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| kanzure | hmph | 05:10 |
|---|---|---|
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| justanotheruser | http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat4384.html | 05:27 |
| justanotheruser | .title | 05:27 |
| yoleaux | Epitaxial growth of two-dimensional stanene : Nature Materials : Nature Publishing Group | 05:27 |
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| kanzure | .title http://archneur.jamanetwork.com/article.aspx?articleid=2398915 | 08:09 |
| yoleaux | JAMA Network | JAMA Neurology | Blood-Borne Revitalization of the Aged Brain | 08:09 |
| kanzure | "Soluble factors present in young or aged blood are sufficient to improve or impair cognitive function, respectively, suggesting an aging continuum of brain-relevant systemic factors. The age-associated plasma chemokine CCL11 has been shown to impair young brain function while GDF11 has been reported to increase the generation of neurons in aged mice. However, the identities of specific factors mediating memory-enhancing effects of young ... | 08:10 |
| kanzure | ... blood and their mechanisms of action are enigmatic. Here we review brain rejuvenation studies in the broader context of systemic rejuvenation research. We discuss putative mechanisms for blood-borne brain rejuvenation and suggest promising avenues for future research and development of therapies." | 08:10 |
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| delinquentme | jury duty is fucking hilarious | 09:33 |
| delinquentme | the title of the intro video is: "IDEALS MADE REAL" | 09:34 |
| kanzure | "jury nullification is a myth" | 09:39 |
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| kanzure | suspected satoshi nakamoto coins are on the move today https://blockchain.info/address/1B8BgCRpoJvwTtwVczRLvUiGY6PToqAJ3E | 09:48 |
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| kanzure | data set of all github public keys https://blog.benjojo.co.uk/post/auditing-github-users-keys | 10:33 |
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| justanotheruser | kanzure: shame! | 11:30 |
| justanotheruser | you are trusting blockchain.info as a source and not taking advantage of the tools you have at your disposal that don't require trust? | 11:31 |
| * justanotheruser says this condendingly after only having read the HN comments section explaining that it was a bc.i bug | 11:31 | |
| kanzure | hm? my post on hacker news was factual, regardless of whether blockchain.info is terrible | 11:32 |
| justanotheruser | no, I'm talking about what you said in here | 11:46 |
| kanzure | ah shit | 11:46 |
| andytoshi | lol, i got burned too, on -wizards no less | 11:48 |
| kanzure | at least i said suspected | 11:48 |
| justanotheruser | andytoshi: >:( | 11:51 |
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| nmz787_i | [C1608X5R0J105K] | 13:05 |
| nmz787_i | http://hackaday.com/2015/08/04/amazons-ai-escapes-its-hardware-prison/ | 13:05 |
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| drethelin | http://www.phil.cam.ac.uk/routledge-lectures/clark-routledge | 13:14 |
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| kanzure | "“As many as 100 trillion viruses and bacteria live on each of us. However much we wash, there are always ten million or so bacteria on every square centimeter on our skin.”1" | 15:37 |
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| math3 | Hello | 15:39 |
| kanzure | .wik cerebritis | 15:42 |
| yoleaux | "Cerebritis is an infection of the brain that normally leads to the formation of an abscess within the brain itself. It is the inflammation of the cerebrum, a structure within the brain, which performs a number of important functions, including most of the things which people associate with being human, such as memory and speech." — https://en.wikipedia.org/wiki/Cerebritis | 15:42 |
| kanzure | "The tenacity of the wisdom of the abscessing brain comes from a study entitled, “Improved survival in central nervous system aspergillosis: a series of immunocompromised children with leukemia undergoing stereotaxic resection of aspergillomas.”22 In each child reported in this series, and in every abscess, successful image-guided resection of the lesion was possible. “Complete resection of the abscess yielded gross findings of a ... | 15:43 |
