2015-02-16.log

--- Log opened Mon Feb 16 00:00:56 2015
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archelsjournal.frontiersin.org/Journal/10.3389/fnsys.2014.00213/full04:34
archels.title http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00213/full04:34
yoleauxFrontiers | Brain-machine interfaces as a challenge to the “moment of singularity” | Frontiers in Systems Neuroscience04:34
archelsfrontiers publishes blogposts now?04:35
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pasky_pretty pictures https://imgur.com/a/HjF2P05:56
kanzurebloop05:57
kanzureaaaah that's not a roadmap06:02
kanzurereally dumb how they think brain emulation wont work without having ai first. are they morons?06:03
kanzurewhy are these images anyway >:(06:06
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justanotheruseragreed. none of that is dependent on the previous step, it's just "this would be cool" "so would this"06:15
justanotheruserI've got good news, this is fresh off of the Futurology subreddit (at least thats the most popular thing linking this)06:17
justanotheruserwith the title "What kind of immortality would you rather come true?"06:18
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kanzureblah06:28
kanzurethankfully that subreddit has not really filtered into here06:28
kanzureexcept FourFire but he's awful anyway06:28
justanotheruser/r/nootropics probably is though06:28
kanzure:(06:28
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kanzureQuashie_: welcome06:39
Quashie_hey06:39
Quashie_I am actually heading off to work in a bit06:39
kanzuredavidad used to show up in here :/06:39
kanzureand then he didn't06:39
kanzurebut let's plot to get him out of twitter06:39
kanzureand back to work on important things06:40
Quashie_maybe I could talk to him about it06:40
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Quashie_all right, be back tonight06:41
heathpaperbot: http://www.nature.com/nm/journal/v17/n8/abs/nm.2408.html07:23
paperbothttp://libgen.info/scimag/get.php?doi=10.1038%2Fnm.240807:23
heathhttp://bme.columbia.edu/samuel-k-sia07:23
heathhttp://engineering.columbia.edu/smartphone-finger-prick-15-minutes-diagnosis%E2%80%94done-007:23
heath.title07:23
yoleauxSmartphone, Finger Prick, 15 Minutes, Diagnosis—Done! | The Fu Foundation School of Engineering & Applied Science - Columbia University07:23
heath.title https://www.youtube.com/watch?v=uGcqZCDvT_407:25
yoleauxMESH: Creative DIY Kit for the Connected Life - YouTube07:25
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heathhttps://www.indiegogo.com/projects/mesh-creative-diy-kit-for-the-connected-life07:25
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heathhttp://www.cell.com/pb/assets/raw/journals/research/cell-systems/do-not-delete/CELS1_FINAL.pdf07:33
heath"Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics"07:33
paperbothttp://libgen.info/scimag/get.php?doi=10.1016%2Fj.cels.2015.01.00107:33
heathhttps://d2zahwnsqpmout.cloudfront.net/map/07:33
heath^ the actual map07:34
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heathhttp://miroculus.com/ ::  miroculus "Imagine a simple blood test that can tell you, at the molecular level, the exact type of disease you have and its severity before presenting any symptoms. Imagine using the same test to monitor the success of the treatment"07:35
heath.title https://technology.grc.nasa.gov/SS-rHealth.shtm07:37
yoleauxThe rHEALTH Sensor07:37
heathhttps://www.youtube.com/watch?v=jB7Wy7Z_Vvw07:37
heath.title07:37
yoleauxNSXC Team DMI - YouTube07:37
heathdifferent way of tracking history with chrome http://www.trailblazer.io/07:39
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heaththis is nice08:09
heathhttps://www.flickr.com/photos/104379556@N08/15758558858/in/photostream/08:09
heatha new car from osvehicle: nika08:10
heathit has windshield and is weatherproof08:10
heathhttps://www.osvehicle.com/connected-car-nika/?utm_source=wysija08:10
heathand by new, it's something i overlooked months ago it seems08:11
heathwonder how much money there is to be had in bringing this to the US08:12
heath.tell juri_ https://www.osvehicle.com/connected-car-nika/08:15
yoleauxheath: I'll pass your message to juri_.08:15
heath.tell juri_ https://www.flickr.com/photos/104379556@N08/15758558858/in/photostream/08:16
yoleauxheath: I'll pass your message to juri_.08:16
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archels"Would you try to understand the universe by simulating every molecule? What would you have achieved? It’s going to be just as complicated as the real thing and you won’t understand it any better."08:41
archelsre the HBP, https://chronicle.com/article/Can-the-Human-Brain-Project-Be/190031/08:42
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kanzurewho cares?08:57
