2015-12-17.log

--- Log opened Thu Dec 17 00:00:39 2015
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AlcyiusI hate gbeing sick00:17
AlcyiusI just slept through wednesday00:17
FourFireHey regarding a book with enough information to reconstruct modern technological civilization with few surviving individuals, I think that would involve a rather large research project about tech trees, and I am somewhat doubtful that all such knowledge currently exists digitially anyway00:37
FourFirestuff like > How to turn the kind of rock that looks like [this] into RAM00:37
FourFireGreetings aurellem !00:46
AlcyiusThat seems like it'd be a massive project00:46
AlcyiusIsn't there a library of forever project trying to do that though?00:46
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FourFireAlcyius, key is to only preserve that imformation which is required for the readers of the book to infer/ quickly discover the rest03:17
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AlcyiusIn that case, I'd give priority to advance farming techniques03:25
AlcyiusFollowed by how to set up an industrial base and the beginnings of electronics03:25
AlcyiusWE achieved in 300 years more than in the past 3000 once the agricultural revolution hit03:25
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ebowdenHow do you invite people?03:31
ebowden(I want to invite my brother.)03:31
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ebowdenOh, derp.03:40
ebowdenIt was a different channel that required invites.03:41
chris_99heh03:41
ebowdenIt was to keep the retards away.03:42
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Alcyiuslol03:43
AlcyiusI was gonna say03:43
AlcyiusI just thought they needed to join the channel03:43
ebowdenDespite this, some still got in, despite the great creationist purge of 2012.03:44
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ebowdenFor some reason creationists are always wanting to crash the biology channel.03:45
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streetyFourFire: as quickly as possible get to microscopes so you can write the last 100 years of technological development really small04:02
streetytesting some of those protocols could be really interesting04:03
FourFirestreety, sure.04:03
FourFireor some form of electronic media which is easy to build an interface for04:03
FourFireyou can fit  lot of text even just into 1GB04:04
streetyI'm not sure there is any electronic media with the same robustness, might be wrong though04:04
FourFirestreety, well you could intergrate, say redundant thin film memory into the structure of the book in question04:05
FourFireor maybe even make the cover an e-reader04:05
ebowdenFourFire, streety, does this channel get trolls?04:07
streetyoccasionally some seriously off topic content but I don't remember any ongoing issues with trolls04:08
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ebowdenI seem to recall some anti transhumanist people.04:09
streetythin film memory could work, potentially both electronically and optically readable?04:09
abowdenI think there are some really good, dense new optical tapes about04:10
archelsI will never grasp the point of these "reconstruct all civilisation from scratch" books/efforts04:10
abowdenwhat are you trying to make? an archive of all humanities works?04:10
ebowdenThat's not how you spell it.04:11
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streetyarchels: development tends not to be a linear process, or even a unidirectional process. Securing a record of humanities greatest technological achievements may help speed the recovery from a technological reversal. Prevent technology being lost forever.04:18
streetyAlso, in learning about what got us to where we are you can develop a deeper understanding of the technology enabling further discovery04:19
abowdenone data storage method I know works well as far as longevity and data density goes is quartz glass, if you want to store more than can reasonably store on microfils, hardrives etc04:23
abowdensomething to keep in mind in your design, in preparation for whenever such technology becomes available to the consumer04:24
abowden*microfilms04:24
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archelsstreety: it would be nice if the development of deeper understanding were driven by a future technological goal rather than just documenting the past04:27
archelsalso the technological reversal argument is a little silly, because if all our technology and/or knowledge is destroyed then probably so will these guides04:27
ebowdenAren't they trying to figure out a way to make information such as that more stable in storage?04:30
abowdenarchels why does every last scrap of technology have to be destroyed for such a guide/archive to be valuable?04:31
