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strangewarp | Hmm. I think citicoline works much better on me than aniracetam. | 00:10 |
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strangewarp | Will switch back to citicoline, in pill form instead of those unwieldy drinks, after a while. | 00:11 |
Stee| | strangewarp: once I have money again, I'm putting together a flavonoid super dose drink to test | 00:23 |
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strangewarp | oh nice. | 00:28 |
strangewarp | Aniracetam improves my mood, and makes me more thoughtful, but only citicoline gives me unwavering massive motivation... | 00:29 |
Stee| | have you tried oxiracetam? | 00:35 |
strangewarp | Traditionally I've had fucking nasty problems with depression and laziness, so the difference was marked. Definitely felt like I'd reclaimed the state I was in back when I was a child prodigy. | 00:35 |
strangewarp | Haven't tried oxiracetam; will probably give it a shot once I'm making money.. | 00:35 |
klafka1 | strangewarp | 00:41 |
klafka1 | hmm i want to try citicoline | 00:41 |
klafka1 | i have massive motivation problems at times | 00:41 |
strangewarp | It may be a personal-reaction, YMMV kind of thing | 00:51 |
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Stee| | Sigh | 01:34 |
Stee| | Thiel, couldn't you have thrown that 500k at something more useful than seasteading | 01:35 |
strangewarp | Nope seasteading is the big dream of people who like their futurism made out of present-day technology and shaped into hundred-year plans | 01:35 |
strangewarp | Same thing with like.. human space exploration | 01:35 |
Stee| | Oh, I'm fond of human space exploration too, but mostly as a resource base | 01:36 |
Stee| | to crash metal prices | 01:36 |
strangewarp | Indeed | 01:36 |
strangewarp | There's gold in that thar moon | 01:36 |
strangewarp | (literally) | 01:36 |
Stee| | fuck gold, get neodynium/lithium/gallium | 01:36 |
strangewarp | mmmmmm | 01:36 |
kanzure | strangewarp: "child prodigy" sounds like a wonderful way to make sure your kid grows up depressed | 01:37 |
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strangewarp | oh definitely, absolutely | 01:37 |
Stee| | it's about 70/30 from what I've seen | 01:37 |
kanzure | the moon is not 70% or 30% gold | 01:38 |
* kanzure sleeps | 01:38 | |
Stee| | I meant whether or not 'child geniuses' turn out depressed or not | 01:38 |
strangewarp | Short answer: I was in an emotionally abusive household and forced through advanced and college programs when I should have been living somewhere else and seeing a therapist | 01:38 |
kanzure | have you tried beating them Stee|? that might increase it | 01:38 |
Stee| | hah :P | 01:38 |
Stee| | I was one of the lucky ones, but I also didn't have any particular thing I was a prodigy at | 01:39 |
Stee| | good at music and english, didn't get a shit about either of them | 01:39 |
strangewarp | I'm pretty much ok now though, aside from mood and sleep problems, and it seems I can control the mood problems with nootropics | 01:39 |
strangewarp | Citicoline was even dampening my sleep problems too; and that was at minimum dose | 01:40 |
strangewarp | 500mg of citicoline might be extremely useful for me, if spendy - I'll see whether I can do enough music gigs to afford the monthly pills | 01:41 |
strangewarp | Music and English are great, hm | 01:42 |
Stee| | yeah, but not really my thing | 01:43 |
strangewarp | I get weird mental pleasure from music - not erotic - and so I've decided to make the kind of music that I would like to hear, but which doesn't exist yet :p | 01:44 |
strangewarp | Woooooaaah. | 02:10 |
strangewarp | 5 months' worth of citicoline is on Amazon for $38. Damn. Okay, that is motivating me to work :P | 02:11 |
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strangewarp | oh right | 02:38 |
strangewarp | klafka1: Forgot to bring this up, but, like the racetams, you need to take choline citrate for your body to absorb citicoline | 02:38 |
lichen | ive heard cdp-choline or centrophenoxine are better sources of choline | 02:40 |
lichen | cross the blood-brain barrier more easily | 02:41 |
lichen | worth looking into if youre buying choline | 02:41 |
strangewarp | indeed, I'll probably look into that the next time I need choline | 02:41 |
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Vicarious | 'morning | 02:54 |
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strangewarp | Hmmm | 04:49 |
strangewarp | Apparently, alpha-GPC is the form of choline that makes Nawgan's delivery of citicoline so effective | 04:50 |
strangewarp | Looks like my next purchase will be citicoline and alpha-GPC.. | 04:50 |
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strangewarp | Wurgh. This slump suspiciously coincides with my switching to a different nootropic. How extremely suspicious. | 05:42 |
kanzure | correlation is not causation and such | 05:42 |
strangewarp | Inverse correlation implies negative causation; correlation implies but does not prove causation and more information is required | 05:43 |
* strangewarp afks for sleep | 05:46 | |
kanzure | pft at-keyboard sleep is perfectly valid sleep | 06:04 |
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kanzure | heee yes http://www.reddit.com/r/shittyaskscience | 07:16 |
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indigenous | Is that a. . a circlejerk for science ? | 07:17 |
kanzure | it's where all the important questions are going from now on | 07:18 |
indigenous | Some lol worthy question titles there | 07:20 |
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indigenous | Just got an email: Humanity+ Nominations Open for Board of Directors. | 07:25 |
* indigenous nominates kanzure | 07:25 | |
kanzure | oh noes not this again | 07:26 |
indigenous | I really have to stop signing up to newsletters | 07:26 |
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kanzure | where did toykeeper go | 08:33 |
Mariu | hmm | 08:33 |
Mariu | hey kanzure | 08:33 |
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kanzure | ok. | 08:36 |
