23 | |
| kanzure | ybit: no rimshots for you | 15:27 |
| -!- jebba [~jebba@198.202.202.21] has joined ##hplusroadmap | 15:27 | |
| -!- jebba [~jebba@198.202.202.21] has left ##hplusroadmap [] | 15:28 | |
| -!- eudoxia [~eudoxia@r190-135-109-227.dialup.adsl.anteldata.net.uy] has quit [Read error: Connection reset by peer] | 15:42 | |
| -!- CryptoQuick [~CryptoQui@c-174-51-232-237.hsd1.co.comcast.net] has joined ##hplusroadmap | 15:48 | |
| -!- jebba [~jebba@198.202.202.21] has joined ##hplusroadmap | 16:01 | |
| -!- jebba [~jebba@198.202.202.21] has left ##hplusroadmap [] | 16:01 | |
| -!- eudoxia [~eudoxia@r190-135-109-227.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 16:24 | |
| -!- Drakkar [~PixelScum@ip98-177-175-88.ph.ph.cox.net] has joined ##hplusroadmap | 16:36 | |
| -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Ping timeout: 250 seconds] | 16:41 | |
| -!- Guest89588 [~Jaakko@host86-131-177-233.range86-131.btcentralplus.com] has quit [Quit: Nettalk6 - www.ntalk.de] | 17:07 | |
| -!- alystair [alystair@24-246-14-18.cable.teksavvy.com] has joined ##hplusroadmap | 18:29 | |
| -!- PixelScum [~PixelScum@ip98-177-175-88.ph.ph.cox.net] has joined ##hplusroadmap | 19:07 | |
| -!- Drakkar [~PixelScum@ip98-177-175-88.ph.ph.cox.net] has quit [Ping timeout: 240 seconds] | 19:10 | |
| -!- jmil [~jmil@SEASNet-148-05.seas.upenn.edu] has quit [Quit: jmil] | 19:11 | |
| -!- jenniside is now known as jennicide | 19:59 | |
| -!- Pabreetzi0 [~Pabreetzi@cpe-174-096-012-143.carolina.res.rr.com] has joined ##hplusroadmap | 20:09 | |
| kanzure | hi Pabreetzi0 | 20:21 |
| Pabreetzi0 | hi bryan | 20:22 |
| Pabreetzi0 | hows it going? | 20:23 |
| Pabreetzi0 | so whats going on with hplus roadmap? | 20:27 |
| -!- eudoxia [~eudoxia@r190-135-109-227.dialup.adsl.anteldata.net.uy] has quit [Quit: quit] | 20:45 | |
| Pabreetzi0 | so many people here, yet no one talking | 21:29 |
| kanzure | we are busy | 21:35 |
| -!- uniqanomaly__ [~ua@dynamic-78-8-84-162.ssp.dialog.net.pl] has joined ##hplusroadmap | 21:40 | |
| -!- uniqanomaly_ [~ua@dynamic-78-8-218-201.ssp.dialog.net.pl] has quit [Read error: Operation timed out] | 21:41 | |
| fenn | we are busy. you will be assimilated. | 21:52 |
| -!- klafka [~textual@cpe-69-205-70-55.rochester.res.rr.com] has quit [Quit: Computer has gone to sleep.] | 23:24 | |
| kanzure | busy busy busy | 23:41 |
| -!- fernan [~pseudo@118.101.154.183] has joined ##hplusroadmap | 23:44 | |
| --- Log closed Sat Jun 25 00:00:07 2011 | ||
Generated by irclog2html.py 2.15.0.dev0 by Marius Gedminas - find it at mg.pov.lt!