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| JayDugger | Good morning, everyone. | 04:17 |
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| kanzure | zoop doot | 06:11 |
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| chris_99 | nmz787, are you about per chance/ | 06:17 |
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| kanzure | thing that parses for file paths from stdin text, to skip having to remember a file path to type later i guess https://github.com/facebook/PathPicker | 06:55 |
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| kanzure | multi-user penetration testing IDE thing https://github.com/infobyte/faraday | 06:56 |
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| kanzure | hardware for automatic breaking of combination locks https://github.com/samyk/combobreaker (this seems like overkill) | 07:11 |
| chris_99 | why does it seem overkill? | 07:12 |
| FourFire | faster means better means you can do more | 07:16 |
| kanzure | quadcopter drone thing that hijacks other drones (the one that had insecure root on a private wireless network, i think) https://github.com/samyk/skyjack | 07:17 |
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| kanzure | "successfully grown healthy intestine atop a 3-D scaffold made of a substance used in surgical sutures; .. researchers report their laboratory-created intestine successfully regenerated gut tissue in the colons of dogs with missing gut lining" | 07:32 |
| kanzure | "Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals" http://www.futuremedicine.com/doi/abs/10.2217/rme.15.70 | 07:33 |
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| kanzure | .title https://www.reddit.com/r/Futurology/comments/3ncujs/bioviva_treats_first_patient_with_gene_therapy_to/ | 07:35 |
| yoleaux | BioViva Treats First Patient with Gene Therapy to Reverse Aging : Futurology | 07:35 |
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| kanzure | "Nikola Danaylov of Singularity Podcast did interview BioViva's CEO Liz Parrish last month" https://www.singularityweblog.com/bioviva-ceo-liz-parrish-on-gene-therapy/ | 07:35 |
| kanzure | ah this is a better summary, as usual https://www.fightaging.org/archives/2015/10/bioviva-moving-ahead-with-human-gene-therapy-for-telomerase-activation.php | 07:36 |
| kanzure | ok just telomerase activation stuff, sorta strange choice for them to go with for gene therapy but ok | 07:36 |
| kanzure | .wik artemisinin | 07:42 |
| yoleaux | "Artemisinin /ɑrtɨˈmɪsɨnɨn/, also known as qinghaosu (Chinese: 青蒿素), and its semi-synthetic derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. It was discovered by Tu Youyou, a Chinese scientist, who was awarded half of the 2015 Nobel Prize in Medicine for her discovery." — https://en.wikipedia.org/wiki/Artemisinin | 07:42 |
| kanzure | .wik ivermectin | 07:42 |
| yoleaux | "Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic drug in the avermectin family." — https://en.wikipedia.org/wiki/Ivermectin | 07:42 |
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| gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8290e98a Bryan Bishop: improve dna synthesis machine summary >> http://diyhpl.us/diyhpluswiki/dna/synthesis/notes/ | 08:07 |
| kanzure | conjugation and ligation steps are still big questionmar | 08:12 |
| kanzure | *questionmark | 08:12 |
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| -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | sponsored by lobsters everywhere, banned by the Federal Death Administration (5 times) | this channel is LOGGED: http://gnusha.org/logs | http://diyhpl.us/wiki | "ray kurzweil is a pessimist" - george church | 13:43 | |
| -!- Topic set by kanzure [~kanzure@unaffiliated/kanzure] [Wed May 20 12:46:25 2015] | 13:43 | |
| [Users ##hplusroadmap] | 13:43 | |
| [@nmz787 ] [ blueskin ] [ drethelin ] [ juri_ ] [ p4nd4 ] [ streety ] | 13:43 | |
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| [ andytoshi ] [ CaptHindsight] [ gnusha ] [ maaku_ ] [ redlegion ] [ TMA ] | 13:43 | |
| [ archels ] [ catern ] [ gnusha_ ] [ Madplatypus ] [ ryankarason ] [ vivi2 ] | 13:43 | |
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| delinquentme | LOLZ | 14:32 |
| delinquentme | kanzure, nmz787 yashgaroth figured out our orientation problem. | 14:32 |
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| delinquentme | juul, | 14:57 |
| delinquentme | any idea if theres an AFM or STM @ omni? | 14:57 |
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| kanzure | what was the orientation problem? | 15:00 |
| maaku | is there anyone working on reversible computing architectures? | 15:18 |
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| kanzure | .title https://www.fbi.gov/about-us/lab/biometric-analysis/codis/stds_testlabs | 15:23 |
| yoleaux | FBI — Standards for DNA Testing Labs | 15:23 |
| kanzure | fbi study of iontorrent's stuff http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757157/ | 15:23 |
