| --- Log opened Wed Feb 11 00:00:51 2015 | ||
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| bci | should be gene_hackman | 00:19 |
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| * bci taps mic | 00:19 | |
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| kanzure | win 2 | 03:52 |
| kanzure | blah | 03:52 |
| kanzure | .title https://news.ycombinator.com/item?id=9031034 | 03:52 |
| yoleaux | Show HN: The Autoprotocol Language Standard for Biology | Hacker News | 03:52 |
| kanzure | http://autoprotocol.org/ | 03:52 |
| kanzure | "Autoprotocol is a language for specifying experimental protocols for biological research in way that is precise, unambiguous, and understandable by both humans and computers. Autoprotocol was originally developed at Transcriptic as a way to define experiments that could be run over the internet on remote robotic automation, with the aim of moving research into the "cloud"." | 03:53 |
| kanzure | https://github.com/autoprotocol/autoprotocol-core | 03:53 |
| kanzure | https://github.com/autoprotocol/autoprotocol-python | 03:53 |
| kanzure | http://autoprotocol-python.readthedocs.org/en/latest/ | 03:53 |
| kanzure | http://autoprotocol.org/community/ | 03:54 |
| kanzure | http://autoprotocol.org/specification/ | 03:54 |
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| kanzure | http://breakingmalware.com/vulnerabilities/one-bit-rule-bypassing-windows-10-protections-using-single-bit/ | 04:03 |
| kanzure | "At Transcriptic we perform experiments using what we call a workcell - a set of devices like liquid handlers (automated pipettors), PCR machines, and plate readers all linked together via a common interface and a robotic arm that moves containers between devices. That interface understands Autoprotocol and executes the instructions accordingly. Autoprotocol itself was designed to be an agreed upon standard for different types of ... | 04:06 |
| kanzure | ... laboratory automation (not just ours) to execute protocols. An example of an experiment someone could run through our cloud laboratory interface would be to monitor the growth rate of bacteria expressing different genes. This would be done using a protocol that contains some pipetting steps to dilute the bacteria and then alternates between incubating the plate at 37 degrees and reading OD600 of its wells using a plate reader at a ... | 04:06 |
| kanzure | ... specified interval for a certain number of repetitions." | 04:06 |
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| kanzure | ycombinator applications are open again http://www.ycombinator.com/apply/#S2015 | 05:54 |
| kanzure | i think the vast majority of these are topics that hplusroadmappers could dominate http://www.ycombinator.com/rfs/ | 05:54 |
| kanzure | so you should apply | 05:54 |
| ParahSailin | transcriptic is too expensive to do any general protocols on | 05:59 |
| kanzure | probably | 06:01 |
| ParahSailin | they should have priced stuff to get people using it | 06:01 |
| kanzure | i think they started with molecular cloning | 06:01 |
| kanzure | maaku was there at the time so we can just pester him i think | 06:01 |
| kanzure | i wonder what transcriptic's response to "unlimited cheap labor (undergrads/grad students)" is | 06:02 |
| ParahSailin | yeah but when i looked there the other day i saw that you can put in custom protocols and it gave quotes based on time spent | 06:02 |
| ParahSailin | that was all new | 06:02 |
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| kanzure | i could definitely see a strong segment using transcriptic related to those virtual drug companies or whatever... e.g. the types with suits and no labs/equipment just lots of outsourcing. | 06:02 |
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| ParahSailin | why dont you apply to yc | 06:06 |
| kanzure | ah i thought i told you | 06:06 |
| kanzure | pm | 06:06 |
| kanzure | on the other hand, getting 5% weekly growth is not entirely obvious for most of those segments | 06:07 |
| kanzure | someone should do a botique designer baby firm that manages the gene selection process for up-and-coming parents, e.g. a few years in advance | 06:17 |
| kanzure | (customers would be paying for the long-term trait planning) | 06:18 |
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| JayDugger | Good morning, everyone. | 07:05 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=42448bd8 Bryan Bishop: devcore - gavin andresen talk >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/gavinandresen/ | 07:06 |