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kanzure | javascript insanity: [].forEach exists but {}.forEach does not | 09:25 |
vrs | kanzure: [].forEach.call({}, f) | 09:25 |
vrs | also forEach is a method of the array prototype, of course Object.prototype doesn't have it | 09:26 |
vrs | it must be said that when you [].forEach.call({}, f), only numeric keys get iterated over and only those that are smaller than the length property of the object | 09:27 |
kanzure | i have a situation where i originally wrote some code assuming an object should be an array | 09:28 |
kanzure | but it turns out that i need relatively constant indexices | 09:28 |
kanzure | i process this object with .forEach in a bunch of places | 09:28 |
kanzure | i think i should just add obj.prototype.forEach for just that | 09:28 |
kanzure | ? | 09:28 |
kanzure | *indices | 09:29 |
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vrs | >add obj.prototype.forEach | 09:32 |
vrs | hell no | 09:32 |
kanzure | why not? | 09:32 |
vrs | or wait, are you writing es5? or for browsers? | 09:32 |
vrs | aka, node or browsers? | 09:32 |
kanzure | i'm writing for phantomjs | 09:32 |
kanzure | it's a headless webkit thing | 09:33 |
kanzure | so.. browsers. | 09:33 |
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kanzure | i mean just myobj, not Object :) | 09:33 |
vrs | then stay away from object.prototype | 09:33 |
vrs | ah | 09:33 |
vrs | yeah, do that | 09:33 |
kanzure | i don't see much damage with modifying this particular .forEach | 09:33 |
kanzure | esp. since it doesn't exist | 09:34 |
vrs | yeah it's ok, the only prototype you really should stay away from is Object | 09:34 |
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kanzure | vrs: why is there no .keys? firefox/chrome are both kind enough to provide a top-level keys() method | 09:35 |
vrs | nonstandard I guess | 09:35 |
kanzure | is there some other way to investigate an object? | 09:35 |
vrs | investigate how? | 09:36 |
vrs | you can always look at it in the debugger of your choice | 09:36 |
kanzure | how does JSON.stringify() figure out what keys your object has | 09:36 |
vrs | for .. in | 09:36 |
kanzure | yes but what mechanism does that use | 09:36 |
vrs | built in | 09:36 |
kanzure | fuck | 09:36 |
vrs | https://developer.mozilla.org/en/JavaScript/Reference/Statements/for...in | 09:37 |
kanzure | i like hasOwnProperty | 09:37 |
vrs | every browser has that | 09:37 |
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Coornail | you can look at objects like hashtables or arrays, and you can walk trough their elements | 09:44 |
Coornail | like [1, 2, 3] is valid, [1, 2, function() {vaaaa();}] is valid as well | 09:44 |
Coornail | an object is just a bunch of functions | 09:44 |
kanzure | yep.. | 09:44 |
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kanzure | "There used to be a scam in England where people would use solvents to wash away the postmark from posted letters, allowing them to sell / re-use the stamps." | 10:48 |
kanzure | "I used to work in a integrated circuit debugging lab. We had a pulse laser that we would use to ablate the layer of glass on top of the metallization so we could probe the die. While goofing around I discovered that I could vaporize the ink of dollar bills. The largest area per pulse was pretty small, 25 microns if I remember right. Maybe 100. So it wasn't very practical, but it worked." | 10:48 |
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kanzure | http://tequals0.wordpress.com/2012/03/12/gfp-project-week-2-extractifying-gfp/ | 11:29 |
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kanzure | "000233 - University of Pennsylvania, Lab of Chris Chen, Bioengineering (Jordan Miller)" | 12:02 |
kanzure | http://wiki.makerbot.com/lineage | 12:02 |
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kanzure | ok.. so in conclusion: people used to buy $200/disc anime without watching it, | 12:35 |
kanzure | and people would buy $2000 encyclopedia sets that they made monthly payments on | 12:35 |
kanzure | what the hell? | 12:35 |
kanzure | also: http://tauday.com/tau-manifesto | 12:35 |
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* Mokbortolan_ writes the "father" of Hobbie-J to ask for a breeding pair of NR2B-over-expressed rats. | 12:47 | |
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jrayhawk | well, the encyclopedias were an investment in your child's future | 13:02 |
kanzure | library card? | 13:02 |
jrayhawk | that's a bit of a barrier to looking stuff up | 13:02 |
kanzure | and shouldn't the school be doing that anyway? | 13:02 |
kanzure | hrmm | 13:03 |
jrayhawk | obviously they were a rather dumb investment after the introduction of encarta and pals | 13:05 |
indigenous | You can pick these sets up very cheaply now in charity shops. Some door to door book sellers like 'the book people' made most of their money of these. In preinternet days it was good for kids to have easy access to information/read and be curious | 13:07 |
indigenous | and precomputer in every household days | 13:07 |
indigenous | I had a bunch of single encylopedias when I was a kid | 13:08 |
kanzure | living in a library sounds better to me | 13:08 |
jrayhawk | this is a good plan | 13:08 |
kanzure | i don't see how to make information consumption reliably work otherwise.. without significant planning/delays | 13:08 |
indigenous | I purchased a rather large websters universal dictionary recently. From around 1940. Most smalll towns severly lack decent library facilities | 13:09 |
kanzure | yes that's another part of my genius plan (don't live in a small town in the 40s) | 13:09 |
indigenous | In my local library there are 6 bookcases for art, 6 for music and only 3 for all of science. This makes me sad. | 13:10 |
kanzure | *if you have to live in the 40s do not live in a small town | 13:10 |
indigenous | I mean the book was from 1940, most small towns in the UK lack decent library facilities now | 13:10 |
Mokbortolan_ | do you think there's a market for rats genetically modified for increased intelligence? | 13:10 |
