| --- Log opened Tue May 12 00:00:09 2015 | ||
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| kanzure | beep | 03:24 |
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| kanzure | .title https://news.ycombinator.com/item?id=9530386 | 04:27 |
| yoleaux | Electric brain stimulation decreases IQ scores and racial prejudice | Hacker News | 04:27 |
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| kanzure | "An overview of ramanujan's notebooks" http://www.math.uiuc.edu/~berndt/articles/aachen.pdf | 04:55 |
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| heath | http://concourse.ci/index.html | 07:47 |
| heath | https://github.com/starkandwayne/concourse-tutorial | 07:47 |
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| -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | sponsored by george church and the NRA, banned by the Federal Death Administration (4 times) | this channel is LOGGED: http://gnusha.org/logs | http://diyhpl.us/wiki | "ray kurzweil is a pessimist" - george church | 10:01 | |
| -!- Topic set by kanzure [~kanzure@unaffiliated/kanzure] [Mon Mar 23 17:39:20 2015] | 10:01 | |
| [Users ##hplusroadmap] | 10:01 | |
| [@fenn ] [ Daeken ] [ kanzure ] [ sheena1 ] | 10:01 | |
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| delinquentme | GGG kanzure, binary searchs through excel files. Is there some magic reason why a excel file search for a string representation in a binary | 10:54 |
| delinquentme | is not matching? | 10:54 |
| kanzure | they encode data differently | 10:55 |
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| delinquentme | kanzure, so you're saying its binary ... but a novel non-standard binary encoding ? | 11:22 |
| delinquentme | sdf | 11:22 |
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| @fenn | "the IQ scores of people who underwent tDCS brain stimulation improved markedly less than did the IQ scores of people in the placebo group." is it just me or does this not make sense? IQ scores are not supposed to change | 13:25 |
| kanzure | heh | 13:26 |
| kanzure | i would expect at least some forms of brain stimulation to cause impairment on iq scoring | 13:26 |
| @fenn | but "improved less" is an odd way of phrasing an impairment | 13:27 |
| kanzure | we don't have nearly enough brain-related SNPs on the genetic modifications wiki page | 13:29 |
| @fenn | "Frohlich expected that most, if not all, IQ scores would improve because of the practice effect" | 13:30 |
| @fenn | lame | 13:30 |
| @fenn | my understanding is that there isn't very much genetics of intelligence research because "racism!" | 13:30 |
| kanzure | http://snpedia.com/index.php/Autism | 13:32 |
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| @fenn | would have expected more | 13:33 |
| @fenn | "Repetitively stacking or lining up objects is a behavior sometimes associated with individuals with autism." | 13:34 |
| kanzure | mathematical ability: rs11225308, rs363449, rs17278234, rs11154532, rs12199332, rs12613365, rs6588923, rs2300052, rs6947045 and rs1215603 | 13:34 |
| @fenn | http://iqdb.cbi.pku.edu.cn/snp.html "IQ related genes database" | 13:35 |
| @fenn | i don't understand the columns and how it is supposed to relate to IQ though | 13:36 |
| @fenn | presumably there is some other data relating IQ to haplotype, which isn't quite direct enough to draw conclusions from | 13:38 |
| archels | P < 0.04999999999 | 13:38 |
| @fenn | genetics is such a pain in the ass | 13:38 |
| archels | no, really, we mean it | 13:38 |
| kanzure | two of the genes from that page: | 13:39 |
| kanzure | .wik NRCAM | 13:39 |
| yoleaux | "Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene." — http://en.wikipedia.org/wiki/NRCAM | 13:39 |
| kanzure | .wik reelin | 13:40 |
| yoleaux | "Reelin is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain." — http://en.wikipedia.org/wiki/Reelin | 13:40 |
| @fenn | "FADS1 fatty acid desaturase - allergic rhinitis dermatitis and eczema" i probably have the bad version of this one | 13:41 |
| kanzure | neurotrophin-3 "The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor ... | 13:43 |
| kanzure | ... to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor).[3]" | 13:43 |
| kanzure | "NT-3 binds three receptors on the surface of cells which are capable of responding to this growth factor" http://en.wikipedia.org/wiki/Neurotrophin-3 | 13:44 |
| kanzure | CHRM2 ("muscarinic acetylcholine receptor M2") "... However, a larger 2009 study attempting to replicate this claim instead found no significant association between the CHRM2 gene and intelligence.[6]" | 13:45 |
| kanzure | "NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity" | 13:48 |
| kanzure | cool | 13:48 |
| @fenn | ...in mice | 13:49 |
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| @fenn | it's hard to believe an acetylcholine receptor is not related to intelligence | 13:59 |
| @fenn | "Using a test of within-family association, which controls for the possible effects of population stratification, a highly significant association was found between the CHRM2 gene and intelligence. The strongest association was between rs324650 and performance IQ (PIQ), where the T allele was associated with an increase of 4.6 PIQ points." N=667 dutch people | 14:00 |
| @fenn | .wik performance IQ | 14:01 |
| yoleaux | "The Wechsler Adult Intelligence Scale (WAIS) is a test designed to measure intelligence in adults and older adolescents. It is currently in its fourth edition (WAIS-IV). The original WAIS (Form I) was published in February 1955 by David Wechsler, as a revision of the Wechsler-Bellevue Intelligence Scale that had been released in 1939." — http://en.wikipedia.org/wiki/Performance_IQ | 14:01 |
| @fenn | is there some other IQ? | 14:01 |
| archels | g | 14:02 |
| @fenn | verbal comprehension and working memory are not included in PIQ | 14:02 |
| archels | http://en.wikipedia.org/wiki/G_factor_%28psychometrics%29 | 14:02 |
| @fenn | i don't get how you're supposed to make a vocabulary test culture-neutral | 14:03 |
| @fenn | a baloo is a bear | 14:04 |
| @fenn | unfairly advantages kids who have watched the cartoon talespin | 14:07 |
| @fenn | (from an actual vocabulary aptitude test i took in elementary school) | 14:10 |
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| kanzure | what are the implications of that memory methylation stuff turning out to be factually true? | 14:13 |
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| kanzure | fenn: i suspect it will end up on us to design a correct and good project for finding interesting brain mutationts | 16:36 |
| kanzure | er, brain mutations | 16:36 |
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| kanzure | "it's a lego car that runs on air!" .... compressed air. which was not compressed with lego. | 21:58 |
| kanzure | with enough compressed air you can make anything move | 21:58 |
| kanzure | complaining about http://www.superawesomemicroproject.com/ | 21:59 |
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| --- Log closed Wed May 13 00:00:10 2015 | ||
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