2014-04-17.log

--- Log opened Thu Apr 17 00:00:42 2014
-!- HashNuke [uid12117@gateway/web/irccloud.com/x-vzymqaxypixbsjkk] has quit [Quit: Connection closed for inactivity]00:12
-!- brownies [~brownies@unaffiliated/brownies] has quit [Ping timeout: 240 seconds]00:17
-!- brownies [~brownies@184.106.201.58] has joined ##hplusroadmap00:18
-!- brownies [~brownies@184.106.201.58] has quit [Changing host]00:18
-!- brownies [~brownies@unaffiliated/brownies] has joined ##hplusroadmap00:18
-!- audy [~audy@unaffiliated/audy] has quit [Ping timeout: 255 seconds]00:27
-!- audy [~audy@heyaudy.com] has joined ##hplusroadmap00:33
-!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has quit [Remote host closed the connection]01:56
-!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has joined ##hplusroadmap01:57
-!- Adifex is now known as Adifex|zzz02:06
-!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap02:20
-!- JayDugger [~jwdugger@pool-173-74-79-151.dllstx.fios.verizon.net] has joined ##hplusroadmap02:26
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap02:54
-!- entelechios [~elysium@181.194.129.122] has joined ##hplusroadmap02:57
-!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap03:13
-!- kyknos_ [~kyknos@89.233.130.143] has quit [Ping timeout: 250 seconds]03:31
-!- entelechios [~elysium@181.194.129.122] has quit [Ping timeout: 265 seconds]03:55
-!- FourFire [~fourfire@191-219-15.connect.netcom.no] has joined ##hplusroadmap04:12
-!- HashNuke [uid12117@gateway/web/irccloud.com/x-fwavcxnebqqamgca] has joined ##hplusroadmap04:28
-!- q2p9e4u7t [1000@117.220.70.46] has joined ##hplusroadmap04:28
-!- q2p9e4u7t [1000@117.220.70.46] has left ##hplusroadmap []04:30
-!- Allah [~tpi@c-107-4-148-59.hsd1.va.comcast.net] has joined ##hplusroadmap04:53
-!- kardan [~kardan@199.254.238.144] has quit [Ping timeout: 250 seconds]05:04
-!- kardan [~kardan@199.254.238.214] has joined ##hplusroadmap05:06
-!- ThomasEgi [~thomas@185.5.8.81] has joined ##hplusroadmap05:52
-!- ThomasEgi [~thomas@185.5.8.81] has quit [Changing host]05:52
-!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap05:52
-!- mosasaur [~mosasaur@178.227.144.43] has joined ##hplusroadmap05:57
-!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap06:01
-!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap06:08
-!- kardan [~kardan@199.254.238.214] has quit [Read error: Connection reset by peer]06:18
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 240 seconds]06:19
-!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap06:38
-!- Shehrazad [~Shehrazad@unaffiliated/shehrazad] has quit [Ping timeout: 265 seconds]06:43
-!- Shehrazad [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap06:50
-!- nsh [~nsh@host86-158-32-224.range86-158.btcentralplus.com] has joined ##hplusroadmap07:28
-!- audy [~audy@heyaudy.com] has quit [Changing host]07:33
-!- audy [~audy@unaffiliated/audy] has joined ##hplusroadmap07:33
-!- HashNuke [uid12117@gateway/web/irccloud.com/x-fwavcxnebqqamgca] has quit [Quit: Connection closed for inactivity]07:42
-!- kuldeepdhaka [~kuldeepdh@unaffiliated/kuldeepdhaka] has joined ##hplusroadmap07:45
ParahSailinkanzure: scroll up in strace08:24
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]08:27
-!- nsh [~nsh@host86-158-32-224.range86-158.btcentralplus.com] has quit [Changing host]08:52
-!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap08:52
-!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving]08:53
@kanzureoh duh08:55
-!- nmz787_i [~nmccorkx@192.55.54.40] has joined ##hplusroadmap08:59
-!- audy is now known as audy-laboratory09:05
@kanzurethese sound like really boring papers: http://peerproduction.net/issues/issue-4-value-and-currency/peer-reviewed-articles/09:13
@kanzurealso these: http://peerproduction.net/issues/issue-2/ (except maybe denisa's, but meh)09:14
-!- fireprfHydra [~fireprfHy@pool-173-70-216-225.nwrknj.fios.verizon.net] has joined ##hplusroadmap09:15
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap09:21
nmz787_iso far the "microfluidics fabrication services" i've contacted have been unhelpful... :/09:24
@kanzurehmm https://github.com/weidai11/extropians/pull/109:24
@kanzurenmz787_i: go on09:25
ParahSailinis anyone having weird kernel stuff going on on their servers?09:25
@kanzurei haven't noticed anything broken09:26
ParahSailinbesides the epoll thing magically appearing since applying heartbleed patches09:27
@kanzureunfortunately i last tried it a month ago, and i might have upgraded stuff prior to heartbleed09:28
-!- mosasaur [~mosasaur@178.227.144.43] has quit [Quit: Leaving.]09:32
nshepoll thing magically appearing?09:46
@kanzurehttp://www.zerohedge.com/news/2014-04-16/ex-chairman-insolvent-uk-bank-busted-possession-cocaine-ketamine-and-crystal-meth09:46
@kanzurensh: yes see https://github.com/gulpjs/gulp/issues/167#issuecomment-4067775909:47
