| --- Log opened Sun Aug 10 00:00:30 2014 | ||
| -!- gully_foyle_ja [~theghosto@pool-71-116-68-251.snfcca.dsl-w.verizon.net] has quit [Ping timeout: 260 seconds] | 00:13 | |
| -!- delinquentme [~dingo@74.61.157.78] has quit [Quit: Leaving] | 00:29 | |
| -!- ebowden_ [~ebowden@147.69.26.236] has quit [Remote host closed the connection] | 00:47 | |
| -!- ebowden [~ebowden@147.69.26.236] has joined ##hplusroadmap | 01:11 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 245 seconds] | 01:17 | |
| -!- Vutral__ [~ss@176.10.107.229] has quit [Ping timeout: 240 seconds] | 01:17 | |
| -!- Vutral_ [~ss@176.10.107.229] has quit [Ping timeout: 240 seconds] | 01:17 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has quit [Excess Flood] | 01:21 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 01:24 | |
| -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has quit [Remote host closed the connection] | 01:25 | |
| -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap | 01:34 | |
| -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has joined ##hplusroadmap | 01:34 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] | 01:38 | |
| -!- sapiosexual [~sapiosexu@d108-180-140-189.bchsia.telus.net] has quit [Ping timeout: 255 seconds] | 01:41 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 01:41 | |
| kyknos_ | paperbot: http://www.sciencedirect.com/science/article/pii/S0022283668800129 | 01:42 |
|---|---|---|
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/d1a31dad420dfe2b63d22bc489e0c236.txt | 01:42 |
| kyknos_ | paperbot: http://www.sciencedirect.com/science/article/pii/0022283670900045 | 01:42 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/70319e776ddd25010374a4dbbc69d84f.txt | 01:42 |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 01:48 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 01:48 | |
| -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-odsoyzonkwkusbcy] has joined ##hplusroadmap | 01:49 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 01:51 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap | 01:52 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] | 01:52 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 01:52 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap | 01:52 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 01:58 | |
| -!- ebowden [~ebowden@147.69.26.236] has quit [Read error: Connection reset by peer] | 01:59 | |
| -!- ebowden [~ebowden@147.69.26.236] has joined ##hplusroadmap | 01:59 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 02:00 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 02:01 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] | 02:19 | |
| kyknos_ | paperbot: http://www.sciencemag.org/content/147/3664/1462.short | 02:22 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1126%2Fscience.147.3664.1462 | 02:22 |
| -!- FourFire [~fourfire@2a02:270:2015:b00b:f0fb:c4c9:1920:6d76] has joined ##hplusroadmap | 02:24 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 02:29 | |
| -!- petrushki [~asakharov@24.60.79.55] has quit [Quit: quit] | 02:32 | |
| kyknos_ | paperbot: http://link.springer.com/article/10.1007/s10739-009-9184-1 | 02:43 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/A%20New%20Insight%20into%20Sangers%20Development%20of%20Sequencing%3A%20From%20Proteins%20to%20DNA%2C%2019431977.pdf | 02:45 |
| -!- gully_foyle_ja [~theghosto@pool-71-116-68-251.snfcca.dsl-w.verizon.net] has joined ##hplusroadmap | 02:45 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 260 seconds] | 03:03 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 03:09 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 03:09 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 03:12 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap | 03:13 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] | 03:13 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 03:13 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 03:22 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 03:22 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 03:28 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap | 03:28 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] | 03:28 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 03:28 | |
