--- Log opened Tue Sep 29 00:00:42 2015 | ||
-!- FourFire [~FourFire@185.7.192.138] has joined ##hplusroadmap | 00:19 | |
-!- FourFire [~FourFire@185.7.192.138] has left ##hplusroadmap [] | 00:24 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 00:58 | |
-!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood] | 01:39 | |
-!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap | 01:39 | |
-!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood] | 01:45 | |
-!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap | 01:46 | |
-!- juri_ [~juri@vpn166.sdf.org] has quit [Ping timeout: 240 seconds] | 02:07 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Remote host closed the connection] | 02:22 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 02:22 | |
-!- CheckDavid [uid14990@gateway/web/irccloud.com/x-epoqhvkurvypvbaq] has joined ##hplusroadmap | 02:33 | |
-!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-ubvrefoxpwolunty] has joined ##hplusroadmap | 02:42 | |
-!- fleshtheworld- [~fleshthew@2602:306:cf0f:4c20:3cf5:ccc3:ad27:f328] has joined ##hplusroadmap | 02:44 | |
-!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:3cf5:ccc3:ad27:f328] has quit [Disconnected by services] | 02:44 | |
-!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has quit [Ping timeout: 240 seconds] | 02:50 | |
-!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has joined ##hplusroadmap | 02:52 | |
-!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 03:09 | |
-!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has quit [Read error: Connection reset by peer] | 03:10 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 244 seconds] | 03:10 | |
-!- poppingtonic1 is now known as poppingtonic | 03:10 | |
-!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Quit: the neuronal action potential is an electrical manipulation of reversible abrupt phase changes in the lipid bilayer] | 03:11 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 264 seconds] | 03:34 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 03:40 | |
kanzure | beep | 04:21 |
---|---|---|
-!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood] | 04:26 | |
fenn | it's kind of embarrassing reading the backlog in #linuxcnc where justanotheruser doesn't have any clue what makes a good machine tool | 04:28 |
-!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap | 04:29 | |
fenn | i've been holding the hand of someone who acquired a used shapeoko as he fixes it | 04:32 |
fenn | the ways are aluminum so you can't use anything harder than aluminum for the wheels, which means the wheels are made of plastic and wear quickly, thus losing even the semblance of accuracy it had from the original bolting-together | 04:33 |
fenn | the whole shapeoko design is bad, and i'm willing to break down exactly why it sucks, if anyone cares | 04:34 |
fenn | but please stop trying to make "a cnc" out of extruded aluminum | 04:38 |
fenn | this looks like about the right way to do it: | 04:59 |
fenn | .title http:youtu.be/ZhICrb0Tbn4 | 04:59 |
yoleaux | fenn: Sorry, that command (.title) crashed. | 04:59 |
fenn | .title http://youtu.be/ZhICrb0Tbn4 | 04:59 |
yoleaux | Hobbing (Gear cutting) on a Mini-Mill with EMC2 - YouTube | 04:59 |
fenn | you can also make an angled rotary axis to fit on a lathe toolpost, it doesn't even need a motor in many cases, just the action of the hob will spin the gear blank | 05:00 |
kanzure | i believe he was interested in reasons why it was bad, or obviously-better alternatives | 05:12 |
kanzure | (frankly i'm just proud he's even bothering) | 05:13 |
kanzure | peer pressure works! | 05:13 |
fenn | well machining is a specialized industrial craft and gear making is even more specialized subset of that | 05:14 |
fenn | just the gear cutting nomenclature takes a while to learn | 05:14 |
fenn | and at the end of the day, you can just buy gears | 05:15 |
fenn | i do think it's worth making your own timing pulleys, those things are way overpriced for what they are | 05:16 |
kanzure | http://finder.nhipulleys.com/ | 05:18 |
fenn | those are not timing pulleys | 05:20 |
kanzure | agreed. | 05:21 |
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] | 05:21 | |
-!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 05:28 | |
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] | 05:43 | |
-!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 05:46 | |