nshty09:47
nmz787_iwell basically it seems either A) I don't appear professional enough to these companies because I'm emailing from a gmail address09:49
nmz787_ior B) there isn't enough demand for these things to make them as cheap as stanford was offering (stanford no longer has a foundry for outsiders)09:49
@kanzurewould you like to email from blackhatbio.com? maybe that would help09:49
nmz787_ior C) I need to email more companies09:50
@kanzurewhat were the prices they were quoting?09:50
nmz787_ione company was ridiculous, quoting like $7k for a one-off and they didn't have valve experience, and maybe didn't even do assembly09:50
nmz787_ithis company in Connecticut seems like they've got all the experience, can do PDMS, glass, silicon (which they can add electrodes to), do assembly, can send out for optical coating09:51
ParahSailinno, thats about right on the cost09:51
nmz787_ibut their responses have been short and unhelpful09:51
nmz787_iParahSailin: stanford was $450 for a multilayer device09:51
@kanzurethat was for a multilayer w/o valves i think09:51
nmz787_ino i don't think they cared09:52
nmz787_isince a valve is just two channels crossing over one another, with a curved profile for one and a square profile for the other09:52
-!- fireprfHydra [~fireprfHy@pool-173-70-216-225.nwrknj.fios.verizon.net] has quit [Ping timeout: 258 seconds]09:52
@kanzurehttp://web.archive.org/web/20110222234927/http://www.stanford.edu/group/foundry/09:52
ParahSailinyou dont really want pdms unless your use case is disposable09:52
nmz787_iyep09:52
nmz787_ii do009:53
nmz787_idon't want contam09:53
nmz787_icarryover, etc09:53
@kanzureonly push up/push down valves09:53
nmz787_iguess I just need to email more companies... but at $7k I could get tons of shit FIBbed locally09:53
ParahSailinok why are we still talking about fib09:54
nmz787_ibecause you don't understand me09:54
nmz787_i:P09:54
nmz787_ibecause its nano/micro CNC09:54
chris_99they use FIB for microfluidicy stuff?09:54
ParahSailinraster is really slow, and you pay by the hour09:54
ParahSailinchris_99: no, nobody actually does09:55
-!- audy-laboratory is now known as audy09:55
nmz787_iyep, its not that slow tho09:55
nmz787_imicrons per second09:55
nmz787_ichris_99: one local company was interested in my project specifically so they could gain experience in that field, since they primarily do system design (of FIBs)09:56
chris_99cool, which project is this, was it some kind of DNA synthesizer?09:57
nmz787_iyes09:57
nmz787_ii ordered a new harddrive the other night so i could try a bunch of CAD programs (i've had no free space for months)09:57
chris_99they've gone pretty reasonable again, a 4TB is pretty decently priced i found09:58
nmz787_iheh, well this is for my laptop, which can only accept 2.5" x 7mm high09:58
chris_99ah heh09:58
nmz787_ii got a 1TB though for not too terrible a price09:58
chris_99so if they're gonna use FIB what material are you using09:58
nmz787_iglass or silicon09:58
nmz787_ican use that for making PDMS casts, but also for the electrode side of things09:59
@kanzureParahSailin: it's funny how he ignores your microfluidics experience09:59
nmz787_iat least those guys were helpful when i spoke with them :/09:59
nmz787_ii never knew ParahSailin had any microfluidics experience09:59
ParahSailinwho knows, maybe they actually have FIBs that can etch 100 micron wide channels, 20-100 um deep in seconds09:59
nmz787_iall he's ever said was 'them dudes don't use fib'10:00
ParahSailinbeen a while since i was in that game10:00
@kanzurenah, he's said other things10:00
@kanzurein the past10:00
nmz787_iyes, they do, i've sent the etch rate link before, here it is again http://www.oregon-physics.com/lab_services/fib_micromachining_milling.html10:01
nmz787_ias beam spot size increases, so does mill rate10:02
nmz787_is/etch/mill/10:02
-!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap10:03
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 240 seconds]10:04
-!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap10:07
-!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 252 seconds]10:09
@kanzure"historical video" https://www.youtube.com/user/britishpathe10:09
@kanzureoh their claim seems to be wrong. they claimed 85,000 video uploads but i only see <200.10:11
@kanzureaha http://www.britishpathe.com/search/recordcategories/Science++Technology/start/1890/end/192010:12
@kanzurethose are much less interesting than i figured10:14
@kanzuresee, if i was alive in the 1890s and in charge of collecting videos, i would try to find much more diverse things that are in danger of disappearing, rather than mundane crap10:14
@kanzurei'm not sure i understand this design http://proofmathisbeautiful.tumblr.com/post/82039490406/zerostatereflex-water-experiment-no-3310:15