| kyknos_ | paperbot: http://www.nature.com/nature/journal/v485/n7397/abs/nature11117.html | 03:33 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1038%2Fnature11117 | 03:33 |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] | 03:36 | |
| -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 03:36 | |
| -!- gully_foyle_ja [~theghosto@pool-71-116-68-251.snfcca.dsl-w.verizon.net] has quit [Quit: Leaving] | 03:37 | |
| -!- FourFire is now known as FF_AFK | 04:22 | |
| -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Remote host closed the connection] | 04:31 | |
| -!- FF_AFK is now known as FourFire | 04:39 | |
| -!- comma8 [comma8@gateway/shell/yourbnc/x-nuvxmnyxbokfpyxk] has quit [Ping timeout: 260 seconds] | 04:54 | |
| -!- comma8 [comma8@gateway/shell/yourbnc/x-mrmckfmcbbtlvcxr] has joined ##hplusroadmap | 05:13 | |
| -!- ebowden [~ebowden@147.69.26.236] has quit [Remote host closed the connection] | 05:17 | |
| -!- ebowden [~ebowden@147.69.26.236] has joined ##hplusroadmap | 05:22 | |
| -!- ebowden [~ebowden@147.69.26.236] has quit [Remote host closed the connection] | 05:27 | |
| -!- kyknos_ [~kyknos@89.233.130.143] has quit [Ping timeout: 260 seconds] | 05:33 | |
| -!- comma8 [comma8@gateway/shell/yourbnc/x-mrmckfmcbbtlvcxr] has quit [Ping timeout: 260 seconds] | 05:35 | |
| -!- FF_HaSp [FourFire@2a02:270:2015:b00b:24b4:7f1d:fcd3:36e4] has joined ##hplusroadmap | 05:48 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] | 06:04 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 06:09 | |
| -!- QuadIngi [FourFire@2a02:270:2015:b00b:ac69:6de5:eb52:5547] has joined ##hplusroadmap | 06:09 | |
| -!- QuadIngi [FourFire@2a02:270:2015:b00b:ac69:6de5:eb52:5547] has left ##hplusroadmap [] | 06:10 | |
| -!- FF_HaSp [FourFire@2a02:270:2015:b00b:24b4:7f1d:fcd3:36e4] has quit [Ping timeout: 240 seconds] | 06:13 | |
| -!- FourFire [~fourfire@2a02:270:2015:b00b:f0fb:c4c9:1920:6d76] has quit [Quit: I left, for whatever reason...] | 06:13 | |
| -!- comma8 [comma8@gateway/shell/yourbnc/x-fbndsejgucllfgat] has joined ##hplusroadmap | 06:33 | |
| -!- comma8 [comma8@gateway/shell/yourbnc/x-fbndsejgucllfgat] has quit [Ping timeout: 250 seconds] | 06:46 | |
| -!- FourFire [FourFire@2a02:270:2015:b00b:b037:3b3f:3f6f:513a] has joined ##hplusroadmap | 06:46 | |
| -!- FourFire [FourFire@2a02:270:2015:b00b:b037:3b3f:3f6f:513a] has quit [Quit: Leaving] | 06:54 | |
| -!- JayDugger [~jwdugger@pool-173-74-79-151.dllstx.fios.verizon.net] has quit [Quit: Leaving.] | 06:55 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 240 seconds] | 07:05 | |
| -!- comma8 [comma8@gateway/shell/yourbnc/x-uphnwexderyirsei] has joined ##hplusroadmap | 07:20 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 07:29 | |
| -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] | 07:39 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 07:47 | |
| kyknos | paperbot, http://onlinelibrary.wiley.com/doi/10.1111/mec.12269/abstract | 08:08 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/a64d08d68b04488e19d32090d347fb37.txt | 08:08 |
| -!- kumavis [~kumavis@107-219-148-42.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap | 08:37 | |
| kanzure | ugh i don't know what he wants me to do with this https://github.com/raj12lnm/OpenNurbs-Python | 08:38 |
| -!- _0bitcount [~big-byte@81.61.209.223.dyn.user.ono.com] has joined ##hplusroadmap | 08:52 | |
| -!- nshlol [~xeb@wikipedia/nsh] has joined ##hplusroadmap | 08:55 | |
| -!- trotsky [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap | 09:06 | |
| -!- kumavis [~kumavis@107-219-148-42.lightspeed.sntcca.sbcglobal.net] has quit [Ping timeout: 246 seconds] | 09:10 | |
| -!- Technicus [~Technicus@166.181.83.221] has joined ##hplusroadmap | 09:18 | |
| -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has joined ##hplusroadmap | 09:22 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 09:33 | |
| -!- Vutral_ [~ss@31.7.56.131] has joined ##hplusroadmap | 10:01 | |
| -!- Vutral__ [~ss@31.7.56.131] has joined ##hplusroadmap | 10:01 | |
| -!- Vutral___ [~ss@31.7.56.131] has joined ##hplusroadmap | 10:02 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Read error: Connection reset by peer] | 10:12 | |
| -!- superkuh [~superkuh@c-24-245-51-196.hsd1.wi.comcast.net] has joined ##hplusroadmap | 10:13 | |
| -!- superkuh [~superkuh@c-24-245-51-196.hsd1.wi.comcast.net] has quit [Changing host] | 10:13 | |
| -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap | 10:13 | |
| -!- nshlol [~xeb@wikipedia/nsh] has quit [Ping timeout: 272 seconds] | 10:14 | |