kanzurelike why would you care about understanding it better or worse?08:57
heath.title https://www.youtube.com/watch?v=YQy0ZCx3UCY08:57
yoleauxCybertopia - Dreams of Silicon Valley (VPRO, Marije Meerman) - YouTube08:58
kanzuredo they even know how software works08:58
kanzurethat's infuriating08:58
kanzure"yeah, you're absolutely right, there's zero value to working emulation software. better pack up and go home. also tell vmware to shove it."08:59
kanzurealso, i forget, but what is the competing project in the US called? there was some project with a very similar name but doing something quite different.08:59
heath.title https://play.spotify.com/album/1j7rFAYUbJXDDAGwjnz1bd09:02
yoleauxSpotify09:02
heathBach in Brazil: Rosauro09:02
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archelskanzure: the BRAIN project?09:05
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kanzureah yes i think so09:07
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archelsinitiative, sorry, not project09:30
archelsfor obvious reasons09:30
archelsits scope can be summarised as "measure everything all the time"09:30
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kanzurenot a bda goal09:48
kanzure*bad09:48
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kanzure"I think the overall problem is that traditional neuro scientists and biologists bring virtually none of the required skills to the table. Moreover while neuroscience is able to show pretty pictures of brain activity, they have made insufficient progress in understanding it. On the other hand the physicists/mathematicians that have invaded the field have a background in computational methods, simulation and hardware development. So for ...10:07
kanzure... example a group at the University I studied had previous experience designing analog chips for feature detection in High Energy Physics, a number of years ago they re-branded themselves as a neurophysics group and recently landed a ~100 million euro+ grant in the context of the Human Brain Project. It is also much easier to learn the jargon and read some of the softer phenomenological articles than to develop a sound understanding of ...10:07
kanzure... the underlying mathematics and physics."10:08
kanzureouch :)10:08
kanzure"Specifically neuroscience subproject funding was removed... This seems like angry academics that lost funding are trying to derail it through the media to my uneducated observance..."10:08
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superkuhhttp://xkcd.com/793/14:08
kanzureyeaaaaah but to be fair you don't see biologists building overwhelmingly large particle colliders14:10
kanzure"Huh? No, I don't need to read your thesis. I can imagine roughly what it says."14:11
superkuhhttp://abstrusegoose.com/15614:11
kanzurethe real magic trick there would be getting all of the cells to separate and stay in tact14:12
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kanzurenmz787: cory says keep phosphoramidites at -20 celsius and they will be good for approximately 12 months14:34
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kanzurepaperbot: http://iopscience.iop.org/0960-1317/24/9/095004/article14:49
kanzure.title14:49
yoleauxOn-chip enucleation of an oocyte by untethered microrobots - IOPscience14:49
paperbothttp://libgen.info/scimag/get.php?doi=10.1088%2F0960-1317%2F24%2F9%2F09500414:49
kanzure"To confirm successful enucleation using this method, we investigated the viability of oocytes after enucleation. The results show that the production rate, i.e. the ratio between the number of oocytes that reach the blastocyst stage and the number of bovine oocytes after nucleus transfer, is 100%"14:50
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kanzurehttp://arstechnica.com/security/2015/02/how-omnipotent-hackers-tied-to-the-nsa-hid-for-14-years-and-were-found-at-last/15:07
nmz787kanzure: cool, so that's a normal freezer15:07
nmz787http://diyhpl.us/~nmz787/pdf/A_high_resolution_MEMS_based_gas_chromatography_column_for_the_analysis_of_benzene_and_toluene_gaseous_mixtures.pdf15:08
nmz7873.6cm x 4.6cm15:08
nmz787This 6.0 m long, 100ym wide, and 100um deep column15:09
nmz787100um*15:09
kanzure6 meters long?15:11
kanzureoh it's compressed space15:11
kanzureor er... geometry magic.. whatever you call that.15:11
kanzurefolded space?15:11
* nmz787 is imagining a spin-coater with array interferometery to detect thickness in real-time, integrated direct-write exposure + development (baking) and making it fast enough to do 3d-printing style15:13
nmz787but i guess that would then require the resin/substrate to be chemically compatible with the protocol you want to carry out15:13
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nmz787i bet there is a way to do this with an e-beam and silicon oxide deposition or something15:14