@kanzureoh they are holes at different locations on each disc10:15
@kanzuredisk10:15
ParahSailinthose etch rates are still terrible compared to wet or dry etch10:17
nmz787_iseem fine though for rapid prototyping10:17
ParahSailinhow do you get to that10:19
nmz787_iit certainly wouldn't cost $7k for one-off10:19
ParahSailinyou know what's awesome for rapid prototyping? inkjet printer on transparency + photoresist patterning and wet etch10:25
ParahSailinyou even dont need to pay for a couple machine days at $200/hr10:26
nmz787_iI really don't care how it gets done, I just want an easy to deal with contractor10:26
@kanzureParahSailin: how many prototypes did you have to churn through?10:28
ParahSailinlots10:28
@kanzurehow many components, valves, gates, whatever on chip?10:29
ParahSailinheh even without any moving parts10:29
ParahSailinim not sure theres any way to do moving parts without having something to foul10:29
ParahSailinso if you want moving parts, its going to be a disposable10:30
-!- nsh [~nsh@wikipedia/nsh] has quit [Ping timeout: 240 seconds]10:31
-!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap10:33
ParahSailinits actually kinda hard to get a circular reservoir to flush, because of the laminar flow thing10:34
ParahSailinthats what typically takes a lot of prototypes10:34
chris_99what kind of moving parts would you want out of interest on such a thing?10:38
nmz787_ivalvels10:38
nmz787_ivalves10:38
nmz787_ibrb10:39
ParahSailinfor serious low cost dna synthesis http://www.mycroarray.com/index.html 20k x 100nt / $150010:41
nmz787_ibut those don't really have very good quality control10:42
nmz787_iwhich for semi-directed evolution would be fine10:43
ParahSailinyeah error rate is high, you need special shit for ligation10:43
ParahSailinbut thats what you want to go with for the raw synthesis part10:43
nmz787_iI want to obliterate transfer steps... text file in, transformed bug culture out10:44
nmz787_ibasically its just coupling synthesis with purification and electroporation10:44
nmz787_i:P10:44
nmz787_i*basically*10:44
nmz787_ithat price point isn't too bad for today tho10:45
ParahSailinbridge amplification & sequencing + ligation10:45
nmz787_iyou could do that, or just size-select and protect already-synthesized from active/destabilizing chemistry10:45
-!- nmz787_i [~nmccorkx@192.55.54.40] has quit [Remote host closed the connection]10:46
-!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap10:47
eudoxiahttp://198.170.115.106/reports/CI93.html this was a cool read from a few years back10:50
eudoxiathat's allegedly the IP of CI, i don't really care10:50
@kanzure"(he had been taking about 150 pills per day, many of which were Life Extension Foundation products). The sudden loss of supplements was undoubtedly a shock to his system."10:53
-!- nmz787_i [~nmccorkx@192.55.55.37] has joined ##hplusroadmap10:54
-!- uberj [~uber@192.241.197.120] has left ##hplusroadmap ["WeeChat 0.4.3"]11:01
@kanzureioctl(6, FIOCLEX)                       = -1 EBADF (Bad file descriptor)11:06
@kanzureParahSailin: it's waiting on a bad fd?11:06
ParahSailinthats weird11:07
ParahSailindo you see an epoll_open anywhere returning 6?11:07
@kanzureepoll_ctl(6, EPOLL_CTL_ADD, 7, {EPOLLIN, {u32=7, u64=7}}) = 011:08
@kanzureno epoll_open anywhere but probably wrong name11:09
ParahSailinepoll_create11:10
@kanzureonly one: epoll_create1(O_CLOEXEC)                = 611:11
ParahSailinok thats right11:11
ParahSailinso somewhere between that and the ioctl 6 its gone?11:11
ParahSailinis there a close(6 somewhere?11:12
@kanzure4532 lines11:12
@kanzurethere's only: ioctl(6, FIOCLEX); epoll_ctl(6, EPOLL_CTL_ADD, 7, {EPOLLIN, {u32=7, u64=7}}) = 0; epoll_ctl(6, EPOLL_CTL_ADD, 9, {EPOLLIN, {u32=9, u64=9}}) = 0; epoll_wait(6, {{EPOLLIN, {u32=9, u64=9}}}, 1024, 4294967295) = 1; epoll_wait(6,  <unfinished ...>;11:12
@kanzureepoll_create1 is 10-15 lines after ioctl(6, ..)11:13
ParahSailinoh11:13
ParahSailinso its waiting on fds 7 and 911:14
@kanzureioctl(7, FIOCLEX)                       = -1 EBADF (Bad file descriptor)11:14
@kanzuresame with 911:14
@kanzureexcept 9 also has: read(9, "\1\0\0\0\0\0\0\0", 1024)11:14
@kanzurewhich is near the end next to the broken epoll_wait11:15
@kanzurefd 7r is pipe and fd 9u is anon_inode (same as 6u)11:15
ParahSailinwhat opens 911:16
@kanzureno lines end with "= 9"11:17
@kanzurei don't see anything that opens it11:17
ParahSailinyou wanna pastebin the whole strace?11:18
@kanzurehttp://diyhpl.us/~bryan/irc/node-strace.txt11:19
@kanzurecan file descriptors be shared between processes?11:20
ParahSailineventfd2(0, O_NONBLOCK|O_CLOEXEC)       = 911:23
ParahSailinyeah they can11:23
@kanzurehow did i miss that line?11:24
@kanzureoh i was using \W9\W11:25
-!- cpopell`gaming is now known as cpopell11:25
ParahSailinwell typically people dont use sendmsg and recvmsg to send file descriptors through domain sockets11:26