| JayDugger | Hollywood 2.0 on the Request for Startup list? | 07:09 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6e50a00d Bryan Bishop: include link >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/gavinandresen/ | 07:13 |
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| kanzure | hello eudoxia | 07:17 |
| eudoxia | hi kanzure | 07:17 |
| eudoxia | kanzure: what's up with h+ | 07:25 |
| eudoxia | s/with/in | 07:26 |
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| heath | kanzure: you're in boston right now? | 07:28 |
| heath | oh, it's being livestreamed | 07:28 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=507cd18c Bryan Bishop: some words from circle inc >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/jeremy-allaire-circle/ | 07:30 |
| heath | good stuff, thank you for this | 07:30 |
| kanzure | i am not in boston | 07:30 |
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| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c7366380 Bryan Bishop: more words from circle inc >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/jeremy-allaire-circle/ | 07:37 |
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| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c1b327b0 Bryan Bishop: even more circle words... >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/jeremy-allaire-circle/ | 07:46 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7dcfe2ed Bryan Bishop: more circle things >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/jeremy-allaire-circle/ | 07:59 |
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| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1536e23e Bryan Bishop: some legal issues >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/james-gatto-marco-santori-bitcoin-law-for-developers/ | 08:25 |
| kanzure | .title https://www.behance.net/gallery/22536831/ROBOTIC-EXTRUSION%286-Axis-KUKAABS-3D-Printing%29 | 08:34 |
| yoleaux | kanzure: Sorry, that command (.title) took too long to process. | 08:35 |
| kanzure | fair enough | 08:40 |
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| ParahSailin | hrt in trans people frequently changes sexual orientation; is sexual orientation purely a result of hormonal balance and sensitivity of receptors in brain? | 08:45 |
| archels | 'is the brain involved in computation?' | 08:49 |
| ParahSailin | if that sounded tautological, i meant specifically the gonadal hormones | 08:51 |
| kanzure | most trans people are humanphiles and are annoyingly inconsistent in their beliefs ("the other gender sucks less, right?") | 08:52 |
| kanzure | insert various rants here | 08:53 |
| archels | ParahSailin: there is plenty of receptor expression in the hypothalamus and other lower areas, of course | 08:58 |
| archels | sexual dimorphism of the hypothalamus comes to mind | 08:58 |
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| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=67ef1eba Bryan Bishop: more law things >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/james-gatto-marco-santori-bitcoin-law-for-developers/ | 09:45 |
| gnusha_ | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=509ee379 Bryan Bishop: gavin session >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-devcore-2015/research-and-development-goals/ | 09:45 |
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| nmz787_i | anyone ever see a clone of openBCI yet? | 11:05 |
| nmz787_i | I searched a bit last night and didn't find anything immediately on ebay/aliexpress/google | 11:05 |
| kanzure | there's the foc.us thing | 11:05 |
| kanzure | dunno if it's a clone though | 11:05 |
| nmz787_i | their price of $450 is pretty steep though it seems for the hardware, and they do offer (kicad I think ) board/schematics | 11:05 |
| kanzure | it's not, nevermind | 11:05 |
| kanzure | dunno maybe there's some openeeg boards flying around on alinope | 11:06 |
| nmz787_i | from this list https://en.wikipedia.org/wiki/Comparison_of_consumer_brain%E2%80%93computer_interfaces | 11:06 |
| nmz787_i | it seems like HiBrain is the best other than openBCI | 11:06 |
| nmz787_i | (currently) | 11:06 |
| nmz787_i | I wonder how long it would take seeedstudio to start making a product if someone sent them that design | 11:06 |
| nmz787_i | https://github.com/OpenBCI/Docs/blob/master/hardware/01-OpenBCI_Hardware.md | 11:08 |
