| --- Log opened Sat May 28 00:00:13 2016 | ||
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| FourFire | I just had a dream about Kanzure: went and visited his lair, he had minions, and used Autistic Savants to do Science, for some reason (my dream version of him) was trying to covince me that I'm just way too lazy, not stupid, like I actually think I am, and could have had everything he has (in the dream) by now | 00:16 |
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| FourFire | I'm going to dig p those forums for large scale biological systems simulation construction now... | 00:17 |
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| abetusk | nmz787, seems a little roundabout to go from 3d polygon geometry to raster back to 2d polygons | 00:29 |
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| maaku | FourFire: your dream sounds accurate. get to work | 03:35 |
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| kanzure | i was talking with someone the other day who was concerned about brain emulation and infinite torture regress stuff | 04:23 |
| kanzure | i think that even if there's enough computational capacity to support that much torture and enslavery, that similar amounts of computational capacity can be used for things that- if you believe in conservation of morality- which could "even things out" i guess. | 04:24 |
| kanzure | e.g. while mass enslavement is probably ungood, you can at least get cool things like endless backups and endless spur-of-the-moment parallelization of yourself or certain groups or crowds towards productive pursuits | 04:25 |
| kanzure | i.o.w the claim is that the benefits might outweigh the negatives of having lots of virtualized torture by sadistic assholes | 04:26 |
| kanzure | and also, that in a singularity scenario with lots of acceleration per unit time, you could also argue that individuals who spend all their computational capacity torturing lots of virtualizations will move less slowly overall compared to folks who use their capacities for other more productive pursuits. | 04:28 |
| kanzure | (especially if computation is not costless) | 04:28 |
| kanzure | with large-scale comparative neuroanatomy (connectomics scanning) we should scan multiple mammalian brains from different species and then factor out the differences because the baseline cognitive ability for most animals is actually fairly high and an interesting starting point. and the differences are probably irrelevant. | 04:34 |
| kanzure | we need a name for connectomics scanning that also includes lots of cycles of antibody labeling + scan + wash. otherwise people are always going to assume folks are talking about connections-only and axons/dendrites/synapses. and even with antibody-labeling i guess folks like russell hanson will be left out re: his synaptic resolution scanning and labeling of receptors/channels. | 04:35 |
| kanzure | for prepared brain slices that have been vitrified and prepared for antibody labeling (or other labeling methods) we should have a standard slice container format that holds the material and also standard physical interconnections for introducing liquids and introducing this kind of standardization can also help with machine design so that you know what the sample specs are. e.g. probably some sort of cartridge format. i would hate to ... | 04:37 |
| kanzure | ... discover that all the connectomics work is using custom physical handling of slices that turns out to be different for each project. what a disaster. | 04:38 |
| kanzure | i wonder if you could do casting of individual slices of neural tissue | 04:41 |
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| kanzure | above when i say "scan multiple mammalian brains from different species" i'm thinking at least 10,000 .. from looking at comparative neuroanatomy literature i'm not convinced that people are doing broad analyses or anything between species or members between multiple species.. in fact it's a little strange that "sequence a thousand human genomes" happened long before low-resolution comparative neuroanatomy since brains are much more ... | 04:44 |
| kanzure | ... physically accessible than DNA. shouldn't folks have looked at this years ago? | 04:44 |
| kanzure | (perhaps everyone was discouraged that structural neuroanatomy would tell us anything between multiple species. and that's a fair assumption i guess. but it doesn't seem like a sufficient reason to not bother.) | 04:45 |
| kanzure | i wonder how hard it is to exert selection pressures on organoids or neural tissue cultures. i assume the problem here is mostly related to reproduction and getting a full pipeline going for creating a new culture from a different/next genome. if this was solved then the microelectrode array neural tissue cultures could be much more rapidly developed to do interesting things. my guess is that unfortunately this process requires growing ... | 04:49 |
| kanzure | ... mice from embryos for multiple weeks and then harvesting and making a tissue culture, which is a lot of ugh and long iteration time. ouch.. | 04:49 |
