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| kanzure | http://www.theguardian.com/science/neurophilosophy/2015/may/20/octopus-skin-contains-light-sensors | 03:36 |
|---|---|---|
| kanzure | Ramirez, M. D. & Oakley, T. H. (2015). Eye-independent, light-activated chromatophore expansion (LACE) and expression of phototransduction genes in the skin of Octopus bimaculoides. J. Exp. Biol. doi: 10.1242/jeb.110908. | 03:37 |
| kanzure | http://jeb.biologists.org/content/218/10/1513.abstract | 03:37 |
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| kanzure | "Although these changes primarily rely on eyesight, we found that light causes chromatophores to expand in excised pieces of Octopus bimaculoides skin. We call this behavior light-activated chromatophore expansion (or LACE). To uncover how octopus skin senses light, we used antibodies against r-opsin phototransduction proteins to identify sensory neurons that express r-opsin in the skin. We hypothesized that octopus LACE relies on the ... | 03:39 |
| kanzure | ... same r-opsin phototransduction cascade found in octopus eyes. By creating an action spectrum for the latency to LACE, we found that LACE occurred most quickly in response to blue light. We fit our action spectrum data to a standard opsin curve template and estimated the λmax of LACE to be 480 nm. Consistent with our hypothesis, the maximum sensitivity of the light sensors underlying LACE closely matches the known spectral ... | 03:39 |
| kanzure | ... sensitivity of opsin from octopus eyes. LACE in isolated preparations suggests that octopus skin is intrinsically light sensitive and that this dispersed light sense might contribute to their unique and novel patterning abilities. Finally, our data suggest that a common molecular mechanism for light detection in eyes may have been co-opted for light sensing in octopus skin and then used for LACE." | 03:39 |
| kanzure | "Experiments performed in the 1960s showed that chromatophores respond to light, suggesting that they can be controlled without input from the brain, but nobody had followed this up until now." | 03:42 |
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| kanzure | .title https://news.ycombinator.com/item?id=9584325 | 05:04 |
| yoleaux | The Unreasonable Effectiveness of Recurrent Neural Networks | Hacker News | 05:04 |
| kanzure | .title https://www.youtube.com/watch?v=xKt21ucdBY0 | 05:04 |
| yoleaux | Automated Image Captioning with ConvNets and Recurrent Nets - YouTube | 05:04 |
| kanzure | "Parsing Natural Scenes and Natural Language with Recursive Neural Networks" http://nlp.stanford.edu/pubs/SocherLinNgManning_ICML2011.pdf | 05:05 |
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| kanzure | "Measuring and mitigating AS-level adversaries with Tor" http://arxiv.org/pdf/1505.05173.pdf https://news.ycombinator.com/item?id=9585466 (astoria) | 05:39 |
| * narwh4l sighs heavily | 05:43 | |
| narwh4l | Neural nets are super cool, but there is a lot more out there | 05:43 |
| Adlai | "The basic idea is that there's a lot of wisdom in these essays, but unfortunately Paul Graham is a relatively slow generator. Wouldn't it be great if we could sample startup wisdom on demand?" | 05:43 |
| Adlai | 'Sometimes it says something that offers a glimmer of insight, such as "a company is a meeting to think to investors"' | 05:44 |
| kanzure | "The state of the art in compressing wikipedia is 1.278bits (on a certain subset)" http://prize.hutter1.net/ | 05:44 |
| kanzure | narwh4l: sure | 05:45 |
| kanzure | narwh4l: the presence of neural network software does not entirely detract from other useful things | 05:45 |
| kanzure | "This same thing (i.e., using recurrent neural networks to predict characters (and even words)) was done by Elman in 1990 in a paper called "Finding Structure in Time"[1]. In that paper, Elman goes several steps further and carries out some analysis to show what kind of information the recurrent neural network maintains about the on-going inputs." http://crl.ucsd.edu/~elman/Papers/fsit.pdf | 05:46 |
| narwh4l | Here's an unpopular opinion: neural networks are bad at predicting things | 05:46 |
| narwh4l | very good at recognizing things which _sometimes_ means they are good at recognizing a predefined type of situation which is kind of a prediction hack | 05:47 |
| narwh4l | but prediction? no, not on their own | 05:47 |
| narwh4l | I'm just saying they are for sure super cool and their existence doesn't detract from anything | 05:48 |
| narwh4l | But sometimes people get focused on the flashy factor and can't see the bigger picture | 05:48 |
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| kanzure | i am certainly not one of those people, considering how bored i get with perceptrons | 05:49 |