Mokbortolan_ | or is that a foolish way to start a doomsday scenario... | 13:11 |
kanzure | Mokbortolan_: rats are kind of hard creatures to love | 13:11 |
kanzure | i was thinking once that someone should start an 'adopt a lab rat' adoption agency | 13:11 |
Mokbortolan_ | bullhockey | 13:12 |
Mokbortolan_ | pet rats are adorable | 13:12 |
kanzure | well there might be enough people who would adopt a smarter rat | 13:12 |
kanzure | or even pay for one | 13:12 |
Mokbortolan_ | I wrote Joe Tsien asking him to collaborate in a pet rat breeding program | 13:12 |
Mokbortolan_ | I offered him full access to the animals and data, and discretion in the trait selection program | 13:13 |
Mokbortolan_ | hopefully he'll bite, or I'll have to start without him and learn how to modify the rats myself :p | 13:14 |
kanzure | you should learn how to do that anyway :) | 13:14 |
Mokbortolan_ | how does one actually go about over-expressing NR2B in the hippocampus? | 13:15 |
kanzure | promoters | 13:15 |
kanzure | lots and lots of promoters | 13:15 |
Mokbortolan_ | I mean, in practical terms, where does the genetic modification take place? | 13:15 |
Mokbortolan_ | egg/sperm combination? | 13:15 |
Mokbortolan_ | modification of the egg or sperm prior to fertilization? | 13:16 |
kanzure | you would probably do in vitro fertilization | 13:16 |
kanzure | http://en.wikipedia.org/wiki/Regulation_of_gene_expression | 13:16 |
kanzure | Genome-wide atlas of gene expression in the mouse brain http://kiefer.stat2.sinica.edu.tw/SBJC/slides/2007-06-20.pdf | 13:17 |
Mokbortolan_ | are those traits heritable? | 13:18 |
kanzure | if you modify the initial genome before in vitro fertilization then that is the genome that the cell has to use | 13:18 |
Mokbortolan_ | so are you talking embryonic modification or germ cell modification? | 13:19 |
* Mokbortolan_ reads. | 13:19 | |
kanzure | in vitro fertilization refers to fertilizing an embryo with specific genomic dna | 13:20 |
kanzure | there's another technique called scnt where you can physically replace the nucleic content of a cell | 13:20 |
kanzure | um i am somewhat embarrassed to admit that i do not have a good overview/review of gene regulation mechanisms to make sure your protein is overexpressed in some known amount | 13:21 |
kanzure | this has a few ok diagrams of how genetic regulatory networks work http://bi.snu.ac.kr/SEMINAR/BioNetwork/Engineered%20gene%20circuits.pdf | 13:21 |
kanzure | oh sometimes it's referred to as 'transcriptional networks' | 13:23 |
Mokbortolan_ | hmm | 13:24 |
Mokbortolan_ | maybe I'll leave the modification to existing experts and focus on breeding protocols :p | 13:24 |
kanzure | why :( | 13:24 |
Mokbortolan_ | one idea I had was to select for rats able to understand human speech, at least better than they do now | 13:24 |
kanzure | and what would you start with to get there? | 13:25 |
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Mokbortolan_ | a regular rat, or if Mr. Tsien is willing, an NR2B rat | 13:26 |
Mokbortolan_ | or did you mean testing protocol | 13:26 |
kanzure | when you want to select for something that doesn't exist yet, you have to start by selecting for something that does | 13:26 |
Mokbortolan_ | oh, right | 13:27 |
Mokbortolan_ | I thought about testing for the successful association between words and reward | 13:27 |
Mokbortolan_ | like, on a display, show the color blue and the word blue, then provide a blue door with food behind it | 13:28 |
Mokbortolan_ | or a similar mechanism (lever, etc) | 13:28 |
Mokbortolan_ | then do the same for "red" | 13:29 |
Mokbortolan_ | then combine the two | 13:29 |
Mokbortolan_ | and alternate between blue/red in a random pattern | 13:29 |
Mokbortolan_ | and then, once the rat was successful at this, take away the display and have him rely on the word alone | 13:30 |
Mokbortolan_ | tracking success all along the path | 13:30 |
Mokbortolan_ | highly successful rats will be bred, and generation 2 will go through the same protocol | 13:31 |
kanzure | i don't think that selection experiment would work because the selector is not sufficiently discriminating | 13:32 |
kanzure | however i have an alternative suggestion | 13:32 |
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Mokbortolan_ | Ok | 13:32 |
kanzure | you can model the rat auditory cortex in NEURON and other simulators and then feed it audio data | 13:32 |
kanzure | then you can tweak different parameters (controlled by different genes) to see when/if auditory processing ability improves | 13:33 |
kanzure | once you know which parameters you are aiming to tweak you can start the selection experiments | 13:33 |
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Mokbortolan_ | and analyze for expression in the breeding program? | 13:34 |
Mokbortolan_ | err, no, I see | 13:36 |
Mokbortolan_ | to determine selection criteria | 13:36 |
kanzure | yes you could analyze for expression (usually by mRNA expression levels or protein expression levels in histological slices) | 13:36 |
kanzure | WHY DO I KNOW THESE THINGS | 13:37 |
kanzure | um right.. so anyway if you know what changes need to be made you could sometimes just make the genetic alterations to whatever defines the auditory cortex | 13:37 |
Mokbortolan_ | that's a bit beyond my skill level | 13:37 |
kanzure | the selection experiment is the run mostly in silico - you will not need 20,000 generations of breeding | 13:37 |
kanzure | 50,000 generations is also beyond your skill level. | 13:37 |
Mokbortolan_ | your'e right | 13:38 |
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Mokbortolan_ | would it really take 50k generations? | 13:38 |
Mokbortolan_ | maybe I could periodically bombard them with ionizing radiation :p | 13:38 |
kanzure | to get the exact mutations on the right set of a few hundred genes? prolly | 13:38 |
Mokbortolan_ | I'm inspired by the russian silver fox domestication program | 13:39 |
kanzure | violence/aggression is much simpler than tweaking an auditory cortex | 13:40 |
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kanzure | do you believe simulations are impossible? | 13:40 |