| ParahSailin | 2146435072 looks like a special number | 10:20 |
| -!- _0bitcount [~big-byte@81.61.209.223.dyn.user.ono.com] has quit [Quit: Leaving] | 10:24 | |
| -!- PoohBear is now known as BearitoEclair | 10:25 | |
| ParahSailin | they went retard here https://github.com/rcallahan/UNAFold/blob/c870c55552082c94ae51fbe94cc0e2ff86b7bd4c/src/hybrid-min.c#L1103 | 10:35 |
| -!- nshlol [~xeb@wikipedia/nsh] has joined ##hplusroadmap | 10:40 | |
| nshlol | paperbot, pap | 10:57 |
| nshlol | paperbot, http://link.springer.com/chapter/10.1007%2F978-3-642-31912-9_16 | 10:57 |
| gradstudentbot | Ugh, my clinical trial isn't going so well. | 10:57 |
| nshlol | paperbot, http://dl.acm.org/citation.cfm?id=2363442 | 10:57 |
| paperbot | http://libgen.org/scimag/get.php?doi=10.1007%2F978-3-642-31912-9_16 | 10:57 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/f68b85d8404b29679d352876504abab6.txt | 10:57 |
| -!- Technicus [~Technicus@166.181.83.221] has quit [Ping timeout: 250 seconds] | 11:05 | |
| -!- nshlol [~xeb@wikipedia/nsh] has quit [Ping timeout: 260 seconds] | 11:06 | |
| kanzure | https://github.com/FeepingCreature/autofab/blob/master/recipes.txt | 11:10 |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap | 11:13 | |
| -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has quit [Quit: Leaving] | 11:14 | |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Read error: Connection reset by peer] | 11:14 | |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap | 11:15 | |
| -!- augur_ [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap | 11:16 | |
| -!- augur__ [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has joined ##hplusroadmap | 11:17 | |
| -!- augur__ [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Read error: Connection reset by peer] | 11:18 | |
| -!- augur__ [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has joined ##hplusroadmap | 11:18 | |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Ping timeout: 250 seconds] | 11:19 | |
| -!- nshlol [~xeb@wikipedia/nsh] has joined ##hplusroadmap | 11:20 | |
| -!- augur_ [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Ping timeout: 272 seconds] | 11:21 | |
| -!- augur__ is now known as augur | 11:21 | |
| dpk | kanzure: pm? | 11:30 |
| -!- Technicus [~Technicus@166.181.81.221] has joined ##hplusroadmap | 11:33 | |
| kanzure | ok | 11:34 |
| -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has joined ##hplusroadmap | 11:40 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] | 11:50 | |
| dingo | http://www.washingtonpost.com/blogs/the-switch/wp/2014/08/06/the-man-who-can-see-the-internet/ <-irssi and python supybot featured on washington post | 11:51 |
| -!- Narp [~blargh@unaffiliated/narp] has joined ##hplusroadmap | 11:55 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 11:58 | |
| kanzure | the future sure does look a lot like 1997 | 12:06 |
| -!- top4o [~chatzilla@93.152.162.95] has joined ##hplusroadmap | 12:22 | |
| -!- poppingtonic [~poppingto@105.230.195.108] has joined ##hplusroadmap | 12:24 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] | 12:38 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap | 12:39 | |
| -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] | 12:39 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap | 12:39 | |
| -!- Guest54510 [~quassel@50-0-37-37.dsl.static.sonic.net] has quit [Quit: No Ping reply in 180 seconds.] | 12:42 | |
| -!- maaku [~quassel@50-0-37-37.dsl.static.sonic.net] has joined ##hplusroadmap | 12:42 | |
| -!- maaku is now known as Guest3970 | 12:42 | |
| -!- Narp [~blargh@unaffiliated/narp] has quit [Quit: http://www.youtube.com/watch?v=20Jcrk6jGfo] | 12:50 | |
| -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Remote host closed the connection] | 12:53 | |
| -!- nshlol [~xeb@wikipedia/nsh] has quit [Ping timeout: 240 seconds] | 12:54 | |
| -!- xeb [~xeb@31.55.68.123] has joined ##hplusroadmap | 12:55 | |
| -!- xeb [~xeb@31.55.68.123] has quit [Max SendQ exceeded] | 12:55 | |
| -!- xeb [~xeb@31.55.68.123] has joined ##hplusroadmap | 13:01 | |
| archels | paperbot: http://link.springer.com/chapter/10.1007%2F978-1-4614-2383-6_5 | 13:05 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/cf5a4ba5c5159d1fb96c0b753c7c84d7.txt | 13:06 |
| -!- trotsky [~ruthie@mailhost.polyglotte.fr] has quit [Remote host closed the connection] | 13:07 | |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap | 13:13 | |