| kanzure | although i would argue that biologically-accurate neuron emulation is understudied | 05:50 |
| narwh4l | It's also true that the performance of an ANN can be dramatically enhanced with the right feature selection, but feature selection just becomes its own problem | 05:50 |
| Adlai | aha, it's this topic again | 05:50 |
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| narwh4l | I agree stronly kanzure | 05:50 |
| narwh4l | strongly* | 05:50 |
| Adlai | biologically-accurate neuron emulation... does that involve modelling all the kroutons bumping into eachother among the synaptic soup? | 05:50 |
| narwh4l | that bio-esque neural nets are WAY understudied | 05:50 |
| Adlai | if not, let's call it "biologically-less-inaccurate" | 05:51 |
| kanzure | Adlai: it involves many things... ion channels, receptors, axons, cell membranes, etc. | 05:51 |
| Adlai | that's a couple more steps in the right direction | 05:51 |
| kanzure | Adlai: http://neuron.yale.edu/neuron/ | 05:51 |
| Adlai | oh look, a link! | 05:51 |
| * Adlai click | 05:51 | |
| kanzure | "User-defined mechanisms such as voltage- and ligand-gated ion channels, diffusion, buffering, active transport, etc., can be added by writing model descriptions in NMODL, a high-level programming language that has a simple syntax for expressing kinetic schemes and sets of simultaneous algebraic and/or differential equations. NMODL can also be used to write model descriptions for new classes of artificial spiking cells. These model ... | 05:52 |
| kanzure | ... descriptions are compiled so that membrane voltage and states can be computed efficiently using integration methods that have been optimized for branched structures. A large number of mechanisms written in NMODL have been made available on the WWW by the authors of published models; many of these have been entered into ModelDB which makes it easy for users to find and retrieve model source code according to search criteria such as ... | 05:52 |
| kanzure | ... author, type of model (e.g. cell or network), ionic currents, etc.." | 05:52 |
| kanzure | "As mentioned above, NEURON also has a GUI tool called the ChannelBuilder that makes it easy to specify voltage- and ligand-gated ion channels in terms of ODEs (HH-style, including Borg-Graham formulation) and/or kinetic schemes. ChannelBuilder channels actually execute faster than identical mechanisms specified with NMODL. Their states and total conductance can be simulated as deterministic (continuous in time), or stochastic (countably ... | 05:52 |
| kanzure | ... many channels with independent state transitions, producing random, abrupt conductance changes)." | 05:52 |
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| kanzure | fenn: http://www.zerohedge.com/news/2015-05-21/where-americas-airplanes-go-die | 06:23 |
| JayDugger | Driven past it. Neat to see, and they've some static displays to see. | 06:26 |
| JayDugger | Including a D-21 drone, which was neat. | 06:28 |
| kanzure | some random number generators https://www.tindie.com/products/ubldit/truerng-hardware-random-number-generator http://ubld.it/products/truerng-hardware-random-number-generator/ | 06:35 |
| kanzure | and https://ssl.araneus.fi/products/alea2/order/en/ | 06:35 |
| kanzure | and https://www.tindie.com/products/WaywardGeek/infinite-noise/ | 06:35 |
| JayDugger | Although the Titan missile silo museum in Tucson is also worth seeing, and much cooler in the summertime. | 06:36 |
| kanzure | is it a single silo turned into a museum? | 06:36 |
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| kanzure | https://github.com/waywardgeek/infnoise | 06:37 |
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| archels | narwh4l: you are very much mistaken about neural networks being bad at prediction | 06:54 |
| archels | this might be the result of having been imbued with perceptron-like things, which are not an ideal choice when it comes to predicting timeseries | 06:54 |
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| archels | random example http://www.ncbi.nlm.nih.gov/pubmed/23146969 | 06:56 |
| archels | Wolfgang Maass is big in this field | 06:56 |
| * archels slaps kanzure around a bit with a large trout for linking NEURON | 06:57 | |
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| kanzure | .title | 07:19 |
| yoleaux | Emergence of complex computational structures from chaotic neural networks through reward-modulated Hebbian learning. - PubMed - NCBI | 07:19 |
| kanzure | archels: what's wrong with NEURON? | 07:19 |
| kanzure | besides its name | 07:19 |
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| archels | NEURON is a textbook example of science advancing one generation at a time | 07:24 |
| archels | it's still stuck in 1995 or whatever | 07:24 |
| kanzure | oh, sure | 07:24 |
| kanzure | there's probably something better out there | 07:25 |
