| --- Log opened Sat Jul 04 00:00:00 2015 | ||
| wrldpc1 | I post a comment on one of Danaylov’s facebook posts promoting his Singularity 101 podcast with Michio Kaku asking whether or not Kaku has answered for the claims that he appropriated the Kardashev scale and was proferring it as his own idea without proper attribution and Danaylov deleted the comment. | 00:01 |
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| kanzure | "The presence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3" http://www.cell.com/neuron/abstract/S0896-6273(15)00428-6 | 05:48 |
| kanzure | "Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular substrates, is poorly ... | 05:49 |
| kanzure | ... understood. Here we find that both memory storage and its underlying synaptic plasticity are mediated by the increase in level and in the aggregation of the prion-like translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein). Genetic ablation of CPEB3 impairs the maintenance of both hippocampal long-term potentiation and hippocampus-dependent spatial memory. We propose a model whereby persistence of ... | 05:49 |
| kanzure | ... long-term memory results from the assembly of CPEB3 into aggregates. These aggregates serve as functional prions and regulate local protein synthesis necessary for the maintenance of long-term memory." | 05:49 |
| kanzure | "CPEB3 forms aggregates after synaptic activity in the hippocampus. After aggregation, CPEB3 promotes the translation of AMPA receptors. CPEB3 conditional knockout mice have impaired long-term memory and LTP. CPEB3 mediates the persistence of memory through a prion-like mechanism." | 05:49 |
| kanzure | "SUMOylation is an inhibitory constraint that regulates the prion-like aggregation and activity of CPEB3" http://www.cell.com/cell-reports/abstract/S2211-1247(15)00493-3 | 05:50 |
| kanzure | "The CPEB3 protein is a functional prion that interacts with the actin cytoskeleton" http://www.cell.com/cell-reports/abstract/S2211-1247(15)00492-1 | 05:51 |
| kanzure | "... Interestingly, deletion analysis of the CPEB3 prion domain uncovered a tripartite organization: two aggregation-promoting domains surround a regulatory module that affects interaction with the actin cytoskeleton." | 05:51 |
| kanzure | hm. but what about the methylation stuff. | 05:54 |
| kanzure | the dna methylation neuron stuff was primarily about memory formation, not memory persistence.. hm. | 06:00 |
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| kanzure | specifically http://diyhpl.us/~bryan/papers2/neuro/DNA%20methylation%20in%20memory%20formation%20-%20emerging%20insights%20-%202015.pdf | 06:02 |
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| kanzure | los angeles biohackers ad for 3d printing stuff http://i.imgur.com/Xr5xdvg.png | 06:08 |
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| kanzure | .wik NEURL | 06:56 |
| yoleaux | "Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene." — https://en.wikipedia.org/wiki/NEURL | 06:56 |
| kanzure | bah | 06:56 |
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| kanzure | neuralized1 overexpression in mice (which influences CPEB3) shows memory improvements http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442370/ | 07:02 |
| kanzure | and also increases the number of synapses | 07:03 |
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| kanzure | some unusual and dumb attempts at music notation https://www.youtube.com/watch?v=8F2Dv27CSuI | 16:09 |
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| JayDugger | Yup. | 17:26 |
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| --- Log closed Sun Jul 05 00:00:01 2015 | ||
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