ParahSailinbut if theres a fork() anywhere you can bet that file descriptors are acessible to another process11:27
dingo:D11:28
eudoxiathat sweet feel when a python script gets killed by the OOM killer11:30
@kanzurehrm so now i have to figure out what's causing that to get called11:31
ParahSailinah right, clone()11:41
ParahSailinso maybe you need the strace -f or -p whatever it is that makes it follow the whole process group11:41
@kanzurehttp://diyhpl.us/~bryan/irc/node-strace2.txt11:42
@kanzure4520 seems to be the hanging pid11:44
@kanzureoh that's the parent11:45
ParahSailinyeah thats teh dad11:45
ParahSailinwhat exactly are the child procs11:46
ParahSailinjust how node does multiprocessing?11:46
@kanzurelibuv stuff11:47
ParahSailinwhen the parent process is left hanging, have the children all died?11:48
ParahSailinyeah i guess so, they get detached11:48
ParahSailinso the children die, and nobody is left to write to the eventfd11:48
-!- Auctus [~Auctus@unaffiliated/auctus] has joined ##hplusroadmap11:48
-!- Auctwo [~Auctus@122-57-138-207.jetstream.xtra.co.nz] has quit [Ping timeout: 252 seconds]11:50
-!- Auctwo [~Auctus@122-57-138-207.jetstream.xtra.co.nz] has joined ##hplusroadmap11:51
-!- Auctus [~Auctus@unaffiliated/auctus] has quit [Ping timeout: 250 seconds]11:53
-!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving]11:57
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]12:01
-!- heath [quassel@unaffiliated/ybit] has quit [Ping timeout: 258 seconds]12:12
-!- heath [quassel@unaffiliated/ybit] has joined ##hplusroadmap12:15
-!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap12:21
delinquentmepaperbot, http://pubs.acs.org/doi/abs/10.1021/nn405097u12:22
paperbothttp://diyhpl.us/~bryan/papers2/paperbot/Compartmental%20Genomics%20in%20Living%20Cells%20Revealed%20by%20Single-Cell%20Nanobiopsy.txt12:22
-!- Shehrazad [~Shehrazad@unaffiliated/shehrazad] has quit [Quit: Leaving]12:24
-!- ElixirVitae [~Shehrazad@95.5.71.250] has joined ##hplusroadmap12:24
-!- ElixirVitae [~Shehrazad@95.5.71.250] has quit [Changing host]12:24
-!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap12:24
-!- sheena1 [~home@d75-155-198-81.bchsia.telus.net] has joined ##hplusroadmap12:26
-!- sheena [~home@d75-155-198-81.bchsia.telus.net] has quit [Ping timeout: 265 seconds]12:28
@kanzurepaperbot: http://www.cell.com/cell/abstract/S0092-8674(14)00418-812:49
@kanzure"Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis"12:49
paperbothttp://diyhpl.us/~bryan/papers2/paperbot/Whole-Brain%20Imaging%20with%20Single-Cell%20Resolution%20Using%20Chemical%20Cocktails%20and%20Computational%20Analysis.pdf12:50
@kanzure"Systems-level identification and analysis of cellular circuits in the brain will require the development of whole-brain imaging with single-cell resolution. To this end, we performed comprehensive chemical screening to develop a whole-brain clearing and imaging method, termed CUBIC (clear, unobstructed brain imaging cocktails and computational analysis). CUBIC is a simple and efficient method involving the immersion of brain samples in ...12:50
@kanzure... chemical mixtures containing aminoalcohols, which enables rapid whole-brain imaging with single-photon excitation microscopy. CUBIC is applicable to multicolor imaging of fluorescent proteins or immunostained samples in adult brains and is scalable from a primate brain to subcellular structures. We also developed a whole-brain cell-nuclear counterstaining protocol and a computational image analysis pipeline that, together with CUBIC ...12:51
@kanzure... reagents, enable the visualization and quantification of neural activities induced by environmental stimulation. CUBIC enables time-course expression profiling of whole adult brains with single-cell resolution."12:51
@kanzurepaperbot: http://www.sciencedirect.com/science/article/pii/S009286741400418812:51
nsh.wa number of cells in human brain12:51
paperbothttp://diyhpl.us/~bryan/papers2/paperbot/2165fbbd0371142b5576fec4d49135c9.txt12:51
yoleauxnsh: Sorry, no result!12:51
nsh(lots)12:51
@kanzureParahSailin: i "solved" the problem by doing a custom build of nodejs :(13:05
ParahSailinyeah, recompiling always solves these things13:05
ParahSailindo you have any assets at illumina?13:09
@kanzurenot to my knowledge?13:15
@kanzureoh wait, hm13:15
@kanzureno13:16
@kanzurei keep forgetting that lifetech was acquired by thermo fisher13:16
cpopellLife is weird sometimes. I just found out the mother of one of my friends growing up went back to school in her late forties for a degree in CS and is getting into predictive analytics.13:18
-!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap13:20
-!- nsh [~nsh@wikipedia/nsh] has quit [Disconnected by services]13:20
-!- nsh_ is now known as nsh13:20
@kanzurehttp://www.consul.io/intro/index.html13:28
