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kanzure | brownies: alas, typing on two keyboards at once is not yet a skill i have | 00:29 |
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foucist | i have mastered dvorak-right and dvorak-left | 01:09 |
foucist | i also separated my left and right brains... half of me designs, the other half codes.. it works great! | 01:11 |
sylph_mako | You did this by corpus collosum excision, I presume? | 01:14 |
sylph_mako | nobody needs that thing. | 01:15 |
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audy | http://www.technologyreview.com/files/87345/SynthBio-Ax616%25202.jpg#.png | 06:52 |
audy | boo! | 06:52 |
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kanzure | "The Google+ Hangouts are better than IRC for some things. Being able to have multiple simultaneous video feeds from multiple people would let the community share techniques, educate people, or just video chat" | 07:48 |
kanzure | :o ok guys we're not allowed to educate each other | 07:49 |
kanzure | audy: what's the point of the #.png in that url? | 07:49 |
kanzure | like, are they trying to fool us? | 07:49 |
superkuh | You can cut it off at, http://www.technologyreview.com/files/87345/SynthBio-Ax616 | 07:51 |
superkuh | Oh. Even further. After the file # ID. | 07:52 |
superkuh | 'needs the / though. | 07:52 |
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kanzure | there was a 'genetic superpowers' thread on diybio the other day (just a list of interesting mutations): https://groups.google.com/forum/?fromgroups#!topic/diybio/sTw7AXt-NaQ | 08:09 |
kanzure | Norovirus resistance and FUT2 W154X | 08:09 |
kanzure | Extra strong bones and LRP5 | 08:09 |
kanzure | Lean muscle and MSTN double null | 08:09 |
kanzure | Greatly reduced heart disease and PCSK9 | 08:09 |
kanzure | CCR5-delta32 to increase resistance to HIV | 08:10 |
kanzure | hDEC2-P385R transcriptional repressor associated with short sleep phenotype | 08:10 |
kanzure | i can't remember the hang-over-resistance gene :( | 08:10 |
kanzure | s/gene/allele | 08:11 |
chido | is being able to detect the smell of cyanide a superpower? | 08:15 |
kanzure | sure why not | 08:15 |
kanzure | there's also that mutation in TASR38 that allows people to taste PTC... perhaps not a power at all :) | 08:16 |
chido | I'm not sure the gene that makes you smell cyanide is identified | 08:17 |
chido | I just read that today morning :) nature has a cool special on taste | 08:17 |
kanzure | ah. genspace/diybio-nyc did a few projects related to TASR38 as "public outreach". | 08:18 |
kanzure | http://diyhpl.us/~bryan/papers2/gene_doping_for_sports_enhancement.png | 08:21 |
kanzure | i suppose i need a better list than this. | 08:21 |
chido | did you catch that Springstein affair in Germany? | 08:23 |
chido | but it was years ago I think | 08:24 |
kanzure | no? | 08:24 |
chido | coach accused of gene therapy doping | 08:24 |
kanzure | oh neat | 08:24 |
kanzure | it wasn't blood doping? | 08:25 |
chido | it was Repoxygen | 08:25 |
kanzure | ah epo | 08:25 |
kanzure | hehehe "World Anti-Doping Code 2006 Prohibited List" | 08:26 |
kanzure | let's see what's on the 12 list.. | 08:26 |
kanzure | *2012 | 08:26 |
kanzure | hrm.. 2009? http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-The-Code/WADA_Anti-Doping_CODE_2009_EN.pdf | 08:27 |
kanzure | aha here's 2012 http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2012/WADA_Prohibited_List_2012_EN.pdf | 08:29 |
kanzure | damn, modafinil is prohibited | 08:30 |
kanzure | "The following, with the potential to enhance sports performance, are prohibited: 1) the transfer of nucleic acids or nucleic acid sequences; 2) the use of normal or genetically modified cells." say whaat. | 08:31 |
chido | yeah I was just about to wonder about the vague-ness of that one | 08:32 |
chido | so if yash succeeds he will never be able to do any sports, ever? | 08:33 |
foucist | you guys are aware of doping with your own cells rihgt? | 08:33 |