| -!- petrika [~asakharov@24.60.79.55] has joined ##hplusroadmap | 13:31 | |
| kanzure | .title http://3dprototypesandmodels.com.au/blog-2/ | 13:50 |
| yoleaux | Low-cost 3D printers and crowdfunding suicide | 13:50 |
| -!- xeb [~xeb@31.55.68.123] has quit [Ping timeout: 240 seconds] | 13:57 | |
| kanzure | hah "Stretch goals are a quadruple-blow on their bottom line. Kickstarter takes more and more money yet the profit on each printer is the same. The additions themselves cost more money, reducing the profit margin further on each printer and now the printer will take longer to make, using even more funds." | 14:01 |
| -!- xeb [~xeb@31.55.68.123] has joined ##hplusroadmap | 14:13 | |
| heath | http://12factor.net/ | 14:24 |
| heath | "The twelve-factor app is a methodology for building software-as-a-service apps" | 14:24 |
| kanzure | first one is silly: why use only one repository? | 14:26 |
| kanzure | #3 is also silly: the environment is not persistent, where are you going to develop your config? | 14:26 |
| kanzure | #7 is dumb, everything is already using ports almost everywhere | 14:27 |
| -!- xeb [~xeb@31.55.68.123] has quit [Ping timeout: 240 seconds] | 14:27 | |
| heath | i had never heard of it | 14:28 |
| heath | referenced in this guy jabbering: https://www.youtube.com/watch?v=f1hSvfDIfbo | 14:29 |
| heath | Baron Schwartz: MySQL, SQL, NoSQL, and Open Source in 2014 and Beyond | 14:29 |
| heath | https://www.youtube.com/watch?v=BUCZJWo9MZo | 14:31 |
| heath | man and computer, from IBM (1965) | 14:31 |
| heath | list of cheap fpgas: http://www.joelw.id.au/FPGA/CheapFPGADevelopmentBoards | 14:33 |
| heath | doesn't mention the cypress boards though | 14:33 |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Remote host closed the connection] | 14:33 | |
| heath | you can get them for less than $5 | 14:33 |
| heath | http://www.cypress.com/?mpn=CY7C65211-24LTXI | 14:33 |
| heath | http://www.cypress.com/?rID=92146 | 14:34 |
| chris_99 | i don't think the psoc4 is an fpga? | 14:35 |
| -!- xeb [~xeb@109.144.191.254] has joined ##hplusroadmap | 14:40 | |
| heath | oh yeah, it offers cpld instead of fpga | 14:44 |
| heath | http://www.cypress.com/?docID=43232 | 14:47 |
| * heath walks away from the IRCs for a bit | 14:47 | |
| chris_99 | oh neat | 14:48 |
| -!- xeb [~xeb@109.144.191.254] has quit [Ping timeout: 246 seconds] | 14:54 | |
| -!- Technicus [~Technicus@166.181.81.221] has quit [Read error: Connection reset by peer] | 14:54 | |
| -!- Technicus [~Technicus@166.181.83.221] has joined ##hplusroadmap | 14:55 | |
| -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] | 14:55 | |
| -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Remote host closed the connection] | 14:56 | |
| -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has joined ##hplusroadmap | 14:57 | |
| -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Ping timeout: 260 seconds] | 15:01 | |
| -!- Technicus [~Technicus@166.181.83.221] has quit [] | 15:02 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] | 15:02 | |
| -!- xeb [~xeb@31.55.127.254] has joined ##hplusroadmap | 15:03 | |
| -!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap | 15:23 | |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap | 15:30 | |
| -!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap | 15:35 | |
| -!- BearitoEclair is now known as PoohBear | 15:40 | |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Ping timeout: 272 seconds] | 15:48 | |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap | 15:56 | |
| -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 16:00 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] | 16:01 | |
| -!- Viper168_ is now known as Viper168 | 16:05 | |
| -!- xeb [~xeb@31.55.127.254] has quit [Ping timeout: 272 seconds] | 16:08 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 260 seconds] | 16:19 | |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Read error: Connection reset by peer] | 16:20 | |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap | 16:21 | |
| -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap | 16:31 | |
| -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 260 seconds] | 16:55 | |
| -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap | 16:57 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 16:57 | |
