2016-02-06.log

--- Log opened Sat Feb 06 00:00:25 2016
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archelsso I looked a little closer into noninvasive glucose monitors, apparently most if not all of it is vapourware04:10
archelshttp://www.mendosa.com/The%20Pursuit%20of%20Noninvsive%20Glucose,%20Fourth%20Edition.pdf04:10
archels2013 review file:///tmp/diagnostics-03-00385.pdf04:10
archelser04:10
archelshttps://www.google.nl/url?sa=t&rct=j&q=&esrc=s&source=web&cd=10&cad=rja&uact=8&ved=0ahUKEwibxpOZjOPKAhWDHQ8KHZrwDaoQFghbMAk&url=http%3A%2F%2Fwww.mdpi.com%2F2075-4418%2F3%2F4%2F385%2Fpdf&usg=AFQjCNG1iqZhfyy5ymXfG5hokHw4ZUhnFw04:12
archelsso let's get on with developing long-term implants instead04:13
streetysomething I have been considering lately is whether there would be a market for finger stick based diagnostics for anything else04:31
streetyglucose and ketones are as far as I know the only two that are sold in this way04:31
streetythere are the dipstick style measurements as well04:32
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streetyhttps://www.tohoku.ac.jp/en/news/research/non_invasive_measurement_of_blood.html just hit my inbox04:55
streetyalong with "Some People with BMIs Categorizing Them As Overweight or Obese May Actually Be Healthy, Study Suggests" surprise surprise04:56
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archelshmm, so it measures inside the mouth06:38
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kanzurehttp://neuroscience.berkeley.edu/2016-neuro-inspired-computational-elements-workshop/07:08
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streetywhether measuring inside the mouth is the key to good performance or just a new take on the existing vaporware I don't know08:43
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CautiousNarwhalhi09:22
Guest34917archels a friend of mine worked on a startup doing surface contact measurement using Riemann spectroscopy09:28
Guest34917Company went bellyup waiting for regulatory approval, but he claims it worked reliably09:28
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CautiousNarwhaldo you guys think it would be awesome to have an online platform for biohacking? ive been contacted by a startup company to help them build one and i was thinking i'd ask here because you guys are so insightful. what would you guys like to see in an online community for biohacking?09:37
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kanzureknowledge, experience.09:39
kanzuremoney- people who build equipment, people who do things.09:40
CautiousNarwhalkanzure that is exactly what I want. people that do things. Im thinking if the space is made for them they will come. so the platform to have various intellectual tools integrated like visual labs (circuit simulators, molecule editors)...09:43
kanzurenope, spaces are irrelevant; what matters is creating the people.09:44
kanzurethere are millions of spaces already setup, so many people keep creating new forums over and over again, it doesn't work, nobody cares, stop trying and i hate you all09:44
CautiousNarwhallmao09:45
CautiousNarwhalhow do we create the people then?09:45
CautiousNarwhaleducation through online sources only goes so far09:47
kanzurewell i have tried yelling at people a lot, this seems to work part of the time09:47
CautiousNarwhalhaha09:48
kanzurebombs away, http://lists.linuxfoundation.org/pipermail/bitcoin-dev/2016-February/012369.html09:49
JayDuggerDoes that count as yelling at people working part of the time?09:59
archelsGuest34917: get him to release the design as open source and/or just make the damn thing in China and sell it himself10:00
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Guest34917Eh he doesn't own the IP, just an early emplyee10:01
JayDuggerBecause that looked suspiciously like a calm, serious, well-reasoned argument.10:03
chris_99you mean raman spectroscopy Guest34917?10:08
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fenn"GlucoWatch measurements were usually consistent with traditional finger-prick tests, but results different by 30 percent or more one-fourth of the time, especially at low glucose levels."13:15
fennThe company site says that it "shuts off early about 25% of the time." It has "certain problems (for example, dislodging the GlucoWatch from your skin) can cause the system to shut off glucose monitoring completely."13:15
