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kanzure | streety: for context, this was something lkke a million mice | 03:09 |
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drethelin | woah | 03:14 |
streety | at the moment I'm not seeing how this system of pipes and valves would be anything other than a massive over-complication. How do you route the cleaning to each pvc tube cage? A million mice is certainly a lot so the processes you would need will be different to a conventional animal housing facility but I think there is a simpler approach that what you are contemplating. | 04:35 |
streety | To house a million mice you probably need something less than 200 people, that's going to be the upper limit on the savings you could make with automation | 04:36 |
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JayDugger | Good morning. To house a million mice you need a million cats. Or one-tenth as many very hungry cats. | 06:45 |
kanzure | 200 people * $10/hour * 8 hours/day = $16k/day. this is equivalent to feeding cost of 5.8 million mice years. | 06:50 |
kanzure | wait, i mean, a year of... er. | 06:51 |
kanzure | a full year of employment at $16k/day could have otherwise paid for 5.8 million mice years for that year | 06:52 |
kanzure | wait, this sounds wrong. mouse feed is not $1/day. it's supposed to be much less. | 06:53 |
JayDugger | $1 per how many mice per day? | 06:58 |
kanzure | $1/mouse-food-day. but real cost is probably half or less. | 07:01 |
JayDugger | Do lab mice have expensive diets? They can have expensive pedigrees. | 07:03 |
JayDugger | Perhaps that $1/mouse-food-day makes sense. | 07:04 |
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fenn | labdiet 5001 rodent chow $40 for a 50lb bag | 08:19 |
fenn | "contains high concentrations of methylmercury and a mixture of inorganic and organic arsenic compounds at a concentration 36 times the EPA-recommended level for drinking water" great | 08:23 |
fenn | "In an ongoing longevity study involving 2,400 mice, measured feeding is ~9% of total costs" apparently measuring the amount of food eaten is expensive | 08:25 |
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kanzure | yeah things i have seen say about 3-4 grams/mouse day | 08:31 |
fenn | wikipedia says 150g food per kg body weight so for a 25g mouse (a large mouse) 4g of food per day, or $2.57 per mouse year | 08:31 |
kanzure | oh geeze i'm way off | 08:32 |
kanzure | prolly cheaper to buy/mix food too | 08:33 |
kanzure | i mean, cheaper than buying bagged branded crap | 08:33 |
fenn | i doubt it | 08:33 |
fenn | quora estimates the traditional cost to keep mice at "It's roughly a dollar a mouse a day. Perhaps half that if you don't need special caging. | 08:35 |
fenn | Divide by grad student stipend for the ratio. | 08:35 |
fenn | which is not encouraging as to the state of automation | 08:35 |
kanzure | afaik none of this is typically automated | 08:36 |
fenn | "When it comes to the price of mice, you pay more for defects. A mouse with arthritis runs close to $200; two pairs of epileptic mice can cost 10 times that." | 08:38 |
fenn | wow i'm in the wrong business | 08:38 |
kanzure | jax labs has somewhat of a monopoly | 08:38 |
kanzure | because researchers want to ensure they get the same strain | 08:38 |
kanzure | kung fury's time hacking scene is the greatest hacking scene of all time | 08:40 |
fenn | well this is a creative solution http://www.stuff.co.nz/auckland/73427243/Waikato-family-deliberately-stunts-disabled-daughters-growth | 08:56 |
poppingtonic | omg how did i not know about kung fury | 08:59 |
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kanzure | .title https://www.youtube.com/watch?v=KEkrWRHCDQU | 09:16 |
yoleaux | HACKERMAN'S HACKING TUTORIALS - How To Hack Time - YouTube | 09:16 |
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nmz787_i | ugh, I hate waking up | 09:36 |
nmz787_i | when are we curing sleep? | 09:36 |
nmz787_i | actually i hate going to sleep and waking up | 09:36 |
nmz787_i | I only recently realized I only 'like' waking up when I go to bed feeling so crappy (meaning it is super late), it is /relatively/ better feeling when I wake up | 09:37 |