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abowdenI don´t get it.04:34
archelsyes, a great deal would have to be destroyed before such a guide could be valuable04:36
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archelsfor the actual purpose of rebuilding04:37
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abowdenif even 20% was gone, it would still be valuable to have a means of getting it back04:39
abowdenso you don´t have to build it all again from the ground up04:39
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abowdenyou can just search the database to find out what yo uneed to know04:40
archelsit's already pretty well documented how to rebuild this 20% from whatever remains04:40
archelswhat are you going to do, describe how to build every last human artefact from raw natural resources? what's the point spending all the time and energy?04:41
abowdendocumented where?04:41
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archelsthere's books on how to make stuff. lots of books04:41
abowdenis it all in one place?04:41
archelsplanet Earth?04:42
abowdenstreety, am I correct in presuming this a doomsday provision?04:42
streetyI'm not sure what FourFire had in mind but I don't think it needs to assume a doomsday event04:44
archelsit's probably more decentralised now than it would be if it were all wrapped up in a single guide04:44
abowdencentralising it would be a good thing, ince it would make it a lot easier to access.04:45
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archelshttps://www.youtube.com/watch?v=zb0ayifhuZw04:47
archels.title04:47
yoleauxDavid Prutchi: Construction of Imaging Polarimetric Cameras for Humanitarian Demining - YouTube04:47
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Diablo-D3http://www.nature.com/ncomms/2015/151208/ncomms9997/full/ncomms9997.html05:42
Diablo-D3.title05:42
yoleauxEPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-[beta] oligomers and plaques : Nature Communications : Nature Publishing Group05:42
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FourFire<archels> I will never grasp the point of these "reconstruct all civilisation from scratch" books/efforts06:27
FourFireNot all of civilizatio, just whatever very useful technology suddenly gets lost postapocalypse, if, say 90% of humanity dies out suddenly, you're going to be missing parts of the specialist toolchan06:28
FourFiretoolchain*06:28
FourFireabowden, which biology channel is this, do they do/discuss anything bioinformatics related?06:30
archelslike all the telephone sanitisers and hairdressers suddenly dying out at once, right06:31
FourFirearchels, you just need to kill off enough people for the survivors to have a hard time locating specific knowledge/records to rebuild/keep running advanced technology06:32
FourFirewhat is the us factor for, say, samsung, or intel, or NASA for that matter?06:32
FourFirearchels, my propsition is to build specialized hardened structures which could survive most apocalyptic events which would kill most humans (probably underground bunkers)06:33
FourFirearchels, do you consider telephone sanitization and/or hairdressing to be "very useful technologies" ?06:38
kanzurehttps://www.reddit.com/r/Bitcoin/comments/3x7mrr/gmaxwell_unullc_no_longer_a_bitcoin_committer_on/06:38
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archelsFourFire: I was being sarcastic (cf. HHGG)06:44
archelsI have no qualms with storing data in a hardened structure so that it survives for a long time06:44
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archelsmy argument was against the effort involved in making a sort of massive "re-engineering civilisation for dummies" volume06:45
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sandeepkrany suggestions for a good circuit to measure galvanic skin response06:50
sandeepkri have seen this one06:50
sandeepkrhttps://courses.cit.cornell.edu/ee476/FinalProjects/s2006/hmm32_pjw32/#SHDesign06:50
sandeepkrbut they have nowhere mentioned how they selected the values for the potentiometer06:50
sandeepkr***sorry  the value of resistors for wheatstone bridge06:51
Diablo-D3http://blogs.discovermagazine.com/neuroskeptic/2015/12/17/the-case-of-the-bishop-brain/06:52
FourFirearchels, of course: I don't expect covilization to die, it's not work my time06:52
Diablo-D3sandeepkr: why are you looking to use galvanic skin response? I thought that was very inaccurate06:52
sandeepkrDiablo-D3, just for some educational purpose.but dont want to follow the circuit blindly06:53
Diablo-D3ahh06:54
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sandeepkrDiablo-D3,  btw inaccurate in what sense ?? i dont plan to measure anything specific. just want to try it out. i already have a data logger.06:56