| kanzure | oh i guess you could do cell transformation things and just electorporate the hell out of neural stem cells in culture... yeah why didn't berger do that. | 04:50 |
| kanzure | anyway the more interesting first thing to select for would be higher neuron resistance to surviving in cell culture. followed by the things that marblestone should have written about in his thesis regarding biocompatibility and other problems of neural interfacing and anything that complicates the tasks of researchers too much (to be fair i think he did write about that, i just don't have reading material in front of me at the moment to ... | 04:53 |
| kanzure | ... confirm). | 04:53 |
| kanzure | re: repairing bad brain scan data for connectomics from yesterday, i can't tell if i sufficiently mentioned that there should be evolutionary search (or random search or other methods) starting from brain scan results. you can also exert selection pressures in simulation to get the scan results to do more interesting things. this would be helpful in the event that you scan brains into computers and then they do almost nothing interesting ... | 04:59 |
| kanzure | ... when emulated. there may be nearby things in design space that suck significantly less. it might also be the case that trivial graph analysis and clustering (made legible for a person to look at) might show obvious problems that a person can guess how to fix to get the emulation to do interesting things. | 04:59 |
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| kanzure | .g picotiter plates | 05:03 |
| yoleaux | kanzure: Sorry, that command (.g) crashed. | 05:03 |
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| kanzure | wait why are micropipette tips often discarded instead of flame washed.. | 05:06 |
| kanzure | when you are done collecting oligo samples from certain wells on a giant plate, you can use the inkjet printhead to deposit wash materials in the wells that have already had samples retrieved from (and therefore discarded). then the travel time/distance until wash can be greatly reduced. still, adding operations like that to dna synthesis will unfortunately slow things down tremendously (my previous estimate was like 1 week~ of pipette ... | 05:09 |
| kanzure | ... movement. are oligos on a giant surface even going to stay stable that long, yeesh). | 05:09 |
| kanzure | if you are doing giant dna arrays to generate aptamer pools for brain component labeling (like channels, receptors, other things) then you should select not only for binding affinity to channels but also how easily the aptamers can be removed from the vitrified brain slice. i'm familiar with techniques for aptamer selection for binding affinity to random things like receptors but dunno about selection for successful watching... or ... | 05:12 |
| kanzure | ... detachment. probably someone has already figured out how to force aptamers to decouple from targets. random guess, heat..... (which might damage vitrified tissue anyway). | 05:13 |
| kanzure | *successful washing | 05:13 |
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| kanzure | .title https://www.youtube.com/watch?v=4jEz03Z8azc | 05:44 |
| yoleaux | First-stage landing | Onboard camera - YouTube | 05:44 |
| kanzure | re: academic publishing, http://bjoern.brembs.net/2016/05/why-havent-we-already-canceled-all-subscriptions/ | 06:05 |
| kanzure | "Host-Symbiont Coevolution in Digital and Microbial Systems" http://etd.lib.msu.edu/islandora/object/etd%3A2442/datastream/OBJ/view | 06:19 |
| kanzure | what the hell is a markov brain | 06:24 |
| kanzure | hmm http://gnusha.org/logs/html2/2015-07-14.log | 06:37 |
| kanzure | er... http://gnusha.org/logs/2015-07-14.log | 06:37 |
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| ybit | https://motherboard.vice.com/read/will-this-fancy-metallic-glue-kill-soldering | 07:24 |
| ybit | http://mio.asminternational.org/amp/201601/files/assets/common/downloads/AMP_DigitalEdition_NovDec.pdf | 07:24 |
| ybit | https://2016.spaceappschallenge.org/awards/global-awards | 07:24 |
| ybit | https://github.com/hamsternz/FPGA_Webserver | 07:25 |
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| maaku | "deep learning hype" = "backpropaganda" | 09:37 |
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| c0rw1n | lol | 09:50 |
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| kanzure | "Ultimate physical limits to computation" http://arxiv.org/pdf/quant-ph/9908043v3.pdf | 13:17 |
| kanzure | "Limits on fundamental limits to computation" http://arxiv.org/abs/1408.3821 | 13:17 |
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| nmz787_i | abetusk: for sure, but I am not sure how to reproduce a slicer otherwise ,at the moment | 16:54 |
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| xentrac_ | I love "backpropaganda" | 17:39 |
| xentrac_ | thanks, maaku | 17:39 |
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| --- Log closed Sun May 29 00:00:14 2016 | ||
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