| --- Log opened Sat Jan 02 00:00:53 2016 | ||
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| docl | I feel smarter when I take modafinil, fwiw | 01:08 |
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| Jawmare | good nootropic for a first timer? | 01:33 |
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| Diablo-D3 | https://en.wikipedia.org/wiki/HCN_channel#Current_brain-related_research | 01:48 |
| Diablo-D3 | I wish they'd further that research | 01:48 |
| Diablo-D3 | Damnit, I'm doing that thing where I read all of wikipedia | 01:51 |
| Diablo-D3 | https://en.wikipedia.org/wiki/Orexin | 01:51 |
| Diablo-D3 | "Orexin-producing cells have recently been shown to be inhibited by leptin (through the leptin receptor pathway), but are activated by ghrelin and hypoglycemia (glucose inhibits orexin production). Orexin, as of 2007, is claimed to be a very important link between metabolism and sleep regulation." | 01:51 |
| Diablo-D3 | see, I didn't know leptin could do that | 01:51 |
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| juul | kanzure: ? | 02:02 |
| Jawmare | so just ordered some noopept and a-GPC | 02:04 |
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| pbunny | hi | 08:27 |
| pbunny | plz any decent studies on reasons for slowing reaction time in aging people | 08:27 |
| pbunny | e.g. in video games | 08:27 |
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| kanzure | "‘Advances in understanding mechanisms of thalamic relays in cognition and behavior" https://www.researchgate.net/profile/Anna_Mitchell3/publication/268233389_Advances_in_understanding_mechanisms_of_thalamic_relays_in_cognition_and_behavior/links/546df3530cf2b5fc176024f8.pdf | 09:14 |
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| flubromazepam | turns out nefiracetam sorts out a coke comedown | 09:37 |
| pbunny | BS | 09:38 |
| pbunny | never had it | 09:38 |
| flubromazepam | then how could you know? | 09:38 |
| pbunny | did you check whether you took coke with it? | 09:39 |
| flubromazepam | i took nefi after my last line to east the comedown | 09:39 |
| flubromazepam | ease* | 09:39 |
| flubromazepam | along with picamilon | 09:40 |
| pbunny | sry, misread as "causes coke comedown" | 09:40 |
| pbunny | nvm | 09:40 |
| flubromazepam | oohhhh | 09:40 |
| flubromazepam | fair one bro | 09:40 |
| flubromazepam | (Y) | 09:41 |
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| kanzure | scihub is back up at http://sci-hub.cc/ | 11:16 |
| kanzure | https://vk.com/sci_hub https://www.facebook.com/sci.hub.org https://twitter.com/Sci_Hub | 11:18 |
| superkuh | Yay? But was it ever really down? sci-hub.io worked for me over the interim. | 11:18 |
| superkuh | Well, worked as long as I was going over Tor. | 11:19 |
| kanzure | scihub22266oqcxt.onion | 11:20 |
| kanzure | .title http://444.hu/2015/12/03/kutatok-gerillaforradalma-zajlik-a-szabadon-hozzaferheto-tudasert | 11:21 |
| yoleaux | Kutatók gerillaforradalma zajlik a szabadon hozzáférhető tudásért - 444 | 11:21 |
| kanzure | https://knowledgeutopia.wordpress.com/2014/01/22/the-burning-of-library-nu/ | 11:22 |
| kanzure | sci-hub.cc/dns suggests using 31.184.194.81 as a dns server, and sci-hub.club | 11:25 |
| kanzure | http://commons.com.ua/ru/na-znak-solidarnosti-z-resursami-library-genesis-ta-sci-hub/ | 11:26 |
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| superkuh | gigapedia -(replace)-> library.nu -(replace)-> libgen -(split)-> sci-hub ? | 11:28 |
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| kanzure | "current city: Kuala Lumpur" | 11:34 |
| kanzure | wat? "Самая крупная и опасная научная секта на пост-советском пространстве" | 11:39 |
| kanzure | "biggest and most dangerous ? science in after soviet ??" | 11:40 |
| kanzure | some sort of paper recommendation engine thingy https://www.pubchase.com/ | 11:43 |
| kanzure | protocols.io only has 345 protocols? next.. | 11:44 |
| kanzure | http://svpow.com/2013/12/06/elsevier-is-taking-down-papers-from-academia-edu/ | 11:44 |
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| kanzure | more libgen http://serious.freeonsciencelibraryguide.com/ | 11:48 |
| kanzure | ouch there is broken php on this page | 11:48 |
| kanzure | .title http://www.nature.com/news/pirate-research-paper-sites-play-hide-and-seek-with-publishers-1.18876 | 11:51 |
| yoleaux | Pirate research-paper sites play hide-and-seek with publishers : Nature News & Comment | 11:51 |