-!- fleshtheworld- [~fleshthew@2602:306:cf0f:4c20:3cf5:ccc3:ad27:f328] has quit [Read error: Connection reset by peer] | 05:49 | |
-!- zadock [~outsider@cthulhu.tuiasi.ro] has joined ##hplusroadmap | 06:08 | |
-!- zadock [~outsider@cthulhu.tuiasi.ro] has quit [Remote host closed the connection] | 06:09 | |
kanzure | "SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate" http://www.cell.com/cell/abstract/S0092-8674(14)01583-9 | 06:09 |
kanzure | for artificial uterus reproduction, should select for embryos that are able to survive the artificial uterus (and somewhat iterating on the device too), instead of only pandering to all of the requirements of currently-available embryos and their current genetic program. | 06:17 |
kanzure | 06:19 < Betawolf> no, wait, you could just freeze a load of them and introduce them to your tweaked uterus | 06:20 |
kanzure | 06:20 < kanzure> perhaps- but embryos themselves might have guards against "oops i am in a womb with 20 other embryos, none of us will survive, abort abort" | 06:20 |
-!- eudoxia [~eudoxia@r167-57-74-100.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 06:30 | |
-!- CheckDavid [uid14990@gateway/web/irccloud.com/x-epoqhvkurvypvbaq] has quit [Quit: Connection closed for inactivity] | 06:36 | |
kanzure | machinist bitcoiner we should stalk: https://www.reddit.com/user/SadieD | 06:37 |
kanzure | re: artificial womb plans above; nutrient problems will be catastrophic, so each stage of growth should be validated by comparing against typical in utero growth results. any deviations should be carefully tracked because otherwise you may end up with brain damage. | 06:41 |
-!- Madplatypus [uid19957@gateway/web/irccloud.com/x-iklkfeyijbmfbmta] has quit [Quit: Connection closed for inactivity] | 06:41 | |
kanzure | (and it's harder to do selection for embryos that don't end up with brain damage, because the brain damage is only noticeable near the later stages, so the timeline is extended and selection frequency has to go down) | 06:42 |
kanzure | not sure how to deal with placenta substitute | 06:43 |
Betawolf | is there a reason you're not just growing a uterus first? | 06:45 |
fenn | grow a pair | 06:45 |
kanzure | growing a uterus is hard | 06:45 |
kanzure | and afaik we can't currently do that | 06:46 |
Betawolf | engineering one might be harder, you have to manage all the hormone controls and the bits which assume there's a larger bloodstream to manipulate a host through | 06:46 |
kanzure | i believe we already have working embryo development up to some number of days (more than one day of development), so selection could continue from that point | 06:47 |
kanzure | but i see your point; would probably be easier to start with some non-human species too. | 06:47 |
Betawolf | legally, certainly | 06:48 |
Betawolf | also in terms of gestation length | 06:48 |
Betawolf | the fallback of mice would be fairly good there, and mice-human generalisability is probably well-studied | 06:49 |
kanzure | "A comparison of placental development and endocrine functions between the human and mouse model" http://humupd.oxfordjournals.org/content/9/6/531.full.pdf | 06:49 |
Betawolf | also, marketable -- an artificial mouse uterus could be valuable to other researchers by itself | 06:50 |
kanzure | that's not as useful | 06:50 |
Betawolf | I guess, mice are pretty cheap | 06:51 |
kanzure | better link http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.325.4526&rep=rep1&type=pdf | 06:51 |
Betawolf | but the ability to manipulate in-utero development with more precision would be good | 06:51 |
kanzure | ah so, in utero electroporation isn't enough for you? | 06:52 |
Betawolf | hadn't heard of that, looking it up, perhaps it negates the benefits here. | 06:56 |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Remote host closed the connection] | 07:02 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 07:03 | |
-!- drethelin [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has quit [Ping timeout: 264 seconds] | 07:07 | |
archels | "1st IEEE IROS Futurist Forum" | 07:20 |
archels | am I going to go to this tomorrow? | 07:20 |
archels | http://www.iros2015.org/index.php/program/futurist-forum | 07:20 |
maaku | why would you go to it? | 07:25 |
archels | well, I'm trying to pick the least boring talks to go to | 07:26 |
kanzure | epistemology stuff is sometimes fun, but "future of society and cognition" does not sound like an epistemology thing | 07:27 |
