| --- Log opened Sun Nov 25 00:00:28 2012 | ||
| -!- mgodinho [~user@pdpc/supporter/active/mgodinho] has joined ##hplusroadmap | 00:20 | |
| -!- user123abc [~sally@c-67-171-79-251.hsd1.pa.comcast.net] has quit [Ping timeout: 265 seconds] | 00:51 | |
| fenn | hum well it's a start. http://fennetic.net/irc/tutorial_part.pdf | 01:30 |
|---|---|---|
| fenn | just some random crap | 01:30 |
| abetusk | what is that? | 02:01 |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Ping timeout: 265 seconds] | 02:05 | |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap | 02:26 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 02:55 | |
| -!- ThomasEgi [~thomas@gw-ko-kostr2.inka-online.net] has joined ##hplusroadmap | 04:21 | |
| -!- ThomasEgi [~thomas@gw-ko-kostr2.inka-online.net] has quit [Changing host] | 04:21 | |
| -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap | 04:21 | |
| -!- user123abc [~sally@c-67-171-79-251.hsd1.pa.comcast.net] has joined ##hplusroadmap | 05:01 | |
| -!- srangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has joined ##hplusroadmap | 05:52 | |
| -!- strangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has quit [Ping timeout: 252 seconds] | 05:53 | |
| -!- srangewarp is now known as strangewarp | 05:53 | |
| @kanzure | maybe a thermocycler thing | 06:15 |
| -!- mgodinho [~user@pdpc/supporter/active/mgodinho] has quit [Quit: Ken sent me.] | 06:30 | |
| -!- EnLilaSko- [~Nattzor@m77-219-226-49.cust.tele2.se] has joined ##hplusroadmap | 06:51 | |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Ping timeout: 245 seconds] | 06:52 | |
| AdrianG | http://www.sciencedaily.com/releases/2011/10/111031215938.htm | 07:24 |
| @kanzure | what is it? | 07:25 |
| streety | that graph is great, two identical lines | 07:31 |
| streety | apparently the enzyme is peroxiredoxin | 07:32 |
| -!- srangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has joined ##hplusroadmap | 07:33 | |
| -!- strangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has quit [Ping timeout: 246 seconds] | 07:35 | |
| -!- srangewarp is now known as strangewarp | 07:35 | |
| -!- delinquentme [~asdfasdf@c-71-236-101-39.hsd1.pa.comcast.net] has joined ##hplusroadmap | 08:02 | |
| -!- chevbird [~chevbird@66-87-85-42.pools.spcsdns.net] has joined ##hplusroadmap | 08:30 | |
| -!- chevbird [~chevbird@66-87-85-42.pools.spcsdns.net] has quit [Read error: Connection reset by peer] | 08:31 | |
| -!- synacktic [~synacktic@unaffiliated/jordyd] has quit [Ping timeout: 252 seconds] | 09:04 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 09:10 | |
| -!- synacktic [~synacktic@99-177-65-98.lightspeed.wepbfl.sbcglobal.net] has joined ##hplusroadmap | 09:17 | |
| -!- synacktic [~synacktic@99-177-65-98.lightspeed.wepbfl.sbcglobal.net] has quit [Changing host] | 09:17 | |
| -!- synacktic [~synacktic@unaffiliated/jordyd] has joined ##hplusroadmap | 09:17 | |
| -!- ElixirVitae [~Shehrazad@95.5.115.59] has joined ##hplusroadmap | 09:20 | |
| -!- ElixirVitae [~Shehrazad@95.5.115.59] has quit [Changing host] | 09:20 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 09:20 | |
| -!- user123abc [~sally@c-67-171-79-251.hsd1.pa.comcast.net] has quit [Quit: Leaving] | 09:21 | |
| -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has joined ##hplusroadmap | 10:07 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap | 11:32 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Read error: Connection reset by peer] | 11:47 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap | 12:04 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Read error: Operation timed out] | 12:08 | |
| -!- chevbird [~chevbird@209-6-62-26.c3-0.sbo-ubr1.sbo.ma.cable.rcn.com] has joined ##hplusroadmap | 12:09 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap | 12:21 | |
| jrayhawk | i would be curious to read those papers to see if they actually controlled with a low-oxidative-stress diet | 12:23 |
| jrayhawk | it would not surprise me in the least to find out that restricting garbage has some benefit | 12:24 |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Ping timeout: 264 seconds] | 12:27 | |
| chevbird | i prefer kraft dinner | 12:33 |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap | 12:39 | |