| -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection] | 16:59 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] | 17:01 | |
| -!- poppingtonic [~poppingto@105.230.195.108] has quit [Ping timeout: 246 seconds] | 17:06 | |
| -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 240 seconds] | 17:08 | |
| -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap | 17:08 | |
| -!- xeb [~xeb@109.144.166.154] has quit [Max SendQ exceeded] | 17:09 | |
| -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap | 17:10 | |
| kanzure | .title http://www.nature.com/news/organic-synthesis-the-robo-chemist-1.15661 | 17:19 |
| yoleaux | Organic synthesis: The robo-chemist | 17:19 |
| kanzure | hmm "A British project called Dial-a-Molecule is laying the groundwork. Led by Whitby, the £700,000 (US$1.2-million) project began in 2010 and currently runs until May 2015. So far, it has mostly focused on working out what components the machine would need, and building a collaboration of more than 450 researchers and 60 companies to help work on the idea." | 17:20 |
| thundara | Accompanying criticisms: http://pipeline.corante.com/archives/2014/08/07/the_synthesis_machine.php ^^ | 17:20 |
| kanzure | "Jamison, for example, is working on flow chemistry at the Novartis–MIT Center for Continuous Manufacturing in Cambridge, and he is part of a team that last year reported1 the first end-to-end, completely continuous synthesis and formulation of a pharmaceutical: aliskiren hemifumarate, a treatment for high blood pressure. Jamison and his colleagues built a machine (now dismantled) that was more than 7 metres long, and about 2.5 metres high ... | 17:21 |
| kanzure | ... and deep. “It took four years of 'everything that can go wrong, will go wrong',” says Bernhardt Trout, head of the MIT centre and leader of the project. After a lot of trial and error, he says, the researchers got to the point at which they merely had to flip the switch and feed in fresh drums of solvent and raw materials. The machine would hum like a large air-conditioning unit as stirrers whipped up chemicals, pumps whirred, ... | 17:21 |
| kanzure | ... filtration units dripped and squeezed, and a screw conveyer pushed solids through a 2-metre drying tube to be injection-moulded. Finally, after 14 operations and 47 hours, finished tablets dropped down a chute. Batch synthesis would have required 21 operations over 300 hours." | 17:21 |
| kanzure | he is really boring, "My guess is that we're going to see many years of machines that can do some things in very well-defined areas, but which will prove useless (or worse) if you try to push them into unknown territory. And unknown territory is what it's all about." | 17:22 |
| kanzure | no, unknown territory is not what it's "all" about.. | 17:22 |
| kanzure | "The following decade, Corey created software called LHASA (Logic and Heuristics Applied to Synthetic Analysis), which could use these rules to suggest sequences of steps towards a synthesis2. But LHASA and its successors have never taken off, says Grzybowski: either the databases have included too few reactions and too many errors, or the algorithms have not properly assessed whether proposed reactions are compatible with all functional ... | 17:23 |
| kanzure | ... groups in the molecule." | 17:23 |
| kanzure | my hardest problem has been getting access to the relevant databases on sane licensing terms | 17:23 |
| kanzure | it's pretty easy to cull out errorful results if there are 10^60 targets | 17:24 |
| -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Ping timeout: 255 seconds] | 17:24 | |
| kanzure | "Grzybowski has spent the past decade building a system called Chematica to address those problems. He started by creating a searchable network of about 6 million organic compounds, connected by a similar number of reactions, drawn from one of the main databases behind Reaxys. " | 17:24 |
| kanzure | except reaxys will bleed you dry so why would you bother | 17:24 |
| -!- Technicus [~Technicus@166.181.83.166] has joined ##hplusroadmap | 17:34 | |
| -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection] | 17:34 | |
| -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 246 seconds] | 17:40 | |
| -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap | 17:40 | |