fenn | maybe you should take melatonin and/or modafinil | 09:38 |
kanzure | probably easier to get lucid dreaming plus exoskeleton, rather than not sleeping at all | 09:38 |
fenn | because sleep-fucking the mailman is better when you have superhuman strength | 09:39 |
kanzure | are you a dog? | 09:39 |
fenn | when i dream | 09:39 |
fenn | maybe i'm just a werewolf | 09:39 |
fenn | it would explain a lot | 09:40 |
nmz787_i | is your mailman hot? | 09:40 |
fenn | it was just an example situation | 09:40 |
kanzure | i am usually at 100% when i wake up | 09:41 |
kanzure | other than needing a few moments for eye adjustment | 09:41 |
nmz787_i | I usually feel like I could puke | 09:41 |
nmz787_i | since I was a kid | 09:41 |
nmz787_i | mornings have always sucked ass | 09:41 |
kanzure | do you use an alarm? | 09:41 |
fenn | i noticed modafinil continues to work the next day so it's easier and faster to wake up | 09:42 |
nmz787_i | yeah, but even if I sleep through it (which is usual, the alarm is more for my partner to wake up) | 09:42 |
nmz787_i | also getting to sleep is always way more drawn out than I want... like a good 15-90 minutes of just laying in bed | 09:42 |
kanzure | one thing i've noticed is that i have fairly consistent mornings especially when i wake up for twenty or thirty minutes half-way through | 09:42 |
fenn | nausea is common symptom of low blood sugar or low blood pressure | 09:42 |
kanzure | although i do notice i had a typo this morning ("lkke"), oops | 09:43 |
nmz787_i | and sometimes I say fuck it and just get back up after an hour of waiting doing seemingly nothing (yeah yeah, my brain immune garbage pump is probably starting up) | 09:43 |
nmz787_i | I've tried melatonin, it seemed inneffective, though I last tried it maybe 10 years ago | 09:43 |
nmz787_i | benzodiazapenes work reliably, but I never thought it would be healthy to take a consistent regime including them | 09:44 |
nmz787_i | i feel like modafinil would affect my sleep, but I guess I don't really remember that being the case the few times I've tried it | 09:45 |
kanzure | ever gone to sleep study lab? | 09:45 |
kanzure | same question for fenn actually | 09:45 |
nmz787_i | i do remember reading that it usually doesn't mess with sleep, at least as compared to amphetamines | 09:45 |
fenn | no | 09:45 |
kanzure | fwiw my sleep does not seem impaired by large quantities of amphetamine | 09:45 |
kanzure | fenn: you should uh.. consider that. | 09:45 |
nmz787_i | hmm, I think when I was a kid they might have monitored me at night once, but I feel like they only listened to me, maybe for breathing issues? | 09:45 |
nmz787_i | kanzure: I actually stopped taking amphetamines in large part because I felt they were still too active at night (even if i'd taken them 12+ hours prior) and sleep was causing troubles with waking up and thus school, so I stopped taking them | 09:46 |
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nmz787_i | but who knows, since I still can't get to sleep 10 years later o | 09:47 |
pasky | i typically need ~1-2 *hours* to wake up :( no matter what sleep phase i wake up at, with redshift the night before, experimented a lot | 09:47 |
kanzure | nmz787_i: my results with amphetamine seem to be an outlier, so whatever | 09:47 |
nmz787_i | maybe they warped my brain since they started shoving the pills down my throat at like, age 6 | 09:47 |
kanzure | i sleep just fine on adderall. even naps. | 09:47 |
kanzure | well, naps make me feel terrible, but i'm capable of getting into a nap. | 09:48 |
maaku | anyone here tried polyphasic sleep? | 09:48 |
kanzure | of course | 09:49 |
kanzure | everyone tries that at some point | 09:49 |
nmz787_i | I don't think I ever really tried it | 09:50 |
nmz787_i | I guess I always must have internally scoffed 'how the hell will I get to sleep 10 times /more/ than I already do, when that already can take a long-ass time?' | 09:51 |
maaku | i haven't had a living situation that would let me try it | 09:51 |
maaku | but i'm curious to see if it worked for anyone else, or if it's another instance of someone trolling on the internet | 09:52 |