| nmz787_i | i was trying to figure out what kind of sensing technique and sample rate it would take to capture my mental audio/self-talk | 11:13 |
| nmz787_i | I've heard that frequency in brains are relatively slow, so to capture something like audio it seems there would have to be a ton of parallel data channels which had low bandwidth but slight phase offset or something | 11:14 |
| nmz787_i | maybe frequency down-conversion too on the higher freq stuff | 11:14 |
| nmz787_i | so I think that would mean the sampling freq could be low, but the parallel data channels would be on top of each other in the data stream, requiring some sort of tomography or phase array sensor technique to resolve the individual channels | 11:16 |
| nmz787_i | (if you were sensing with an antenna/eeg) | 11:16 |
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| justanot1eruser | kanzure: do you think there is an optimal ratio of amphetamine to dextroamphetamine in adderall for each individual? Or do you think it doesn't improve much beyond 50/50 | 12:09 |
| kanzure | no idea, sorry | 12:09 |
| kanzure | just dextroamphetamine and just amphetamine might be fine | 12:10 |
| justanot1eruser | too bad. Would be cool if pharma companies sold different ratios and you could find optimums. | 12:12 |
| kanzure | hmm http://blog.ycombinator.com/yc-open-source-sales-agreement | 12:12 |
| kanzure | eventual comments at https://news.ycombinator.com/item?id=9035256 | 12:12 |
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| kanzure | in conclusion, always check the manufacturer | 12:28 |
| nmz787_i | justanot1eruser: I think the mix is racemic, meaning it's just the ratio that the reacton spews out... not really something they tuned for | 12:31 |
| nmz787_i | justanot1eruser: presumably since they can pull out the dextro, they also have the levo somewhere for something | 12:31 |
| justanot1eruser | nmz787_i: so 50% is probably 50% by molarity? | 12:32 |
| nmz787_i | probably | 12:32 |
| justanot1eruser | Thats a smarter reason than I assumed.. | 12:32 |
| nmz787_i | i guess molarity is in liquids though, so might not make perfect sense since tablets are solid | 12:33 |
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| kanzure | there's also issues with the delivery mechanism | 12:49 |
| kanzure | shire still has a patent on the good one | 12:49 |
| ParahSailin | shire patented insufflation?! | 12:50 |
| ParahSailin | invade hobbiton | 12:52 |
| nmz787_i | the Barr time-release balls seem magical in how long they've kept some dex good | 12:54 |
| ParahSailin | its a fairly stable molecule | 12:54 |
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| kanzure | barr seems to work for me. shire works. teva doesn't. | 13:06 |
| kanzure | crap now you guys know a useful delivery mechanism for my receptors | 13:09 |
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| justanotheruser | does insufflation even work? | 13:46 |
| justanotheruser | I mean, obviously it goes down your throat... | 13:46 |
| kanzure | can you say that again but in caps? | 13:47 |
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| archels | nmz787_i: got a link for HiBrain? is it open source? | 13:56 |
| nmz787_i | archels: the wiki page directs to http://www.hyperneuro.com/ | 14:01 |
| archels | yeah that's what I got | 14:02 |
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| nmz787_i | 64-channel eeg from openeeg mailing list http://www.eeg64.com/?p=47 | 14:03 |
| nmz787_i | .title | 14:04 |
| yoleaux | nmz787_i: Sorry, that command (.title) crashed. | 14:04 |
| nmz787_i | "EEG64 Cost – Quotes" | 14:04 |
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| archels | hmm, looks a bit inchoate | 14:19 |
| archels | the OpenEEG project is pretty dead afaik--but one could also say it's mature | 14:19 |
| nmz787_i | well openBCI or that eeg64 are using all-in-one ICs pretty much | 14:21 |
| nmz787_i | so there shouldn't be too much to do outside software and simple power supply type PCB stuff | 14:22 |
| archels | that's not necessarily simple on an ultra-low-noise design | 14:23 |
| archels | also not seeing any galvanic isolation | 14:24 |
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| archels | hmm, apparently someone at a local lab broke a 200 ul pipette by pipetting 6 ul with it | 14:26 |
| archels | how does that work? | 14:26 |
| archels | "General rule, don’t go below 10 % of the maximum volume!" | 14:26 |