archelsFourFire: or anyone's, imho06:56
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Diablo-D3sandeepkr: if you're under or over hydrated, it can change results dramatically06:57
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Diablo-D3sandeepkr: theres a list of stuff that basically makes it a bit hokey06:57
sandeepkrDiablo-D3,  right.but there will still be a variation.06:57
Diablo-D3which sucks because a ton of sports watches now have that built in06:57
sandeepkrlike what else?06:57
Diablo-D3sandeepkr: sweating also seems to piss them off06:58
Diablo-D3which, again, common component of a lot of _sports_ watches06:58
FourFiresandeepkr, interested in statistical techniques you have for masuring variation, I'm looking to messing around with low quality eeg signals quite soon06:58
sandeepkrDiablo-D3, im not trying to find out anything specific.just want to try it out.06:59
Diablo-D3ahh06:59
* Diablo-D3 goes back to wishing someday a watch one suck ;(06:59
Diablo-D3ms band 2, so close, sooooo close07:00
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sandeepkrDiablo-D3, do you have any clue how the guys in the link i posted above slected the values of resistors for the wheatstone bridge07:00
Diablo-D3sandeepkr: that I can't tell you07:00
Diablo-D3I've never built one07:00
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sandeepkrFourFire, i have been working on a high speed datalogger.have bindings for python.07:01
sandeepkraround 100ksps07:01
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Diablo-D3kilo whats per second?07:02
sandeepkrFourFire, i dint get actually  what you were trying to say about staistical techniques07:02
sandeepkrDiablo-D3, funny where did you see the W in there ? its kilo samples per second07:02
Diablo-D3thats what I was asking07:03
Diablo-D3I said what, not watt =P07:03
kanzuredidn't we ban you07:16
Diablo-D3no?07:17
Diablo-D3and why would you do that?07:17
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FourFiresandeepkr, well with the galvanic response, a temperature change would lead to readings which were all skewed to some extent during the period of time following the temperatue change.07:18
FourFirehow do you account for this07:19
FourFirebecause the readings will still contain the data you want,07:19
FourFireyou just have to be able to interpret a higher average and median of reads for a given period of time as a shift in the zero point07:20
sandeepkrFourFire, do you think it will be problem in a living room?07:23
sandeepkrthe temp change07:23
FourFiresandeepkr, temperature difference is only one example of such a drift07:24
FourFirecause*07:24
FourFireyou'll want to be reading some of the other possible causes but not all of them, I suppose07:24
sandeepkrFourFire,right.that can be be done.07:25
sandeepkri can easily attach other sensors for that.07:25
sandeepkrbut right now, im just curious about taking some reading.07:26
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AlcyiusI think the biggest issue for such an "Ark" project07:44
AlcyiusIs the language barrier07:44
AlcyiusYou have no guarantee that whoever finds it will speak ANY modern day language, let alone the one its in07:44
AlcyiusWhich I guess you could solve by having all the data be stored pictographically07:45
AlcyiusOr by having a Rosetta stone type thing, with a version in every modern language07:45
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kanzuretech tree is a far more critical problem than that.07:53
kanzuretech tree can be made like vlsi where large-scale plans can be used without having someone read a million billion pages of documentation07:53
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kanzurehmm i appreciate that yoleaux replaced "β" with "[beta]" earlier today07:58
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kanzurehttp://mathbabe.org/2015/12/15/notes-on-the-oxford-iut-workshop-by-brian-conrad/08:03
kanzurethis is re: http://www.kurims.kyoto-u.ac.jp/~motizuki/Inter-universal%20Teichmuller%20Theory%20I.pdf08:03
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JayDuggerIsn't that the Japanese mathematician Ted Nelson thinks is Satoshi Nakamoto?08:05
JayDuggerYup, same guy.08:08
pasky.title http://www.nature.com/articles/srep1808708:09
yoleauxA single-nucleotide exon found in Arabidopsis : Scientific Reports08:09
paskyheh, understanding dna is really hard08:10
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nmz787_ihowdy10:12
kanzuregreetings fleshlings10:12
nmz787_iI am trying to open a electrical CAD .brd file... and convert it to kicad... so far I've run the file through TRId and scanned it for file signatures. I used two different sig databases, and one says 100% chance that it is a dBase database file... the other says 50% that file, 50% a MapInfo file10:15