fenni talked with someone who worked at glucowatch and he said it worked13:16
fennthe company had long since gone out of business so there was no reason for him to lie about it13:18
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fennhmm the glucowatch sensor was used up after 13 hours and cost $7.50 so it would have been $5k/year just for continuous measurement13:21
streetyworking only 75% of the time when you need it most is not a fantastic definition of it working13:22
fenni feel like problems with bumping the watch during measurement could have been worked out eventually13:23
streetyit doesn't sound like that is the only issue with the measurements though13:24
fennwow this mendosa guy sure is bitter13:33
fenner, i mean "john l. smith" author of "the pursuit of noninvasive glucose"13:34
kanzure:o "As I said, there are people who have said they will spin up thousands of full nodes to help prevent possible Sybil attacks"13:52
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cluckj2 sensor changes a day for 24 hour coverage?14:12
cluckjthat's nuts14:12
fennnot really14:12
fennit's just not ideal14:12
cluckjthere's site fatigue too, where the skin gets too irritated to use the same spot14:12
fennyes14:13
cluckjthere's a kind of invasive glucose monitor that is out in the UK right now14:14
cluckjhttp://diatribe.org/abbott-freestyle-libre-transforming-glucose-monitoring-through-utter-simplicity-fingersticks14:14
cluckjit doesn't provide the sheer number of data points that something like dexcom does, but it's accuracy is equivalent to a finger stick (apparently)14:16
fenn"The sensor remains inserted for 14 days" yeegh14:17
cluckjit's not so bad14:18
cluckja scab forms around the insertion site14:18
cluckjI usually keep my sensors in for 2+ weeks at a time14:18
streetynot just sensor changes for the glucowatch but two devices are needed for 24 hour coverage. The first 3 hours are unusable apparently14:19
cluckjyucko14:19
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cluckjno wonder it failed14:20
cluckjI didn't realize they made blood ketone meters that work off finger sticks14:22
cluckjthat's great!14:22
cluckjthe urine dipsticks are terrible14:22
fennsummary of why glucowatch failed: https://en.wikipedia.org/wiki/Cygnus_Inc14:24
kanzurewhat does john gilmore have to do with that? what14:25
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cluckjthe "according to the company..." is nice14:25
fennwhat does john gilmore have to do with what?14:25
cluckjwhat?14:26
kanzurewhen did cygnus get into biotech? wtf is this14:26
kanzurehttps://en.wikipedia.org/wiki/John_Gilmore_(activist)14:26
cluckjwrong cygnus14:26
kanzurewhat?14:26
kanzuregod damn it14:26
fenncygnus is a constellation14:26
kanzureugh14:26
cluckj^14:26
fennit's like how samsung and mitsubishi mean the same thing14:27
cluckjarchels, I think long-term implantables are in the pipeline for the companies that make the short-term ones14:29
fennare there really not any implantable wireless glucose sensors?14:30
cluckjthey're all semi-implanted with the sensor in the body and transmitter outside14:30
fennwhy?14:30
cluckjthe reagents on the sensors degrade14:30
streetythe ketone finger sticks are ~$3 each but definitely available, even on amazon and the like14:31
cluckjsome folks have hacked on the dexcom to make the sensors last a month or two, but it really really depends on the particular sensor14:32
cluckjsometimes they last 2 weeks, sometimes they can last for 3 months14:32
cluckjby "make them last" I mean use medical adhesives, tape, and custom software without built-in failure modes14:33
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kanzurehttps://git.wiki.kernel.org/index.php/LinusTalk200705Transcript15:20
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kanzuremore crispr drama http://www.latimes.com/business/hiltzik/la-fi-hiltzik-20160206-column.html16:57
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kanzure"Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System" http://www.cell.com/abstract/S0092-8674(15)01200-318:41
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streetyis there anything actually new in the latimes article? Just a rehashing of the same story doing the rounds for weeks?18:43
streetyany ideas on what the colorful item on the top shelf at the left might be?18:44
kanzureyea same story18:58
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