kanzure | what's the holdup? i don't understand | 13:40 |
Mokbortolan_ | no, I just don't know enough about them | 13:40 |
Mokbortolan_ | maybe i could participate more fully with a research group | 13:41 |
kanzure | you have an insufficient level of hubris | 13:41 |
kanzure | hmm | 13:41 |
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Mokbortolan_ | I am constantly downgrading the estimation of my own competence :p | 13:42 |
Mokbortolan_ | with each new thing I learn | 13:42 |
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Mokbortolan_ | or just bug the shit out of you until I learn enough to be effective | 13:43 |
kanzure | also.. i might be wrong but iirc mice/rats are able to be trained on auditory ques | 13:43 |
Mokbortolan_ | they are | 13:43 |
Mokbortolan_ | but, I would want the exceptional ones | 13:44 |
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Stee| | they are | 13:44 |
kanzure | Functional organization and population dynamics in the mouse primary auditory cortex http://neuro.bcm.edu/_web/jc/sn/nn_2484(2)(1).pdf | 13:44 |
Mokbortolan_ | but variability might be an issue | 13:44 |
Stee| | kanzure, there was a recent study where they hooked up neuroprosthetics to rats | 13:44 |
Stee| | with an auditory tune feedback | 13:44 |
Stee| | *tone | 13:44 |
Mokbortolan_ | Yeah! i read that one | 13:45 |
Mokbortolan_ | genius | 13:45 |
Stee| | Mokbortolan_, there's a thread now by a guy who builds/sells tDCS machines | 13:45 |
kanzure | was it "Changing tune in auditory cortex"? | 13:45 |
kanzure | a thread? | 13:45 |
Stee| | kanz, lemme check | 13:46 |
Stee| | http://scienceblog.com/52514/new-hope-for-natural-feeling-neuroprosthetics/ | 13:46 |
Mokbortolan_ | Stee|: please don't say "flowstateengaged" | 13:46 |
Stee| | Mokbortolan_, what? | 13:47 |
Mokbortolan_ | www.flowstateengaged.com | 13:47 |
Mokbortolan_ | "Our tDCS kit is the shit. Here's why." | 13:48 |
Mokbortolan_ | ugh | 13:48 |
kanzure | bah blah blah more marketing | 13:48 |
kanzure | marketing is lame | 13:48 |
Mokbortolan_ | especially when there's NO PRODUCT | 13:48 |
kanzure | and even if there is product "Learn faster. Learn more. Be awesome." is not actually guaranteeable with tdcs | 13:48 |
kanzure | Mokbortolan_: if you do some reading on gene regulation, i'd appreciate some paper contributions for my collection | 13:49 |
kanzure | esp. any reviews of specific control of expression levls of multiple elements | 13:50 |
kanzure | like say... 2 or 10 or 100 simultaneously different expression levels. that would be nice to know. | 13:50 |
kanzure | > I can't believe the countless hoards that seem intent on forever | 13:51 |
kanzure | > prohibiting exactly what I spent 10 years of my life and over $100,000 of my | 13:51 |
kanzure | > money at university learning how to do. I have the knowledge, skills, and | 13:52 |
kanzure | > desire to read and write the scripting language of life. But instead now, | 13:52 |
kanzure | > because of people like this, I drive a taxi cab. With all these | 13:52 |
kanzure | > bioconservative apes in charge, in the US, a biology degree might as well be | 13:52 |
kanzure | > a degree in music appreciation. | 13:52 |
ThomasEgi | Mokbortolan_, want one? if there is enough demand to justify a few hours work i have to spend i can build that constant-current controll you would need for tdcs | 13:52 |
kanzure | ThomasEgi: btw what did you price your time at? | 13:52 |
Mokbortolan_ | I've got the parts, I just need 1-3hrs to sit down and construct it | 13:52 |
Mokbortolan_ | I'm in the middle of moving, sothat doesn't help | 13:52 |
Stee| | ThomasEgi, do you have the magnetic implants? | 13:52 |
ThomasEgi | kanzure, i dont see this community as a commecrial entity, so i wont ask for money of my worktime. just the materials i use. that would be only a few bucks for pcb's and parts | 13:53 |
ThomasEgi | Stee|, only an rfid. i am still waiting for better shaped/coated magnets, that are easier to inject. | 13:53 |
Mokbortolan_ | ThomasEgi: I do want one though :p | 13:53 |
Mokbortolan_ | the guy who moderates the tDCS forum came up with a *really* elegant design | 13:54 |
ThomasEgi | i might skipp the magnets altogether. and go straight for the bigger ones | 13:54 |
ThomasEgi | Mokbortolan_, link? | 13:54 |
Stee| | okay. ThomasEgi, if/when you do get them, I have some experimental protocols I'd like to test | 13:54 |
Mokbortolan_ | he hasn't posted about it yet | 13:54 |
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ThomasEgi | Mokbortolan_, a controllable current-source with 2mA isn"t very difficult to do, the circuit parts are hardly worth 2 $ | 13:55 |
Mokbortolan_ | the trick is making 99.9999999% sure the thing doesn't let loose with too much current | 13:56 |
ThomasEgi | there is no such thing is 100% | 13:56 |
ThomasEgi | and meantime between failures is hard to calculate. | 13:57 |
Mokbortolan_ | fuses help there | 13:57 |
ThomasEgi | usualy you have your resistors, they tend to never fail and limit the current even in case of the most catastrophic events | 13:57 |
ThomasEgi | in the design i had in mind. there are only 3 active parts | 13:58 |
ThomasEgi | one transistor. 2 diodes. | 13:58 |
Mokbortolan_ | can it adjust for varying load resistance? | 13:59 |
ThomasEgi | unless you kill it with too high supply voltage or by massive ESD surges. they wont fail | 13:59 |
ThomasEgi | sure | 13:59 |
ThomasEgi | it is a constant current source. | 13:59 |
ThomasEgi | you have a knob. that allows you to set the current between 0 and 2mA | 13:59 |
Mokbortolan_ | can you post a schematic? I'd love to know how it works | 13:59 |
ThomasEgi | i already did post a link here. some weeks ago. lemme find it again | 14:00 |
ThomasEgi | http://home.arcor.de/positiveelectron/files/controllable-cc-source.png | 14:01 |
ThomasEgi | pretty much a textbook circuit, with slight adaption to make the current-controll indebendant of the supply voltage | 14:01 |
ThomasEgi | if you want, you can add an additional protection resistor at the top-wire. | 14:02 |
Mokbortolan_ | hmm | 14:02 |