kanzure | "Reconstructed Brain Models for Virtual Bodies and Robots" talks about human brain project robotics platform thingy | 07:28 |
maaku | futurist events are places for peoplele hwo don't do anything to feel better about someone else doing the work :( | 07:28 |
maaku | the real question is who is going and whether it is worth going to corner them in the hallways | 07:29 |
kanzure | also the stuff under "2nd International Workshop on Aerial Open Source Robotics" looks interesting | 07:29 |
kanzure | https://ras.papercept.net/conferences/conferences/IROS15/program/IROS15_ProgramAtAGlanceWeb.html#mowsafternoon-22 | 07:29 |
kanzure | maybe "Real-Time Cognitive Computing for Service Robots" | 07:30 |
fenn | isn't "cognitive computing" an ibm trademark | 07:31 |
archels | that one's already in the past, I went for the Bremen University lab tours instead | 07:32 |
archels | definitely going to Gewaltig's plenary, but the other talks so far have kindof disappointed | 07:32 |
kanzure | "Unmanned Aerial Systems 1/2" or "Surgical Robots 1/2" or "Manipulation Planning and Control 1/2" or "Biologically-Inspired Robots 1/2" or "Joint/Mechanism Design" all look somewhat tolerable | 07:32 |
archels | there's lots of robot hardware here (pics later), but the control of it all is pretty shit | 07:33 |
archels | I think my expectations are too high | 07:33 |
kanzure | "wearable robots" | 07:34 |
kanzure | "Space Robotics and Automation" | 07:34 |
kanzure | "Actuation and Mechanism" | 07:34 |
kanzure | "Robotics in Construction" | 07:34 |
kanzure | "New Actuators" | 07:34 |
kanzure | "Bioinspired Underwater Robotics" | 07:35 |
kanzure | alright that's all i see | 07:35 |
archels | yeah had no idea underwater robotics was so big. But there's lots of money in it, obviously. | 07:36 |
fenn | it's a huge growth area | 07:37 |
archels | did you know there's a fibre-based underwater 100 Mbps network off the West coast of the states, hundreds of kilometres into the pacific? | 07:37 |
fenn | only 100Mbit? | 07:37 |
kanzure | new ed boyden stuff: http://syntheticneurobiology.org/publications | 07:38 |
cpopell4 | kanzure : biologically inspired unmanned aerial surgical robots | 07:39 |
archels | there are junction boxes at set intervals that the ROVs, tethered to the ship, plug the robots into that they're releasing | 07:39 |
kanzure | "Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery" http://syntheticneurobiology.org/publications/publicationdetail/238/25 | 07:40 |
kanzure | oops bad link, i mean http://syntheticneurobiology.org/PDFs/15.05.bernstein.FULL.pdf | 07:40 |
kanzure | "Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance" http://syntheticneurobiology.org/PDFs/15.03.madisen.FULL.pdf | 07:40 |
kanzure | "Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory" http://syntheticneurobiology.org/PDFs/15.07.li.pdf | 07:40 |
fenn | cpopell4: now you know what the harvard bee is for | 07:40 |
kanzure | "Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording" http://syntheticneurobiology.org/publications/publicationdetail/234/25 | 07:41 |
kanzure | gah i keep doing that | 07:41 |
kanzure | wanted http://syntheticneurobiology.org/PDFs/15.02.scholvin.pdf | 07:41 |
kanzure | "A direct-to-drive neural data acquisition system" http://syntheticneurobiology.org/PDFs/15.09.kinney.pdf | 07:41 |
kanzure | man.. what. how is that novel? that's so sad. we literally haven't had people dumping data from an ADC straight to storage? | 07:42 |
archels | bandwidth becomes a bit restrictive with the new ~10^3 contact site probes | 07:44 |
kanzure | http://syntheticneurobiology.org/PDFs/15.05.guo.FULL.pdf "Cell-type specific expression is trivial to realize in laboratory animals, where Cre-loxP transgenic recombination systems used in conjunction with Cre-dependent viruses ensure that transcription of viral constructs are limited to the cell | 07:44 |
kanzure | type of interest[52]" | 07:44 |
kanzure | [52] Madisen, L. et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing, Nature Neuroscience 15, 793–802 (2012) | 07:45 |
archels | people messing around with PCI cards and so | 07:45 |
archels | after they come to the realisation that USB is too slow | 07:45 |
kanzure | [53] Dittgen, T. et al. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc. Natl. Acad. Sci. USA 101, 18206–18211 (2004). | 07:45 |
justanotheruser | fenn: sorry to disappoint | 07:58 |
fenn | it's always surprising to find that people don't think the way you do | 08:01 |
