| --- Log opened Sat Jul 27 00:00:37 2013 | ||
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| superkuh | paperbot: http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2013164a.html | 07:46 |
|---|---|---|
| paperbot | http://libgen.org/scimag/get.php?doi=10.1038%2Fnpp.2013.164 | 07:47 |
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| archels | http://vimeo.com/71064267 | 08:43 |
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| @kanzure | .title | 09:54 |
| yoleaux | Glassified: Ruler with transparent display to supplement physical drawing on Vimeo | 09:54 |
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| @kanzure | paperbot: http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/285/ra62 | 10:47 |
| @kanzure | .title | 10:47 |
| yoleaux | Superresolution Microscopy Reveals Nanometer-Scale Reorganization of Inhibitory Natural Killer Cell Receptors upon Activation of NKG2D -- Pageon et al. 6 (285): ra62 -- Science Signaling | 10:47 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1126%2Fscisignal.2003947 | 10:48 |
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| @kanzure | shopbot is using kickstarter as part of their launch campaign for a product.. http://www.handibot.com/ | 10:50 |
| @kanzure | "Our plan is that the Handibot will be open source hardware tool (initial model now available on GitHub), that it will be operated by task- or job-oriented "apps" that will be made available as free and open or paid (depending on the developers choice)," | 10:50 |
| @kanzure | i can't find the promised git repository.. | 10:50 |
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| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=664283c6 Bryan Bishop: link to the recent nature.com article | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0752d919 Bryan Bishop: diybio group in bogotá, columbia | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=643c82dc Bryan Bishop: biohacker in kiev, ukraine | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d5f68ccd Bryan Bishop: update biohackers in pittsburgh | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8e3a69f1 Bryan Bishop: update biotechnbeyond members | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7cb58718 Bryan Bishop: even more pittsburgh people | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=64ebb355 Bryan Bishop: document an indiana biohacking group | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=89c58153 Bryan Bishop: place div anchors near columbia group | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a83188e5 Bryan Bishop: fix biohacker in lawrence, kansas | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=3853b4a2 Bryan Bishop: biohackers in perth, australia | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f01a6844 Bryan Bishop: patrik and other hackers at counterculturelabs.org | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=06a63be1 Bryan Bishop: biohackers in moscow | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=33560598 Bryan Bishop: another biohacker in ukraine | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=350c7c57 Bryan Bishop: some biohackers in italy | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=27873b8e Bryan Bishop: hackers from são paulo, brazil | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=87c7b56a Bryan Bishop: diybio group in minneapolis, minnesota | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=30ba7c17 Bryan Bishop: biology team in philadealphia | 11:24 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=046109df Bryan Bishop: fix up the houston biohacking peeps | 11:24 |
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| @kanzure | oh darn, i didn't even notice the philadealphia TYPO | 11:26 |
| -!- mode/##hplusroadmap [+oooo fenn ParahSail1n klafka heath] by kanzure | 11:28 | |
| @kanzure | heath: you should add yourself to that file | 11:28 |
| @kanzure | any chance i can convince one of you to try brlcad + swig? | 11:56 |
| @kanzure | oh yuck.. http://www.bulletproofexec.com/51-transhumanism-technology-the-future-with-natasha-vita-more-podcast/ | 11:56 |
| @kanzure | jrayhawk_: it's spreading | 11:56 |
| * heath didn't think <div /> was valid | 12:05 | |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5b7f6a71 heath: | 12:08 |
| @heath | added (with no comment, oops) | 12:08 |
| @kanzure | the divs are just for link anchors instead of <a name=>. | 12:11 |
| @kanzure | huh, is this guy saying that you can do cookie tossing from a gmail html attachment that loads an iframe? is that even allowed? http://homakov.blogspot.com.es/2013/07/googleusercontentcom-fun-or-snowden-is.html | 12:12 |
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| @kanzure | i don't think the content is worth reading, but the title was chuckle worthy http://blog.penelopetrunk.com/2009/01/08/5-time-management-tricks-i-learned-from-years-of-hating-tim-ferriss/ | 13:00 |
| * heath is curious what are the sequences used for gates in this paper | 13:37 | |
| @heath | http://dna.caltech.edu/Papers/DNA_logic_circuits2006.pdf | 13:37 |
| @heath | .title | 13:37 |
| yoleaux | heath: Sorry, that doesn't appear to be an HTML page. | 13:37 |
| @heath | eh, it doesn't do pdfs, i forget | 13:37 |
| @heath | Enzyme-Free Nucleic Acid Logic Circuits. | 13:37 |
| @kanzure | it's almost as if you've never read the paper that resulted from my work on that topic | 13:42 |
| @heath | because i haven't | 13:42 |
| @heath | linkage? | 13:42 |
| @heath | is it the one where you weren't credited? | 13:42 |
| @kanzure | yes. | 13:43 |
| @kanzure | http://diyhpl.us/~bryan/papers2/ellington/Modelling%20amorphous%20computations%20with%20transcription%20networks%20-%202009.pdf | 13:43 |
| @kanzure | jrayhawk_: what was your earlier point about me being a terrible person for not having a long list of non-engineering-related tasks for people to do? | 13:45 |
| @kanzure | jrayhawk_: i can't remember the full structure of that argument/complaint. | 13:45 |