| kanzure | ... viscous fluid contained by a firm rubbery wall surrounded by soft capsule.”22 Even under SICKness (vide supra), the brain retains its balance between innate immunity and reasoned reactivity." | 15:44 |
| math3 | Does anyone here have experience with Nootropics? | 15:44 |
| c0rw1n | not mine personally but you can go read http://www.gwern.net/Nootropics | 15:54 |
| math3 | Okay | 15:55 |
| math3 | I was just wondering what would be the best nootropic for learning | 15:55 |
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| kanzure | yashgaroth: find me a non-destructive brain infecting microbe | 16:12 |
| yashgaroth | toxoplasmosis? | 16:13 |
| kanzure | oh yeah | 16:13 |
| kanzure | i want some sliced cortex images and arrows pointing to the little fuckers, what paper do i want to read for this? | 16:13 |
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| kanzure | looks like it might form cysts? page 5 figure 1 http://stuorgs2.uwsp.edu/PREVET/Resources/Toxoplasma%20reading%20from%20Dr.%20Huspeni.pdf | 16:15 |
| yashgaroth | seems to be | 16:16 |
| kanzure | ah here we go http://web.natur.cuni.cz/~flegr/pdf/cysts.pdf | 16:16 |
| kanzure | "The striking interindividual differences in the total parasite load and cyst distribution indicate a probabilistic nature of brain infestation. Still, some brain regions were consistently more infected than others. These included the olfactory bulb, the entorhinal, somatosensory, motor and orbital, frontal association and visual cortices, and, importantly, the hippocampus and the amygdala. By contrast, a consistently low incidence of ... | 16:17 |
| kanzure | ... tissue cysts was recorded in the cerebellum, the pontine nuclei, the caudate putamen and virtually all compact masses of myelinated axons." | 16:17 |
| kanzure | perfect | 16:17 |
| yashgaroth | dare I ask | 16:17 |
| kanzure | oh look they recorded mean number of cysts per brain region, how nice of them | 16:18 |
| kanzure | yashgaroth: microbial nootropics; feed microbes to mice, slice brains and recover microbes that migrated to specific regions. iterate. | 16:18 |
| Taek | +1 | 16:19 |
| yashgaroth | soo they can then secrete nootropic compounds or what | 16:19 |
| kanzure | well, migration is the first step | 16:19 |
| kanzure | second step is testing maze solving abilities or some shit | 16:19 |
| kanzure | and maybe adding large plasmids with neural growth factor genes or something | 16:20 |
| kanzure | and site-specific mutagenesis regarding regulation of those neural growth factors | 16:20 |
| yashgaroth | well, hmm | 16:22 |
| yashgaroth | it's certainly promising from a zombie pandemic perspective | 16:23 |
| kanzure | what is it with you people and zombie apocalypses | 16:23 |
| kanzure | isn't viable nootropics more interesting, come on | 16:24 |
| yashgaroth | but the military applications...! | 16:24 |
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| kanzure | i suspect the primary military application might be no sleep | 16:24 |
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| yashgaroth | yeah sleeping zombies would be a big drawback | 16:25 |
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| yashgaroth | I thought modafinil was pretty good for sleep already | 16:25 |
| kanzure | i'd be most interested in "more working memory" tho | 16:26 |
| kanzure | or "language acquisition" | 16:27 |
| kanzure | page 6 figure 4: they even made a highly colorful diagram for my amusement. aren't they the best? | 16:28 |
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| yashgaroth | translating it into humans can be problematic, especially if you're trying to select for language acquisition in mice | 16:31 |
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| kanzure | yashgaroth: true, but you could use old people, although i agree it's problematic | 16:34 |
| juri_ | so.. are we ever going to start on that dna printer? :P | 16:35 |
| justanotheruser | What is the most practical synthesis for a printer? | 16:36 |
| kanzure | juri_: well, nobody figured out the chemistry or gene assembly yet | 16:38 |
| kanzure | justanotheruser: what? | 16:38 |
| justanotheruser | what | 16:39 |
| kanzure | restate your question | 16:39 |
| juri_ | kanzure: understood. wish i could help, but not my skill area. | 16:39 |