kanzure | well, this org doesn't seem to be a government body.. i dunno who listens to them | 08:33 |
foucist | for instance some athletes have extracted blood cells and then injected that back in later | 08:33 |
foucist | for extra oxgen | 08:34 |
chido | mind you, the mind sports olympics use the code too so he can't play go or chess there either :D | 08:34 |
foucist | nevermind, i need to read the backlog more often | 08:34 |
foucist | kanzure: which part are you saying what to | 08:35 |
kanzure | chido: so if you take anabolic steroids, build up tons of muscle mass.. you can't play chess? :( | 08:35 |
kanzure | foucist: what? | 08:35 |
foucist | kanzure: "say whaat." which part | 08:35 |
foucist | the nucleic acids? the normal cells? | 08:35 |
chido | it was a bit of an affair here because the srongest go players here in CZ almost couldn't participate in the mind sports olympics because of weed | 08:36 |
kanzure | foucist: the whole thing :( i was hoping they would outline some useful things for me. | 08:36 |
kanzure | but instead, they just say no to everything. | 08:37 |
chido | kanzure: I assume the "regular" events like league games and local championship don't give a damn about doping, at least in go, not sure about chess | 08:37 |
chido | kanzure: welcome to europe and its take on genetic modification :D | 08:37 |
kanzure | huh? i thought you guys hate GMO | 08:38 |
chido | "no to everything" is standard policy | 08:38 |
audy | kanzure so my irc client displays the image inline | 08:38 |
kanzure | yikes why would you want that | 08:39 |
chido | easier than sorting through the details | 08:39 |
kanzure | like what if i link to pain3.jpg? | 08:39 |
kanzure | or whatever that file is. supergoatse. | 08:39 |
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kanzure | http://angel.co/cambrian-genomics | 09:59 |
kanzure | peeps: anselm levskaya, reese jones, george church, john mulligan, sagar indurkhya, austen heinz | 10:00 |
kanzure | oh and lukman winoto | 10:00 |
kanzure | SCOTUS ruling re: obamacare http://www.supremecourt.gov/opinions/11pdf/11-393c3a2.pdf | 10:02 |
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delinquentme | What is the string search algo thats really german sounding and has "distance" in its name?? | 10:38 |
delinquentme | its a string comparison operation | 10:38 |
kanzure | levenshtein? | 10:38 |
kanzure | but that's russia | 10:39 |
kanzure | *russian | 10:39 |
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archels | oh wow, this guy is claiming that "if I were an upload, I would never again have to sleep" | 10:40 |
delinquentme | YES | 10:41 |
delinquentme | LEVENSHTEIN | 10:41 |
delinquentme | kanzure, damn you're good | 10:41 |
kanzure | aren't most processes spending most of their time in zombie state in the linux kernel? | 10:41 |
kanzure | i guess that's not sleeping exactly | 10:41 |
kanzure | (e.g. waiting for input) | 10:41 |
kanzure | erm, wait.. zombie != waiting for input. don't listen to me. | 10:41 |
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delinquentme | http://www.warpdrivebio.com/engine.php | 10:43 |
delinquentme | oh lulz | 10:43 |
delinquentme | php | 10:43 |
delinquentme | well lets hope the hardware is on something a little better | 10:43 |
delinquentme | anyways " CHEMOMEMES " | 10:43 |
delinquentme | and geo church | 10:43 |
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kanzure | yashgaroth: today we're ashamed that we don't have a longer list of 'easy alleles for genetic improvements' | 10:52 |
kanzure | do you have a list somewhere? i know that's my job and all, but uh apparently i don't | 10:52 |
yashgaroth | define 'easy' | 10:52 |
kanzure | 'known alleles that provide interesting changes' | 10:52 |
kanzure | http://www.snpedia.com/index.php/I3003626 | 10:52 |
yashgaroth | get all those weird ashkenazi recessive brain disorders, give people one copy of the normal and one copy of the bad, with 50% expression on both | 10:53 |