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Aurelius_Work2 | I didn't bother trying polyphasic | 09:54 |
kanzure | maaku: didn't have useful results for me. but i wasn't trying to find the important variables, either. | 10:00 |
fenn | biphasic (siesta/witching hour) is much more likely to work | 10:01 |
kanzure | this claims that knockout mice cost $100k/strain to generate, http://www.nih.gov/science/models/mouse/deltagenlexicon/NatureMedicine1105.pdf | 10:01 |
kanzure | but scienceexchange is selling 'em for like <$3500 | 10:01 |
kanzure | (new strains, even) | 10:01 |
kanzure | this article claims that some mouse knockout facilities demand royalties on downstream products or discoveries resulting from using their purpose-specific/knockout mouse strain. hah. | 10:02 |
fenn | how about "NO" | 10:03 |
maaku | fenn: biphasic is the natural state of human beings. quite a bit of knowledge about that | 10:03 |
fenn | everyone i know who has tried the uberman sleep schedule said it didn't work | 10:04 |
fenn | i have occasionally done an "eversion" where instead of rotation completely around 24 hours i shifted by 12 hours by increasing siesta sleep and decreasing normal sleep | 10:08 |
fenn | i haven't looked at the long term patterns around that move though | 10:08 |
kanzure | what you really need is a 10 hour "cryotherapy" nap | 10:10 |
fenn | too soon | 10:12 |
nmz787_i | there must be some way to have severly reduced mental capacity while staying awake and also getting the brain-cleanup stuff to happen | 10:25 |
nmz787_i | I could, for example, clean up code stylings that don't conform to PEP8... not hard, but can be tedious | 10:26 |
maaku | nmz787_i: it's called sleepwalking | 10:26 |
nmz787_i | more like sleep de-linting | 10:27 |
maaku | nmz787_i: no, i mean there is a clinical state of being active but mentally impaired while your brain de-toxes itself | 10:28 |
maaku | it's called sleepwalking, and there are drugs to induce it | 10:28 |
nmz787_i | hmm, what drugs? | 10:28 |
maaku | people do all sorts of things while 'sleepwalking' | 10:28 |
maaku | (often things they regret later) | 10:28 |
maaku | https://encrypted.google.com/#q=induced+sleepwalking | 10:29 |
nmz787_i | /me damn, I never should have wrote that code while sleepwalking | 10:29 |
maaku | more like damn, I shouldn't have had questionable sex while sleepwlaking | 10:29 |
nmz787_i | no results for "induced sleepwalking for profit" | 10:31 |
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nmz787_i | hmm, I'm not sure how to search for positive sleepwalking data/experiences. | 10:35 |
nmz787_i | 'sleepwalking for utility' etc, comes up with totally non-relevant links | 10:35 |
nmz787_i | unless that means that there is no utility in sleepwalking | 10:36 |
nmz787_i | or none that has heretofore been discovered | 10:36 |
kanzure | try "sleepwalking violence" | 10:36 |
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kanzure | or sleep eating | 10:38 |
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fenn | .wik dion mcgregor | 10:40 |
yoleaux | "Dion McGregor (1922–1994) was an American songwriter known for talking in his sleep. An LP of his dream diatribes – The Dream World Of Dion McGregor (He Talks In His Sleep) – was released to minor acclaim by Decca Records in 1964." — https://en.wikipedia.org/wiki/Dion_McGregor | 10:40 |
kanzure | .title https://www.youtube.com/watch?v=5X5av3mF1Hw | 10:40 |
yoleaux | Dion McGregor: The Mustard Battle - YouTube | 10:40 |
fenn | hmm i don't have that one | 10:41 |
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kanzure | .title https://www.youtube.com/watch?v=qxc1ZoG9MIo | 10:43 |
yoleaux | Dion McGregor: The Operation - YouTube | 10:43 |
fenn | they're not all so straightforward and logical | 10:44 |
kanzure | not sure i want transcripts of my dreams | 10:55 |
kanzure | but i'll be sure to hold on to a keyboard one of these nights | 10:56 |
kanzure | not sure how to stop myself from exiting vim though | 10:57 |
nmz787_i | need a burner device for the night | 11:03 |
nmz787_i | something that doesn't know your passwords and such | 11:03 |
kanzure | dream bryan might be an even better hacker than wakeful bryan, so i dunno if that would stop me | 11:05 |