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| @heath | unfortunately i don't have much of antying to say except i don't know why it' | 15:05 |
| @heath | s Frezza et. al. in section 3.3 and Winfree and co-workers earlier in the paper :) | 15:05 |
| @heath | it was a short, plesant read, not sure why i never took the time to read it previously | 15:06 |
| @heath | what does the C stand for in C1.0 and C2.0? | 15:10 |
| @heath | "construct" | 15:10 |
| @heath | it's the name of the oligo | 15:11 |
| @heath | yeah? | 15:11 |
| @heath | ^directed at anyone who cares to read the paper, not necessarily le bryan | 15:13 |
| * heath rereads | 15:15 | |
| @heath | just a variable name it seems | 15:17 |
| @heath | .title https://www.youtube.com/watch?v=yXd4EJMg4aA | 15:26 |
| yoleaux | Where computation and fabrication meet: Using computers to mimic biology (Zack Booth Simpson) - YouTube | 15:26 |
| @heath | that's played about 3 times now in the background | 15:27 |
| * heath is curious what happened which prevented you, kanzure, from being credited | 15:27 | |
| @kanzure | didn't stick around at that lab long enough | 15:34 |
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| @heath | any idea how much dictionary.com is bringing in? | 17:30 |
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| @kanzure | google groups is incorrectly parsing email headers, https://groups.google.com/forum/#!topic/diybio/qyUPU9HhXYg | 18:13 |
| @kanzure | here's the raw headers: https://groups.google.com/forum/#!original/diybio/qyUPU9HhXYg/_3A5AscNj08J | 18:14 |
| @kanzure | oops i mean https://groups.google.com/forum/message/raw?msg=diybio/qyUPU9HhXYg/_3A5AscNj08J | 18:14 |
| @kanzure | it looks like the problem is with the Content-Type header | 18:14 |
| @kanzure | the headers are getting into his message text and also it's acting like his reply is a new thread (although it's possible that he intentionally stripped whatever headers are necessary for figuring out which thread/email he was replying to) | 18:17 |
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| @kanzure | fellowman: hi | 18:33 |
| @ParahSail1n | paperbot, http://endo.endojournals.org/content/102/6/1925.long | 18:35 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1210%2Fendo-102-6-1925 | 18:35 |
| @ParahSail1n | paperbot: http://dx.doi.org/10.1210%2Fendo-102-6-1925 | 18:36 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/bd3371bca2ab3881b095dce21ed0794b.txt | 18:36 |
| @ParahSail1n | paperbot: http://dx.doi.org/10.1210%2Fendo-102-6-1925 | 18:36 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/11c3dd4254ada964207578912fc880a6.txt | 18:36 |
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| @kanzure | the next version of pdfparanoia is going to be dubbed nsaparanoia | 19:46 |
| @ParahSail1n | we all know you're a fed | 19:46 |
| @heath | i don't understand how we are able to engineer proteins and yet protein design is NP hard | 19:48 |
| @kanzure | it depends on how you define engineering | 19:49 |
| @heath | kanzure: if you have time, would you expand on this? this has been bugging me a little while now | 19:50 |
| @kanzure | if i delete a fragment of a protein by removing a few domains, is that engineering? | 19:50 |
| @kanzure | it's mostly just a philosophical debate and it doesn't matter | 19:50 |
| @ParahSail1n | the amount of "engineering" in what people are doing these days is very primitive | 19:55 |
| gradstudentbot | Someone stole my pipette. | 19:56 |
| @kanzure | it's a hugely ridiculous amount of guesswork | 19:56 |
| @kanzure | sometimes there are practical and obvious reasons to not put two residues next to each other | 19:57 |
| yashgaroth | most protein engineering is directed evolution | 19:57 |
| @kanzure | there is some under the name 'rational protein design' or something | 19:57 |
| @kanzure | but yeah much more in forced selection projects | 19:58 |
| yashgaroth | if you have the crystal structure I imagine that makes it a bit easier to manually tinker | 19:58 |
| yashgaroth | or there's protein fusion, the lazy man's engineering | 19:58 |
| @ParahSail1n | people have made de novo enzymes and theyve been crap, but still pretty amazing they worked at all | 19:59 |
| yashgaroth | yeah the baker lab does some amazing stuff considering | 20:00 |
| @kanzure | my experience with protein engineering has been limited to just deleting or adding extra residues in dna polymerase variants | 20:04 |
| @kanzure | i am still unhappy with ribbon models to visualize protein structure | 20:05 |
| * kanzure pokes proteinbot | 20:06 | |
| @heath | thanks | 21:10 |
| @heath | from the video linked earlier | 21:10 |
| @heath | """As long as we were trying to mimic birds, we never suceeded. it was when we gave up trying to mimic them and started an engineering discicipline of building wind tunnels and isolating lift from drag, that we begin to make progress. And only once we had an engineering discipline of aeronautics were we able to go back and ask the question "how do birds fly?" So engineering and science are coupled to each other, you have to have both of them to make | 21:10 |
| @heath | progress.. and biology has been constrained for centuries by the fact that it has not had an engineering discipline that goes along with it.""" | 21:10 |
| @ParahSail1n | i think flapping is a big part of their flying | 21:13 |
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| @heath | if you have the space... | 21:29 |
| @heath | http://archive.org/details/Best_of_8_Bit_Collective-2006-2011 | 21:29 |
| @heath | it's worth all 19gb | 21:29 |
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| @heath | are these overlapping? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860119/figure/F1/?report=objectonly | 23:56 |
| @heath | these +channels | 23:56 |
| @heath | hm, or is this a 3d microfluidic chip... | 23:56 |
| --- Log closed Sun Jul 28 00:00:38 2013 | ||
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