| -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 260 seconds] | 17:52 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 18:29 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] | 18:29 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 18:32 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] | 18:32 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 18:39 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] | 18:42 | |
| -!- augur [~augur@73.163.157.101] has joined ##hplusroadmap | 18:53 | |
| -!- augur [~augur@73.163.157.101] has quit [Ping timeout: 250 seconds] | 18:57 | |
| -!- cpopell [~cpopell@c-76-26-144-132.hsd1.dc.comcast.net] has quit [Ping timeout: 272 seconds] | 19:09 | |
| -!- cpopell [~cpopell@c-76-26-144-132.hsd1.dc.comcast.net] has joined ##hplusroadmap | 19:10 | |
| -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has quit [Quit: Lost terminal] | 19:35 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 19:36 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 272 seconds] | 19:38 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 260 seconds] | 19:40 | |
| -!- Vutral___ [~ss@31.7.56.131] has quit [Ping timeout: 260 seconds] | 19:57 | |
| -!- Vutral__ [~ss@31.7.56.131] has quit [Ping timeout: 245 seconds] | 19:57 | |
| -!- Vutral_ [~ss@31.7.56.131] has quit [Ping timeout: 240 seconds] | 19:57 | |
| -!- augur [~augur@73.163.157.101] has joined ##hplusroadmap | 19:58 | |
| -!- Vutral [~ss@176.10.107.236] has joined ##hplusroadmap | 19:58 | |
| -!- Vutral_ [~ss@176.10.107.236] has joined ##hplusroadmap | 19:58 | |
| -!- Vutral [~ss@176.10.107.236] has quit [Changing host] | 19:59 | |
| -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap | 19:59 | |
| -!- Vutral__ [~ss@176.10.107.236] has joined ##hplusroadmap | 19:59 | |
| -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has joined ##hplusroadmap | 19:59 | |
| kanzure | "Eli Lily actually has something really close to this. It's a completely automated organic synthesis machine. I don't know how many they have but I saw the one in the Indianapolis lab. I don't think people are supposed to know about it though." | 20:04 |
| kanzure | "I just want a robot to run chromatographic columns for me, honestly" huh? | 20:05 |
| -!- augur [~augur@73.163.157.101] has quit [Read error: Connection reset by peer] | 20:15 | |
| -!- augur [~augur@73.163.157.101] has joined ##hplusroadmap | 20:16 | |
| -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has quit [Quit: Leaving] | 20:19 | |
| -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-odsoyzonkwkusbcy] has quit [Quit: Connection closed for inactivity] | 20:22 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has joined ##hplusroadmap | 20:25 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has quit [Ping timeout: 260 seconds] | 20:31 | |
| -!- augur [~augur@73.163.157.101] has quit [Remote host closed the connection] | 21:01 | |
| -!- PoohBear is now known as zombiehands | 21:05 | |
| -!- sapiosexual [~sapiosexu@d75-156-88-72.bchsia.telus.net] has joined ##hplusroadmap | 21:19 | |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap | 22:01 | |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Read error: Connection reset by peer] | 22:03 | |
| -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap | 22:03 | |
| -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has quit [Quit: Leaving] | 22:09 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has joined ##hplusroadmap | 22:32 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has quit [Excess Flood] | 22:32 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 22:49 | |
| -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 22:51 | |
| -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] | 22:54 | |
| -!- Viper168_ is now known as Viper168 | 23:01 | |
| -!- zombiehands is now known as PoohBear | 23:22 | |
| -!- top4o [~chatzilla@93.152.162.95] has quit [Ping timeout: 240 seconds] | 23:31 | |
| -!- drewbot [~cinch@ec2-107-21-140-100.compute-1.amazonaws.com] has quit [Remote host closed the connection] | 23:32 | |
| -!- drewbot [~cinch@ec2-54-242-105-54.compute-1.amazonaws.com] has joined ##hplusroadmap | 23:32 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has joined ##hplusroadmap | 23:48 | |
| -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap | 23:52 | |
| -!- Vutral- [~ss@2a01:198:35a::101] has quit [Ping timeout: 260 seconds] | 23:52 | |
| --- Log closed Mon Aug 11 00:00:31 2014 | ||
Generated by irclog2html.py 2.15.0.dev0 by Marius Gedminas - find it at mg.pov.lt!