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| kanzure | beep | 09:34 |
|---|---|---|
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| superkuh | paperbot: http://www.sciencemag.org/content/345/6197/637 | 10:37 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1126%2Fscience.1254234 | 10:37 |
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| kanzure | paperbot: http://www.nber.org/papers/w19430 | 11:09 |
| kanzure | .title | 11:09 |
| yoleaux | Do fixed patent terms distort innovation? Evidence from cancer clinical trials | 11:09 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/Do%20fixed%20patent%20terms%20distort%20innovation%3F%20Evidence%20from%20cancer%20clinical%20trials.pdf | 11:09 |
| kanzure | "Patents award innovators a fixed period of market exclusivity, e.g., 20 years in the United States. Yet, since in many industries firms file patents at the time of discovery (“invention”) rather than first sale (“commercialization”), effective patent terms vary: inventions that commercialize at the time of invention receive a full patent term, whereas inventions that have a long time lag between invention and commercialization ... | 11:09 |
| kanzure | ... receive substantially reduced - or in extreme cases, zero - effective patent terms. We present a simple model formalizing how this variation may distort research and development (R&D). We then explore this distortion empirically in the context of cancer R&D, where clinical trials are shorter - and hence, effective patent terms longer - for drugs targeting late-stage cancer patients, relative to drugs targeting early-stage cancer patients ... | 11:09 |
| kanzure | ... or cancer prevention. Using a newly constructed data set on cancer clinical trial investments, we provide several sources of evidence consistent with fixed patent terms distorting cancer R&D. Back-of-the-envelope calculations suggest that the number of life-years at stake is large. We discuss three specific policy levers that could eliminate this distortion - patent design, targeted R&D subsidies, and surrogate (non-mortality) clinical ... | 11:09 |
| kanzure | ... trial endpoints - and provide empirical evidence that surrogate endpoints can be effective in practice." | 11:09 |
| dingo | am i correct in supposing that, if i knew your login and password, and sniffed your ssh session (with which you authenticated using password, not a private key), then the encryption of your transport is weaker? | 11:15 |
| dingo | i imagine it would be weaker, i just don't know to what degree | 11:16 |
| dingo | openbsd's anoncvs is 'anoncvs@cvs.openbsd.org' with no password, on the other hand, so they must think it protects the transport, at least -- they're not trying to secure against easedropping, just packet injection in such case | 11:17 |
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| nsh | where can i find an acronis true-image file to analyse the format for magic strings? | 11:31 |
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| delinquentme | kanzure, ParahSailin ... I still growing older .. and looks like i gonna die within the next 100 years | 11:47 |
| delinquentme | makes sad. | 11:47 |
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| jrayhawk | dingo: SSH does D-H key exchange; you can't sniff anything useful. | 14:03 |
| jrayhawk | Password exchange happens with the D-H'ed transport. | 14:04 |
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| kanzure | evidence? "The Propeller 1 is open source! Ready to play with the Verilog code?" | 14:26 |
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| jrayhawk | http://www.parallax.com/downloads/propeller-1-design | 14:33 |
| gradstudentbot | Who got mustard on my cell culture? | 14:34 |
| jrayhawk | presumably physical circuits are left as an exercise for the reader | 14:35 |
| kanzure | aha "Propeller 1 design and example files to be run on DE0-Nano or DE2-115 development board for Propeller 1 design experimenters" | 14:36 |
| kanzure | that is acceptable evidence | 14:36 |
| gradstudentbot | That would be highly informative, wouldn't it? | 14:38 |
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| dingo | 17:35 < jrayhawk> http://www.parallax.com/downloads/propeller-1-design | 14:51 |
| dingo | thats what runs my Apple I replica :) | 14:51 |
| dingo | http://www.brielcomputers.com/wordpress/wp-content/uploads/2010/06/replica1plus_med.jpg | 14:51 |
| dingo | it does mostly the video terminal work, its still a real 6502 cpu and 1mhz clock, but theres a seperate channel for the parallax | 14:52 |
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| superkuh | paperbot: http://standards.ieee.org/getieee/C95/download/C95.1-2005.pdf | 15:00 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/556302d2ba263ec942f88cb01ae8ac49.txt | 15:00 |
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| [nsh] | is there not a standard unix tool for finding largest common substrings in [binary] files? | 16:14 |
| catern | hmmmmmmm | 16:17 |
| kanzure | blast? | 16:18 |
| kanzure | actually i feel like i did that for pokemon | 16:18 |
| kanzure | nsh: https://github.com/kanzure/pokemon-reverse-engineering-tools/blob/master/pokemontools/comparator.py | 16:19 |
| gradstudentbot | I'll be at the microscope. | 16:19 |