nmz787_i | huh, this is neat https://github.com/mame/quine-relay | 11:11 |
nmz787_i | .wik quine(Computing) | 11:13 |
yoleaux | "A quine is a non-empty computer program which takes no input and produces a copy of its own source code as its only output. The standard terms for these programs in the computability theory and computer science literature are "self-replicating programs", "self-reproducing programs", and "self-copying programs"." — https://en.wikipedia.org/wiki/Quine_(computing) | 11:13 |
CaptHindsight | kanzure: is this really something new to this industry? http://datacenterfrontier.com/immersion-cooling-bitcoin/ | 11:13 |
nmz787_i | "Such an empty program, submitted as "the world's smallest self reproducing program", once won the "worst abuse of the rules" prize in the International Obfuscated C Code Contest." | 11:13 |
nmz787_i | heheh http://blog.dustinkirkland.com/2014/12/hollywood-technodrama.html | 11:23 |
nmz787_i | .title | 11:24 |
yoleaux | From the Canyon Edge: Hollywood Technodrama -- There's an App for that! | 11:24 |
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kanzure | CaptHindsight: nah, not new, but lots of the big mining operations moved to where geothermal energy made cooling more convenient and easy... | 11:42 |
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nmz787_i | hi chris_99 | 12:12 |
chris_99 | hey nmz787_i, how goes? | 12:12 |
nmz787_i | alright, found out yesterday OSHpark | 12:13 |
nmz787_i | OSHPark's fab didn't silkscreen my PCBs, so I am getting double | 12:14 |
nmz787_i | since the non-silk screened are electrically correct | 12:14 |
chris_99 | heh cool, what's the PCB for | 12:14 |
nmz787_i | photodiode with a MOSFET and some amplifiers... for xray detection eventually (hopefully) | 12:16 |
chris_99 | neat :) | 12:17 |
chris_99 | i think i've decided i'm gonna try and implement the logic for the clock generation for the ADC+CCD, in an FPGA, so i'm gonna try and learn VHDL or Verilog | 12:18 |
nmz787_i | you gonna try for a delta sigma ADC too? | 12:19 |
nmz787_i | idk how fast the system clock needs to be for that to get high enough rates | 12:20 |
nmz787_i | chris_99: have you heard of myhdl... it is a Python library that also features python to VHDL or verilog | 12:20 |
chris_99 | nope i haven't, i'd like to learn a hardware definition language though i think | 12:21 |
nmz787_i | there is a #myhdl room, and the guy cfelton even showed me some automagic-ification scripts to interact with the vendor compier tools, so I basically did nothing to get an LED to blink | 12:21 |
nmz787_i | chris_99: the thing is, Python is just as suitable as the other languages | 12:21 |
nmz787_i | the library just adds the appropriate decorators for HDL | 12:22 |
chris_99 | hmm, but python is really designed to be run on a processor | 12:22 |
nmz787_i | well HDL is also | 12:22 |
nmz787_i | neither are directly suitable for FPGA netlist synthesis | 12:22 |
nmz787_i | and not all HDL is synthesizable in general | 12:22 |
nmz787_i | a lot of HDL is just there so you can write a simulator for your hardware side of things | 12:23 |
chris_99 | i'm not sure what you mean, VHDL etc, are designed to enable synthesis to FPGA etc. | 12:25 |
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nmz787_i | that was the intent originally, but then programmers forgot how to use other languages (or were EEs and were never taught other languages) so they extended those HDLs to include non-synthesizable code/techniques... specifically to enable test-benches | 12:31 |
chris_99 | oh gotcha | 12:32 |
nmz787_i | fast forward 20-30 years and some FPGA programmer realized he could just add HDL features to python using decorators, and then wrote the simulator for the test-bench side of things, along with the Python to VHDL or Verilog converters | 12:32 |
nmz787_i | so you can write most stuff in Python, test it, simulate it... convert to VHDL or Verilog, add other VHDL/verilog, test simulate more if you like, or go straight to FPGA synthess | 12:33 |
chris_99 | interesting | 12:35 |
nmz787_i | they already had test code for my DE0-nano... so it was an easy experiment for me to try it out | 12:35 |
