2015-10-03.log

--- Log opened Sat Oct 03 00:00:46 2015
JayDuggerYeah, well, if kanzure's going to speak, best he knows the audience.00:08
kanzurewell htat's okay it's not like we needed two stars in our system anyway00:14
kanzuredoesn't look like they have room00:14
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kanzurehis presidential campaign is more amusing than i anticipated http://www.transhumanistparty.org/ZoltanIstvan.html07:01
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CaptHindsightpresident Zoltan sounds great07:04
kanzureright?07:04
CaptHindsightwas picturing him in a silver suit or similar07:04
kanzureyou mean like http://i2.wp.com/www.timemachinego.com/linkmachinego/wordpress/wp-content/uploads/2009/08/neil-before-zod.jpg?resize=338%2C270 ?07:06
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CaptHindsighthttps://upload.wikimedia.org/wikipedia/commons/thumb/2/23/Day_the_Earth_Stood_Still,_1951_-_trailer.ogv/220px--Day_the_Earth_Stood_Still,_1951_-_trailer.ogv.jpg07:08
kanzureah, well that's the style these days, you know07:08
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justanotheruserthat page looks like its for a '96 election08:05
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kanzureyes well he's also a time traveler08:56
kanzure.title https://www.youtube.com/watch?v=NdSD07U5uBs09:05
yoleauxAlan Kay, 2015: Power of Simplicity - YouTube09:05
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kanzure.title http://arxiv.org/abs/1509.0717511:25
yoleaux[1509.07175] Exploration and Exploitation of Victorian Science in Darwin's Reading Notebooks11:25
kanzure"Darwin built his theory of natural selection in part by synthesizing disparate parts of Victorian science. When we analyze his extensively self-documented reading we find shifts, on multiple timescales, between choosing to remain with familiar topics and seeking cognitive surprise in novel fields. On the longest timescales, these shifts correlate with major intellectual epochs of his career, as detected by Bayesian epoch estimation. ...11:25
kanzure... When we compare Darwin's reading path with publication order of the same texts, we find Darwin more adventurous than the culture as a whole."11:25
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kanzure"Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector "12:59
kanzure"... we developed a single lentiviral system to express a Cas9 variant, a reporter gene and up to four sgRNAs from independent RNA polymerase III promoters that are incorporated into the vector by a convenient Golden Gate cloning method. Each sgRNA is efficiently expressed and can mediate multiplex gene editing and sustained transcriptional activation in immortalized and primary human cells...12:59
kanzurefrom http://nar.oxfordjournals.org/content/42/19/e14712:59
kanzure"Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells" http://nar.oxfordjournals.org/content/42/11/e8913:00
kanzure"Using cultured Drosophila melanogaster S2-cells and the phosphoglycerate kinase gene as a model, we reached targeted integration frequencies of up to 50% in drug-selected cell populations. Homology arms as short as 29 nt appended to the PCR primer resulted in detectable integration, slightly longer extensions are beneficial."13:00
kanzure"A high-resolution network model for global gene regulation in Mycobacterium tuberculosis" http://nar.oxfordjournals.org/content/42/18/1129113:02
kanzurei am still okay about meganucleases13:03
kanzure"A platform for rapid prototyping of synthetic gene networks in mammalian cells" http://nar.oxfordjournals.org/content/42/21/1344013:05
kanzure"We demonstrate the potential of this framework by assembling and integrating different functional mammalian regulatory networks including the largest gene circuit built and chromosomally integrated to date (6 transcription units, 27kb) encoding an inducible memory device. Using a library of 18 different circuits as a proof of concept, we also demonstrate that our method enables one-pot/single-flask chromosomal integration and screening ...13:05
kanzure... of circuit libraries"13:05
kanzurereview of discovery of endonucleases http://nar.oxfordjournals.org/content/42/1/313:06
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kanzurefenn: hexagons http://brtmr.de/index.html14:33
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justanotheruseris anything from cppcon other than bjarne and herbs talks worth watching?16:06
kanzurei haven't looked16:59
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kanzureopencascade/oce/occt scheduled chat on monday october 5 at 9pm UTC at https://gitter.im/tpaviot/oce17:26
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JayDugger[1509.07175] Exploration and Exploitation of Victorian Science in Darwin's Reading Notebooks[1509.07175] Exploration and Exploitation of Victorian Science in Darwin's Reading Notebooks22:18
JayDuggerThank you for the link.22:18
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mginhow do you stay motivated22:25
JayDuggerIn general?22:29
JayDuggerIn particular?22:29
mginare you confused by a simple fucking question22:30
JayDuggerGenerally, no. I think that question might connote many different things.22:32
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JayDuggerNo offense meant, but I don't even no if you meant it in any serious sense, or whether you made a sarcastic remark.22:32
JayDuggerExcuse me, s/no/know/22:33
JayDuggerAssuming the latter case, I find coffee helpful.22:36
mginrofl22:37
cpopellmgin : greed as a terminal value?22:40
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--- Log closed Sun Oct 04 00:00:47 2015

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