nmz787that seems like it would be compatible with lots of chemistry15:14
nmz787and maybe optically clear too?15:14
nmz787.title http://www.ncbi.nlm.nih.gov/pubmed/1712905015:15
yoleauxFabrication and functionalization of nanochannels by electron-beam-... - PubMed - NCBI15:15
nmz787' by electron-beam-induced silicon oxide deposition.'15:15
kanzureis the government really saving that much money by not putting the entire title in the title? :/15:15
nmz787paperbot: http://pubs.acs.org/doi/abs/10.1021/la061321c15:17
paperbothttp://diyhpl.us/~bryan/papers2/paperbot/Fabrication%20and%20Functionalization%20of%20Nanochannels%20by%20Electron-Beam-Induced%20Silicon%20Oxide%20Deposition.txt15:17
nmz787http://diyhpl.us/~nmz787/pdf/Fabrication_and_Functionalization_of_Nanochannels_by_Electron-Beam-Induced_Silicon_Oxide_Deposition.pdf15:19
nmz787"The electron beam decomposes the adsorbed precursor tetraethyl orthosilicate (Si(OC2H5)4, TEOS) within a small area around the pore to solid silicon oxide and volatile organic compounds."15:20
nmz787bah, circular and parabolic channels seem like enough to think about for now15:27
kanzurespirals.15:31
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nmz787http://diyhpl.us/~nmz787/pdf/Electrodeposition_of_3D_microstructures_on_silicon.pdf15:37
nmz787kanzure: i meant the cross-section of channels being circular or parabolic/similarly-curved15:39
kanzurearen't sharp edges bad for pumping fluid through15:40
kanzurewere those square edges in the micro chromatograph?15:40
kanzureor even pumping gas15:40
kanzureor anything15:40
nmz787http://diyhpl.us/~nmz787/pdf/Mixing_in_curved_tubes.pdf15:42
nmz787I couldn't tell what their 'turn arounds' looked like in the GC column paper15:42
nmz787i guess my best answer is that some channel shapes are better for certain applications15:43
nmz787maybe sharp and square corners and channels matters less in gas-phase15:44
heathsuggestions on what to visit while in boston?15:52
heathi have a few people scouted from the wyss institute15:52
heathand i've never been to the mit fablab15:52
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kanzurepaperbot: http://jap.physiology.org/content/112/10/162516:11
kanzure.title16:11
paperbothttp://libgen.info/scimag/get.php?doi=10.1152%2Fjapplphysiol.00435.201116:11
yoleauxTranscriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults | Journal of Applied Physiology16:11
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kanzurepaperbot: http://physreports.physiology.org/content/2/11/e12212.abstract16:22
kanzure.title16:22
yoleauxResistance exercise increases active MMP and β1‐integrin protein expression in skeletal muscle | Physiological Reports16:22
paperbothttp://libgen.info/scimag/get.php?doi=10.14814%2Fphy2.1221216:22
kanzure"Recent studies indicate that matrix metalloproteinases (MMPs) and critical linkage proteins in the extracellular matrix (ECM) regulate skeletal muscle mass, although the effects of resistance training (RT) on protein expression and activity are unclear. Thus, the purpose of the present study was to investigate the effects of RT on MMP activity and expression of ECM‐related proteins. Ten male Sprague–Dawley rats were randomly ...16:22
kanzure... assigned to 1 bout (1B) or 18 bouts (18B) of electrical stimulation. The right gastrocnemius muscle was isometrically contracted via percutaneous electrical stimulation (five sets of 5 sec stimulation × five contractions/set with 5 sec interval between contractions and 3 min rest between sets) once (1B) or every other day for 5 weeks (18B). The left leg served as a control."16:22
kanzureisn't science great?16:22
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heathhttp://panorender.com/magic-leap-is-surely-making-the-best-out-of-those-ui-concepts/17:17
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kanzurepaperbot: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.011152117:30
kanzure.title17:30
yoleauxPLOS ONE: Hormonal and Neuromuscular Responses to Mechanical Vibration Applied to Upper Extremity Muscles17:30
paperbothttp://diyhpl.us/~bryan/papers2/paperbot/9cf9458ee436b51eaa01114807065843.txt17:30
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kanzurehomebrew testosterone http://imgur.com/a/1Kie818:00
kanzure.title https://www.youtube.com/watch?v=0LL7bL4F9G418:01
yoleauxAnabolic Steroids: an evolving black market - YouTube18:01
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kanzurehttp://www.reddit.com/r/steroids/comments/1j4pu4/homebrew_wpics/18:23
heath~"value results over activity"18:25
kanzurehahaha http://www.reddit.com/r/steroids/comments/2dtrnl/effects_of_taking_aas_without_lifting/18:25