@kanzurehttp://www.consul.io/docs/internals/architecture.html13:28
@kanzurehttp://www.consul.io/intro/vs/serf.html13:28
-!- bertm [~bertm@remote.pacificlighttech.com] has joined ##hplusroadmap13:34
-!- FourFire [~fourfire@191-219-15.connect.netcom.no] has left ##hplusroadmap ["Leaving"]13:39
-!- eudoxia [~eudoxia@r186-53-74-21.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap13:43
delinquentmehttps://www.youtube.com/watch?v=uL6e3co4Qqc13:47
delinquentmeTHIS is awesome13:49
delinquentmeand I need to pee13:49
delinquentmeTTYL!13:49
* delinquentme licks ParahSailin 13:49
-!- delinquentme [~dingo@74.61.157.78] has quit [Quit: Leaving]13:49
eudoxiawow licking people on IRC, how rude is that13:49
-!- ielo [~ielo@129-2-129-26.wireless.umd.edu] has joined ##hplusroadmap13:52
-!- kardan [~kardan@199.254.238.183] has joined ##hplusroadmap14:03
jrayhawkkanzure: did you meet delinquentme in real life and, if so, did delinquentmy at any point attempt to lick you?14:06
jrayhawks/my/me14:06
-!- devrando1 is now known as devrandom14:12
-!- ielo [~ielo@129-2-129-26.wireless.umd.edu] has quit [Ping timeout: 245 seconds]14:20
-!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap14:26
-!- _Sol_ [SolGr@c-50-166-90-49.hsd1.nj.comcast.net] has joined ##hplusroadmap14:39
-!- kardan [~kardan@199.254.238.183] has quit [Quit: Ciao!]14:40
@kanzure"Human Somatic Cell Nuclear Transfer Using Adult Cells" http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00137-414:41
@kanzure"•Adult cell reprogramming via SCNT is not successful via the conventional protocol"14:41
@kanzure"•Improved success was achieved with a recently developed approach"14:41
@kanzure"•hESCs were derived via SCNT from 35- and 75-year-old males"14:41
@kanzure"Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus far has only been reported with fetal or infant somatic cells. In this study, we describe the application of a recently developed methodology for the generation of human ESCs via SCNT ...14:41
@kanzure... using dermal fibroblasts from 35- and 75-year-old males. Our study therefore demonstrates the applicability of SCNT for adult human cells and supports further investigation of SCNT as a strategy for regenerative medicine."14:41
-!- kuldeepdhaka [~kuldeepdh@unaffiliated/kuldeepdhaka] has quit [Excess Flood]14:43
-!- eudoxia [~eudoxia@r186-53-74-21.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving]14:45
delinquentmeTheres some nordic fashion designer whos spending money in the bahamas or jamaca or someplace warm to bring about research in SCNT14:46
delinquentmegood news for him14:46
@kanzurehttp://opensslrampage.org/14:46
delinquentmeBlahhhhhh kanzure should I work for academia.edu14:46
@kanzure“So the OpenSSL codebase does “get the time, add it as a random seed” in a bunch of places inside the TLS engine, to try to keep entropy high. I wonder if their moto is “If you can’t solve a problem, at least try to do it badly”.”14:47
@kanzurehahaha no14:47
@kanzureno way man14:47
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap14:47
delinquentmeI mean its could be good connections and the money would be solid.14:47
@kanzuregood connections with what14:47
delinquentmekanzure, I also just realized that with the right circuitry the research in fishingline muscles could be REALLY handy in quad copters / the work being done w 3drobotics14:48
delinquentmeI mean I'd quickly be able to vet tons of people within academic circles14:48
-!- Auctus [~Auctus@unaffiliated/auctus] has joined ##hplusroadmap14:58
-!- Auctwo [~Auctus@122-57-138-207.jetstream.xtra.co.nz] has quit [Ping timeout: 258 seconds]15:00
-!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap15:01
-!- nsh [~nsh@wikipedia/nsh] has quit [Ping timeout: 258 seconds]15:02
-!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Remote host closed the connection]15:08
-!- nsh_ is now known as nsh15:11
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Remote host closed the connection]15:28
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap15:28
-!- trotsky [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap15:33
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Ping timeout: 265 seconds]15:33
-!- ielo [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has joined ##hplusroadmap15:43
-!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 252 seconds]15:43
-!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer]16:07
-!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap16:19
-!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap16:20
-!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection]16:22
-!- trotsky [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Remote host closed the connection]16:24
@kanzurehttp://www.nlm.nih.gov/news/welcome_library_agreement.html "NLM and Wellcome Library Establish Agreement to Make 150 Years of Biomedical Journals Freely Available Online"16:24