| kanzure | from https://news.ycombinator.com/item?id=10366974 | 15:23 |
| kanzure | .title http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8356106&fileId=S1742360000000976 | 15:24 |
| yoleaux | Episteme - Epistemics for Forensics - Cambridge Journals Online | 15:24 |
| delinquentme | HOWDO: high fidelity long chain PCR | 15:25 |
| delinquentme | like gigabase length | 15:25 |
| delinquentme | someone suggested redux what venter did ... but that seems like a fucking pain in the ass | 15:26 |
| kanzure | in vitro compartmentalized directed evolution of polymerases that correctly replicate gigabase length dna | 15:26 |
| kanzure | but probably starting with shorter lengths | 15:26 |
| delinquentme | hahaha | 15:27 |
| delinquentme | thanks kana | 15:27 |
| delinquentme | kanzure, | 15:27 |
| kanzure | do most polymerases suck at really long dna? what's the limit? | 15:28 |
| kanzure | i mean they do 10 kbp/sec, they can't fall off after only 100 kbp..... | 15:28 |
| delinquentme | unsure but theres a thing as high fidelity tax polymerase | 15:28 |
| delinquentme | this is bad. | 15:30 |
| delinquentme | i already think I'm fucking god. | 15:30 |
| kanzure | if they do fall off after a few minutes, you could select for polymerases that stay attached for a few hours or days. but you would have to cycle between selecting for grip duration and also ability to actually polymerize, because otherwise you'll just get a dna binding enzyme. | 15:30 |
| kanzure | i don't think god appreciates your sexual advances | 15:30 |
| delinquentme | appreciation isn't part of it | 15:31 |
| delinquentme | it just happens | 15:31 |
| kanzure | not familiar with tax polymerase | 15:32 |
| delinquentme | http://www.hindawi.com/journals/mbi/2014/287430/ | 15:32 |
| kanzure | .title | 15:33 |
| yoleaux | kanzure: Sorry, that doesn't appear to be an HTML page. | 15:33 |
| kanzure | "Error Rate Comparison during Polymerase Chain Reaction by DNA Polymerase" | 15:33 |
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| delinquentme | just the thought that i can build these tools ... | 15:44 |
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| delinquentme | i kinda can't wipe this smile off my face | 15:44 |
| delinquentme | http://www.hindawi.com/journals/mbi/2014/287430/tab1/ | 15:47 |
| delinquentme | "phusion hot start " enzyme supposed to be 50x fidelity of typical taq polymerase | 15:48 |
| yashgaroth | it sure is | 15:57 |
| yashgaroth | p.s. 15–30 seconds/kb | 15:58 |
| delinquentme | yashgaroth, so far so good btw ... nobody has come up w a counter to my hypothesis that ligase is non-magical | 15:59 |
| delinquentme | so i've got an engineer friend of mine who's helping me build some STMs | 15:59 |
| delinquentme | we plan on making 5 | 15:59 |
| delinquentme | because they're fucking cheap ... and redundant prototypes are the best | 15:59 |
| delinquentme | plz place orders now | 16:00 |
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| kanzure | eh maybe i'll get in on some of that | 17:09 |
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| kanzure | .title http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2015108a.html | 17:50 |
| yoleaux | Molecular Psychiatry - A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence | 17:50 |
| kanzure | hrm "This observation is consistent with the hypothesis that rare functional alleles are more frequently detrimental than beneficial to intelligence." | 17:51 |
| kanzure | "If you want a concrete example of genetic limits, look at running in the olympics. ALL olympic sprinters have the "fast twitch" muscle gene." | 17:53 |
| kanzure | .title http://www.ncbi.nlm.nih.gov/pubmed/23644052 | 17:54 |
| yoleaux | Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. - PubMed - NCBI | 17:54 |
| kanzure | .wik glutamate-glutamine cycle | 18:03 |
| yoleaux | "In biochemistry, the glutamate-glutamine cycle is a sequence of events by which an adequate supply of the neurotransmitter glutamate is maintained in the central nervous system." — https://en.wikipedia.org/wiki/Glutamate-glutamine_cycle | 18:03 |
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| Jawmare | while I am at it, any paper request? | 18:53 |
| fenn | reminds me of the ACME corporation's "portable hole" from looney tunes http://www.extremetech.com/extreme/186229-its-like-staring-into-a-black-hole-worlds-darkest-material-will-be-used-to-make-very-stealthy-aircraft-better-telescopes | 19:26 |
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| kanzure | Jawmare: thanks for asking, but nothing in the queue at the moment | 19:58 |
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| kanzure | lake: hi | 22:13 |
| lake | kanzure: hi, was reading | 22:25 |
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| --- Log closed Sun Oct 11 00:00:53 2015 | ||
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