| nmz787_i | archels: they're just pistons in a cylinder with a screw to adjust the displacement | 14:29 |
| nmz787_i | so setting it too small probably just put more stress on the plunger seal or something | 14:29 |
| nmz787_i | or it messed up the spring | 14:30 |
| ParahSailin | dead volume | 14:34 |
| archels | wouldn't there have been more dead volume, not less? | 14:36 |
| archels | someone reply-alled asking for clarification, but he's either being stonewalled or told off through private channels | 14:41 |
| nmz787_i | on the pipet? | 14:41 |
| nmz787_i | that seems like a reasonable thing to ask for clarificationon | 14:41 |
| nmz787_i | clarification on | 14:41 |
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| justanotheruser | paperbot http://onlinelibrary.wiley.com/doi/10.1002/npr.4040030405/abstract | 15:48 |
| fenn | paperbot: http://www.sciencedirect.com/science/article/pii/S0011224065801134 | 15:48 |
| kanzure | .title | 15:48 |
| yoleaux | Functional survival of kidneys subjected to extracorporeal freezing and reimplantation | 15:48 |
| kanzure | hm | 15:48 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/%0A%20Functional%20survival%20of%20kidneys%20subjected%20to%20extracorporeal%20freezing%20and%20reimplantation%0A%20.txt | 15:48 |
| kanzure | womp womp | 15:48 |
| justanotheruser | ;_; | 15:48 |
| kanzure | paperbot: http://acw.sciverse.com/SSOCore/update?acw=5995d4102fa7b41989f39a7-19d540c783c2acf2%7C%24%7CmCsSeOz6L9xAK5sYMadOfDnCxXeIt%2B%2Fj8swmlb0YWXRDvzMSGPHrw9dP22R9nvN2QOcrZLYUmWbyrehM3VuTo8iN9hCgJnzG&utt=6995d4102fa7b41989f39a7-19d540c783c2acf2 | 15:49 |
| justanotheruser | kanzure: what is the best pdf host | 15:49 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/54ada348e51a30613f92eb641ec58b0e.txt | 15:49 |
| kanzure | "The article you are trying to access is not included" | 15:50 |
| kanzure | fenn: those results were discussed in http://imsear.li.mahidol.ac.th/bitstream/123456789/134785/1/jiafm2007v29i3p10.pdf | 15:52 |
| kanzure | .. briefly.. | 15:52 |
| paperbot | http://diyhpl.us/~bryan/papers2/paperbot/3fe0ebcd79d48eac9bde9e1938d97a6b.txt | 15:52 |
| kanzure | hehe "Whole organ preservation: I. A technique for in vivo freezing canine intestine using intraarterial helium and ambient nitrogen" | 15:52 |
| kanzure | "Survival of canine kidneys after treatment with dimethyl-sulfoxide, freezing at− 80° C, and thawing by microwave illumination" | 15:53 |
| kanzure | "Factors involved in successful freezing of kidneys for transplantation. Preliminary experimental observations" | 15:53 |
| fenn | yes i read the logs to find the article link, unfurtunutely no can read | 16:01 |
| fenn | the actual abstract says 2/14 dogs survived, not 4/37 (although 9/14 had "some" function) | 16:02 |
| kanzure | http://diyhpl.us/~nmz787/pdf/FUNCTIONAL_SURVIVAL_OF_KIDNEYS_SUBJECTED_TO_EXTRACORPOREAL_FREEZING_AND_REIMPLANTATION.pdf | 16:12 |
| fenn | kewl | 16:13 |
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| nmz787_i | funded in 25 minutes https://www.kickstarter.com/projects/1186001332/pyimagesearch-gurus-become-a-computer-vision-openc | 16:21 |
| nmz787_i | "Out of the box IPython Notebooks were never designed to run in a (secure) multi-user environment. And unfortunately, current approaches to creating mutli-user IPython Notebook environments are glued together using shell scripts and bubblegum. Instead of building my own mutli-user IPython Notebook management system, I am currently looking into two companies that provide this service: Wakari and Sage Math Cloud. Some of the funds | 16:22 |
| nmz787_i | from this Kickstarter will go into licensing this software." | 16:22 |
| nmz787_i | I am confused by his statement, isn't this free? https://github.com/sagemath/cloud | 16:23 |
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| nsh | asking for donations so you can license software is particularly distasteful | 17:31 |
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| nmz787 | nsh: agreed | 18:16 |
| nmz787 | especially when they say it's free for commercial too https://github.com/sagemath/cloud/wiki/FAQ#com | 18:16 |
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| nsh | mm | 19:14 |
| JayDugger | Good evening, everyone. | 19:15 |
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| --- Log closed Thu Feb 12 00:00:52 2015 | ||
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