| -!- ParahSailin [~parah@unaffiliated/parahsailin] has quit [Read error: Connection reset by peer] | 12:55 | |
| -!- ParahSailin [~parah@unaffiliated/parahsailin] has joined ##hplusroadmap | 12:56 | |
| -!- augur_ [~augur@c-75-74-129-116.hsd1.fl.comcast.net] has quit [Ping timeout: 244 seconds] | 13:15 | |
| curt1s | last i heard about those caloric restriction diets, they were turning out to be bullshit | 13:16 |
| curt1s | this stuff is new though | 13:17 |
| chevbird | anyone read the CDPPB/MGluR5 paper from earlier this month? | 13:23 |
| chevbird | i just came across it...very interesting | 13:24 |
| chevbird | (fowler et al.) | 13:24 |
| -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has joined ##hplusroadmap | 13:27 | |
| brownies | jrayhawk: eh? i thought that latest news on caloric restriction on primates showed it had no effect | 13:44 |
| jrayhawk | diet's really complicated; a single study isn't going to cover the problemspace | 13:45 |
| jrayhawk | the primate one at least showed that the rodent models are not applicable slam-dunks for longevity in humans, but there's a lot more work yet to be done in characterizing what sort of restriction is beneficial | 13:57 |
| jrayhawk | like we already know that periodic protein fasting and carb fasting each produce some pretty useful metabolic adaptations | 13:58 |
| jrayhawk | but these diet studies don't really get more sophisticated than macros and calories, which is a damned shame | 13:59 |
| brownies | what other dimensions are worth studying ? | 14:01 |
| jrayhawk | Oxidative/inflammatory stressors is the biggest one. | 14:03 |
| jrayhawk | http://www.sciencedaily.com/releases/2011/10/111031215938.htm which this looks like it was admirably interested in, but not to the point of identifying specific stressors in the diet. | 14:03 |
| brownies | intriguing. | 14:08 |
| brownies | have those stressors been identified? | 14:08 |
| @kanzure | yes, all the foods | 14:08 |
| brownies | i.e. before exploring diets that reduce those, we should find out what the causes are | 14:08 |
| brownies | kanzure: damn, i like to eat those. | 14:08 |
| jrayhawk | Yeah, we know severe inflammation/oxidative stress pathways for linoleic acid, fructose, and gliadin (and, by anecdote and inference, other prolamines) | 14:20 |
| -!- chevbird [~chevbird@209-6-62-26.c3-0.sbo-ubr1.sbo.ma.cable.rcn.com] has quit [Quit: Leaving] | 14:22 | |
| jrayhawk | like, just searching scholar.google.com for each of those things plus keywords like oxidative or cytokine generates lots of interesting hits | 14:23 |
| jrayhawk | http://scholar.google.com/scholar?q=linoleic+acid+cytokines+-conjugated+-alpha | 14:23 |
| -!- ParahSailin [~parah@unaffiliated/parahsailin] has quit [Read error: Connection reset by peer] | 14:24 | |
| -!- EnLilaSko- is now known as EnLilaSko | 14:25 | |
| -!- EnLilaSko [~Nattzor@m77-219-226-49.cust.tele2.se] has quit [Changing host] | 14:25 | |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap | 14:25 | |
| @kanzure | there's also nice diagrams on reactome and KEGG | 14:25 |
| @kanzure | although that's only for known metabolic/catabolic pathway stuff | 14:25 |
| -!- ParahSailin [~parah@adsl-69-151-150-200.dsl.hstntx.swbell.net] has joined ##hplusroadmap | 14:28 | |
| -!- ParahSailin [~parah@adsl-69-151-150-200.dsl.hstntx.swbell.net] has quit [Changing host] | 14:28 | |
| -!- ParahSailin [~parah@unaffiliated/parahsailin] has joined ##hplusroadmap | 14:28 | |
| jrayhawk | Joey added linkmap support to the graphviz plugin for Ikiwiki. I occasionally get tempted to start doing heavily hyperlinked biochemistry diagrams. | 14:28 |
| jrayhawk | imagemap | 14:28 |
| jrayhawk | whatever the term is for that | 14:28 |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] | 14:30 | |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap | 14:31 | |
| @kanzure | jrayhawk: i'm not sure if auto-summarization is the answer, but definitely some of the stuff in longevity/ should be consolidated somehow | 14:32 |
| -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] | 14:40 | |
| nmz787 | IYbio has been slow lately | 14:50 |
| nmz787 | DIYbio* | 14:50 |