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yashgaroth | actually you could apply that to a lot of persistent recessive disorders, sickle cell for example | 10:53 |
yashgaroth | SNPs are good but they're almost always just associated with the gene...but yeah delta-CCR5 would be good | 10:55 |
yashgaroth | I think it makes you slightly more susceptible to some exotic viruses, but it's probably worth it for resistance to HIV and the plague | 10:55 |
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yashgaroth | you can get a couple of inducible genes in with tetracycline-response elements, just gotta pick the most useful | 10:56 |
yashgaroth | that WADA document is annoying - they get all specific on steroids, but myostatin is just "all drugs which inhibit myostatin" | 10:57 |
yashgaroth | oh and extra p53 expression couldn't hurt | 10:58 |
kanzure | this is an interesting one: http://www.snpedia.com/index.php/Rs314263 | 10:59 |
kanzure | "faster rate of growth at age 10 and about a tenth of an inch less in adult height" | 10:59 |
kanzure | http://www.snpedia.com/index.php/Height | 11:00 |
yashgaroth | is there a link which shows you what gene they're near? it's doubtless some hormone regulator | 11:00 |
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yashgaroth | oooh that pepck-c overexpression would be a good one | 11:02 |
yashgaroth | oh and alpha-galactosidase in the digestive tract | 11:03 |
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yashgaroth | I probably should make a list huh | 11:03 |
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* chido would appreciate a list | 11:05 | |
kanzure | yashgaroth: can you dump that into a text file for us? | 11:07 |
yashgaroth | blaaaaahokay | 11:07 |
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kanzure | rs1265507 looks possibly interesting | 11:20 |
yashgaroth | k http://dl.dropbox.com/u/82637557/germline%20genetic%20modification.txt | 11:34 |
yashgaroth | I'm forgetting at least a half-dozen but it's my birthday so deal with it | 11:34 |
gnusha | diyhpluswiki.git: 9a80e1c germline genetic modifications via yashgaroth | 11:35 |
yashgaroth | argh where the hell is a euro 2012 stream | 11:35 |
yashgaroth | nm | 11:38 |
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kanzure | haha the fbi trading cards have an iphone app.. http://itunes.apple.com/au/app/bioagents-education/id520691350?mt=8 | 12:04 |
chido | I've been trying to find a source of the cards online | 12:05 |
kanzure | so, with george church being an "advisor" to anything, i wonder if you can just slap his name on things and expect people to believe it | 12:06 |
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-!- kanzure changed the topic of ##hplusroadmap to: biohacking, nootropics, transhumanism, open hardware | backed by george church | http://gnusha.org/logs/ http://groups.google.com/group/diybio | 12:07 | |
* yashgaroth throws money at the channel | 12:08 | |
@kanzure | maybe we can find some guy named george church to make that legitimate | 12:08 |
nmz787 | ? | 12:09 |
nmz787 | along with NRA | 12:09 |
-!- kanzure changed the topic of ##hplusroadmap to: biohacking, nootropics, transhumanism, open hardware | backed by george church and the NRA | http://gnusha.org/logs/ http://groups.google.com/group/diybio | 12:10 | |
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@kanzure | i've learned of at least three new things today advised by george | 12:12 |
@kanzure | that new cambridge x-risk group, | 12:13 |
@kanzure | cambrian genomics (via angel.co), | 12:13 |
@kanzure | and i don't even remember the third one. | 12:13 |
@kanzure | i should make a list and sell it back to him or something | 12:13 |
nmz787 | lol | 12:14 |
nmz787 | thta cambrian genomics is the gene laser company right? | 12:14 |
nmz787 | DNA laser sounds ever so bogus | 12:14 |
@kanzure | anselm told us that he was doing sequencing of dna to improve the reliability | 12:15 |