| justanotheruser | What is the most practical synthesis of DNA for a printer? | 16:40 |
| kanzure | justanotheruser: phosphoramidite chemistry, http://diyhpl.us/wiki/dna/synthesis/notes/ | 16:40 |
| justanotheruser | so proposal 7 can be accomplished with an open source POSaM? | 16:44 |
| kanzure | those proposals are sort of outdated, but yes | 16:44 |
| kanzure | justanotheruser: http://www.ustream.tv/channel/overstockceo | 16:47 |
| juri_ | i heard various proposals on drop manipulation. do we have anything on checking a droplet for success? | 16:48 |
| kanzure | which particular step of quality control are you talking about? | 16:50 |
| juri_ | I don't have a good enough knowlege of the chemestry to know, honestly. | 16:54 |
| kanzure | truly this conversation couldn't get more vague | 16:54 |
| jrayhawk | so is byrne going to talk about how his technology works at any point, or... | 17:04 |
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| jrayhawk | oh christ why are the 720p streams so unstable | 17:06 |
| kanzure | jrayhawk: it's just counterparty/medici hooked up to fix and nasdaq. | 17:06 |
| jrayhawk | oh, that's less bad than i was expecting | 17:06 |
| jrayhawk | i was all worried it would be some awful ripple-like thing | 17:06 |
| justanotheruser | icbc | 17:08 |
| jrayhawk | Industrial and Commercial Bank of China, I guess? | 17:09 |
| justanotheruser | fun watching this speech next to the counter party price chart | 17:09 |
| justanotheruser | it's like a live tracker of how well his speech is going | 17:09 |
| jrayhawk | haha | 17:10 |
| kanzure | "ICBC is the Comcast of insurance companies" | 17:10 |
| justanotheruser | t0 | 17:11 |
| justanotheruser | leet encrypted url, anonymous digital wallet | 17:11 |
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| jrayhawk | i think i have a whole 0.1 XCP | 17:14 |
| jrayhawk | I'M RICH | 17:14 |
| jrayhawk | oops, nope, that's 0.1 mXCP | 17:15 |
| justanotheruser | tcpip and mount | 17:16 |
| jrayhawk | ah, but is it kernel space national science foundation, or userspace national science foundation | 17:16 |
| jrayhawk | huh, blockchain-agnosticism was a bit of a surprise | 17:17 |
| jrayhawk | but i guess "yeah, we'll support it, whatever, give us money" is a sensible way to go | 17:18 |
| kanzure | is it? all the blockchains are just copy-paste of bitcoin source code. | 17:18 |
| jrayhawk | with varying degrees of bad architectural decisions | 17:18 |
| c0rw1n | umm Namecin? | 17:18 |
| c0rw1n | yeah it's a copypaste but at least it does SOMEthing additional | 17:18 |
| kanzure | what about it? | 17:18 |
| kanzure | the interface is exactly the same | 17:19 |
| c0rw1n | yeah | 17:19 |
| justanotheruser | I think ledger agnostic means they will ride the blockchain buzz and use a trusted ledger | 17:21 |
| c0rw1n | trusted how? | 17:21 |
| c0rw1n | "trust us, we own the server" ? | 17:21 |
| c0rw1n | (singular) | 17:21 |
| justanotheruser | yes | 17:21 |
| jrayhawk | presumably whichever one best fulfills any given customer's conception of trust | 17:22 |
| justanotheruser | more specifically, trust us, we are overstock | 17:22 |
| jrayhawk | which is not any given one | 17:22 |
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| jrayhawk | http://blockscan.com/assetInfo/KANZURE so does this mean i own once percent of you, bryan | 17:23 |
| jrayhawk | s/once/one/ | 17:23 |
| justanotheruser | can we buy kanzure shares? | 17:24 |
| kanzure | "presumably whichever one best fulfills any given customer's conception of trust" | 17:24 |
| kanzure | justanotheruser: make me an offer | 17:24 |
| jrayhawk | i think i got a dividend in the form a silly hat once | 17:25 |
| justanotheruser | kanzure: $100 for 0.1% of yearly production | 17:25 |
| kanzure | that's the worst lowball in the history of forever | 17:25 |
| justanotheruser | heh | 17:25 |
| justanotheruser | too many ways you can abuse it, can't offer higher, sorry | 17:26 |
| kanzure | yes if i wanted to torpedo myself sure | 17:27 |
| justanotheruser | though, I will give you $100/year for every year that h+ related projects increase my lifespan | 17:27 |
| * justanotheruser prepares for permenant endebtment | 17:28 | |
| kanzure | i don't need $100 i need $100M | 17:28 |
| justanotheruser | good news is $100 will be nothing by the time I'm getting my life extended | 17:28 |