| nmz787 | stupid turkey day screwing up people's internet lives | 14:50 |
| nmz787 | how do i close a channel in irssi? | 14:52 |
| @kanzure | /wc | 14:53 |
| nmz787 | how do i change which server i want when joining a channel? | 15:00 |
| -!- synacktic [~synacktic@unaffiliated/jordyd] has quit [Ping timeout: 265 seconds] | 15:00 | |
| @kanzure | nmz787: ctrl-x i think | 15:03 |
| @kanzure | look in window 0 to see which server you are currently running commands on | 15:03 |
| @kanzure | i think you can also use /server but that might only be for connecting | 15:03 |
| nmz787 | yeah if i issue the cmd from a channel that is the server i get | 15:22 |
| nmz787 | it's that channel's server* | 15:22 |
| @kanzure | yes, so i just issue it from window 0 | 15:24 |
| -!- audy- is now known as audy | 15:32 | |
| -!- audy [~audy@heyaudy.com] has quit [Changing host] | 15:32 | |
| -!- audy [~audy@unaffiliated/audy] has joined ##hplusroadmap | 15:32 | |
| -!- delinquentme [~asdfasdf@c-71-236-101-39.hsd1.pa.comcast.net] has quit [Ping timeout: 264 seconds] | 16:00 | |
| fenn | jrayhawk: do you take NAC? or antioxidant supplements? just curious | 16:01 |
| fenn | neat idea of the day: photo-enhanced diffusion of hydrogen from hollow glass microspheres, to maximize gravimetric energy density by eliminating valves | 16:06 |
| fenn | http://ceer.alfred.edu/Research/glassspheres.html | 16:08 |
| jrayhawk | The only antioxidant thing I take is glutathione precursor in the form of Vitamin D | 16:09 |
| jrayhawk | And I eat a shitton of bone broth for glutamate and various other things for sulfer. I don't actually know what's used to maintain endogenous NAC levels, come to think of it. | 16:14 |
| jrayhawk | glutamate and glycine in bone broth | 16:14 |
| jrayhawk | ah, methionine | 16:15 |
| jrayhawk | 'Methionine, an essential amino acid, is found mainly in egg whites and fish' I suspect I'm good, then! | 16:16 |
| jrayhawk | i guess vitamin d isn't really a precursor, but it does tend to determine production rates regardless | 16:18 |
| -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Ping timeout: 276 seconds] | 16:27 | |
| -!- torwag` [~user@130.34.206.97] has left ##hplusroadmap ["ERC Version 5.3 (IRC client for Emacs)"] | 16:32 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] | 17:22 | |
| -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap | 18:13 | |
| -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Read error: Connection reset by peer] | 18:22 | |
| -!- wizrobe is now known as Leia-SpaceHo | 19:22 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Ping timeout: 248 seconds] | 20:00 | |
| -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap | 20:17 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Remote host closed the connection] | 20:44 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap | 20:46 | |
| nmz787 | kanzure: have you seen any PDMS safe DNA synthesis papers? | 21:24 |
| -!- RebelBunny [~RebelBunn@108-250-133-41.lightspeed.irvnca.sbcglobal.net] has joined ##hplusroadmap | 21:36 | |
| @kanzure | hm, apparently not | 21:50 |
| -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap | 22:16 | |
| @kanzure | commit c4b92829d8203ec988be10d433fe0150065cba4f | 22:21 |
| @kanzure | Author: Bryan Bishop <kanzure@gmail.com> | 22:21 |
| @kanzure | Date: Sun Nov 25 16:03:24 2012 -0600 | 22:21 |
| @kanzure | i have no memory of this | 22:21 |
| fenn | so it seems fish oil is not just fish oil anymore: http://www.ascentahealth.com/health-science/science-articles/fish-oil-triglycerides-vs-ethyl-esters-as-nature-intended | 22:26 |
| fenn | oh ethyl ester purification was invented in 1980's | 22:33 |
| -!- augur [~augur@208.58.5.87] has quit [Remote host closed the connection] | 23:09 | |
| -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap | 23:12 | |
| -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has quit [Quit: Leaving] | 23:34 | |
| -!- archels [~foo@sascha.esrac.ele.tue.nl] has quit [Ping timeout: 256 seconds] | 23:43 | |
| -!- archels [~foo@sascha.esrac.ele.tue.nl] has joined ##hplusroadmap | 23:45 | |
| --- Log closed Mon Nov 26 00:00:30 2012 | ||
Generated by irclog2html.py 2.15.0.dev0 by Marius Gedminas - find it at mg.pov.lt!