| --- Log opened Thu May 17 00:00:12 2012 | ||
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| fenn | jrayhawk: do you eat nuts? i've been reading about phytic acid and food soaking. easy enough to do, you soak the nuts overnight in water with a bit of cultured whey or yogurt added; the warm wet environment activates phytases in the nuts so phytic acid won't bind to magnesium etc | 03:57 |
|---|---|---|
| fenn | the acid environment prevents bad bacteria from growing | 03:58 |
| fenn | i think this is why most people are mineral deficient, their food isn't soaked prior to eating | 03:58 |
| fenn | currently i believe mg deficiency leads to allergies, depression, back pain | 04:01 |
| ThomasEgi | http://www.bbc.co.uk/news/science-environment-18074644 | 04:01 |
| fenn | "viral electronics goes viral!~" | 04:02 |
| ThomasEgi | very interesting approach to use viruses as piezoactive generators. | 04:03 |
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| fenn | holy crap why are HPLC systems so expensive | 05:19 |
| ParahSailin | because they can | 05:32 |
| fenn | it's just a tube with some crap in it | 05:34 |
| ParahSailin | they can because their customers are mostly government | 06:03 |
| ParahSailin | who can get a grant for however much because they dont bear the cost | 06:03 |
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| fenn | does anyone know of diy or at least less than $10k HPLC systems? | 06:08 |
| fenn | i mean this is just absurd | 06:08 |
| @kanzure | peanut butter | 06:09 |
| fenn | any writeup on that? | 06:09 |
| @kanzure | i think some diybio person pooped in a tube and used that, but i don't have a link | 06:09 |
| fenn | great. -_- | 06:09 |
| fenn | any sage advice before i return to my coffin for the day? | 06:10 |
| @kanzure | hrm for some reason http://diyhpl.us/~bryan/irc/diytranshuman_projects.v4.html is a search result when i go looking for el-cheapo hplc | 06:11 |
| @kanzure | nmz787 or yashgaroth will have a better link for the peanut butter thing | 06:13 |
| fenn | hm. well in the meanwhile i'll watch the MIT videos i guess | 06:14 |
| fenn | we did this in organic chem lab but i forgot all of it | 06:15 |
| fenn | probably because i was (unintentionally) high on fumes | 06:15 |
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| delinquentme_ | fenn, tyrant should have shit on this | 07:51 |
| delinquentme_ | HLPC is afterall what he was given 100k to develop | 07:51 |
| kanzure | i thought he was given money to skip college | 07:53 |
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| delinquentme_ | the pitch was he was going to build a hLPC machine | 08:28 |
| delinquentme_ | this was in print material a number of places | 08:28 |
| delinquentme_ | https://twitter.com/#!/delinquentme/status/203144675467599873 | 08:29 |
| delinquentme_ | fenn, kanzure whats up with you guys and the project? | 08:30 |
| delinquentme_ | theres so much fucking money and hell to be made | 08:30 |
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| delinquentme_ | was reading a research paper the other day on progress being made in a minimal ecoli genome :D | 08:35 |
| delinquentme_ | we're talking the biological equivalent of a stripped down operating system | 08:36 |
| delinquentme_ | rovely | 08:36 |
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| delinquentme_ | nmz787, when we going driving man? | 08:43 |
| delinquentme_ | i can go tomorrow but all I've got is a bike atm | 08:44 |
| kanzure | follow-up on the c60 claims: http://diyhpl.us/~bryan/papers2/longevity/2012-05-17-c60-claims.txt | 08:50 |
| nmz787 | driving? | 08:53 |
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| kanzure | hi Algo | 09:52 |
| delinquentme_ | coooool http://spectrum.ieee.org/automaton/robotics/industrial-robots/jpl-designing-spinyfingered-grippers-for-robotic-drilling-on-asteroids | 10:07 |
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| nmz787 | can anyone get this: http://informahealthcare.com/doi/abs/10.3109/15368378509040362 | 10:35 |
| kanzure | --2012-05-17 10:39:10-- http://informahealthcare.com/doi/pdfplus/10.3109/15368378509040362 | 10:39 |