| c0rw1n | in capital, right. Over how many years ? | 17:28 |
| jrayhawk | don't worry, $100 gets half as valuable ever few decades | 17:28 |
| kanzure | c0rw1n: asap, it's useless to me later | 17:28 |
| justanotheruser | kanzure: what will you buy | 17:29 |
| c0rw1n | then sell a year of total output in 0.1% increments for $100 apiece, that's *exactly* what you need :p | 17:29 |
| kanzure | you mean besides the soul of freeman dyson? | 17:29 |
| kanzure | well i have a huge need for a few million mice | 17:30 |
| kanzure | so.. probably a few million mice. | 17:31 |
| justanotheruser | that it? | 17:31 |
| justanotheruser | why a few million? Why not a thousand and a ton of mice food | 17:31 |
| c0rw1n | ... acquire two mice and a ton of flour? | 17:31 |
| c0rw1n | yeah | 17:31 |
| kanzure | also i need more machine shop and more goons | 17:32 |
| kanzure | goons are expensive | 17:32 |
| justanotheruser | Why not get a few goons and a ton of goon food? | 17:34 |
| c0rw1n | too long to breed | 17:35 |
| c0rw1n | and train | 17:35 |
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| kanzure | good excuse | 17:49 |
| juri_ | I'm still training myself. functional programming breaks my brain. | 17:50 |
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| kanzure | "Second, a low incidence of the parasite in the cerebellum has been reported repeatedly (present study, [21,30,31]). The low level of infection might be caused by the cerebellar cytoarchitecture. The cerebellum features an extremely high cellular density, very small neurons and a low glia to neuron ratio [55,56]. Given that neurons are much less efficiently infected by T. gondii than are astrocytes, and that cerebellar granular neurons ... | 18:39 |
| kanzure | ... are still less efficiently infected in vitro than hippocampal neurons (for review, see [57]), it is tempting to speculate that a high proportion of small, tightly packed granular neurons constitutes a limiting factor for T. gondii zoites proliferation and subsequent cyst formation." | 18:39 |
| kanzure | yashgaroth: what sorta flush/kill mechanism could be used? i think inserting just 1000 microbes with no replication could work, until you find something that improves language acquisition. not sure. | 18:41 |
| c0rw1n | ... antibiotics? | 18:42 |
| kanzure | well you don't want to kill all your bacteria | 18:43 |
| c0rw1n | true, but most of them replicate | 18:43 |
| yashgaroth | to flush the toxo out of the organism/brain? antibiotics won't travel past the BBB, and they don't have apoptotic pathways so no luck there...maybe a very tightly regulated porin to lyse them | 18:43 |
| c0rw1n | how is toxo cured then | 18:44 |
| yashgaroth | heh | 18:44 |
| c0rw1n | ( inb4 "community, niceness and civilization" : not *that* toxoplasma ) | 18:45 |
| kanzure | no you're thinking of neurosyphilis | 18:45 |
| yashgaroth | oh hmm apparently sulfadiazine gets into the brain, good to know | 18:45 |
| yashgaroth | only a bacteriostatic though | 18:47 |
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| kanzure | perhaps they could age and die on their own | 19:03 |
| kanzure | although there's no guarantee that their effects wont be permanently damaging anyway, so i'm not sure it's important to be able to flush them | 19:03 |
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| mgin | risk of getting arrested for banging an "escort"? | 19:52 |
| c0rw1n | if you're done ? zero | 19:53 |
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| kanzure | what about a diet that the microbes require, and then you stop eating the vitamin or something | 20:54 |
| c0rw1n | oooh good idea | 20:55 |
| yashgaroth | if you can find something they need, that we don't use, then maybe | 20:59 |
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| juul | what happened to paperbot? | 21:26 |
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| xtalmath | in which materials has superfluidity been observed? | 22:41 |
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| kanzure | juul: paperbot has lots of bugs at the moment and nobody has fixed it | 23:53 |
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| --- Log closed Wed Aug 05 00:00:31 2015 | ||
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