kanzure"I read a study somewhere of where they tested the effects of taking steroids without working out (WO) There were 4 groups: No WO/No AAS, WO/No AAS, No WO/AAS, and WO/AAS. They all did the same workouts (except the first group) and had the same diet, adjusted to bodyweight of course. No WO/No AAS stayed roughly the same. WO/No AAS gained ~4lbs of muscle. No WO/AAS gained ~7lbs of muscle. WO/AAS gained ~13lbs of muscle."18:26
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kanzurepaperbot: http://www.nejm.org/doi/full/10.1056/NEJM19960704335010118:27
kanzure.title18:27
yoleauxMMS: Error18:27
kanzure"The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men"18:27
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paperbothttp://libgen.info/scimag/get.php?doi=10.1056%2FNEJM19960704335010118:28
maakuso taking steroids and sitting on my ass is 75% better than working out?18:32
kanzureyou're welcome18:33
nmz787fenn: I don't understand why you chose to use 8mm thrust bearings for the laser etcher when the threaded rod chosen is 3/8" (~9.5mm)18:36
maakukanzure: is taking steroids dangerous?18:36
kanzuremaaku: i strongly recommend steroids18:36
kanzurethere are many concerns to be aware of, however18:36
maakukanzure: do you have or can point in the direction of a good writeup?18:37
kanzurenone of which i feel like outlining... it's all fairly obvious stuff... like test your supplies, buy safely, learn good technique, don't be a moron.18:37
kanzureehh no i don't think i do at the moment. i'll think some on it. i might have seen a thing once..18:37
nmz787all the good stuff is reserved for sex changes18:38
nmz787i wonder if you could go complain you aren't feeling 'masculine enough'18:38
maakuwell, if there were serious health concerns I'd avoid it. a dead body is not aethetically pleasing18:38
kanzurenmz787: you can definitely get your doctor to prescribe you testosterone18:39
kanzurenmz787: this is currently a fad actually18:39
nmz787it's more like supply chain management concerns IMO18:39
maakunmz787: makes you a jerk though18:39
kanzure"under 80 nanograms per gigaliter?"18:39
nmz787all the other info is available online18:39
kanzuremaaku: eh i think that's overstated18:39
kanzuremaaku: like maybe steroid users just fucking hate you18:39
kanzureetc18:39
kanzureoh wait, sorry18:39
kanzureyes i do think there's possible increased aggression, but i am highly suspicious of the roid rage stuff18:40
maakubut i hear contrary information about steroids -- some say it actually is health beneficial in small dosages, other say it isn't studied, etc.18:40
JayDuggerI'm not.18:40
kanzuremany people are prescribed steroids for all sorts of reasons18:40
maakui'm willing to try anything that will make me healthier, or allow me to leverage the small amount of time I have into improving my well-being (I do not work out enough)18:41
JayDuggerAh...my mistake. Should've read the log farther back.18:41
kanzuremaaku: there's also lots of historical reasons why steroid use has been advocated against.. and the reasons are all lousy (like "those pesky soviets invented them, so you shouldn't use them")18:41
maakualso, baseball. but i'm not a pro athelete, so I care fuck all about that18:42
nmz787JayDugger: you're not what?18:42
maakukanzure: the "makes you a jerk" statement was about testosterone18:42
JayDuggerSkeptical of "roid rage."18:42
kanzurewell surely not all steroid users are throwing chairs at kittens or whatever18:42
maakuT can make you a confident asshole18:43
maakuor so i'm told by my transgender family members who are on it18:43
kanzurei would be very interested in a drug that can make me more of an ass18:43
kanzuremy only requirement is that it must make me a good and righteous ass18:44
JayDuggerRight. There exists a big difference between taking prescription steroids under medical supervision and buying them "at the gym."18:44
JayDuggerHeh...your options on that one are pretty broad. Best ask your doctor what's right for you. :)18:45
maakuwell i mostly haven't ventured into nootropics, steroids, etc. because i haven't the time to investigate, I don't want to be a guinnea pig myself, and I didn't know asking a doctor could be an option18:46
kanzureolder men can easily ask for testosterone and get it18:46
kanzureit's being marketed under the name "low T"18:46
kanzureor rather, the condition that your doc has been incentivized to treat18:46
maakuwhat do you say? "I'm too busy to work out more than once a week. Can you prescribe me some 'roids please?"18:47
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kanzurefor testosterone specifically? nah just go in with typical manly problems. "doc, i don't have the same youthful energy i once had, is there anything you can give me that will put hair back on my chest?"18:47