nmz787_iI haven't been able to get anywhere with linux tools like dbf2csv (or is it dbfdump?) or the dbfread python library10:16
kanzuretry using the `file` tool10:16
kanzurealso when in doubt just look at the raw data: hexdump -C myfile.blah10:17
nmz787_inot sure what to do now aside from some bioinformatics type approaches... look for repeats (maybe headers in sections of the file)10:17
kanzureor er, hexdump -C myfile.blah | less10:17
nmz787_iyeah file just says 'data'10:17
nmz787_icat shows some strings, xxd isn't terribly more interesting10:17
nmz787_iidk if hexdump -C is any diff than xxd10:17
kanzureto see strings just use the `strings` tool instead10:18
nmz787_imy hope is that the file actually consists of multiple compressed files or something, with headers and some ASCII in between10:18
nmz787_iand my hope is also that the compressed files unzip to yield ASCII text files10:18
kanzurea-cortesi wrote some interesting binary data file visualization tools which are helpful for figuring out weird data formats10:18
nmz787_ioh, hmm, I wonder if I saw a talk on that recently10:19
kanzureno that was anothe rdude10:20
kanzure... another dude.10:20
kanzure(cantor dust)10:20
nmz787_ii remember some 80s hacker-movie style GUI, with 3D visualizations, and the person rotated the cube and maybe hid some layers and could see bitmap data in some section of the image10:22
nmz787_iyeah cantor dust seems more like what I remember10:23
kanzureyes but cortesi is the one who wrote some lightweight software to do the same thing10:24
kanzurehttp://binvis.io/10:25
nmz787_iand it appears cantor.dust isn't available10:25
nmz787_ithis seems to be a take on cantor.dust as well: https://github.com/wapiflapi/binglide10:25
xrrIf the bytes look like /dev/urandom, I'd guess it's packed or crypted10:28
xrrSo perhaps it would get you somewhere to find a large block of random looking bytes and try to figure out any header in front of the block10:29
nmz787_ibinwalk shows a bunch of files paths which match the extensions of the ASCII strings I could discern (since I know what some of the CAD text files look like already)10:33
nmz787_ibut I don't see it mention anything compressed... though the tool depends on pylzma... so maybe it did decompression itself10:34
nmz787_ineed to try binvis too10:34
nmz787_iit also lists a bunch of DER certificates (x.509)10:35
nmz787_ibut I'm not sure if that is interesting or not (some leaked keys or something???)... maybe mis-detection10:36
nmz787_ihuh binvi.io is some kind of client-side web app10:40
nmz787_ihmm, it reports the file has high entropy in most areas10:41
nmz787_iif anyone wants to look too, download the middle file (.brd) here http://www.intel.com/content/www/us/en/support/boards-and-kits/intel-galileo-boards/000005980.html10:45
xrrI'm failing to find any region that actually looks like packed. Too many 0x00-s everywhere10:50
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nmz787_iyeah... I wonder if the encoding mixes ASCII with number data or something10:57
nmz787_isince this is a PCB layout, I am looking for coordinates of line points or something10:58
kanzure.title https://news.ycombinator.com/item?id=1075139611:03
yoleauxThere's Math.random(), and then there's Math.random() | Hacker News11:03
xrrSo this is a proprietary format of Cadence Allegro right? Perhaps it can export11:07
nmz787_iyeah I don't want to go the export route just yet11:12
nmz787_isince then you'd need that software to get any existing .brd files that are online already11:12
nmz787_iand maybe that's against their license terms or something11:12
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kanzureaurellem: there were some questions from docl in the backlog (around 21:15 in the logs) http://gnusha.org/logs/2015-12-16.log was wondering if you could look12:21
aurellemok12:22
aurellemdocl asked about the "paramagnetic" CPA idea -- yes it's the magnetocaloric effet12:24
aurellem*effect12:24
aurellemand unfortunately, yes you can only get like 0.1°C out of it12:24
aurellemit would be neat if you could get something like 15°C instead, because the magnetocaloric effect is one of the only things I know of that bypasses the surface area / volume problems of tradational organ cooling. It's also about as "instantaneous" as you can get12:25
doclit can't be boosted by ultra high tesla fields?12:26
aurellemI believe that it's a property of how much wider you make the state space of the system by turning off the field12:26
aurellemso you need the right sort of system12:27
aurellemand the best ones only get like 0.1°C right now12:27
fennthe cells alive system doesn't seem to use the magnetocaloric effect12:30
fennit depends on low strength alternating magnetic fields to prevent crystal nucleation12:31