Mokbortolan_ | I'd ask you how it works, but that would probably require you to explain elementary theories :p | 14:03 |
ThomasEgi | that would limit the current even in the catastrophic event of a transistor-break-through AND both diodes breakthrough at the same time | 14:03 |
ThomasEgi | hm. well i could give you the short version. | 14:03 |
ThomasEgi | but it wouldnt make sense unless you have at least a basic understanding of how electronic works | 14:03 |
ThomasEgi | so if you are fine with currents and voltages i cant try to explain | 14:04 |
Mokbortolan_ | I know what each of the components do invidivually | 14:04 |
ThomasEgi | okay. so. i will start left to right | 14:04 |
ThomasEgi | D1 and R1 make a constant-voltage source. the output forks of to RV1. it will usualy be the zener-diode-voltage (in this case 4.7V) | 14:05 |
ThomasEgi | RV is a poti acting as voltage-divider. followed by the diode D2, that simply drops 0.65V(i will get to that later) | 14:06 |
ThomasEgi | so the output of RV1 will vary, depending on your knob-position. between 0.65V and 4.7V | 14:06 |
ThomasEgi | that voltage is put on the base of the NPN transistor. that is where a bit of magic happens. | 14:07 |
ThomasEgi | the transistors base-emmiter voltage is (in this case, pretty fixed) about 650mV (the same as D1) | 14:08 |
ThomasEgi | so if you put 4.7V on the base. roughly 0.7 will be dropped over the B-E trace of the tranistor. the remaining 4V have to be dropped at R2 | 14:08 |
ThomasEgi | R2 is 4Kohm , so if you put 4V on it, according to ohm's law , it will flow a current of 4V/2000ohm. that is 2mA | 14:09 |
ThomasEgi | given, that current cant be drawn from the collector of the transistor | 14:09 |
ThomasEgi | if not. it will be less. | 14:09 |
ThomasEgi | it pretty much doesnt matter if you directly connect the collector to the battery. or if you have 100ohms on it. | 14:10 |
ThomasEgi | in worst case. your resistance will be so high, that that will be the current limiting parts. | 14:11 |
ThomasEgi | but over a very wide range of load-resistances , the current will be very stable and constant. | 14:11 |
ThomasEgi | turning the knob to lower the voltage at the transistor base, will lineary decrease the current too. | 14:12 |
ThomasEgi | down to 0, or pretty close to 0 V | 14:12 |
ThomasEgi | if you operate the circut from a single 9V block battery, i would adapt the Zener voltage to something like 2.7V, and R2 to 1kOhm | 14:13 |
ThomasEgi | the whole circuit is stable, wont oscillate, is vastly independand from the transistor properties (any npn transistor rated the maximum voltage of your battery supply should do) | 14:14 |
ThomasEgi | if you want extra-protection you can also add a simple FET based current limiter in the electrode wire. | 14:15 |
ThomasEgi | i wouldn't sell that thing as medical-grade system. but for most hobbyist who know what they are doing, that should be perfectly fine as long as you dont spill coke over the circuit or anything like that | 14:16 |
ThomasEgi | questions/suggestions? | 14:17 |
Stee| | ask me in two months :P | 14:18 |
Stee| | lol | 14:18 |
ThomasEgi | i guess the thing is pretty easy to build yourself. but if anyone feels so terribly unskilled i could easily make a few boards next time i build pcb's in my lab. | 14:19 |
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Mokbortolan_ | argh | 14:29 |
Mokbortolan_ | pidgin crashed | 14:29 |
Mokbortolan_ | I need a new client | 14:29 |
kanzure | Mokbortolan_: irssi, xchat, bitchx, osx people like uh... textual or something | 14:30 |
Stee| | I use virc | 14:30 |
Stee| | but it's not 7 compatible | 14:30 |
indigenous | I use quassel. Good support on #quassel | 14:30 |
indigenous | I use it on winodws but i is multiplatform | 14:31 |
indigenous | *windows | 14:31 |
indigenous | What it looks like on windows: http://i.imgur.com/RWam4.png | 14:34 |
jrayhawk | Mokbortolan: let me know if you want an ssh account somewhere you can keep a persistent session. | 14:34 |
indigenous | Not as feature full as mIRC with NoNamescript but probably the best up and coming. As you can tell I really like it :) | 14:35 |
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thylane | 54 nicks. (sweet jeezus) | 14:37 |
kanzure | hello thylane | 14:37 |
thylane | hi | 14:37 |
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kanzure | hi A-Lusion | 14:38 |
A-Lusion | HOLY SHIT | 14:38 |
Mokbortolan_ | xchat is not free :( | 14:38 |
A-Lusion | I Love you guys already | 14:38 |
Stee| | I love us too. | 14:38 |
Stee| | what's up | 14:38 |
A-Lusion | I was recommended from #ai | 14:38 |
uniqanomaly | ;) | 14:38 |
A-Lusion | Omg nootropics | 14:38 |
A-Lusion | biohacking | 14:39 |
Mokbortolan_ | jrayhawk: Thanks! I need to implement that myself | 14:39 |
Mokbortolan_ | though | 14:39 |
A-Lusion | Someone set me up with more info, I been looking at ordering some nootropics myself! | 14:39 |
A-Lusion | I was thinking piracetum and chloline | 14:39 |
Mokbortolan_ | right now I'm using a "persistent session" in the form of a laptop behind my TV at home :p | 14:39 |
uniqanomaly | A-Lusion: http://reddit.com/r/nootropics | 14:39 |
kanzure | A-Lusion: well the best supplier online at the moment is Mokbortolan_ | 14:39 |
Mokbortolan_ | changed the RDP port to 443 and Bob's your uncle | 14:39 |
A-Lusion | Have you guys heard of the protein that is showing evidence of photographic memory? | 14:40 |
Mokbortolan_ | kanzure: I'm out of piracetam | 14:40 |
kanzure | Mokbortolan_: dude you had like a shipping container of it | 14:40 |
Mokbortolan_ | I had 28kg | 14:40 |
kanzure | A-Lusion: no can you link me to the pdb file? | 14:40 |
Mokbortolan_ | blew through it in 2.5mo, it was crazy | 14:40 |
A-Lusion | My friend has the article he will be here in a matter of minutes | 14:41 |
A-Lusion | HOWEVER | 14:41 |
kanzure | A-Lusion: http://diyhpl.us/~bryan/papers2/longevity/ | 14:41 |
Mokbortolan_ | A-Lusion: HardRhino is the cheapest good-reputation seller right now | 14:41 |
A-Lusion | I am sure you guys are aware of the article "zapping your brain into the fast lane to pure focus" | 14:41 |