| kanzure | 2012-05-17 10:39:11 ERROR 403: Forbidden. | 10:39 |
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| _Sketch_ | nmz787: That informahealthcare.com link is working again. ($43 for a PDF for 24 hours?! What?!) | 11:18 |
| jrayhawk | fenn: I don't tend to eat nuts; they have a lousy lipid profile, are expensive, and are a pain in the ass to prepare. | 11:31 |
| jrayhawk | If I were to prepare them, I would probably go for 1) buy organic since phosphate fertilizers amp up the phytic acid content 2) soak 3) dehydrate 4) roast | 11:32 |
| jrayhawk | sprouting is also a good way to decrease phytic acid, but that moves it from $8/lb to, like, what, $16? horrifying numbers | 11:33 |
| jrayhawk | anyway, mineral deficiencies are caused in large part caused by phytic acid, but also by industrial agriculture depleting soils and making minerals biounavailable | 11:35 |
| jrayhawk | and, of course, active phytates are also present in grains in legumes, so nuts don't deserve all the blame, there. | 11:36 |
| jrayhawk | All this stuff, along with fermentation, decreases active phytates in grains and legumes, too. | 11:38 |
| jrayhawk | handy propaganda from the ancestral health world: http://chriskresser.com/another-reason-you-shouldnt-go-nuts-on-nuts http://www.westonaprice.org/food-features/living-with-phytic-acid | 11:39 |
| jrayhawk | and, of course, people taking magnesium supplements are taking really shitty magnesium supplements | 11:41 |
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| jrayhawk | multivitamins are infuriating. half the nutrients on offer in those are either biounavailable or some terrible oxidized form that make everything worse | 11:43 |
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| nmz787 | jrayhawk: how do the oxidized vitamins make things worse? | 12:01 |
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| kanzure | yashgaroth: fenn was wondering about some diy hplc options | 13:02 |
| yashgaroth | ya I've just been catching up on the logs | 13:02 |
| kanzure | i told him that some diybioer pooped in a tube for his bead media | 13:02 |
| kanzure | ok cool | 13:02 |
| yashgaroth | columns usually aren't the expensive part, they're 'only' 1-2 grand | 13:03 |
| yashgaroth | the machinery is all about very fine pressure control, since if the pressure level gets disrupted you have to rebalance | 13:03 |
| yashgaroth | it depends what sort of hplc you're trying to do though | 13:04 |
| yashgaroth | i.e. whether you're measuring the purity of cocaine or analyzing protein aggregation | 13:04 |
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| kanzure | i haven't seen anyone doing their own protein chromatography gittup | 13:08 |
| Utopiah | nice "Welcome to Life: the singularity, ruined by lawyers" http://www.youtube.com/watch?v=IFe9wiDfb0E | 13:14 |
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| nmz787 | protein chromatography can be easy, not needed HPLC for that | 13:20 |
| nmz787 | I just did some HPLC in lab though, and it would take a considerable amount of time+money to get a DIY/from-scratch setup up and going | 13:21 |
| nmz787 | seems like the pro setups are complicated enough as is | 13:21 |
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| nmz787 | though the software could use some minor usability improvements | 13:21 |
| nmz787 | although recent HPLC/lab tool software may be much nicer than what i used | 13:21 |
| yashgaroth | no it's still shitty | 13:22 |
| nmz787 | affinity chromatoraphy, ion exchange, TLC... are all pretty straightforward though | 13:22 |
| nmz787 | you probably don't need fine pressure control if you want crappy/good-enough results, but I wouldn't trust it for something I was going to ingest/inject | 13:23 |
| ThomasEgi | Utopiah, bullseye :) thx for sharing | 13:23 |
| nmz787 | i think pulsing would just causing band broadening | 13:23 |
| yashgaroth | you mean with the pump? yeah, but if your resin's gonna be all DIY and crappy then you need all the resolution you can get | 13:24 |
