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| pasky | https://scholar.google.cz/scholar?hl=cs&q=%22experimental+brian+research%22&btnG= | 03:36 |
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| pasky | noothing for bryan though | 03:36 |
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| Diablo-D3 | [01:58:48] <juri_> it's a lasercutter, and a 3d printer. | 03:40 |
| Diablo-D3 | heh Im going through the log, click and Im like "wait, is that a 3d printer or a lasercutter" | 03:40 |
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| archels | has anyone gone through the NIPS2015 list of papers yet? | 07:06 |
| archels | it's quite... long | 07:06 |
| kanzure | nipswho? | 07:07 |
| kanzure | where are the society for neuroscience 2015 papers? | 07:08 |
| kanzure | http://www.abstractsonline.com/plan/start.aspx?mkey={D0FF4555-8574-4FBB-B9D4-04EEC8BA0C84} | 07:08 |
| kanzure | http://www.abstractsonline.com/plan/Browse.aspx | 07:09 |
| archels | speaking of long lists of submissions | 07:09 |
| archels | not sure if SfN accepts full papers though; NIPS does | 07:10 |
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| archels | https://nips.cc/Conferences/2015/AcceptedPapers | 07:11 |
| kanzure | this list is way too machine-learny | 07:15 |
| kanzure | and also has no links | 07:15 |
| kanzure | "Synaptic Sampling: A Bayesian Approach to Neural Network Plasticity and Rewiring" | 07:15 |
| kanzure | "Memory engram storage and retrieval" (2015) http://www.sciencedirect.com/science/article/pii/S0959438815001270 | 07:22 |
| kanzure | ".. We highlight recent advances catalyzed by memory engram labeling technology." cool | 07:22 |
| poppingtonic | NIPS: Neural Information Processing Systems | 07:23 |
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| kanzure | "Engram technology is based on the experimental fusion of immediate early gene (IEG) labeling and optogenetics. The expression of IEGs, such as c-fos or arc, is a marker of neuronal activity [ 36]. Thus the promoters of IEGs can be co-opted to tag neurons that are active during a given learning experience with an exogenous target protein (Figure 1) [37••]. Temporal specificity of labeling is achieved by engineering the labeling ... | 07:24 |
| kanzure | ... mechanism to be inhibited by administering doxycycline (DOX). When engram cells of the hippocampus dentate gyrus (DG) are labeled during contextual fear conditioning with channelrhodopsin-2 (ChR2) [38], their subsequent stimulation with blue light is sufficient to elicit retrieval of a target contextual fear memory, as measured by conditioned freezing behavior [35••]." | 07:24 |
| kanzure | "Optogenetic mutagenesis in Caenorhabditis elegans" http://www.nature.com/ncomms/2015/151203/ncomms9868/full/ncomms9868.html | 07:26 |
| kanzure | huh... that's a useful technique. | 07:26 |
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| archels | haha they just delivered a replacement for the totally-busted PC they shipped to our office a few weeks ago | 07:32 |
| archels | status: totally busted. hard drive rack came free and bounced around inside the case | 07:33 |
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| poppingtonic | http://media.nips.cc/Conferences/2015/NIPS-2015-Conference-Book.pdf | 07:35 |
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| poppingtonic | kanzure: Here are the links for NIPS 2015 | 07:39 |
| poppingtonic | .title https://papers.nips.cc/book/advances-in-neural-information-processing-systems-28-2015 | 07:39 |
| yoleaux | NIPS 2015 Proceedings | 07:39 |
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| kanzure | .title https://news.ycombinator.com/item?id=10845068 | 11:57 |
| yoleaux | Lumosity fined $2M for deceptive ads of “Brain Training” app | Hacker News | 11:57 |
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| nmz787_i | lol | 12:05 |
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| nmz787_i | those commercials always seemed suspect | 12:06 |
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| kanzure | lots of weirdness here http://slatestarcodex.com/2015/12/27/things-that-are-not-superintelligences/ | 13:14 |
| kanzure | what does he have against iq 90 individuals making space probes? what's so bad about that. | 13:14 |
| kanzure | and for his eight-year-olds, you don't need the eight-year-olds to individually become "smart enough" to beat a chess grandmaster, that's not how the "crowd chess" tournaments work.... | 13:14 |