| kanzure | this is obviously a very not generic implementation | 16:19 |
| [nsh] | hmm, looking thanks | 16:20 |
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| bbrittain | [nsh]: strings | 16:28 |
| bbrittain | it's just called strings | 16:28 |
| * [nsh] makes eyes at bbrittain | 16:28 | |
| bbrittain | wait. what. I'm serious. | 16:29 |
| [nsh] | i have three binary files. i want to put the names of those binary files as arguments to a piece of software that will then produce the longest sequence of bytes that they all have in common | 16:30 |
| [nsh] | how do you think strings is going to help? | 16:31 |
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| bbrittain | [nsh]: ahh, see you said substrings. strings can help with that :P | 16:33 |
| bbrittain | but not just random bytes | 16:33 |
| * [nsh] nods | 16:33 | |
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| bbrittain | [nsh]: why would you want to do this out of curiosity? | 16:34 |
| [nsh] | to determine known plaintext of a file format to use for a cryptographic attack against pkzip encryption | 16:35 |
| kanzure | because he is singing the mission impossible song very loudly and he can't keep doing it for the next 8 hours | 16:35 |
| kanzure | so he needs software to speed it up | 16:35 |
| * [nsh] smiles | 16:35 | |
| [nsh] | i bet i could sing the mission impossible theme for 8 hours | 16:36 |
| [nsh] | *100 hours | 16:36 |
| bbrittain | [nsh]: http://dl.acm.org/citation.cfm?id=2004100 | 16:42 |
| bbrittain | paperbot: http://dl.acm.org/citation.cfm?id=2004100 | 16:42 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1007%2Fs11263-011-0430-6 | 16:42 |
| bbrittain | have fun :) | 16:43 |
| * [nsh] smiles | 16:43 | |
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| bbrittain | I just went to coursera | 17:16 |
| bbrittain | they tried to get me to sign an NDA | 17:16 |
| bbrittain | I left | 17:16 |
| kanzure | that's cute | 17:18 |
| bbrittain | like. what the hell. | 17:18 |
| kanzure | they are part of the alternative universe where uh.. | 17:19 |
| kanzure | well i'm not sure. | 17:19 |
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| * heath is eating dinner.. | 17:26 | |
| heath | recommended videos? | 17:26 |
| * heath wants a video explaining toehold dna strand displacement | 17:26 | |
| kanzure | heath: i can only give you https://www.youtube.com/watch?v=JUgEmezpS_E | 17:27 |
| ParahSailin | kanzure: my project for today https://github.com/rcallahan/UNAFold/blob/master/src/hybrid-ss-min.c | 17:28 |
| ParahSailin | search for g_ in browser, each little yellow marker is a global | 17:29 |
| kanzure | do you just hate me or something | 17:29 |
| kanzure | i wonder if llvm could clean this crap up | 17:30 |
| ParahSailin | so ive refactored it, now just hunting for all the memory leaks | 17:30 |
| kanzure | no // comments | 17:30 |
| kanzure | only 40 /* comments */ | 17:30 |
| ParahSailin | i guess thats because // is not ansi c or something | 17:30 |
| kanzure | i like how everyone and their mom thinks they have to reimplement matrix math | 17:31 |
| ParahSailin | this is actually not matrix math | 17:31 |
| ParahSailin | it is just matrix lookup tables | 17:31 |
| kanzure | hmm. | 17:31 |
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| ParahSailin | also note that it only works with -DINTEGER and -DPRECISION=1000 | 17:34 |
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| delinquentme | kanzure, are you familiar w the igem business model? | 18:16 |
| delinquentme | is it closed source? | 18:16 |
| delinquentme | I though it was open ... or are people just paying for the built biobrick sequence molecules? | 18:16 |
| kanzure | their wiki was originally based on open source software i think, but they have heavily modified it | 18:17 |
| kanzure | with piles of perl | 18:17 |
| kanzure | the competition definitely has entrance fees, which i'm sure they are using to fund their use of venues (at least) | 18:18 |
| kanzure | and probably also to fund the creation and distribution of the biobrick catalogs to every team | 18:18 |
| kanzure | i think most of the sequences are available online, but only a handful (less than 30?) are marked as "biobrick public license" | 18:19 |
| delinquentme | OHHH so MOST of the biobricks you actually have to pay the $3500 to get access to | 18:21 |
| kanzure | physical access? iirc they do not ship to anything that isn't an igem team. | 18:22 |
| delinquentme | nah like can I only get access to the "biobrick public license" genes? | 18:28 |
| ParahSailin | igem is .org so no business model | 18:30 |
| delinquentme | ParahSailin, is that a real conclusion? | 18:32 |
| delinquentme | haha sorry that was unnecessarily flippant | 18:32 |
| delinquentme | but they're taking income :D | 18:32 |
| kanzure | .orgs have business models | 18:48 |
| kyknos_ | paperbot: http://www.nature.com/nrg/journal/v11/n1/pdf/nrg2626.pdf | 18:55 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/bdc53a04e56b2e2d7d5f2a26c68d35ea.pdf | 18:55 |
| kyknos_ | thank you lady | 18:56 |
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| kanzure | musicstuff https://www.youtube.com/watch?v=c5IpYXnfpvQ | 20:05 |
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| --- Log closed Sat Aug 09 00:00:29 2014 | ||
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