kanzure | http://diyhpl.us/~bryan/papers2/stem-cells/ | 14:41 |
uniqanomaly | Mokbortolan_ 373g/day? ;D | 14:41 |
kanzure | http://diyhpl.us/~bryan/papers2/neuro/ | 14:41 |
kanzure | have some papers.. | 14:41 |
Mokbortolan_ | uniqanomaly: I was a reseller | 14:41 |
kanzure | A-Lusion: tdcs is interesting but the localization is weak | 14:41 |
uniqanomaly | Mokbortolan_: yeah just kidding ;D | 14:41 |
thylane | >_> http://www.wired.co.uk/magazine/archive/2012/03/how-to/make-a-biohack-lab | 14:41 |
uniqanomaly | Mokbortolan_: just imagine it | 14:42 |
kanzure | A-Lusion: ultrasound has 2mm resolution (or better) http:/diyhpl.us/~bryan/papers2/neuro/ultrasound | 14:42 |
uniqanomaly | ;D | 14:42 |
Mokbortolan_ | kanzure: I posted a paper on the tDCS reddut about a group that found a way to focus it more tightly | 14:42 |
kanzure | thylane: i keep track of diybio articles here http://bit.ly/diybionews2 | 14:42 |
A-Lusion | Holy shit so many links and information <3_<3 | 14:42 |
Mokbortolan_ | using multiple anodes to guide the current | 14:42 |
kanzure | Mokbortolan_: and how specific is it | 14:42 |
kanzure | i am not amused | 14:42 |
Mokbortolan_ | fairly specific, IIRC | 14:42 |
Mokbortolan_ | lemme get you the link | 14:42 |
kanzure | i'm just not generally convinced :x | 14:42 |
kanzure | i'd like that | 14:42 |
A-Lusion | tdcs stands for? | 14:43 |
kanzure | transcranial direct current stimulation | 14:43 |
kanzure | but really.. try ultrasound http:/diyhpl.us/~bryan/papers2/neuro/ultrasound | 14:43 |
A-Lusion | Aha! yes are there DIY methods out that are.. safe | 14:43 |
A-Lusion | Ultrasound | 14:43 |
kanzure | it depends on how safe you want safe to man | 14:43 |
kanzure | *mean | 14:43 |
Mokbortolan_ | http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5754695 | 14:43 |
Mokbortolan_ | I have the actual text of the article too | 14:43 |
kanzure | Mokbortolan_: haha yes but the abstract is vague | 14:44 |
kanzure | what's the actual resolution | 14:44 |
thylane | I need to biohack histrionicotoxin. PM me if you know how. | 14:44 |
kanzure | thylane: why PM?? | 14:44 |
kanzure | wtf is this | 14:44 |
thylane | o_o | 14:44 |
Stee| | kanzure doesn't like pms | 14:44 |
Stee| | they don't get logged into the gnusha logs/aren't public :P | 14:44 |
kanzure | thylane: what do you mean by 'biohack'.. what do you need to do | 14:45 |
Mokbortolan_ | oh wow | 14:45 |
Mokbortolan_ | I thought they were just doing better localization on the exterior bits, but no, they're focusing on deep areas | 14:46 |
kanzure | well, how good? | 14:46 |
thylane | histrionicotoxins cannot be synthesized outside of million-dollar labs. So biohack | 14:47 |
kanzure | thylane: ok so you want to synthesize them | 14:47 |
Stee| | histrionicotoxins are synthetically challenging, apparently | 14:47 |
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kanzure | is this chemical synthesis or protein purification? | 14:48 |
kanzure | looks like a chemical | 14:48 |
kanzure | i bet there's some biochemical pathway that synthesizes it | 14:48 |
Mokbortolan_ | hmm | 14:49 |
Mokbortolan_ | they don't talk about area besides the electrode size, 2cm | 14:49 |
uniqanomaly | Mokbortolan_: anything about stimulating few areas at once? | 14:50 |
Mokbortolan_ | the diagrams seem to show multiple channels between the electrodes converging on a targeted region | 14:50 |
uniqanomaly | a few* | 14:51 |
Mokbortolan_ | http://www.mediafire.com/?3338ilt03r6gun6 | 14:51 |
Mokbortolan_ | here's the paper | 14:51 |
Mokbortolan_ | it's a simulation, btw | 14:52 |
uniqanomaly | thx | 14:52 |
Mokbortolan_ | it doesn't appear to be something that is accessible by the DIY tDCS'er | 14:53 |
Mokbortolan_ | ... yet | 14:53 |
kanzure | why is a simulation inaccessilbe? | 14:53 |
kanzure | *inaccessible | 14:53 |
Mokbortolan_ | matlab licenses are expensive? I dunno, I guess I'm just speaking for myself :p | 14:55 |
kanzure | matlab is not necessary for simulations | 14:55 |
kanzure | mA/m^2 in "right inferior parietal lobe" | 14:56 |
kanzure | running 1 mA through it | 14:57 |
thylane | http://www.reddit.com/r/DIYbio/ | 14:59 |
kanzure | thylane: this is more active http://groups.google.com/group/diybio | 15:01 |
thylane | http://www.newscientist.com/article/mg21328501.600-zap-your-brain-into-the-zone-fast-track-to-pure-focus.html?full=true&print=true | 15:02 |
kanzure | thylane: scroll up :P | 15:02 |
thylane | i found | 15:06 |
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strangewarp | Okay, I can't stand regular people | 15:39 |
strangewarp | All caring about Pez and Minecraft and Democrats and shit | 15:39 |
strangewarp | I am witnessing, in one of my old haunts, an argument about the shape of Pez candies | 15:40 |
strangewarp | Last night I was advised by relatives to give up them dang brain pills and eat some whole grains. | 15:40 |
* strangewarp boggles | 15:40 | |
jrayhawk | yes, because the CXCR/zonulin cascade is so much healthier | 15:40 |
jrayhawk | GOOD PLAN, GUYS | 15:41 |
uniqanomaly | fuck whole grains, keto ftw | 15:47 |
uniqanomaly | keto/paleo | 15:50 |
Mokbortolan_ | Zombie paleo ftw | 15:51 |
* Mokbortolan_ only eats running, screaming people. | 15:51 | |
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kanzure | Receiving objects: 100% (4117/4117), 5.75 MiB | 372 KiB/s, done. | 16:00 |
kanzure | fatal: Out of memory, malloc failed (tried to allocate 85018625 bytes) | 16:00 |
kanzure | fatal: index-pack failed | 16:00 |
jrayhawk | impressive | 16:00 |
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strangewarp | zombie paleo, hahaha | 16:13 |
strangewarp | I will definitely go paleo once there's some dang vat-meat on the shelves. | 16:14 |
strangewarp | Right now eating meat gives me a nasty case of the guilts. | 16:14 |
strangewarp | Could probably do vegetarian paleo, and counteract the increased estrogen from the tofu by eating a lot of button mushrooms... bit spendy and inconvenient though | 16:19 |
strangewarp | Pressing tofu is annoying, basically, and processed soy is spendy | 16:19 |
Steel2 | I just eat meat | 16:20 |
strangewarp | barbarian :p | 16:20 |