fenn | we don't have enough spare brain matter to simulate an entirely alien way of thought so it just loops back onto your normal mental process with some footnotes attached | 08:02 |
justanotheruser | I have zero experience with machining | 08:05 |
justanotheruser | let me take that back, I watched someone cut some metal for me once | 08:05 |
justanotheruser | horizontally, no fancy shapes | 08:05 |
fenn | if you are interested in learning, the standard advice is to take a course at a night school or vocational college | 08:06 |
kanzure | bring candy to the resident machinists employed by your university | 08:06 |
kanzure | or pizza | 08:06 |
kanzure | pizza is less weird | 08:06 |
fenn | show up in a white van with lots of blankets in the back? (so the scrap metal doesn't scratch up the interior you pervs) | 08:07 |
maaku | yeah actually taking a basic machine shop class is pretty enlightening | 08:07 |
maaku | and relatively cheap at a community college, vocational school, or tech shop | 08:08 |
fenn | tech shop won't teach you the theory and practice | 08:08 |
justanotheruser | Does a standard class teach hobbing, milling, routing, and all the other important stuff? | 08:08 |
kanzure | university's machine shop probably does free training | 08:08 |
fenn | probably not hobbing or routing | 08:08 |
justanotheruser | mhm | 08:08 |
kanzure | will be found below the mechanical engineering building | 08:08 |
fenn | there is a whole crapton of knowledge beyond basic safety training | 08:08 |
fenn | it's not something you master in a weekend (or a lifetime) | 08:09 |
justanotheruser | no machining or milling related club | 08:09 |
justanotheruser | we have a 3d printing club | 08:09 |
justanotheruser | perhaps night school is the best option | 08:09 |
maaku | justanotheruser: wouldn't expect there to be a club | 08:09 |
maaku | as kanzure says, looks to the mechanical engineering dept | 08:10 |
fenn | physics building sometimes has a shop but you probably need to be a grad student to use it | 08:10 |
justanotheruser | We have one in our research park, looking into training | 08:10 |
justanotheruser | nah, it looks like they just do work | 08:10 |
justanotheruser | I'll see if the mechanical engineering dept has one | 08:11 |
fenn | anyway just poking your nose in and looking around will give you an idea of what works and what doesn't work | 08:11 |
justanotheruser | check out this retro page https://engineering.purdue.edu/MECL/pshop/ | 08:11 |
fenn | you won't see any 80/20 extrusions doing metal removal | 08:11 |
kanzure | looks about right | 08:11 |
fenn | i have those black dial calipers on my desk 4 inches from the keyboard | 08:12 |
justanotheruser | I'll talk to some vocational school instead | 08:17 |
fenn | https://engineering.purdue.edu/MECL/pshop/tour/shop4.jpg | 08:20 |
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 08:21 | |
fenn | looks like a pretty well equipped teaching shop, you'd be spoiled after that | 08:24 |
-!- eudoxia_ [~eudoxia@r167-56-136-245.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap | 08:40 | |
-!- eudoxia_ [~eudoxia@r167-56-136-245.dialup.adsl.anteldata.net.uy] has quit [Remote host closed the connection] | 08:40 | |
-!- eudoxia [~eudoxia@r167-57-74-100.dialup.adsl.anteldata.net.uy] has quit [Read error: Connection reset by peer] | 08:40 | |
kanzure | 08:41 <@gwern> Burninate: I looked at it but the whole area of willpower is very confusing right now | 08:42 |
kanzure | 08:41 <@gwern> ever since kurzban's big review pretty much demolishing it | 08:42 |
kanzure | good | 08:42 |
fenn | link? | 08:42 |
kanzure | maybe this one: http://slatestarcodex.com/2015/03/12/book-review-willpower/ | 08:43 |
kanzure | or maybe http://epjournal.net/blog/2011/08/glucose-is-not-willpower-fuel/ | 08:43 |
fenn | no | 08:43 |
fenn | maybe | 08:43 |
kanzure | maybe http://lesswrong.com/lw/jan/kurzban_et_al_on_opportunity_cost_models_of/ | 08:43 |
fenn | "the fact that the brain is an information-processing system" uh huh | 08:45 |
fenn | sure it is | 08:45 |
fenn | and so is my pet rock | 08:45 |
kanzure | even a rock has information processing capacity, but it might be only one bit or something | 08:45 |
fenn | it computes being a rock | 08:46 |
Burninate | That was from https://www.reddit.com/r/science/comments/3mtp80/selfcontrol_saps_memory_resources_new_research/ | 08:46 |
kanzure | "it computes being a rock" i think this is why you're not a scientist | 08:46 |