| kanzure | http://online.golibgen.com/ is a useful redirecter | 11:51 |
| kanzure | https://twitter.com/libgen_project | 11:52 |
| kanzure | http://librusec.ucoz.de/forum/26 | 11:53 |
| kanzure | http://cyberleninka.ru/ http://expaper.cn/ (although i could never figure out how to use expaper... so far.) | 11:54 |
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| kanzure | .title http://custodians.online/ | 12:24 |
| yoleaux | In Solidarity with Library Genesis and Sci-hub | 12:24 |
| kanzure | weird that they are motivating this with complaints about profit margins. i think there are much better reasons to use. | 12:25 |
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| kanzure | buncha translations of that page... http://monoskop.org/log/?p=15700 etc. | 12:26 |
| kanzure | 1K4t2vSBSS2xFjZ6PofYnbgZewjeqbG1TM (scihub) | 12:28 |
| poppingtonic | the fact that they charge at all is the problem? | 12:29 |
| kanzure | yeah i am kinda surprised to see this so poorly argued | 12:31 |
| poppingtonic | let's make a better one, then. | 12:32 |
| kanzure | nah faster to just write good code | 12:32 |
| kanzure | why did it take her that long to bother with tor? http://vk.com/sci_hub?w=wall-36928352_5896 | 12:38 |
| kanzure | that was november 2015 | 12:38 |
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| kanzure | wow marcin emailed me for once | 12:58 |
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| AdrianG | so sci hub is like an elsevier dump or something? | 13:14 |
| kanzure | nah they just have ezproxy passwords | 13:15 |
| kanzure | https://github.com/kanzure/ezproxy-urls/blob/master/urls.txt | 13:15 |
| kanzure | and then scihub proxies over ezproxy proxies | 13:15 |
| kanzure | proxies all the way down | 13:15 |
| AdrianG | oic | 13:15 |
| AdrianG | bless russia and their refusal to enforce copyright | 13:16 |
| kanzure | kuala lumpur is not russia | 13:16 |
| AdrianG | vk.com is a russian website? | 13:16 |
| AdrianG | they are actually in kuala lumpur..? | 13:16 |
| kanzure | alexandra is in kuala lumpur | 13:16 |
| kanzure | (apparently) | 13:17 |
| AdrianG | who's alexandra? sry i just re-connected. | 13:18 |
| kanzure | go away and fuck off | 13:19 |
| AdrianG | why u so rude, srsly? | 13:19 |
| kanzure | if you can't even be bothered to read then why the fuck should i believe that you are going to spontaneously read new messages from me? | 13:20 |
| kanzure | it's a completely fucking unjustifiable position for you to have and i hope you die | 13:20 |
| AdrianG | i will be honest. | 13:20 |
| AdrianG | i dont know how to grep the previous log, actually lol | 13:20 |
| AdrianG | never learned for this client. | 13:20 |
| AdrianG | oic. its sci hub's founder. | 13:24 |
| AdrianG | you could've just said that. | 13:24 |
| kanzure | she already got upset about me doxxing her the first time | 13:25 |
| kanzure | it's a legitimate concern in my opinion. | 13:25 |
| AdrianG | why would you doxx her? | 13:26 |
| kanzure | (although ultimately it wasn't my uncovering that lead them to discovering its operator) | 13:26 |
| kanzure | well at the time i thought it was obvious that she was the only person on the internet with a 90 degree rotated profile pic of her | 13:26 |
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| AdrianG | she is either very naive, or has very rich/well connected parents. | 13:29 |
| kanzure | more likely she was unaware that i would recognize her profile pic again, or that i would remember her from harvard | 13:30 |
| kanzure | or unaware of reverse image search | 13:30 |
| AdrianG | its not about that. | 13:31 |
| AdrianG | that she publically would write letters to a judge about the elsevier lawsuit, etc etc etc | 13:31 |
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| CautiousNarwhal | is there a way to highlight messages on the logs page of the channel? like a java script or something like that? | 13:45 |
| maaku | Yes but Then it wouldn't be text | 13:46 |
| kanzure | i have not found an irc log to html converter that i like.. | 13:47 |
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| kanzure | this is a surprisingly stupid and bad idea https://github.com/mgedmin/irclog2html/blob/cfefff0d191a17cbdab4bab4c99a638ce9d15105/src/irclog2html/irclog2html.py#L631 | 13:53 |
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| pompolic | oh wow | 13:57 |
