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| kanzure_ | something anti-patent http://cultureandempire.com/html/cande.html | 10:55 |
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| kanzure_ | https://leastauthority.com/blog/a_bug_in_libsnark.html | 11:06 |
| juri_ | http://faikvm.com/20150403_191643.jpg | 11:21 |
| juri_ | one of my students has surpassed me. | 11:21 |
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| kanzure | "A conditional knockout mouse line, called Prkcztm1a(EUCOMM)Wtsi[23][24] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[25][26][27]" | 11:48 |
| kanzure | i wonder whether they have the same idea of "high-throughput" as i do, heh | 11:49 |
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| kanzure | "As of 2008, Val66Met is probably the most investigated SNP of the BDNF gene, but, besides this variant, other SNPs in the gene are C270T, rs7103411, rs2030324, rs2203877, rs2049045 and rs7124442." | 12:01 |
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| kanzure | http://diyhpl.us/~bryan/papers2/neuro/DNA%20methylation%20in%20memory%20formation%20-%20emerging%20insights%20-%202015.pdf | 12:40 |
| kanzure | this is a pretty good review | 13:25 |
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| kanzure | archels: yes/no on the memory methylation paper? | 14:02 |
| kanzure | .wik calcineurin | 14:15 |
| yoleaux | "Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell, cytoplasmic (NFATc), a transcription factor, by dephosphorylating it." — http://en.wikipedia.org/wiki/Calcineurin | 14:15 |
| archels | no time right now, but have it open in a tab | 14:17 |
| kanzure | those diagrams are awful | 14:34 |
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| archels | okay, I'm trying out some new nootropics, so I just read most of the paper | 15:04 |
| archels | memory suppressors vs. memory promoters, interesting | 15:04 |
| archels | too bad they're only making experimental suggestions for tipping the balance towards suppression. Where's the hplus in that?? | 15:05 |
| archels | =) | 15:05 |
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| kanzure | er, i think suppression in that context just means potentiation suppression, which is not the same thing as forgetting | 15:24 |
| kanzure | i'm sure it's possible to imagine a system where data is remembered by suppression only | 15:25 |
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| archels | indeed, like the seesaw in their diagrams, only the net outcome of (promotion - suppression) matters | 15:28 |
| kanzure | https://z4ziggy.wordpress.com/2015/05/17/sniffing-gsm-traffic-with-hackrf/ | 15:30 |
| archels | the idea of accumulation of some factor due to hippocampal replay is also very interesting | 15:32 |
| archels | apparently double-stranded methylation is very stable long-term, then | 15:32 |
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| kanzure | sounds like there's some way to compare shor-term or working memory to long-term memory, and then adjust signals to attempt to kick methylation towards the correct direction for long-term retrieval reasons? | 15:34 |
| kanzure | *short-term | 15:35 |
| kanzure | oh maybe there are projection neurons that are used to direct or route to more efficient ways to store long-term data | 15:36 |
| kanzure | to more specific neurons | 15:36 |
| kanzure | rather than requiring lots of feedback to tweak a long-term memory based on methylation and gene expression shit | 15:36 |
| kanzure | http://www.ivanyu.ca/blog/2014/2/2/wireless-das-keyboard-modification | 15:40 |
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| archels | not sure, iterating something over and over again to get it into long-term storage is one thing, but mechanisms of forgetting are probably vastly different | 15:41 |
| kanzure | i would be surprised if replay is the only mechanism | 15:44 |
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| archels | indeed | 15:51 |
| archels | a lot of learning seems to be based around repetition, but I'm not sure how unique the hippocampus is when it comes to one-shot learning, so to speak | 15:51 |
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| kanzure | one-shot learning does not imply that replay/repetition isn't happening inside the head somewhere | 15:53 |
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| archels | well yeah, as with the hippocampus-mediated system | 16:15 |
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| fredox | that guy talking about cost gravity must not have bought a pc recently | 17:56 |
| fredox | cost per benchmarked processing power has increaed ~30% over the last 5 years | 17:57 |
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| andytoshi | thx for http://cultureandempire.com/html/cande.html it is very encouraging | 18:32 |
| andytoshi | kanzure: ^ | 18:32 |
| cluckj | that seems like a bit of a rant-and-rave | 18:58 |
| yoleaux | 11 May 2015 21:11Z <kanzure> cluckj: could you find me an anthropologist to organize #bitcoin-wizards logs? | 18:58 |
| cluckj | lol | 18:58 |
| cluckj | thanks yoleaux | 18:59 |
| cluckj | kanzure, I don't know of anyone doing work with bitcoin stuff | 18:59 |
| andytoshi | cluckj: shouldn't need too much bitcoin expertise, the stuff is generally either accessible or requires a ton of mathematical expertise to understand (in which case blindly categorizing it should be fine) | 19:05 |
| cluckj | grinding logs might be a good use for some qualitative data crunching software | 19:07 |
| andytoshi | cluckj: kanzure and i have tried this (him much much more than me i think) and it doesn't seem to work | 19:07 |
| cluckj | in atlas ti or something? | 19:08 |
| andytoshi | uh no i just strongarm stuff into spamassassin and call that "text analysis" | 19:08 |
| cluckj | hahaha | 19:08 |
| cluckj | I hadn't thought of that as doing some level of text analysis | 19:13 |
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| cluckj | a specialized qualitative data analysis software might give you something interesting that you wouldn't see just by reading the logs | 19:14 |
| andytoshi | i'd be very interested in the results of that | 19:15 |
| andytoshi | i tried using some python package to do stuff but didn't get to the point of understanding the lingo used by text classification people | 19:15 |
| cluckj | I have no idea how to use that software though, I can't help out there | 19:16 |
| cluckj | all my software is in meatspace | 19:16 |
| cluckj | I think everyone I know that has the need to use that kind of software uses atlas ti, or some crazy IBM package | 19:18 |
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| archels | heh, DEFON tickets are cash at the door only? | 23:46 |
| archels | no pre-registration | 23:47 |
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| --- Log closed Mon May 18 00:00:15 2015 | ||
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