Steel2 | yeh | 16:21 |
Steel2 | I'll uplift some animals or some shit to make up for it in a couple hundred years | 16:21 |
Steel2 | [/sarcasm] | 16:21 |
strangewarp | hahahah | 16:21 |
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Mokbortolan_ | I just wish quorn would see greater acceptance | 16:35 |
Mokbortolan_ | it's the food-stuff (emphasis on 'stuff') of the future (we will spend living underground)! | 16:36 |
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kanzure | the real barbaric act is eating at all | 16:40 |
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kanzure | clearly the most buddhist of the buddhist are those who do not eat.. or something | 16:40 |
strangewarp | I would love to have a body that doesn't require food, or sleep | 16:41 |
Mokbortolan_ | kanzure: the dalai lama eats meat | 16:41 |
kanzure | or a body that didn't require a body | 16:41 |
Mokbortolan_ | though, he eats what he's given | 16:41 |
strangewarp | kanzure: indeed | 16:41 |
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kanzure | https://geoloqi.com/blog/2012/03/data-portraits-powered-by-3-5-years-of-data-and-2-5-million-gps-points/ | 17:09 |
kanzure | the coloring looks really great | 17:10 |
kanzure | i wonder what sort of blur/filter that is | 17:10 |
thylane | Lets create a strange new bacteria. In the garage. | 17:10 |
thylane | using DNA | 17:10 |
thylane | let's do this | 17:10 |
kanzure | i don't understand how you would do it without DNA | 17:10 |
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Mokbortolan_ | you can do it with UV radiation | 17:11 |
Mariu | nanites | 17:11 |
Mokbortolan_ | it's the bacteria doing stuff with DNA | 17:11 |
kanzure | Mokbortolan_: because of DNA, yes.. | 17:11 |
kanzure | Mariu: that doesn't exist (except if you include viruses) | 17:11 |
Mariu | kanzure: gotcha | 17:11 |
kanzure | thylane: are you a biologist? | 17:12 |
strangewarp | nanites? needs more manites | 17:12 |
Mariu | lol | 17:13 |
strangewarp | convert your manly chest into gold. now that's a treasure chest | 17:13 |
strangewarp | oh god, help | 17:13 |
kanzure | strangewarp: you have been promoted to head of ##hplusroadmap marketing | 17:13 |
strangewarp | no, no | 17:13 |
strangewarp | this is the worst decision | 17:13 |
strangewarp | all I have is an associate's degree, chiptunes, and a sarcastic twitter | 17:14 |
kanzure | http://guy.com/a/wp-content/uploads/2012/02/Gaston-Beauty-and-the-Beast-chest.jpg | 17:14 |
kanzure | thylane: no but really.. are you a biologist? | 17:15 |
strangewarp | that image, ow. | 17:15 |
uniqanomaly | http://www.imdb.com/title/tt1017460/ dis | 17:19 |
uniqanomaly | Splice muvi | 17:20 |
kanzure | A-Lusion: who's the friend you mentioned? | 17:21 |
kanzure | mokbor's earlier ref. paper regarding targetted tDCS: | 17:24 |
kanzure | http://diyhpl.us/~bryan/papers2/neuro/A%20novel%20array-type%20transcranial%20direct%20current%20stimulation%20(tDCS)%20system%20for%20accurate%20focusing%20on%20targeted%20brain%20areas%20-%202011.pdf | 17:24 |
kanzure | superkuh: what do you think? | 17:24 |
kanzure | i'm a little suspicious if nobody has been working on 'deep' brain targetting and this is the first paper of the sort to test it | 17:26 |
kanzure | it looks like the cited abhishek work was only for one particular configuration of an 'array', which is somewhat of an odd choice | 17:27 |
kanzure | ha they used tetgen.. that's nice of them. | 17:28 |
kanzure | somewhat better than using netgen | 17:28 |
kanzure | "However, the approach required heavy computational burden as the FEM solver needed to be executed repeatedly for every iteration, which made it difficult for the approach to be used in practical applications." | 17:29 |
kanzure | iteration = different configuration? or iteration=treatment? | 17:30 |
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jrayhawk | "16:14 < strangewarp> Right now eating meat gives me a nasty case of the guilts." while i don't presume to understand your value system, here, keep in mind croplands are vast ecological monocultures supported with ground bones and involving devastation of what meager habitat they provide at harvest time | 17:35 |
jrayhawk | so if you value biodiversity or stable ecology or bioadvancement, free-range cows wind up being a fairly good option | 17:36 |
jrayhawk | (or if animal bones aren't involved, there's *even more* soil mineral depletion) | 17:37 |
jrayhawk | basically you should be feeling constant crippling guilt about everything all the time | 17:37 |
jrayhawk | YOU CAN NEVER ESCAPE HA HA HA | 17:38 |
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kanzure | joe you are a master at your art. | 17:39 |
kanzure | a professional, even. | 17:39 |
strangewarp | it's an issue, then, of the guilt of destroying the resource-base and being complicit in animal suffering, versus the guilt of being the explicit reason for animal suffering and the redemption of shoring up scarce resources | 17:39 |
jrayhawk | have you met steve | 17:39 |
kanzure | i'm pretty sure you're steve | 17:39 |
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kanzure | and jenna pietrzyctyl is jules or something | 17:40 |
jrayhawk | i am the entire internet | 17:40 |
jrayhawk | this is all a rouse | 17:40 |
JayDugger | Good evening, everyone. | 17:44 |
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Mariu | hey, Jay | 17:48 |
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kanzure | yashgaroth: two things in the logs for you to look at.. first is that i am lacking any good reviews in my collection regarding comprehensive lists of gene regulators, second is the localized tdcs paper | 17:55 |
yashgaroth | k | 18:00 |
yashgaroth | so first, I know barely anything about neuro so I can't comment on any tdcs stuff; second, the sort of review would be "the entire field of molecular genetics" so you're better off asking a specific question | 18:09 |
superkuh | I might be misinterpreting the infographics and my first reading of the paper, but it it does not seem very localized to me. | 18:09 |