nmz787 | its a horrible hack to use several $150k machines to get cheap DNA | 12:15 |
@kanzure | i don't recall him mentioning lasers | 12:15 |
nmz787 | yeah | 12:15 |
nmz787 | http://angel.co/cambrian-genomics | 12:15 |
nmz787 | DNA laser printing | 12:15 |
nmz787 | "" | 12:16 |
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chido | so is the NRA thing a thing? any progress? | 12:18 |
yashgaroth | about as much as george church is | 12:18 |
@kanzure | haha | 12:19 |
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nmz787 | chido, did you get to eat any of these while you were here? http://en.wikipedia.org/wiki/Cheetos | 12:28 |
chido | nmz787: no, I didn't | 12:31 |
chido | I didn't eat a burrito either | 12:32 |
nmz787 | wait, weren't you at the taco place after noisebridge the very first night before the workshop started? | 12:32 |
chido | even though yash made it clear to me that leaving California without ever having eaten Mexican is a sacrilege | 12:32 |
chido | no | 12:32 |
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chido | I wasn't at noisebridge until the day the BART fire | 12:33 |
nmz787 | ooo | 12:33 |
chido | we met there for the first time | 12:33 |
nmz787 | yeah burritos are sacrilicious | 12:34 |
chido | "Cheetos have been found in shapes which resembled the appearance of popular or historical figures" | 12:36 |
nmz787 | like that jesus toast that sold on ebay years ago | 12:36 |
yashgaroth | cheetos are arguably more important than mexican food tbh | 12:37 |
chido | apparently a Michael Jackson Cheeto sold too | 12:37 |
chido | I seemed to have missed out on an important cultural aspect here | 12:37 |
nmz787 | problem today is you can forge jesus toast with a laser cutter | 12:38 |
yashgaroth | cheetos and mountain dew are like the nerd eucharist | 12:38 |
nmz787 | i bet catholics hate lasers now | 12:38 |
chido | I read an article on how jetlag is linked to permament memory damage so I am not sure if I am ever coming back for the Cheetos | 12:38 |
nmz787 | hah | 12:38 |
nmz787 | just take a bunch of sleeping pills to avoid the lag | 12:38 |
nmz787 | then its not jet lag, its hangover lag | 12:39 |
nmz787 | benzodiazapenes are really handy for international trips | 12:39 |
nmz787 | as well as my bugs bunny full-size bedroom pillow | 12:39 |
yashgaroth | xanax is the only way to fly | 12:39 |
nmz787 | any benzos really | 12:39 |
nmz787 | i've really only had restoril | 12:40 |
nmz787 | so i think i'm gonna apply to a security consulting firm | 12:41 |
nmz787 | fuck biotech bitch work | 12:41 |
yashgaroth | like biosecurity or what | 12:41 |
nmz787 | get a high paying job coding, work on opensource projects with that practice | 12:41 |
nmz787 | nah application security, chipsets, protocols, etc... | 12:41 |
yashgaroth | less competition for me | 12:42 |
nmz787 | i know enough about a lot of topics in the field, and i think i could hang... tho my coding skills are a bit weak in the webapp stuff, i think i can make up for it with hardware concepts | 12:42 |
nmz787 | exactly | 12:42 |
nmz787 | live birth MRI http://www.youtube.com/watch?v=8W02HgvEVR4 | 12:43 |
nmz787 | aww thats not the full vid | 12:44 |
nmz787 | http://www.youtube.com/watch?v=kxwNqYwvaAI&feature=player_embedded | 12:45 |
nmz787 | thats actual video, but still not full length | 12:45 |
nmz787 | SOURCE: Bamberg C, Rademacher G, Güttler F, et al. Human birth observed in real-time open magnetic resonance imaging. Am J Obstet Gynecol 2012;206:505.e1-6. | 12:48 |
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nmz787 | http://www.ajog.org/article/S0002-9378(12)00023-3/abstract | 12:49 |
nmz787 | same video in the supplementary content | 12:50 |
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delinquentme | Today’s consumer electronics are more beautiful than ever. The shininess level is soaring way above nine thousand. | 13:01 |
delinquentme | http://www.wellsriley.com/blog/2012/stop-shipping-hardware-products-that-are-only-beautifully-designed/ | 13:01 |