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nmz787_i | this was the automagifier that enabled the myhdl to also kickoff FPGA synthesis https://github.com/cfelton/rhea | 12:36 |
chris_99 | that was one fpga board i've looked at which looks pretty good | 12:36 |
nmz787_i | oh, huh, he seems to have removed the purely blinky LED example, but added some more complex (including the sdram example that was developed via a GSOC project) | 12:37 |
chris_99 | i was looking at http://www.wvshare.com/product/CoreEP4CE6.htm but i'm gonna try writing the code first using Quartus to check it would fit | 12:39 |
nmz787_i | chris_99: I think the main thing to look for in any FPGA board is probably a high purity oscillator | 12:41 |
nmz787_i | I'm not familiar enough with PLLs to know how much they can drift and such... I assume jitter is low, but I'm not sure about it, and then yeah drift can be another issue | 12:42 |
chris_99 | hmm you wouldn't need something like an OCXO though right, as that would seem a bit overkill | 12:42 |
nmz787_i | I was studying high purity clock generation a few years ago, but didn't get too invested in it | 12:43 |
nmz787_i | I remember seeing oscillators in the ppb range for purity | 12:43 |
nmz787_i | while most are in the ppm | 12:43 |
nmz787_i | 'cheap crystals' | 12:43 |
nmz787_i | chris_99: there's also the zynq | 12:44 |
nmz787_i | I think someone arduino-ized it | 12:44 |
chris_99 | yeah i've heard of them | 12:44 |
chris_99 | im assuming they're not cheap | 12:44 |
chris_99 | though | 12:44 |
nmz787_i | or I at least saw it on hackaday a few times recently | 12:44 |
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nmz787_i | chris_99: this is something to watch out for in the future, says $55 (when it is released) https://www.crowdsupply.com/krtkl/snickerdoodle | 12:55 |
chris_99 | neat | 12:56 |
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nmz787_i | $99 http://www.myirtech.com/list.asp?id=502 | 13:05 |
nmz787_i | huh, and that has 96 LVDS pairs... | 13:05 |
chris_99 | doesn't the parallella | 13:05 |
chris_99 | have a zynq | 13:05 |
chris_99 | onboard | 13:05 |
chris_99 | apparently it does | 13:06 |
nmz787_i | ah, that last one has at most 10% of the FPGA gates as the snickerdoodle | 13:07 |
nmz787_i | (i think) | 13:07 |
kanzure | .title https://news.ycombinator.com/item?id=10459894 | 13:07 |
yoleaux | FDA Inspectors Call Theranos Blood Vial ‘Uncleared Medical Device’ | Hacker News | 13:07 |
kanzure | http://www.fda.gov/ucm/groups/fdagov-public/@fdagov-afda-orgs/documents/document/ucm469395.pdf | 13:08 |
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lake_ | looking for rcommendable sites selling Piracetam and have found sites but am wanting quality.any suggestions? | 13:29 |
nmz787_i | 'The Librarian of Congress has granted security researchers and others the right to inspect and modify the software in their cars and other vehicles, despite protests from vehicle manufacturers. The Electronic Frontier Foundation (EFF) filed the request for software access as part of the complex, triennial rulemaking process that determines exemptions from Section 1201 of the Digital Millennium Copyright Act (DMCA).' | 13:29 |
nmz787_i | https://supporters.eff.org/civicrm/mailing/view?reset=1&id=1234 | 13:30 |
kanzure | lake_: maybe http://www.coinrx.com/ | 13:31 |
lake_ | ty | 13:31 |
kanzure | hm nevermind, they are dead | 13:31 |
lake_ | yep dead' | 13:31 |
nmz787_i | kanzure: what is the easiest way to send someone bitcoin? | 13:31 |
nmz787_i | (this week) | 13:31 |
nmz787_i | (easiest way this week) | 13:32 |
kanzure | a bitcoin transaction | 13:32 |
nmz787_i | :/ | 13:32 |
nmz787_i | I mean practically to do that | 13:32 |
kanzure | open up your bitcoin client, make a bitcoin transaction and send the transaction to the bitcoin network | 13:32 |
nmz787_i | Can I send them with a credit card? | 13:32 |
nmz787_i | ok, but what I am asking is what is the easiest way? | 13:33 |
nmz787_i | I don't have a bitcoin client | 13:33 |
nmz787_i | I don't know what exists | 13:33 |
kanzure | do you have any bitcoin? | 13:33 |