| kanzure | makes anchor links useless when there are multiple messages in a single time period | 14:00 |
| kanzure | should be using a counter instead | 14:00 |
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| pompolic | or... a library to generate html | 14:05 |
| pompolic | for that matter | 14:05 |
| pompolic | instead of printf | 14:05 |
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| xentrac | kanzure: the profit margins thing makes sense --- the money that universities are obliged to pay to Elsevier is money that they could have paid to adjunct faculty or simply not charged in tuition in the first place | 15:53 |
| xentrac | I mean monopoly power is not bad in itself; it's bad because it has bad effects, which are things like adjunct faculty living in poverty and graduates struggling under student loan debt | 15:54 |
| xentrac | and the causal link there runs through the large profits (and large payrolls!) of the publishing companies that are abusing the monopoly power | 15:56 |
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| kanzure | xentrac: i think a stronger argument would be "yo this is tax payer dollars doing research and intellectual property doesn't seem to make sense, has anyone noticed how the patent system was not designed for any of this" | 16:00 |
| kanzure | and then insert some more complaints about copyright law | 16:00 |
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| xentrac | most people will want to see that intellectual property law causes bad outcomes in order to reject it | 16:01 |
| kanzure | there was a study about this, i mean not about their expectations but rather about the patent system | 16:03 |
| kanzure | http://archive.mises.org/18812/andrew-torrance-patents-and-the-regress-of-useful-arts/ | 16:03 |
| poppingtonic | kanzure: I think they already made that argument, except the detail about patents. | 16:03 |
| kanzure | ugh they changed their site | 16:03 |
| kanzure | aaaa not available http://web.archive.org/web/*/https://mises.org/blog/18812/andrew-torrance-patents-and-the-regress-of-useful-arts | 16:03 |
| kanzure | i hate everyone | 16:03 |
| xentrac | haha | 16:04 |
| xentrac | also patents are not really relevant to sci-hub | 16:04 |
| kanzure | it's relevant to complaining about tax dollars and research | 16:04 |
| kanzure | and closed-access stuff | 16:05 |
| kanzure | i think we have to start manually archiving all linked content in here :| | 16:07 |
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| streety | why manually? | 16:19 |
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| poppingtonic | making sure stuff we link to here is also on the Internet Archive, by requesting that they archive a specific link. Easier on storage costs. | 17:10 |
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| kanzure | manually as in "ourselves" | 17:35 |
| kanzure | internet archive also doesn't do recursion when you request them to save a link | 17:35 |
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| kanzure | what algorithm or method does boston dynamics use? | 17:54 |
| kanzure | also, what is the actual difficulty in bipedalism? calculating centers of mass ? | 17:54 |
| kanzure | .title https://news.ycombinator.com/item?id=10076817 | 18:10 |
| yoleaux | Ask HN: If deep learning is so effective why dont Boston Dynamics robots use it? | Hacker News | 18:10 |
| kanzure | haha | 18:10 |
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| AdrianG | kanzure: i think the difficulty is not so much the center of mass, but detecting slippage/sensors, rebalancing quick enough | 18:51 |
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| kanzure | "A minute analysis (experimental) of the various movements produced by stimulating in the monkey different regions of the cortical centre for the upper limb" (1887) | 20:04 |
| kanzure | apparently there were early motor cortex mapping efforts https://en.wikipedia.org/wiki/Motor_cortex#History | 20:04 |
| kanzure | "The clearest example of the coordination of muscles into complex movement in the motor cortex comes from the work of Graziano and colleagues on the monkey brain.[11][24] They used electrical stimulation on a behavioral time scale, such as for half a second instead of the more typical hundredth of a second. They found that this type of stimulation of the monkey motor cortex often evoked complex, meaningful actions. For example, ... | 20:07 |