| kanzure | but i haven't heard about it yet | 07:25 |
| archels | yeah, there's the rub | 07:26 |
| archels | there's a bunch of promising stuff, but much less mature than NEURON | 07:26 |
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| kanzure | .title http://osvdb.org/121842 | 09:05 |
| yoleaux | Just a moment... | 09:05 |
| kanzure | "121842 : Interoperable Telesurgery Protocol (ITP) Plaintext Unauthenticated MitM Hijacking" | 09:06 |
| kanzure | "The Interoperable Telesurgery Protocol (ITP) contains a flaw as it does not use any form of encryption or authentication. By intercepting / replaying or spoofing packets, an attacker with the ability to intercept network traffic (e.g. MitM, DNS cache poisoning) can control any device based on it. This could allow an attacker to completely control a telesurgery robot, causing physical harm to a patient during a procedure. Currently, ... | 09:06 |
| kanzure | ... there are no known upgrades or patches to correct this vulnerability. It is possible to temporarily mitigate the flaw by implementing the following workaround: Researchers have demonstrated that ITP can be operated over TLS/DTLS, using certificate-based authentication to ensure the security and integrity of the protocol." | 09:06 |
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| kanzure | "Use of Adaptive Laboratory Evolution To Discover Key Mutations Enabling Rapid Growth of Escherichia coli K-12 MG1655 on Glucose Minimal Medium" | 09:58 |
| kanzure | "Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae" | 09:59 |
| kanzure | "Rational design of a synthetic Entner–Doudoroff pathway for improved and controllable NADPH regeneration" | 09:59 |
| kanzure | "Directed evolution combined with synthetic biology strategies expedite semi-rational engineering of genes and genomes" | 10:00 |
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| xrr | kanzure, when did you start to study biology? | 10:44 |
| kanzure | that's a weird question | 10:49 |
| xrr | just wondering. you seem to be digging around in some fun articles. most of this is still tough to grasp for me. I started looking into biology a year ago | 10:53 |
| kanzure | you should not judge your progress against mine | 11:42 |
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| delinquentme | kanzure, you near plano texas? | 12:39 |
| delinquentme | Ima come live w you for a while | 12:39 |
| delinquentme | ACTUALLY. dude. | 12:40 |
| delinquentme | why havn't we hungout? | 12:40 |
| delinquentme | whats an effing flight to texas ... $200? | 12:40 |
| kanzure | actually we have hung out before | 12:42 |
| delinquentme | kanzure, true~! | 12:46 |
| delinquentme | wuz awesome | 12:46 |
| delinquentme | you typed fast | 12:46 |
| delinquentme | and found lots of images of mol mech | 12:46 |
| delinquentme | and pissed people off :DDDD | 12:47 |
| delinquentme | when do again? | 12:47 |
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| kanzure | .title http://www.youtube.com/watch?v=8Bq1fyl6hS8 | 14:18 |
| yoleaux | Beyond Boundaries (Outro) ft. Aubrey de Grey - Neon Future 1 - Steve Aoki - YouTube | 14:18 |
| kanzure | yesssss | 14:18 |
| kanzure | .title https://www.youtube.com/watch?v=TV2qY-LMmss | 14:27 |
| yoleaux | suicide commando - neuro suspension - YouTube | 14:27 |
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| kanzure | "Tara Expeditions Executive Director Romain Troublé said the schooner sailed about 87,000 miles (140,000 km) during the research voyage." | 17:59 |
| kanzure | "The scientists conducted the largest DNA sequencing effort ever done in ocean science, pinpointing around 40 million plankton genes, most previously unknown." | 17:59 |
| kanzure | ""A good way of thinking about this is that there are roughly 200 million viruses in every mouthful of seawater, and most of those viruses are infecting the roughly 20 million bacteria found in every mouthful of seawater."" | 18:00 |
| kanzure | who uses a mouthful as a measurement | 18:00 |
| kanzure | besides porn stars | 18:01 |
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| fredox | they can't use the measurement 'jigger' anymore - sounds double racist | 20:21 |
| @fenn | .wa jigger | 20:33 |
| yoleaux | jigger (English word): Definitions: 1: noun: a small glass adequate to hold a single swallow of whiskey; 2: noun: any small mast on a sailing vessel; especially the mizzenmast of a yawl; 3: noun: larval mite that sucks the blood of vertebrates including human beings causing intense irritation; Hyphenation: jig-ger (6 letters: 2 syllables); First known use in English: 1836 (179 years ago); Inflected form: jiggers | 20:33 |
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| --- Log closed Sat May 23 00:00:19 2015 | ||
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