JayDuggerNo, complain of depression, low energy, apathy, and then in the follow-up questions admit to low sex drive as if embarrassed.18:47
kanzureyep18:47
JayDuggerkanzure's suggestion might work better, depending on your doctor.18:48
kanzurenah, JayDugger's is more accurate18:48
JayDuggerMy luck has been to have doctors who get suspicious when you recite ad keywords at them.18:48
kanzurealso they will measure your blood level18:48
JayDuggerWhich is why I can't get a scrip for NuVigil from my PCP.18:48
JayDuggerYeah, that too.18:48
kanzurewhich you can manipulate since ytou know ahead of time when the blood test will be18:48
JayDuggerReally? How would you manipulate the blood test?18:49
kanzurei've heard a few tricks regarding not eating or not sleeping, i forget which18:49
kanzuresomething trivial like that18:49
JayDuggerProbably not sleeping. My intermittent fasting hasn't affected my blood test, I don't think...18:50
maakuhrm those symptoms aren't a stretch anyway, although in my case i think it's just the stress of balancing work & family18:50
JayDuggerI'd have to look through a bunch of old test results to make certain of that.18:50
maakuwell if anyone has some published research they recommend looking at, i'd appreciate it18:51
kanzuremaaku: on a related note, have you seen the muscle montage video that joseph jackson uploaded years ago?18:51
maakuno...18:51
nmz787so apparently fancy mass-specs don't ensure great results for seemingly simple experiments (nicotine detection in tobacco extract)18:52
kanzurehe's a transhumanist friendly of ours who used to do bodybuilding (and some powerlifting?)18:52
kanzuremaaku: https://www.youtube.com/watch?v=kmTNtSs1UQY18:52
nmz787and the chemists blame it on 'the matrix'18:52
kanzurehe posted that to facebook once and i gnabbed it :p18:52
kanzureand now he will be reminded for eternity how ridiculous it was18:52
maakuheh i'll check it out in a few minutes18:53
kanzuremaaku: jojack was the one that started the biocurious lab and the one in la jolla18:54
kanzurebiotechnbeyond i mean18:54
kanzureanyway.... given a choice between very little muscle mass and.. lots.. go with lots.19:12
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kanzure"The development of muscle-building properties of testosterone was pursued in the 1940s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters. In response to the success of Russian weightlifters, the U.S. Olympic Team physician John Ziegler worked with synthetic chemists to develop an anabolic steroid with reduced ...19:36
kanzure... androgenic effects.[167] Ziegler's work resulted in the production of methandrostenolone, which Ciba Pharmaceuticals marketed as Dianabol. The new steroid was approved for use in the U.S. by the Food and Drug Administration (FDA) in 1958. It was most commonly administered to burn victims and the elderly. The drug's off-label users were mostly bodybuilders and weight lifters. "19:36
kanzurehmm i need a reference for the "eastern bloc countries" testosterone programs19:36
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fennnmz787: the leadscrew would have been turned down to 8mm to fit the 8mm radial bearings20:06
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maakukanzure: The Millennial Project? wow that brings back memories20:30
kanzurehe just sits at home writing constantly20:31
kanzurethat's like his superpower20:31
maakui am not ashamed to admit that book is what introduced me (indirectly) to futurism and transhumanism20:31
maakutotally, absolutely incorrect on every count (Savage had no engineering background at all and it shows in retrospect), but I was 12 and impressionable and it was quite a vision20:32
kanzurewell, look at his revisions20:32
kanzureor uh v220:32
kanzurehttp://tmp2.wikia.com/wiki/Main_Page20:32
maakui'm looking at it now.20:33
maakui've always wanted someone to go back and redo TMP20:33
kanzurewell, there you go haha20:33
maakuit was a beautiful vision, one which still shapes my goals. it's why i'm here and doing what I do. solving death? that's just so I and everyone I know can have a chance to experience the vision underlying TMP.20:35
maakuthe vision, because the implementation described in the book was bonkers :P20:35
maakui'll definately reach out to him in any case20:36
kanzureyou're sitting in the only eric hunting fan club20:36
kanzurealthough i think fenn's our resident eric hunting stalker more than i am20:36
maakuthink he cares about bitcoin?20:39
kanzureyeah i've been emailing him about bitcoin for a while now20:41
kanzurehe is very much an email person20:41
maakucool20:42
kanzurehe is excellent at getting high-level themes right and being historically accurate or plausible, and recently i have been helping him get started on basic programming20:42
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