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delinquentme | yashgaroth> cheetos and mountain dew are like the nerd eucharist | 13:04 |
delinquentme | ROFL | 13:04 |
* chido thinks the raspberry pi is beautiful | 13:04 | |
delinquentme | MOTD? | 13:04 |
chido | tastes vary | 13:04 |
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@kanzure | "according to a major United Nations report on the Economics of Ecosystems and Biodiversity, the total economic value of pollination by insects worldwide was in the ballpark of $200 billion in 2005" | 13:56 |
Mokbortolan_ | so, basically what they're saying, is that if all the insects stopped pollinating, it would only cost the world 200 billion. | 13:57 |
Mokbortolan_ | seems a little low | 13:57 |
Mokbortolan_ | or are they trying to calculate the hourly wages by respective mass | 13:58 |
nmz787 | or maybe thats how much edibles are produced by pollinators? | 13:58 |
nmz787 | grains, fruits, veggies??? | 13:59 |
nmz787 | hmm | 13:59 |
nmz787 | yeah thats a weird statement | 13:59 |
Mokbortolan_ | maybe they figure that they can just send out $200 billion worth of migrant laborers with tiny paintbrushes | 13:59 |
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@fenn | not sure what the use of "poor man's screw library" is, since bolts are cheaper than the plastic to print plastic bolts | 14:35 |
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chido | fenn: how's the devious smuggler fish doing? | 14:44 |
@fenn | seems like the author of the screw thread library knows what he's doing: http://www.thingiverse.com/thing:8776 | 14:45 |
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@kanzure | hrm | 16:15 |
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@kanzure | rmcl: hi | 18:06 |
rmcl | kanzure: howdy. sorry for all the join/leaves | 18:06 |
@kanzure | how do you do? | 18:07 |
rmcl | good thanks. hbu? | 18:07 |
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nmz787 | azonenberg: how's the photolith? | 19:41 |
azonenberg | nmz787: my new roommate is a mechanical engineer and is going to be helping me make a better spin coater | 19:42 |
azonenberg | ETA on that is a month or two depending on how long it takes us to source components | 19:42 |
azonenberg | next on the list of improved tooling is a contact mask aligner for 2" wafers complete with vacuum chuck and two adjustable-distance microscopes | 19:43 |
nmz787 | can i buy plans from you someday | 19:43 |
nmz787 | ? | 19:43 |
nmz787 | will be needing a spin coater in about 9 months or so | 19:44 |
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@kanzure | 2009-07-16.log:19:07 < Smari> essentially what I'm getting at is a machine readable Merck index that can be traversed. I point a piece of software at my personal invent | 23:00 |
@kanzure | ory and say, "I want to build an airplane", and it searches through this database of processes and finds the shortest path from my inventory to the airplane and tells m | 23:00 |
@kanzure | e what that path is and what else I'm going to need. | 23:00 |
@kanzure | so why didn't he do that? | 23:01 |
yashgaroth | how the hell did you find that | 23:01 |
@kanzure | yashgaroth: just some old hplusroadmap logs | 23:05 |
yashgaroth | yeah but still | 23:05 |
@kanzure | we used to do things in here | 23:05 |
yashgaroth | except that guy, apparently | 23:06 |
@kanzure | smari ended up becoming the leader of the icelandic pirate party instead, or something | 23:06 |
@kanzure | i dunno, it's not my job to track you guys... oh wait | 23:06 |
yashgaroth | AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation | 23:47 |
yashgaroth | man this Hicks guy hates drugs but loves gene therapy, I'm not sure what to think: AAVrh.10-Mediated Expression of an Anti-Cocaine Antibody Mediates Persistent Passive Immunization That Suppresses Cocaine-Induced Behavior | 23:49 |
--- Log closed Fri Jun 29 00:00:54 2012 |
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