| kanzure | ... stimulation of one site in cortex would cause the hand to close, move to the mouth, and the mouth to open. Stimulation of another site would cause the hand to open, rotate until the grip faced outward, and the arm to project out as if the animal were reaching." | 20:07 |
| kanzure | [24] Complex movements evoked by microstimulation of precentral cortex http://www.cell.com/neuron/abstract/S0896-6273(02)00698-0 | 20:07 |
| kanzure | "According to the principle of proper mass, “the mass of neural tissue controlling a particular function is appropriate to the amount of information processing involved in performing the function.[63]”" (Jerison, Harry (1973). Evolution of the Brain and Intelligence) | 20:09 |
| kanzure | but.. shouldn't information processing amounts have a unit of measurement? | 20:09 |
| kanzure | "Enhancements to the motor cortex (and the presence of opposable thumbs and stereoscopic vision) were evolutionarily selected to prevent primates from making mistakes in the dangerous motor skill of leaping between tree branches (Cartmill, 1974; Silcox, 2007). As a result of this pressure, the motor system of arboreal primates has a disproportionate degree of somatotopic representation of the hands and feet, which is essential for ... | 20:10 |
| kanzure | ... grasping (Nambu, 2011; Pons et al., 1985; Gentilucci et al., 1988)." | 20:10 |
| kanzure | cool there is a book called "Textbook of therapeutic cortical stimulation" | 20:11 |
| kanzure | http://librusec.webtalk.ru/ | 20:21 |
| AdrianG | awesome. | 20:27 |
| AdrianG | now we can all learn to swing from tree to tree, just like the gibbons. | 20:27 |
| kanzure | i think librusec is "ЛИБРУСЕК" | 20:27 |
| AdrianG | :o | 20:27 |
| kanzure | something something opds tinyopds http://lib.rus.ec/opds | 20:27 |
| AdrianG | lol hosted in equador, NICE | 20:28 |
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| AdrianG | very nice jurisdiction arbitrage. | 20:28 |
| kanzure | http://booktracker.org/ | 20:30 |
| AdrianG | kanzure: isnt this chat publically logged | 20:32 |
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| AdrianG | kanzure: you will find this interesting. | 20:47 |
| AdrianG | http://downloads.hindawi.com/journals/bmri/2015/814068.pdf | 20:47 |
| AdrianG | .title http://downloads.hindawi.com/journals/bmri/2015/814068.pdf | 20:47 |
| yoleaux | AdrianG: Sorry, that doesn't appear to be an HTML page. | 20:47 |
| AdrianG | doesnt extract from PDFs i guess. | 20:47 |
| AdrianG | Phytochemicals That Regulate Neurodegenerative Disease byTargeting Neurotrophins: A Comprehensive Review | 20:48 |
| AdrianG | very nice review of currently available neurotrophins. | 20:48 |
| kanzure | "Dissociation between mental fatigue and motivational state during prolonged mental activity" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499755/ | 20:49 |
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| kanzure | "The motor cortex communicates with the kidney" http://www.jneurosci.org/content/32/19/6726.long | 20:51 |
| CautiousNarwhal | nice find | 20:51 |
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| AdrianG | kanzure: very nice find on mental fatigue. | 20:58 |
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| kanzure | "Cerebellar networks with the cerebral cortex and basal ganglia" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645327/ | 21:06 |
| kanzure | "The dominant view of cerebellar function has been that it is exclusively concerned with motor control and coordination. Recent results from neuroanatomical, behavioral and imaging studies have profoundly changed this view. Neuroanatomical studies using virus transneuronal tracers have demonstrated that the output from the cerebellum reaches vast areas of the neocortex, including regions of prefrontal and posterior parietal cortex. ... | 21:07 |
| kanzure | ... Furthermore, it has recently become clear that the cerebellum is reciprocally connected with the basal ganglia, indicating that the two subcortical structures are part of a densely interconnected network. Altogether, these results provide the neuroanatomical substrate for cerebellar involvement in non-motor functions mediated by the prefrontal and posterior parietal cortex, as well as in processes traditionally associated with the ... | 21:07 |
| kanzure | ... basal ganglia." | 21:07 |
| Jawmare | so I ordered some noopept and a-GPC.. should I run a GC/MS analysis on it? | 21:07 |