aurellemI don't think that the cells alive system actually works12:36
aurellemtheir paper should have tested the CAS system with the field on vs off12:37
kanzurewhat's the reference for breaking gaussian barrier12:37
aurellembut instead it tested the CAS system with the field on vs a tradational bio freezer12:37
aurellemif anyone has any actually good data on the CAS system I'd really like to see it12:37
aurellemsee for example http://www.sciencedirect.com/science/article/pii/S001122401200028412:38
aurellemas far as I know there's not anything out there that gives clear evidence that CAS works12:39
kanzure.title12:41
yoleauxElectric and magnetic fields in cryopreservation12:41
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doclkanzure: here's the free link http://www.21cmpublications.com/PubFiles/89/2012-ElectricandMagnetic.pdf13:00
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nmz787_ihttps://www.indiegogo.com/projects/dracos-may-be-effective-against-all-viruses13:13
bjonnhbs13:15
nmz787_i.title http://www.sciencedirect.com/science/article/pii/S001122401300428813:17
doclaurellem: can you comment on this? (Ben Best mentioning something he heard at a conference) http://www.evidencebasedcryonics.org/2009/09/13/the-2009-sens-conference/13:17
doclDr. Kletetschka’s approach is based on the idea that if a cryonics patient were perfused with a solution containing gadolinium (nanoparticles would be best), an entire vitrified brain could be cooled uniformly by the magnetocaloric effect.13:17
yoleauxA ferromagnetic model for the action of electric and magnetic fields in cryopreservation13:17
doclit sounds to me like maybe Ben misunderstood, or Gunther was being wildly optimistic.13:18
fennyes, cooled uniformly by 0.1C13:19
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sandeepkrhi kanzure13:27
doclI wonder if some specific kinds of nanoparticle would exhibit the effect at a higher level. more state space to expand into.13:28
fennwhy would nanoparticles be better?13:29
kanzuresandeepkr: yes?13:29
sandeepkrkanzure, there used to be a guy by the name of thomas egi on this and DIYBIO channel.13:30
kanzureindeed13:30
sandeepkrkanzure, is he not coming now a days??13:30
kanzurelast seen 2015-08-1913:31
kanzurelast message 2015-06-2013:31
sandeepkrkanzure, okay thanks.wanted to know some thing about his project.13:31
doclfenn: for surface area reasons, or specific shape/size affecting crystaline properties of some kind13:33
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fennfound this while stalking thomasegi: http://home.arcor.de/positiveelectron/files/biohackflowchart.pdf13:42
AlcyiusHeh13:43
AlcyiusThe ahole who jacked up the toxoplasmosis drug price got arrested for fed security fraud13:43
fennthat's like a rite of passage in his social circles13:44
AlcyiusYeah fair enough13:44
kanzurei suspect that the system design is mostly to blame not for individuals acting in their interest...13:44
kanzurei'm sure he's an asshole but that's irrelevant13:44
AlcyiusThe medical system shouldn't be composed of people "acting in their own interest" when it comes to people's lives13:45
kanzurewe are still lacking a comprehensive pharmaceutical funding pipeline reform plan; lotta "innovation health prize funds" have been proposed but there's a bunch of trouble at the intersection of venture capital and health funds and patents and biotech and medicine..13:45
fenni would settle for something that just got the research results we already have into clinical practice13:46
fenni don't think "pharmaceutical funding" is the problem13:46
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kanzure"nobody is going to spend $200M on this if they can't recoup their costs" is the common argument13:47
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fennpharmaceuticals are what is being funded because that's what VC's can make money on, patentable mass-produced small molecules13:47
fennthe artificially high barriers to certifying a new type of medical treatment are what is the problem13:47
fennonly pharmaceuticals have enough funding behind them to jump that barrier13:48
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kanzureyes would be helpful if basic research costs were not high13:48
fennit's not even the research costs, it's the clinical trials costs13:49
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kanzurehealth insurance? underwriting?13:49
AlcyiusAnd again, I really don't think that "recouping $200m" should be the goal when it comes to saving peoples lives. I get that our current system makes it impossible for anyone but major pharma corps to research new drugs, but maybe the whole profit motivation isn't the best way to do it here13:49
kanzurewhat does that have to do with condemning him as an asshole?13:50