archels | .wik Kidnapped robot problem | 08:47 |
yoleaux | "In robotics, the kidnapped robot problem commonly refers to a situation where an autonomous robot in operation is carried to an arbitrary location." — https://en.wikipedia.org/wiki/Kidnapped_robot_problem | 08:47 |
fenn | kanzure: it's somewhat tongue in cheeck, the MIT CBA people look at the world that way | 08:48 |
fenn | i get pissy when people think the brain is a {watch, computer, $machine_of_the_day} | 08:48 |
archels | $metaphorOfTheDay | 08:49 |
kanzure | yes yes, i know. it was funny. | 08:49 |
archels | the brain is a switchboard! | 08:49 |
fenn | a tank of water! | 08:50 |
fenn | oh wait that was a battery | 08:50 |
archels | thet brain is a battery! It generates potentials! | 08:50 |
fenn | hey let's hook up the human race to pods and use them to generate electricity | 08:51 |
fenn | it'll be the least efficient lulz generator ever | 08:51 |
archels | dude, there are lots of robots around me now staring back at me. stop freaking me out | 08:51 |
kanzure | don't worry, they are busy being preoccupied with the existential horror of their existence | 08:52 |
archels | ah, that must be why they invariably seem so stricken with ennui | 08:52 |
fenn | i wonder if anyone has looked at waste-accumulation as the "resource" that is being "depleted" | 08:59 |
kanzure | there was someone that looked at waste removal/cleanup and sleep | 08:59 |
fenn | yes | 08:59 |
archels | sounds Aubrey de Grey-ish | 09:01 |
archels | or did you mean on the shorter term | 09:01 |
kanzure | nope wasn't him | 09:01 |
archels | there was the whole CSF and intracellular spacing thing | 09:01 |
kanzure | .title http://www.sciencemag.org/content/342/6156/373 | 09:02 |
yoleaux | Sleep Drives Metabolite Clearance from the Adult Brain | 09:02 |
kanzure | there was also another one that was about waste-specific physical pathways for draining or something. not sure. | 09:02 |
-!- CheckDavid [uid14990@gateway/web/irccloud.com/x-kjezprzmqdmizflg] has joined ##hplusroadmap | 09:03 | |
archels | yeah that's the one | 09:03 |
-!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-ubvrefoxpwolunty] has quit [Quit: Connection closed for inactivity] | 09:33 | |
fenn | i'm mildly disappointed that kurzban wasn't the handle of someone who hated kurzweil | 09:33 |
-!- QuadIngi [~FourFire@185.7.192.138] has joined ##hplusroadmap | 09:34 | |
kanzure | kurzwreked | 09:38 |
fenn | "Remarkably, given that fatigue has been studied formally for well over 100 years, there is still no scientifically mature theory of its origins and functions." | 09:40 |
* fenn remarks | 09:41 | |
-!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 09:43 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 272 seconds] | 09:44 | |
-!- poppingtonic1 is now known as poppingtonic | 09:44 | |
maaku | fenn: meaning mental fatigue? | 09:53 |
fenn | yes | 09:54 |
kanzure | mental whatnow? :-) | 09:56 |
fenn | that thing that happens when you stop taking adderall | 09:58 |
-!- Daeken [~daeken@demoseen.com] has quit [Quit: Lost terminal] | 09:59 | |
fenn | one day i realized that the reason it seemed like i never got anything done was because everyone else was cheating and drinking coffee | 09:59 |
-!- Daeken [~daeken@demoseen.com] has joined ##hplusroadmap | 09:59 | |
kanzure | or because they are lying; try tracking what they claim to have accomplished versus actual results. | 10:00 |
* fenn clears some brain metabolites | 10:04 | |
kanzure | .title http://www.nature.com/ncomms/2015/150915/ncomms9264/full/ncomms9264.html | 10:05 |
yoleaux | Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans : Nature Communications : Nature Publishing Group | 10:05 |
-!- drethelin [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has joined ##hplusroadmap | 10:05 | |
-!- vivi2 [~vivi@inhu.me] has quit [Read error: Connection reset by peer] | 10:24 | |
-!- vivi2 [~vivi@inhu.me] has joined ##hplusroadmap | 10:24 | |
-!- omanomanooer [~omanomano@unaffiliated/omanomanooer] has joined ##hplusroadmap | 10:43 | |
-!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 11:02 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 264 seconds] | 11:03 | |
-!- poppingtonic1 is now known as poppingtonic | 11:03 | |
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] | 11:15 | |
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap | 11:16 | |
-!- marchtemp [~bitnami@ec2-54-69-125-142.us-west-2.compute.amazonaws.com] has left ##hplusroadmap ["WeeChat 0.4.2"] | 11:47 | |