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| Jawmare | before consuming it | 21:08 |
| kanzure | "Prior neuroanatomical approaches for examining cerebro-cerebellar and cerebello-basal ganglia circuits have been hindered by a number of technical limitations. Chief among these limitations is the multisynaptic nature of these pathways and the inability of conventional tracers to label more than the direct inputs or outputs of an area. To overcome these and other problems, neurotropic viruses have been used as transneuronal tracers in ... | 21:08 |
| AdrianG | Jawmare: you have access to mass spec? | 21:08 |
| kanzure | ... the central nervous system of primates (for references and a review, see [10, 138]. Selected strains of virus move transneuronally in either the retrograde or anterograde direction [10]. Thus, one can examine either the inputs to or the outputs from a site. The viruses used as tracers move from neuron to neuron exclusively at synapses, and the transneuronal transport occurs in a time dependent fashion. Careful adjustment of the ... | 21:08 |
| kanzure | ... survival time after a virus injection allows for the study of neural circuits composed of two (2nd order), three (3rd order), or four (4th order) synaptically connected neurons [139]." | 21:08 |
| kanzure | [10] Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. | 21:08 |
| kanzure | [138] Rabies as a transneuronal tracer of circuits in the central nervous system. | 21:08 |
| Jawmare | AdrianG, my uni have a characterization service | 21:08 |
| kanzure | [139] Transneuronal tracing with neurotropic viruses reveals network macroarchitecture. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920982/ | 21:09 |
| Jawmare | or just take an NMR | 21:09 |
| AdrianG | Jawmare: pls do that and tell me your result | 21:10 |
| AdrianG | i am interested in reliability testing of nootropic suppliers. | 21:10 |
| kanzure | gwern might have done this already | 21:11 |
| Alcyius | this is interesting http://arstechnica.co.uk/science/2016/01/reusable-sugar-based-polymer-purifies-water-fast/ | 21:13 |
| Jawmare | AdrianG, just a lowly undergrad... when I am doing my Master/PhD I can use an NMR without supervision | 21:14 |
| Jawmare | when I will* | 21:15 |
| kanzure | "Cerebellar networks with basal ganglia: feasibility for tracking cerebello-pallidal and subthalamo-cerebellar projections in the human brain" https://www.researchgate.net/profile/Marc_Tittgemeyer/publication/251567953_Cerebellar_networks_with_basal_ganglia_feasibility_for_tracking_cerebello-pallidal_and_subthalamo-cerebellar_projections_in_the_human_brain/links/54e376290cf2b2314f5d2ece.pdf | 21:17 |
| AdrianG | kanzure: idk about gwern. but after seeing the mass spec/nmr some of the post | 21:17 |
| AdrianG | quite a few of them sell dirty batches, its obvious. | 21:18 |
| AdrianG | some of the suppliers* | 21:18 |
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| AdrianG | kanzure: how did you develop your interest in modifying neural circuits with viruses/etc? | 21:24 |
| AdrianG | it sounds very much like something vernor vinge wrote in his novels. | 21:24 |
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| kanzure | "The extensive functional coupling of the cerebellar cortex with association neocortical areas likely reflects an expanded role for the human cerebellum in non-motor function. This notion is supported by the finding that the non-motor domain in the cerebellar cortex of great apes and humans has expanded to mirror the enlargement of the prefrontal cortex [54]. Difussion tractography MRI results also provide evidence for corresponding ... | 21:27 |
| kanzure | ... increases in prefrontal contributions to the cortico-ponto-cerebellar system in humans [55]. Interestingly, some association cortical regions that have limited or no known projections to the cerebellum in the monkey (such as ventral area 46 and regions in orbitofrontal cortex, see [1] and Figure 1) show functional coupling to cerebellar cortex in the human. Thus, an expanded array of neocortical areas may interact with the cerebellum ... | 21:27 |
| kanzure | ... in humans." | 21:27 |
| kanzure | [54] Evolution of the cerebellar cortex: the selective expansion of prefrontal-projecting cerebellar lobules. http://web.stanford.edu/class/cs379c/archive/2012/suggested_reading_list/supplements/documents/BalstersetalNEUROIMAGE-09.pdf | 21:27 |
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