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| justanotheruser | kanzure: what is the new paperbot alternative again? | 13:44 |
| justanotheruser | could have sworn libgen.ru, but that seems to be something else | 13:44 |
| chris_99 | sci-hub? | 13:45 |
| superkuh | sci-hub.io accessed over Tor is what I've been using lately. | 13:46 |
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| nmz787_i | so i tried getting the dependencies for that brlcad2gcode.sh script, but linuxcnc is required for something and it won't "make install" (compiles fine), thus I think I need to mess with paths | 14:22 |
| kanzure | you could install linuxcnc stuff into a chroot or separate vm or a container. | 14:23 |
| nmz787_i | nah... I think I have a better path forward for a brlcad to gcode with slicer... i'll just do a combination with a rectanguloid, then generate an image of a projection from the Z perspective (either SVG, DXF, or PNG)... | 14:23 |
| nmz787_i | there are PNG to SVG or gcode converters I think | 14:24 |
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| nmz787_i | the thickness of the rectanguloid would be the slice thickness, and its X and Y dimensions would be the max build X and Y dimensions | 14:25 |
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| xentrac | juri_: that's a very nice toy. do you put a honeycomb metal thingy on top of the main surface for laser cutting? | 14:29 |
| xentrac | I thought linuxcnc was an RT-Linux thing for doing real-time control of motors with your parallel port and whatnot | 14:29 |
| xentrac | nmz787_i: going from CSG or BRep to raster would seem to be a wrong-way path on your way to vector G-Code toolpaths! | 14:30 |
| xentrac | I mean maybe you can make it work but it's a lot like printing out an Excel spreadsheet and faxing it to somebody who then OCRs it | 14:31 |
| xentrac | (except kind of worse because you care about dimensional precision) | 14:33 |
| xentrac | if it turns out to be the most expendient path, that is an extremely harsh indictment of our existing code base | 14:33 |
| kanzure | linuxcnc has a bunch of things in it | 14:35 |
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| xentrac | you'd think that the things that are involved in generating G-code would be things that you could apt-get install on any Debian system though | 14:47 |
| xentrac | unless it wants to consult the parameters of your milling machine setup or something | 14:47 |
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| nmz787_i | xentrac: well as long as the rasterized output has enough resolution, it should be OK I think, since the machine itself has some minimal resolution... I am not familiar enough with g-code (especially since I haven't looked at it for a few months) to remember if it specifies discrete points, or some kind of math equation variables (center point and a radius of a circle/arc for example) | 15:14 |
| nmz787_i | even if the latter, the g-code interpreter would still have to crunch those equations back into discrete locations for the stepper motors | 15:14 |
| nmz787_i | so I think as long as the raster output is big enough, I shouldn't notice much if anything | 15:14 |
| xentrac | well, so there are G02 and G03 for circular arcs | 15:15 |
| xentrac | but lots of machines don't support them | 15:16 |
| xentrac | including e.g. the standard RepRap firmware last time I checked | 15:16 |
| xentrac | Marlin does boast arc support | 15:17 |
| xentrac | it's much more common to just use G01 for RepRap stuff, especially since the slicer input is usually STL, at which point you've already reduced everything to straight lines (or rather triangular facets) | 15:21 |
| xentrac | I'm pretty sure that e.g. Grbl and Redeem don't handle G02/G03 arcs, and even though the current mainline RepRap firmware draws a lot from Marlin, I think it doesn't have arc support either | 15:24 |
| nmz787_i | yeah the laser i have uses grbl | 15:29 |
| xentrac | ah good | 15:31 |
| xentrac | I used raster for http://canonical.org/~kragen/sw/dev3/gears/ with some success | 15:31 |
| xentrac | but it was a big hassle | 15:32 |
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| justanotheruser | why do you access sci-hub over tor? Is there an actual significant legal risk? | 15:58 |
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| superkuh | Because they block my home IP and US ssh proxies. | 19:25 |
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| justanotheruser | weird | 19:28 |