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| nmz787 | i really wanna try peanuts as a packing | 13:27 |
| nmz787 | they seem pretty nonpolar on their surface | 13:28 |
| yashgaroth | what's wrong with diatomaceous earth | 13:28 |
| nmz787 | no idea | 13:28 |
| jrayhawk | nmz787: re: oxidized nutrients: increase in random reactivity. omega 3 and folate (or, rather, in this case folic acid) are examples of supplements that actually worsen health outcomes as a result of how ineptly prepared they are. | 13:39 |
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| delinquentme | fenn, kanzure nmz787 i've got a kid @ CMU who is part of that system and is looking for a grad project | 15:10 |
| delinquentme | shes working on another PCR machine ( =/ ) but I think w the right heads in that mix she might be persuaded to hit up the CMU foundtry | 15:10 |
| delinquentme | foundry** | 15:10 |
| delinquentme | you guys wanna live in pittsburgh :P | 15:10 |
| kanzure | no | 15:10 |
| delinquentme | i could totes get us 20g in funding here | 15:10 |
| delinquentme | its not much but pittsburgh is pretty cheap | 15:11 |
| kanzure | what are the terms of this $20,000? | 15:11 |
| delinquentme | alpha lab is the accelerator | 15:11 |
| kanzure | ok, and they want equity? | 15:11 |
| delinquentme | you get office space for like 5 months? | 15:11 |
| delinquentme | yeah between 3 and 7 % | 15:11 |
| kanzure | not interested | 15:11 |
| delinquentme | they also happen to be associated w a bigger VC group called innovation works | 15:12 |
| delinquentme | kanzure, thats stupid | 15:12 |
| kanzure | $20,000 isn't a lot of money | 15:12 |
| delinquentme | saying not interested as an absolute is retarded | 15:12 |
| delinquentme | yes i know | 15:12 |
| kanzure | anyone can make that in 2 months | 15:12 |
| delinquentme | however thats working a job | 15:12 |
| kanzure | and, equity means they want companies only | 15:12 |
| delinquentme | not a startup 24/7 | 15:12 |
| kanzure | which probably means they want things like patents | 15:13 |
| delinquentme | so you're against incorporating? | 15:13 |
| kanzure | no | 15:13 |
| delinquentme | whats up with the cutter? | 15:13 |
| kanzure | i'm just skeptical of their value | 15:13 |
| delinquentme | wheres the update | 15:13 |
| kanzure | what update | 15:13 |
| delinquentme | the value is you're 5 minutes from a microfluidics foundry and CMU | 15:13 |
| kanzure | making a microfluidics foundry isn't a big deal | 15:13 |
| delinquentme | which is at least half-decent | 15:13 |
| delinquentme | .... | 15:13 |
| delinquentme | ... | 15:13 |
| delinquentme | . | 15:14 |
| delinquentme | ....................... | 15:14 |
| delinquentme | sure so whats up with the cutter? | 15:14 |
| kanzure | and even if it was, i don't see why i should prefer CMU's over UT's | 15:14 |
| kanzure | or over stanford's | 15:14 |
| delinquentme | well whatever works really | 15:14 |
| delinquentme | i mean if i could get $20 grand to let you guys sit at home and visit PGH once in a while | 15:14 |
| delinquentme | as well as constant access to a foundry thats not half bad | 15:15 |
| kanzure | it's not constant access, those usually close after business hours | 15:15 |
| kanzure | i don't see what you have against building out your own foundry | 15:15 |
| delinquentme | nothing | 15:15 |
| delinquentme | just faster == better | 15:15 |
| delinquentme | and we dont have one yet | 15:15 |
| delinquentme | you* guys dont have one yet | 15:15 |
| kanzure | *shrug* it's coming along | 15:16 |
| delinquentme | i mean lets be honest | 15:17 |
| delinquentme | that isn't " the gantrys complete" | 15:17 |
| delinquentme | or "weve gotten it down to micron resolution" | 15:17 |
| delinquentme | its pretty damn nebulous amirite? | 15:18 |
| kanzure | so far there's nothing wrong with the gantry | 15:18 |
| delinquentme | is there something I can help with? | 15:18 |
| kanzure | yeah, you can go find fenn for me | 15:18 |
| delinquentme | are you guys designing it to run on an arduino? | 15:18 |
| kanzure | no | 15:18 |
| kanzure | absolutely not | 15:18 |
| kanzure | it's going to be linux running on something above the embedded classification | 15:20 |