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] | 11:49 | |
-!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 11:57 | |
-!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap | 12:06 | |
-!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 250 seconds] | 12:08 | |
-!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] | 12:10 | |
-!- QuadIngi [~FourFire@185.7.192.138] has quit [Ping timeout: 255 seconds] | 12:28 | |
kanzure | cathal posting about libgen stuff https://www.reddit.com/r/Scholar/comments/3bs1rm/meta_the_libgenscihub_thread_howtos_updates_and/cu5oebb | 12:28 |
kanzure | maaku: quite sneaky of you https://www.reddit.com/r/Transhuman/comments/3l59ou/opportunities_to_further_the_goals_of/ | 12:32 |
cpopell4 | maaku if you're ex-nasa, are you MD based? | 12:37 |
-!- math3 [uid54897@gateway/web/irccloud.com/x-nbmlxhhwphjjhzcr] has joined ##hplusroadmap | 12:38 | |
-!- justanotheruser [~Justan@unaffiliated/justanotheruser] has quit [Read error: Connection reset by peer] | 12:38 | |
-!- justanotheruser [~Justan@unaffiliated/justanotheruser] has joined ##hplusroadmap | 12:40 | |
kanzure | can't find this in the logs, not sure if i've mentioned this, but kent kemmish had an idea about doing one-pot large batch selection of dna polymerase for responsiveness to electrical conduction somehow. i don't remember the exact details of the technique, but it didn't require emulsions for some reason. | 12:40 |
-!- archels_ [charl@toad.stack.nl] has joined ##hplusroadmap | 12:42 | |
-!- archels [charl@toad.stack.nl] has quit [Ping timeout: 264 seconds] | 12:44 | |
kanzure | crispr-cpf1 http://www.cell.com/cell/abstract/S0092-8674(15)01200-3 | 12:46 |
kanzure | .title | 12:46 |
yoleaux | kanzure: Sorry, that doesn't appear to be an HTML page. | 12:46 |
kanzure | "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System" | 12:47 |
kanzure | "Cpf1 is a CRISPR-associated two-component RNA-programmable DNA nuclease; Targeted DNA is cleaved as a 5-nt staggered cut distal to a 5′ T-rich PAM; Two Cpf1 orthologs exhibit robust nuclease activity in human cells" | 12:47 |
-!- FourFire [~FourFire@19-68-11.connect.netcom.no] has joined ##hplusroadmap | 13:04 | |
-!- HEx1 [~HEx@hexwab.plus.com] has quit [Ping timeout: 240 seconds] | 13:09 | |
-!- c0rw|zZz [~c0rw1n@91.176.79.56] has quit [Ping timeout: 246 seconds] | 13:11 | |
-!- Madplatypus [uid19957@gateway/web/irccloud.com/x-bvqardjnftwvvdgr] has joined ##hplusroadmap | 13:18 | |
-!- HEx [~HEx@hexwab.plus.com] has joined ##hplusroadmap | 13:22 | |
-!- HEx is now known as Guest45818 | 13:23 | |
-!- FourFire [~FourFire@19-68-11.connect.netcom.no] has left ##hplusroadmap ["Leaving"] | 13:28 | |
-!- sandeepkr [~sandeepkr@111.235.64.135] has quit [Ping timeout: 250 seconds] | 13:44 | |
-!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:f9c7:d289:1342:6f32] has joined ##hplusroadmap | 13:46 | |
maaku | cpopell4: california. nasa ames | 14:19 |
maaku | kanzure: it just happened to be the convenient truth | 14:19 |
cpopell4 | maaku : ahh, k. My GF is at JHUAPL | 14:19 |
maaku | cpopell4: ah that's a cool place to work | 14:25 |
maaku | i interfaced with a bunch of people over ther | 14:25 |
cpopell4 | maaku : yeah, though she's moving to private enterprise next year | 14:27 |
kanzure | "If/since some/most experiments show no benefit from youthful plasma/blood exchange, then I hypothesize that in heterochronic parabiosis, what is happening is that the young mouse's entire organism/systems (Not its unmodified young blood) are responding to the old mouse's biomarkers carried into the young mouse via the aged mouse blood. These Old markers are interpreted as (for instance) injury and anomalous characteristics by the young ... | 14:35 |
kanzure | ... mouse's systems that are no longer considered anomalous by the old mouse's systems. If this hypothesis has merit, it predicts that simple plasma or whole blood exchanges will NOT induce reversal of aging. I believe this experiment has already happened and has been falsified via chronic blood transfusions in (for instance) early dialysis patients and others who have had to have multiple transfusuons. Statistically, many of such ... | 14:36 |
-!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap | 14:36 | |