nmz787_i | you gave me 1 like 2 years ago | 13:33 |
nmz787_i | but I just have it written on some paper, or no, in a text file | 13:33 |
kanzure | you'll have to use a wallet like electrum, mycelium, coinbase.com, etc. | 13:33 |
nmz787_i | and I have no idea how to split it and send just a small chunk | 13:34 |
kanzure | you can use coinbase.com to buy bitcoin using a credit card after you upload your passport and sign a blood oath | 13:34 |
nmz787_i | ew | 13:34 |
kanzure | you want to use a wallet's "sweep" function to transfer it to a new address that the wallet controls | 13:34 |
nmz787_i | I wonder if paypal likes me again | 13:34 |
nmz787_i | and if they do bitcoin | 13:34 |
kanzure | or you can manually construct a bitcoin transaction (just make sure to send the remainder/change back to yourself, otherwise you will lose money) | 13:34 |
kanzure | paypal does not transfer bitcoin at the moment | 13:34 |
kanzure | electrum works reasonably well | 13:35 |
kanzure | coinbase.com for a paypal-like experience | 13:35 |
nmz787_i | hmm, electrum is a download thing? | 13:35 |
nmz787_i | hrmm | 13:36 |
nmz787_i | what about android apps? | 13:36 |
nmz787_i | do those exist in any secure fashion? | 13:36 |
nmz787_i | oh, I see some app called mycelium | 13:37 |
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lake_ | https://www.privateinternetaccess.com/blog/2012/04/how-to-buy-bitcoins-anonymously-in-the-us-instantly/ this might help, will look for others | 13:45 |
kanzure | there's generally no way to get instant bitcoin because of credit card chargeback risk (there's no chargebacks on the bitcoin network, so nobody is willing to risk that when selling you bitcoin) | 13:45 |
kanzure | which makes purse.io even more strange | 13:47 |
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kanzure | nmz787_i: coinbase.com is a web wallet and you can send by just typing an email address, then they do onboarding/signup for that new user. but web wallet has different security implications. degraded security in many cases. | 14:08 |
nmz787_i | someone told me to just use android bitcoin wallet and blockchain.info | 14:10 |
kanzure | don't use blockchain.info; their site displays wrong data, they frequently get things wrong, etc. | 14:11 |
kanzure | android bitcoin wallet i'm not sure about, you'll have to snoop around on the interwebs to check that one out | 14:11 |
nmz787_i | anyone here use this ? https://mosh.mit.edu/ | 14:32 |
nmz787_i | fenn: maybe? ^ | 14:32 |
kanzure | gmaxwell and maaku swear by mosh, but i seem to do pretty well with just ssh + tmux | 14:33 |
nmz787_i | someone is mentioning this in relation to mosh | 14:34 |
nmz787_i | "Note that mosh-client receives an AES session key as an environment variable. If you are porting Mosh to a new operating system, please make sure that a running process's environment variables are not readable by other users." | 14:34 |
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maaku | never used mosh, but heard good things about it | 15:14 |
maaku | i'm a dinosoar, i still use screen not tmux | 15:14 |
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fenn | mosh looks pretty useful | 16:32 |
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kanzure | links from #lesswrong logs http://hvgrx.net/lwlinkscount.txt | 17:58 |
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catern | M-x sort-numeric-fields | 19:28 |
catern | handy | 19:28 |
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nmz787_i | kanzure: did you see this ? http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137652 | 20:03 |
nmz787_i | .title | 20:03 |
yoleaux | PLOS ONE: AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach | 20:03 |
kanzure | nope | 20:07 |
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lake_ | http://peerproduction.net/wp-content/uploads/2014/11/JoPP_Peer-book.pdf | 21:37 |
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lake_ | http://www.oreilly.com/biocoder/?intcmp=il-na-free-lp-intsrch_biocoder_ct | 21:47 |
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--- Log closed Wed Oct 28 00:00:09 2015 |
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