| delinquentme | so linux CNC is going to be doing the pulsing? | 15:21 |
| kanzure | that's the current design | 15:21 |
| kanzure | delinquentme: extra cash isn't going to accelerate things at this point | 15:25 |
| delinquentme | true | 15:25 |
| delinquentme | ummmmmm what was I gonna say...... | 15:25 |
| delinquentme | OH but i mean having a foundry to start running protos might ? | 15:26 |
| delinquentme | and cmu might have some experience right? | 15:26 |
| delinquentme | any rough ideas on what the channels should look like? | 15:26 |
| delinquentme | Liiiiike you should have an answer for that right? | 15:35 |
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| kanzure | bleh not sure about theze: http://www.meetup.com/Biohackers-NYC/about/ "instead of direct modification or tinkering with DNA to more macro level interventions like modifying nutrition , fitness regimens, and mindfulness practices" .. boooring | 15:39 |
| kanzure | delinquentme: i'm not particularly interested in paying CMU to design my chip | 15:39 |
| delinquentme | nah if theres a grad they're obligated to it | 15:42 |
| delinquentme | its part of her research | 15:42 |
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| delinquentme | Ultracenterfuge fail @ 30kg http://i.imgur.com/c772a.jpg | 18:04 |
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| ThomasEgi | my 2ยข . but that day this happaned.. someone spilled his coffee | 18:21 |
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| Juul | it's so cold in the lab | 19:13 |
| Juul | maybe it will warm up | 19:13 |
| Juul | doot de doot | 19:13 |
| Juul | if i open another tab | 19:13 |
| kanzure | each tab probably heats up one cubic mm by 1 degree celsius for 10 minutes over its life | 19:14 |
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| Juul | if only i had a shrink ray so i could fit within 1 cubic mm | 19:15 |
| kanzure | Juul: first you have to reach critical mass http://www.youtube.com/watch?v=8nHKYWc-rnY | 19:16 |
| Juul | haha | 19:17 |
| kanzure | i've been waiting since 2010 to use that video in context | 19:17 |
| kanzure | damn. | 19:17 |
| Juul | :-/ | 19:18 |
| Juul | no-one mentioned shrinking anything in all of 2011 | 19:18 |
| Juul | how sad | 19:18 |
| kanzure | well, or shrink ray | 19:19 |
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| Juul | what does my eye spy in my inbox | 19:22 |
| Juul | is that a duolingo invite | 19:22 |
| kanzure | hah their concept is funky | 19:23 |
| kanzure | translate a website, but they teach you in the process? | 19:23 |
| Juul | you translate snippets of text it looks like | 19:23 |
| Juul | and you can look up words by hovering over them if you don't know them | 19:23 |
| Juul | very polished interface it looks like | 19:23 |
| kanzure | every time you see a polished interface, someone like me gains a single grey hair | 19:24 |
| kanzure | looks like twitter bootstrap actually | 19:25 |
| Juul | twitter bootstrap? | 19:27 |
| kanzure | Juul: http://twitter.github.com/bootstrap/ | 19:27 |
| Juul | ah cool | 19:27 |
| delinquentme | Gew night all! | 19:27 |
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| kanzure | Juul: sorta popular among web app developers | 19:28 |
| kanzure | because everyone hates reinventing the wheel | 19:28 |
| Juul | yeah, I've been playing with ExtJS but it's kinda sluggish | 19:28 |
| Juul | not as nice and simple as it could be | 19:29 |
| kanzure | oh sencha's thing? | 19:29 |
| Juul | yeah | 19:29 |
| kanzure | i prefer to use phonegap, but that's not a js framework i guess | 19:29 |
| kanzure | phonegap+backbone hits most platforms, including desktop | 19:29 |
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| kanzure | hi skinmocha | 19:30 |
| skinmocha | hi | 19:30 |
| skinmocha | reddit is just too screwed up to use | 19:30 |
| kanzure | don't use reddit | 19:30 |
| skinmocha | It clearly takes your posts, because you can SEE THEM PLAIN AS DAY in the user profiles | 19:30 |
| Juul | wow, problem solved in 3.5 words | 19:30 |