AlcyiusI mean, he's an asshole regardless, that was just a critique of our medical research establishment in general13:50
kanzurealso, that seems contrary to "people shouldn't be acting in their interests"13:50
kanzurehealth is definitely in my own interest. so.....13:51
* kanzure goes away confused13:51
AlcyiusMore, it shouldn't be up to the private sector to research live-saving medical treatment13:51
AlcyiusI mean, by all means they CAN, but there needs to be something more13:51
AlcyiusThough I don't trust the government as it is13:51
AlcyiusBut yeah, the clinical trial and research costs are the biggest barrier13:52
kanzuretoday is not a good day13:53
AlcyiusMeh13:53
AlcyiusSorry I'm not being clear, I'm a bit distracted atm13:53
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Richard_M_Nixon_hrm14:14
Richard_M_Nixon_Interesting channel topic.14:14
Richard_M_Nixon_So some of you know about actual nootropics?14:14
Richard_M_Nixon_I have brain damage from taking zyprexa for a bit over a year now (almost off it)14:14
Richard_M_Nixon_and in the past risperdal14:14
Richard_M_Nixon_also amphetamines from like 10-13 for ADHD and back on thosea gain14:14
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Richard_M_Nixon_any good nootropics for that stuff?14:14
Richard_M_Nixon_I know depakote and lithium are neuroprotective14:15
Richard_M_Nixon_actually together they are neurogenerative14:15
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nmz787_iI feel like my mom was on risperidone and if I'm correct that was the one that gave her some sort of lasting allergies14:23
nmz787_i(whatever it was she was on, it was for off-label neuronal pain... and wasn't effective for her)14:24
CautiousNarwhalhas anyone tried adrafinil?14:28
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kanzure.title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705323/15:30
yoleauxInfluence of Amino Acids, Dietary Protein, and Physical Activity on Muscle Mass Development in Humans15:30
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aurellemdocl: look here: https://en.wikipedia.org/wiki/Magnetic_refrigeration17:39
aurellemI don't quite understand how you would be able to remove the heat from the dipoles once they're inside the brain17:40
aurellemso you would, at best, get only one shot to do this, which wouldn't be enough17:40
aurellemwell unless you were perfusing I guess17:40
aurellembut then you could just cool the perfusate with actual refridgerators17:40
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doclhmm. the particles all would increase in magnetic field as soon as they warm back up due to surrounding fluid being warmer.18:14
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aurellemso lets say you get the particles into the brain slowly, with a strong magnetic field18:15
docltheoretically, that makes a pulse of electromagnetism, i.e. visible or radio spectrum18:15
doclright18:15
aurellemthen you can release the field and it will cool the brain down instantly18:15
aurellembut then you can't do it again18:15
doclright18:15
aurellemand the effect is really small18:15
aurellemeven with the materials that Best is talking about18:16
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aurellemlike with REALLY strong magnets and undre ideal conditions, you MIGHT get 1°C, and that's really stretching it18:17
aurellemwork out the math and see what you get18:17
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doclstill trying to grok the math, had to look up the curly d symbol (and here fenn thinks calculus is useless :P)19:28
docland today I learned the reason I could never put my finger on what greek letter that was, apparently, is because it isn't a greek letter at all, just some french guy's weird cursive version of a d19:31
fennit's a lowercase delta19:31
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doclhttps://en.wikipedia.org/wiki/%E2%88%82 this one19:32
doclcompare to: https://en.wikipedia.org/wiki/Delta_%28letter%29#Lower_case19:33
fennoh the first one hooks over to the left instead of the right19:34
fenni've seen it both ways19:34
doclhttps://en.wikipedia.org/wiki/List_of_mathematical_symbols refers to the left hook one as rounded d. it redirects from https://en.wikipedia.org/wiki/Rounded_d to the unpronounceable unicode link above.19:38
doclright hook one is functional derivative. left hook (rounded d) is partial derivative.19:39
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kanzuregood movie. was fun.22:07
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nmz787_ithat star related movie?22:26
Diablo-D3http://www.cc.gatech.edu/georgia-tech-researchers-demonstrate-how-brain-can-handle-so-much-data22:36
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