@kanzure"Representatives of the US National Library of Medicine (NLM), a component of the National Institutes of Health, and the Wellcome Trust recently signed a memorandum of understanding to work together to make thousands of complete back issues of historically-significant biomedical journals freely available online. The terms of the MOU include a donation of £750,000 ($1.2 million) to the NLM that will support coordination of the three-year ...16:24
@kanzure... project to scan original materials from NLM's collection at the article level, and Wellcome's work to secure copyright clearances and permissions for electronic deposit from publishers. NLM will undertake conservation of the original material to ensure its preservation for future generations."16:24
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap16:24
@kanzureum... "and Wellcome's work to secure copyright clearances and permissions for electronic deposit from publishers."16:24
@kanzurecopyright permissions for 100 year-old papers?16:24
-!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has joined ##hplusroadmap16:26
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Ping timeout: 258 seconds]16:29
-!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has quit [Remote host closed the connection]16:33
-!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has joined ##hplusroadmap16:36
-!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has quit [Remote host closed the connection]16:37
-!- nmz787_i [~nmccorkx@192.55.55.37] has quit [Quit: Leaving.]16:41
-!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has joined ##hplusroadmap16:44
@kanzureperformance of hashing in javascript crypto libraries http://dominictarr.github.io/crypto-bench/16:47
-!- HashNuke [uid12117@gateway/web/irccloud.com/x-wepzhlvcwayqijmt] has joined ##hplusroadmap16:53
@kanzureyahoo mail emails are breaking mailman with DMARC p=reject http://www.dmarc.org/pipermail/dmarc-discuss/2014-April/002445.html16:54
-!- entelechios [~elysium@181.194.129.122] has joined ##hplusroadmap17:06
-!- entelech1os [~elysium@181.194.129.122] has joined ##hplusroadmap17:09
-!- entelech1os [~elysium@181.194.129.122] has quit [Client Quit]17:10
-!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has joined ##hplusroadmap17:13
-!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 258 seconds]17:14
-!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has quit [Ping timeout: 250 seconds]17:18
-!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap17:26
-!- nsh [~nsh@wikipedia/nsh] has quit [Ping timeout: 258 seconds]17:28
-!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has joined ##hplusroadmap17:31
-!- ielo is now known as amillers_boyfrie18:03
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap18:03
-!- amillers_boyfrie is now known as jamesz18:03
-!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has joined ##hplusroadmap18:05
cpopellhttp://scholar.google.com/scholar?hl=en&q=a+fundamental+study+and+modeling+of+the+micro-droplet+formation+process+in+near-field+electrohydrodynamic+jet+printing&btnG=&as_sdt=1%2C47&as_sdtp=18:06
-!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap18:08
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 276 seconds]18:10
-!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap18:15
-!- jamesz [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has quit [Ping timeout: 245 seconds]18:17
ParahSailinhttp://www.state.gov/j/drl/p/224863.htm18:21
-!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 258 seconds]18:22
@kanzureParahSailin: i don't think they will particularly accept the "let's send lots of open source molecular biology equipment to north korea" proposal18:27
entelechioslol18:28
entelechioshttp://www.koryogroup.com/ north korea vacations18:29
-!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Remote host closed the connection]18:29
entelechiosi saw some bearded gringo with a sorta angry look on his face wearing a red tshirt that said 'COMMUNIST' on it walking out of a cuban bar the other day and all i could do was lol18:30
ParahSailindangit18:30
ParahSailinhow about design the freedom virus?18:31
@kanzureonly if it's sexually transmitted18:31
entelechioshttp://cdn.pophangover.com/wp-content/uploads/2013/04/kim-jong-un-fx_o_1241392.gif18:32
-!- drewbot [~cinch@ec2-54-205-5-34.compute-1.amazonaws.com] has quit [Remote host closed the connection]18:32
-!- drewbot [~cinch@ec2-50-17-42-27.compute-1.amazonaws.com] has joined ##hplusroadmap18:32
ParahSailinoh god18:33
-!- delinquentme [~dingo@131.107.200.34] has joined ##hplusroadmap18:37
-!- HEx1 [~HEx@hexwab.plus.com] has quit [Quit: Leaving.]18:42
-!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap18:42