| skinmocha | But then they don't appear on the damned subreddit itself | 19:30 |
| kanzure | Juul: i'm just not convinced of its utility | 19:31 |
| skinmocha | And I'm talking like, inside a subreddit which I myself created, I pown, and I moderatre | 19:31 |
| kanzure | skinmocha: who are you | 19:31 |
| skinmocha | If I am an "approved submitter" my posts should appear within the subreddit /within seconds/ | 19:31 |
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| skinmocha | This crap where you go "well...the website is just a tad slow today" is totall bullshit. I can SEE THE SUBMISSION right ther plain as day on the user profile! | 19:32 |
| kanzure | why are you ranting about reddit in here? | 19:32 |
| skinmocha | So the WEBSITE STORED IT. Fact. | 19:32 |
| -!- mode/##hplusroadmap [+o kanzure] by ChanServ | 19:33 | |
| Juul | maybe they have nowhere else to rant? | 19:33 |
| @kanzure | Juul: there's ##reddit | 19:33 |
| @kanzure | and #redit | 19:33 |
| skinmocha | No... those channels are empty | 19:33 |
| @kanzure | i typoed the second one | 19:33 |
| skinmocha | 19:34 | |
| -!- skinmocha was kicked from ##hplusroadmap by kanzure [skinmocha] | 19:34 | |
| @kanzure | off you go | 19:34 |
| @kanzure | how did that happen? | 19:34 |
| _Sketch_ | Weird. | 19:35 |
| Juul | odd | 19:35 |
| @kanzure | "Hi, is this alcoholics anonymous? Transgenic biology, you say? Well, I have this problem with reddit..." | 19:35 |
| @kanzure | some light reading.. http://nextbigfuture.com/2012/05/how-complex-is-mouse-brain.html | 19:38 |
| @kanzure | allen brain institute video http://www.youtube.com/watch?fv=73lUjX_8-T4 "Hongkui Zeng: 2011 Allen Institute for Brain Science Symposium" | 19:39 |
| @kanzure | "Existing knowledge is incomplete and scattered around in the literature, she said, and this project will map connections throughout the mouse brain via a scalable, reproducible method. With a desired total scope of 300-500 locations in the brain, the Allen Mouse Brain Connectivity Atlas will trace connections in the mouse brain using both Cre-transgenic -- genetically engineered to target specific cell-types -- and wild-type mice." | 19:39 |
| @kanzure | "Using over a hundred Cre lines, the Atlas will reveal to where in the brain axons project by tracing axonal fiber bundles from specific focal sites through the brain to both major and minor projection sites." | 19:39 |
| @kanzure | oh neat.. http://www.youtube.com/user/AllenInstitute | 19:40 |
| Juul | 1000 times as many neurons? | 19:41 |
| Juul | that's more more than i would have thought | 19:41 |
| @kanzure | their marketing video is pretty great.. http://www.youtube.com/watch?v=e74pCJmd07s | 19:41 |
| Juul | yeah it's well-made | 19:49 |
| @kanzure | i remember writing some random code to crunch their data in 2008 | 19:49 |
| @kanzure | but didn't know about their youtube presence | 19:49 |
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| @kanzure | henry markram video from supercomputing 2011 http://www.youtube.com/watch?v=_rPH1Abuu9M | 19:57 |
| @kanzure | apparently he also wrote "augmenting cognition" http://www.youtube.com/watch?v=fQOnzzk3ByU | 20:00 |
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| @kanzure | ugh that's a terrible video actually | 20:02 |
| skinmocha | Henry Markram's voice makes me all sleepy | 20:03 |
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| @kanzure | skinmocha: "Reporters see much to like: Markram is tall, striking and explains his ideas with the clarity, quotability and urgency of a South African version of the late Carl Sagan. He has "a hypnotic effect", says Richard Hahnloser, a computational neuroscientist at the INI." | 20:04 |
| @kanzure | 'hypnotic' | 20:04 |
| skinmocha | lolol | 20:05 |
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| skinmocha | this vid cuts off early http://www.youtube.com/watch?v=_rPH1Abuu9M | 20:47 |
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| @kanzure | skinmocha: it's a multi-part video | 21:18 |
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| --- Log closed Fri May 18 00:00:13 2012 | ||
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