kanzure | ... individuals should have benefitted from a lucky coin flipping outcome, and thus experienced significant benefits. If true, this implies that Aging to a significant degree appears to be based on a countdown clocking system that may be very widely distributed in an organism. In other words, aging is a program." | 14:36 |
-!- erasmus [~esb@unaffiliated/erasmus] has quit [Max SendQ exceeded] | 14:36 | |
maaku | kanzure: unfortunately StealerofSuns needs a bouncer. he showed up here a few days ago and then disappeared | 14:37 |
-!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap | 14:38 | |
-!- erasmus [~esb@unaffiliated/erasmus] has quit [Read error: Connection reset by peer] | 14:39 | |
-!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap | 14:44 | |
-!- erasmus [~esb@unaffiliated/erasmus] has quit [Max SendQ exceeded] | 14:44 | |
-!- c0rw|zZz [~c0rw1n@91.176.79.56] has joined ##hplusroadmap | 14:44 | |
-!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap | 14:44 | |
-!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] | 15:22 | |
-!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has joined ##hplusroadmap | 15:32 | |
-!- c0rw|zZz is now known as c0rw1n | 15:40 | |
-!- omanomanooer [~omanomano@unaffiliated/omanomanooer] has quit [Remote host closed the connection] | 15:43 | |
maaku | kanzure: you got something against clifford wolf? | 15:45 |
kanzure | openscad | 15:46 |
maaku | ah | 15:48 |
kanzure | triangles everywhere | 15:48 |
kanzure | reinventing languages just for cad? weak | 15:48 |
kanzure | he has since moved on though | 15:49 |
maaku | I once looked down on complicated geometrical representations, since any 3d polymesh can be represented with triangles | 15:53 |
maaku | then i tried writing finite element analysis and getting consistent results | 15:53 |
kanzure | hard to express curves with just triangles | 15:53 |
maaku | oh well yeah you need some curve structure too. although just one will do | 15:54 |
kanzure | boolean operations on surface-surface intersections is ugh, and triangle representation leads to loss of quality | 15:54 |
kanzure | plus, as the size of your model increases, memory consumption balloons | 15:54 |
kanzure | (with triangle bag approach) | 15:54 |
kanzure | but anyway; none of this necessitates a custom new language integrated into an IDE or whatever. | 15:55 |
kanzure | maaku: have i complained about opencascade to you before? http://diyhpl.us/wiki/cad/opencascade/ | 15:56 |
-!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 255 seconds] | 15:56 | |
maaku | no not yet | 16:00 |
kanzure | opencascade is one of the few canonical example of open-source cad kernels (other than brlcad, which is written by the military) | 16:01 |
-!- yashgaroth [~ffffff@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap | 16:03 | |
kanzure | yashgaroth: how goes summer of freedom? | 16:06 |
yashgaroth | awaiting exit interview thursday morn | 16:06 |
yashgaroth | the urge to burn bridges is strong, but if I've learned anything about biotech, it's an very incestuous community | 16:07 |
-!- Guest45818 is now known as HEx1 | 16:10 | |
-!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has joined ##hplusroadmap | 16:19 | |
-!- Betawolf [~matthew@xn--bta-yla.net] has quit [Ping timeout: 256 seconds] | 16:23 | |
-!- abetusk [~abe@c-66-31-30-204.hsd1.ma.comcast.net] has quit [Ping timeout: 246 seconds] | 16:33 | |
-!- thundara_ [~thundara@jean.markov.codes] has quit [Ping timeout: 246 seconds] | 16:33 | |
-!- thundara [~thundara@jean.markov.codes] has joined ##hplusroadmap | 16:34 | |
-!- abetusk [~abe@c-66-31-30-204.hsd1.ma.comcast.net] has joined ##hplusroadmap | 16:34 | |
-!- abetusk is now known as Guest3589 | 16:34 | |
-!- Guest3589 is now known as abetusk | 17:28 | |
gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=28eda632 Bryan Bishop: transcript of mike walfish talk on snarks >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/a-wishlist-for-verifiable-computation/ | 17:37 |
-!- drewbot [~cinch@ec2-54-196-16-177.compute-1.amazonaws.com] has quit [Remote host closed the connection] | 17:48 | |
-!- drewbot [~cinch@ec2-54-81-165-74.compute-1.amazonaws.com] has joined ##hplusroadmap | 17:48 | |
-!- erasmus [~esb@unaffiliated/erasmus] has quit [Quit: Namaste] | 18:04 | |
-!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap | 18:10 | |
-!- erasmus [~esb@unaffiliated/erasmus] has quit [Quit: Namaste] | 18:23 | |
gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ac254d8e Bryan Bishop: transcript: eran tromer, snarks >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/snarks-and-their-practical-applications/ | 18:24 |
gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=9fd6306e Bryan Bishop: typofix: greg -> craig >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/a-wishlist-for-verifiable-computation/ | 18:25 |
-!- CheckDavid [uid14990@gateway/web/irccloud.com/x-kjezprzmqdmizflg] has quit [Quit: Connection closed for inactivity] | 18:26 | |
kanzure | http://selenianboondocks.com/2015/09/mars-surface-shielding-from-radiation/ | 18:38 |
-!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Remote host closed the connection] | 18:46 | |
-!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap | 18:46 | |
-!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Client Quit] | 18:47 | |
-!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap | 18:47 | |
-!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Client Quit] | 18:47 | |
-!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap | 18:47 | |
kanzure | http://garzikrants.blogspot.com/2015/09/decoupling-financial-indices-with.html | 19:10 |
kanzure | " Simple injections of young 'blood' were sufficient to increase neurogenesis in the brain of older animals - and that is impossible given your thesis as there's no involvement of the entire young animal in that. Also Saul Villeda showed that simple injections of eotaxin, a chemokine that accumulates with age, were enough to decreases neurogenesis in the brain. Now it would seem, if nothing else, that the injection experiments ... | 19:20 |
kanzure | ... necessarily show some 'positive' factors in young blood plasma (able to incite old neural precursors to become neurons) - as no dilution was involved, while the original Villeda experiments show that negative factors exist in the blood of old animals able to repress neurogenesis. And of course all the old tissue and organ transplantation experiments show that it's the old tissues that become rejuvenated by purely humoral factors, ... | 19:20 |
kanzure | ... there are no cellular inputs from the hosts." | 19:20 |
catern | brb injecting baby blood | 19:24 |
catern | will it work if i just drink it? | 19:25 |
kanzure | ask the priests | 19:25 |
yashgaroth | gotta mainline that shit | 19:30 |
JayDugger | I hear anointing, if done properly, also works. | 19:32 |
-!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap | 20:05 | |
-!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap | 20:21 | |
erasmus | justanotheruser is a convicted pedophile and has a record. | 20:34 |
justanotheruser | I thought you said you were going to use your botnet to harass me? this is too easy :( | 20:34 |
erasmus | it's known he likes little boys. | 20:34 |
erasmus | pedophile | 20:34 |
erasmus | you make me sick | 20:35 |
erasmus | you are as bad as bluelobster | 20:35 |
-!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has quit [Read error: Connection reset by peer] | 20:37 | |
erasmus | justanotherchild_offender. | 20:37 |
fenn | offend all the children! | 21:32 |
fenn | inject their young "blood"! | 21:32 |
fenn | heil kkkrist http://2.bp.blogspot.com/-6arA2h1sOSs/UdBHs3DC-II/AAAAAAAAGrs/1EN5LDA0mcY/s1600/IMG_0267.JPG | 21:34 |
-!- sandeepkr [~sandeepkr@111.235.64.135] has joined ##hplusroadmap | 21:40 | |
cpopell | hurrah, I understand the most basics of church numerals! | 21:46 |
mgin | what the fuck? | 21:50 |
-!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has quit [Ping timeout: 244 seconds] | 21:58 | |
-!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has joined ##hplusroadmap | 22:11 | |
fenn | "The inventor has been invited to the white house, got a job offer at facebook and twitter, will be admitted at stanford and is probably going to pass 2 million followers" <- any guesses as to what the invention was? | 22:13 |
Stskeeps | fenn: the exocortex says an electro-mechanical clock with liquid display :P | 22:16 |
-!- math3 [uid54897@gateway/web/irccloud.com/x-nbmlxhhwphjjhzcr] has quit [Quit: Connection closed for inactivity] | 22:30 | |
-!- yashgaroth [~ffffff@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] | 22:33 | |
-!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood] | 22:44 | |
-!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap | 22:51 | |
-!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-yhgakdcsjzfqhgfj] has joined ##hplusroadmap | 23:49 | |
--- Log closed Wed Sep 30 00:00:43 2015 |
Generated by irclog2html.py 2.15.0.dev0 by Marius Gedminas - find it at mg.pov.lt!