@kanzure"Kepler-186f is an exoplanet orbiting the red dwarf Kepler-186, 500 light-years from the Earth. It is the first planet with a radius similar to Earth's discovered in the habitable zone of another star." https://en.wikipedia.org/wiki/Kepler_186f18:45
@kanzure18:29 < justanot1eruser> Looking at the scrollback for the interplanetary Bitcoin, is there a way to prove you're on a certain planet that is cryptographically verifiable?18:50
@kanzure"how fast would the fastest human run 100m?" http://freakonometrics.hypotheses.org/1388018:51
dingolol18:55
-!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection]18:57
-!- delinquentme [~dingo@131.107.200.34] has quit [Read error: No route to host]19:00
-!- HashNuke [uid12117@gateway/web/irccloud.com/x-wepzhlvcwayqijmt] has quit [Quit: Connection closed for inactivity]19:02
-!- ruthie [~ruthie@c-98-225-143-81.hsd1.pa.comcast.net] has joined ##hplusroadmap19:03
-!- jamesz [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has joined ##hplusroadmap19:05
-!- Qfwfq [~Qfwfq@cm113.kappa36.maxonline.com.sg] has joined ##hplusroadmap19:21
-!- Qfwfq [~Qfwfq@cm113.kappa36.maxonline.com.sg] has quit [Client Quit]19:21
-!- jamesz [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has quit [Ping timeout: 258 seconds]19:28
-!- HashNuke [uid12117@gateway/web/irccloud.com/x-ivjfzfqxytqfxlww] has joined ##hplusroadmap19:31
-!- Adifex|zzz is now known as Adifex19:47
heathwhere is biologik located?19:52
@kanzurehis smile is annoying19:57
@kanzure"He would like nothing more than to become a master of manipulating DNA through complexity science"19:57
@kanzurehe's also apparently an idiot about dna19:57
entelechiosimma mad scientist, watch me style my hair like einstein put on a lab coat and spout off bullshit19:59
entelechioshey look i have a flask with green koolaid in it and googly eyes20:00
@kanzureyour own eyes are googly?20:01
entelechiosand i have a german accent20:01
cluckjwat20:03
@kanzure'parently it's fucked up o'clock in here20:08
heathfig is pretty great20:11
heathi've been using packer for about two weeks now20:12
* heath was rereading the logs, just saw your fig stuff kanzure20:12
heathi havent' used docker though20:15
heathand subsequently fig20:16
@kanzurethe major downside with fig is service discovery20:16
@kanzureit forces you to do a lot of service discovery stuff upfront20:17
@kanzureinstead of ignoring it until your infrastructure is breaking20:17
heathfig looks a lot like ansible, which we've been using20:17
heathi don't know that i'll have much use for it unless i use docker20:19
@kanzureprobably not20:19
heathoh yeah, i've been working remotely for awhile :)20:21
heathand i don't plan on changing this20:21
heathnot a fan of cubicle culture20:22
heathkanzure: you've been working away on the pokemon disassembly for awhile, where are you heading with this?20:24
heathplease say you're making google's april fool's joke a reality20:24
heathjuri_: why haven't you been all over osvehicle?20:24
@kanzurei didn't see their latest thing. something about a map and pokemon?20:24
@kanzurein which case, no20:24
@kanzurewhen i was 11 i was doing lots of trial-and-error gamesharking on pokemon20:26
@kanzurethe disassembly is my way of squashing my inner child20:26
@kanzureviolently20:27
@kanzureinstead of trial and error you can look at things like reality! and make progress on things!20:27
@kanzurebut also if you're asking for TODOs it's mostly related to removing the dependency on baserom.gbc20:28
xmjgood morning20:34
xmjkanzure: does disassembling and looking at the inner plumbing feel more 'fun' ?20:35
@kanzuremore fun than what?20:37
xmjtrial/error20:38
@kanzurei've been able to think about stuff like asm injection and stack busting20:38
@kanzurejrayhawk: was there ever any "real-time" non-turn-based interactive fiction?20:39
juri_heath: there's a link to it on my wiki page.20:45
-!- Qfwfq [~Qfwfq@unaffiliated/washirving] has joined ##hplusroadmap20:45
juri_it looked way too not-printable, to me.20:45
xmjkanzure: that doesn't answer my question20:47
@kanzurei haven't really evaluated it on the spectrum of fun, ever20:48
@kanzurei guess i've forgotten to20:48
xmjah20:49
xmjhow sad20:49
@kanzureif you say so20:50
-!- Qfwfq [~Qfwfq@unaffiliated/washirving] has quit [Ping timeout: 276 seconds]21:02
-!- cluckj [~cluckj@cpe-24-92-63-104.nycap.res.rr.com] has quit [Ping timeout: 245 seconds]21:05
jrayhawkkanzure: you'll have to be a bit more specific in your definition of "interactive fiction" and "real time"21:06
-!- cluckj [~cluckj@cpe-24-92-63-104.nycap.res.rr.com] has joined ##hplusroadmap21:07
jrayhawkthe stanley parable probably matches most of the definitions you could come up with21:08
-!- petora [~asakharov@24.60.79.55] has joined ##hplusroadmap21:09