superkuh | And this is portrayed as a positive quality. | 18:09 |
yashgaroth | but if Mok wants to expression that transgene in rat hippocampi, I'd check the allen brain atlas for a gene that only gets expressed there, and copy its whole regulatory region | 18:10 |
yashgaroth | -ion* | 18:10 |
yashgaroth | also IVF and SCNT are wholly outside of any garage tech, so I'd look into sperm-mediated gene transfer | 18:11 |
kanzure | what's wrong with scnt :( | 18:16 |
yashgaroth | how tiny can you make a needle | 18:17 |
Steel2 | inner or outer diameter | 18:17 |
kanzure | i was preoccupied with making cantilevers for afms once | 18:17 |
yashgaroth | both | 18:17 |
kanzure | but those were not hollow | 18:17 |
Steel2 | inner diameter, my lab has 5um needles | 18:17 |
yashgaroth | SMGT is fine for this and it's literally "centrifuge sperm, resuspend in PBS with plasmid, inseminate" | 18:18 |
yashgaroth | also where is the tsien paper, can't you just copy his regulatory region | 18:19 |
kanzure | i'm familiar with *some* regulatory regions | 18:19 |
kanzure | but not in a comprehensive way | 18:19 |
kanzure | you know.. in the way that matters | 18:19 |
yashgaroth | that whole field is still a clusterfuck, you can't just plug something in | 18:19 |
Mokbortolan_ | Set Ruby = CreatObject("Adodb.wat") | 18:26 |
kanzure | s/wat/wut | 18:26 |
yashgaroth | oh also Mok, lemme know when you get some more piracetam in | 18:26 |
Mokbortolan_ | I don't think I'm gonna, hardrhino beat my price | 18:27 |
yashgaroth | nooo okay then | 18:27 |
Mokbortolan_ | I just wanted to start a price war | 18:27 |
yashgaroth | p.s. silverex has the free version of xchat for windows if you're still looking for a client | 18:33 |
Mokbortolan_ | Ahh, ok, I'll check it out | 18:35 |
Mokbortolan_ | btw I'm not against carrying piracetam, I just don't see the point when a higher-volume reseller is matching my price | 18:35 |
Mokbortolan_ | of course, if they raise their prices, I'll definitely carry it again | 18:36 |
Mokbortolan_ | I will be carrying other things though, noopept, aniracetam, centrophenoxine, and l-theanine | 18:36 |
yashgaroth | competition's important, but if the threat of competition is enough, then hey | 18:36 |
Mokbortolan_ | I was just concerned about the reduction in the number of sellers and the rising price | 18:37 |
yashgaroth | might be good to at least stock up, just in case the gov't gets too interested | 18:38 |
Mokbortolan_ | true | 18:40 |
Steel2 | easy enough to import it yashg | 18:40 |
yashgaroth | ...for now | 18:41 |
yashgaroth | I'll base my opinion on how long my modafinil gets held up in customs, I'm at 3 days now | 18:41 |
yashgaroth | oh and if anyone asks, I totally have narcolepsfgmdkl; | 18:47 |
Mokbortolan_ | uhoh | 18:54 |
yashgaroth | whoa what happened guys? I have this condition | 18:54 |
Mokbortolan_ | I'd talk more about that, but this channel is publicly logged | 18:54 |
Mokbortolan_ | transparency ftw! | 18:55 |
yashgaroth | yay | 18:55 |
Steel2 | my abs hurt like a mofo | 18:59 |
jrayhawk | did animals punch you in the solar plexus and steal your lunch money after you mocked them | 19:00 |
Steel2 | nah | 19:19 |
Steel2 | dragon flags | 19:19 |
JayDugger | eh? | 19:19 |
Steel2 | it's a type of exercise | 19:20 |
JayDugger | http://www.unique-bodyweight-exercises.com/dragon-flag.html | 19:20 |
JayDugger | That it? | 19:20 |
JayDugger | It looks like a recipe for back pain without first having a good strong back. | 19:22 |
Steel2 | yeah, I have that too | 19:23 |
JayDugger | Back pain or a strong back? | 19:24 |
Steel2 | strong back | 19:26 |
Mariu | later guys | 19:41 |
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strangewarp | Noting, here, that PZ Myers is a douche, who uses the word "rational", but in his use thereof, merely refers to that which is approved by the slow-moving traditional science community. | 22:40 |
strangewarp | Also, he is pro-circumcision-without-consent for some mind-boggling reason. | 22:41 |
strangewarp | Because you can use that sense of "rational" to disprove false things, like spirit-animals and homeopathy, he assumes that anything that can be disproven therewith is similarly false. This is an oversight. This is also why he makes fun of singularity stuff, and short-timeframe transhumanist stuff. | 22:47 |
kanzure | singularity is not beyond the grasp of humor | 23:03 |
kanzure | short-timeframe transhumanist stuff is passing him by anyway | 23:04 |
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kanzure | welp from now on this is how i'm showing off python | 23:27 |
kanzure | http://people.csail.mit.edu/pgbovine/python/tutor.html#mode=edit | 23:27 |
kanzure | and this isn't that bad for js: | 23:27 |
kanzure | http://learnjs.info/#mode=visualize | 23:27 |
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Utopiah_ | nice | 23:33 |
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kanzure | ThomasEgi: what about an array setup for tdcs? http://diyhpl.us/~bryan/papers2/neuro/A%20novel%20array-type%20transcranial%20direct%20current%20stimulation%20 | 23:44 |
kanzure | erm | 23:44 |
kanzure | http://diyhpl.us/~bryan/papers2/neuro/A%20novel%20array-type%20transcranial%20direct%20current%20stimulation%20(tDCS)%20system%20for%20accurate%20focusing%20on%20targeted%20brain%20areas%20-%202011.pdf | 23:44 |
ThomasEgi | need to controll each current output independently? | 23:46 |
kanzure | think so yes | 23:46 |
kanzure | and their setup looks a little small.. i would expect a larger number of array elements | 23:47 |
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ThomasEgi | kanzure, i havent looked too closely at the thing. need to go to university now, exam time. | 23:48 |
ThomasEgi | i may or may not be bakc within a few hours. but in.. probably 8 hours i will be back online | 23:49 |
kanzure | man all this school is getting in the way of important things | 23:49 |
ThomasEgi | if all you need is more current-sources. it should be no problem | 23:49 |
ThomasEgi | well it is digital signal processing exam. it isnt that bad^ | 23:49 |
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