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| kanzure | hmph there are no kolmogorov complexity estimates for human or primate motor planning plan complexity | 20:22 |
| xentrac | I am constantly amused by your annoyance that the singularity has not happened yet | 20:24 |
| kanzure | it's incredibly inconvenient | 20:27 |
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| xentrac | well, it has the advantage for you that you're still alive | 20:33 |
| xentrac | better enjoy this human body while you can! | 20:34 |
| AdrianG | are you both singularitarians? | 20:34 |
| kanzure | xentrac: "living" is just yet another one of those ambiguous things | 20:36 |
| AdrianG | kanzure: what happened to those other apes that lived around the time of mitochondrial Eve and Y-chromosome Adam? | 20:40 |
| AdrianG | did they leave any genetic heritage at all, or vanished entirely? | 20:41 |
| xentrac | I am not a singularitarian | 20:41 |
| xentrac | of course they did --- most of our genetic material comes from them | 20:41 |
| AdrianG | how so, if all our maternal lines converge on x-eve, and paternal on y-adam | 20:42 |
| AdrianG | This is the most recent woman from whom all living humans today descend, in an unbroken line, on their mother’s side, and through the mothers of those mothers, and so on, back until all lines converge on one person. | 20:44 |
| AdrianG | converge on _one_ person. so that mtDNA (and its subsequent mutations) is the root of all mitochondrial DNA every human carries | 20:45 |
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| xentrac | Mito-Eve had, let's say, a daughter, who had a son with a man who was not Mito-Eve's son. | 21:22 |
| xentrac | This son had 100% Mito-Eve's mitochondrial DNA. But he also had a quarter of his non-sex-chromosome, non-mitochondrial DNA from his other grandmother. | 21:23 |
| xentrac | That is, his maternal line ran through Mito-Eve. | 21:24 |
| xentrac | But he had lots of genetic material from his other grandmother. | 21:24 |
| AdrianG | sure, but the mtDNA would be derived from mt-Eve only,no? | 21:24 |
| xentrac | Yes. | 21:24 |
| xentrac | Mitochondrial DNA and Y-chromosome DNA are special in that they follow exclusively maternal or exclusively paternal lines, but most DNA is happy to hop back and forth between maternal and paternal lines like a pachinko ball. | 21:25 |
| AdrianG | thats right, but that means most of our DNA is actually from very, very few individuals. | 21:25 |
| xentrac | No. | 21:25 |
| AdrianG | +mutations/shift/etc | 21:26 |
| AdrianG | mtdna = 1? | 21:26 |
| AdrianG | y-chromosome = 1? | 21:26 |
| xentrac | That means that a very small amount of our DNA --- specifically, our Y-chromosomes and mitochondrial DNA --- is actually from very, very few individuals. | 21:26 |
| xentrac | But most of our DNA comes from a wide range of humans. | 21:26 |
| xentrac | That's why we have as much genetic diversity as we do. | 21:26 |
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| xentrac | Mitochondrial Eve was only about five or ten thousand generations back, and Y-Adam even more recently. | 21:27 |
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| xentrac | If we only had five thousand generations of mutations, we'd only have about five hundred thousand mutations. | 21:27 |
| AdrianG | why cant you have multiple mutations? | 21:28 |
| xentrac | You can have multiple mutations. | 21:29 |
| AdrianG | https://en.wikipedia.org/wiki/Most_recent_common_ancestor | 21:29 |
| AdrianG | Assuming that no genetically isolated human populations remain, the human MRCA may have lived 2,000 to 4,000 years ago. | 21:29 |
| AdrianG | the less restrictive the criteria, the closer is the common ancestors, it seems. | 21:30 |
| xentrac | Yes. | 21:30 |
| xentrac | we're 128th cousins! | 21:30 |
| xentrac | but probably not patrilineally and even less likely matrilineally. | 21:31 |
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| AdrianG | that still sounds like speciation events are bottlenecks, really. | 21:34 |
| xentrac | Without a doubt. By definition, really. | 21:34 |
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| AdrianG | so every speciation is a smaller and smaller gene pool? | 21:39 |
| AdrianG | well. i guess depends on how many de-novo mutations happen in between the events | 21:40 |
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| --- Log closed Wed Jan 06 00:00:22 2016 | ||
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