jrayhawkif "real time" means "matches the flow of time outside the game" then a fair number of mmorpgs might qualify, though usually narratives can only be loosely guided through those21:10
jrayhawkearly Ultima Online and Matrix Online had lots of real-time narrative elements.21:10
@kanzure"real time" as in, if you don't type an action, stuff is happening on your screen21:12
@kanzuredo MUDs count? or do things only happen in MUDs once you enter a command21:12
jrayhawkMUDs don't usually have much plot to speak of; they're usually stereotypical "RPG" hedonic treadmills.21:15
yashgarotha kobold arrives from the north21:15
jrayhawkAnd/or player-driven dramas.21:15
@kanzurethat's disappointing. glad i never bothered.21:15
yashgarothaww c'mon the discworld mud was pretty good21:15
jrayhawkplayer-invented dramas can get fairly entertaining, as seen with EVE21:15
jrayhawkthe forces of recursive tribal power concentration versus space nihilists21:16
jrayhawkmost of the game industry consists of products that are not turn based and contain a narrative, so you'll probably want to be more specific21:17
@kanzure"a kobold arrives from the north" while you're typing "north"21:18
yashgarothand begins to attack you; anyway yes stuff happens in MUDs without you entering commands21:18
@kanzurei've only seen MUDs that send me text after i hit enter21:19
jrayhawkThat does not sound like a good multi-user interaction model.21:19
yashgarothby necessity in a multi-user environment, at the least another player's actions will appear21:20
@kanzurewell, i was thinking single-player originally, but i suppose multi-user counts as interactive fiction too21:20
jrayhawkwhat exactly do you think "MUD" stands for21:20
@kanzurei don't know who you're asking anymore21:20
@kanzurei know that the server game state is updating in that scenario, but i'm talking about async updates on the user's screen21:21
-!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has quit [Remote host closed the connection]21:21
jrayhawkYeah, MUDs did that even back in, like, 1990, though how often that feature was relevant was a matter of game dynamics.21:22
@kanzurewas it.. a good dynamic?21:22
@kanzureor just annoying21:22
jrayhawkI never played MUDs in the internet era where multiplayer was somewhat more meaningful, so I couldn't tell you.21:23
jrayhawkI think I know a guy who can recommend some if you want to give them a whirl.21:23
@kanzurewell i was pondering a text-based dinoslaughter onslaught21:23
jrayhawkvioletland/crimsonland aren't good enough for you, huh?21:24
@kanzureno sorry21:24
@kanzure(i'm not sorry)21:25
jrayhawkhttp://www.topmudsites.com/21:27
jrayhawki am told aardwolf is pretty good21:27
jrayhawkin that it is a large community and has active development21:29
-!- nsh_ [~nsh@wikipedia/nsh] has quit [Ping timeout: 252 seconds]21:30
jrayhawkdwarf fortress is a single player sandbox game with anomalously strong procedurally/emergently generated narrative elements21:35
jrayhawki think you get to stop time whenever, though21:35
jrayhawkit's just a particularly outstanding example of how to do unstructured narratives21:35
jrayhawkSpace Station 13 is also pretty innovative21:38
@kanzureyes, dwarf fortress counts, although they rely a lot on ascii art21:39
@kanzure"interactive fiction" at one point referred almost exclusively to infocom i think21:39
jrayhawkah, okay21:40
jrayhawkyeah, that's not really my area of expertise. There's a big community focused around http://www.ifwiki.org/index.php/Main_Page at least.21:42
@kanzuregot it, so you have dominion over arcade games, but not anything earlier :p21:42
-!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap21:43
-!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has quit [Quit: Leaving]21:59
petorajrayhawk  Someone really needs to build a GUI frontend to dwarf fortress22:05
petoraI mean one with mouse click windows22:05
@kanzurep. sure that exists somewhere22:07
petorait doesnt really exist actually22:09
petorastill have to keyboard everything22:09
petoraand then ESC-ESC-ESC-ESC to get back to the top of the  keypress tree22:10
petorapeople have only been troubled enough to build GUIs "on top of" the underlying mechanics22:15
cpopellpetora: not as advanced, but you could play Gnomoria22:22
@kanzurethat sounds like the name of ParahSailin's freedom virus22:23
-!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has quit [Quit: Lost terminal]23:13
-!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has joined ##hplusroadmap23:13
-!- nsh_ [~nsh@wikipedia/nsh] has quit [Ping timeout: 240 seconds]23:21
JayDuggerGood morning, everyone.23:23
-!- kuldeepdhaka [~kuldeepdh@unaffiliated/kuldeepdhaka] has joined ##hplusroadmap23:28
-!- kyknos__ [~kyknos@89.233.130.143] has joined ##hplusroadmap23:58
--- Log closed Fri Apr 18 00:00:43 2014

Generated by irclog2html.py 2.15.0.dev0 by Marius Gedminas - find it at mg.pov.lt!